• The Korean Journal of Physiology
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• v.24 no.1
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• pp.131-144
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• 1990

It is well known that the atrial natriuretic peptide (ANP) has a prepro-hormone of 151 amino-acids which loses their hydrophobic signal peptide to form 126 amino acid prohormone. The whole prohormone is released and then cleaved by proteases into more than one circulating forms. Recently, Winters et al. (1988a, b) reported that high concentrations of N-terminal fragments of prepro-ANP $(26{\sim}55),\;(56{\sim}92)\;and\;(104{\sim}123)$ were detected in human plasma. However, their physiological roles have not been established. The present study was conducted to determine whether the N-terminal fragments of pro-ANP have any effect on the renal function and to compare the effect with those of G-terminal fragments of pro-ANP The results indicate that intrarenal arterial infusions of prepro-ANP $(26{\sim}41),\;(26{\sim}55),\;(56{\sim}92)\;and\;(104{\sim}123)$ induced no significant changes in renal function. Whereas ${\alpha}-human$ ANP $(prepro-ANP,\;124{\sim}151)$ and pro-ANP caused a significant increase in urine volume, renal plasma flow, glomerular filtration rate, urinary excretions of sodium, chloride and potassium, and fractional excretion of sodium. These results suggest that the N-terminal fragments of pro-ANP are ineffective, while the C-terminal fragments retain the natriuretic and diuretic activities.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.11
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• pp.34-39
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• 2009

In this study, we have proposed the random function arbitration method using a random function manager in other to use the merits and overcome the demerits of fixed priority and round-robin, Starvation phenomenon can be generated from the master having low priority in fixed priority method. Also, round-robin method can't give a priority to important master, however, as the proposed random function arbitration method can be random set the rate of fixed priority and round-robin, we can solve the problems of conventional arbitration methods. From TLM simulation, we confirmed that the bus utilization of master could be controled from 32% to 16% and the starvation phenomenon of master could be prevented.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.10
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• pp.1561-1570
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• 1997

This study explores the treatment of the max-value cost function over a parameter interval in parametric optimization. To avoid the computational burden of the transformation treatment using an artificial variable, a direct treatment of the original max-value cost function is proposed. It is theoretically shown that the transformation treatment results in demanding an additional equality constraint of dual variables as a part of the Kuhn-Tucker necessary conditions. Also, it is demonstrated that the usability and feasibility conditions on the search direction of the transformation treatment retard convergence rate. To investigate numerical performances of both treatments, typical optimization algorithms in ADS are employed to solve a min-max steady-state response optimization. All the algorithm tested reveal that the suggested direct treatment is more efficient and stable than the transformation treatment. Also, the better performing of the direct treatment over the transformation treatment is clearly shown by constrasting the convergence paths in the design space of the sample problem. Six min-max transient response optimization problems are also solved by using both treatments, and the comparisons of the results confirm that the performances of the direct treatment is better than those of the tranformation treatment.

• Journal of the Korea Society of Computer and Information
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• v.19 no.8
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• pp.27-34
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• 2014

In this paper, we propose a pupil detection method using hybrid projection function and rank order filter. To reduce error to detect eyebrows as pupil, eyebrows are detected using hybrid projection function in face region and eye region is set to not include the eyebrows. In the eye region, potential pupil candidates are detected using rank order filter and then the positions of pupil candidates are corrected. The pupil candidates are grouped into pairs based on geometric constraints. A similarity measure is obtained for two eye of each pair using template matching, we select a pair with the smallest similarity measure as final two pupils. The experiments have been performed for 700 images of the BioID face database. The pupil detection rate is 92.4% and the proposed method improves about 21.5% over the existing method..

• Journal of Nutrition and Health
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• v.33 no.2
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• pp.134-140
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• 2000

This study was performed to investigate the effects of n-3 fatty acids on renal function in male Sprague-Dawley rats of different ages 5-, 15- and 19-months old. The rats were fed a 20%(w/w) lipid diet containing 10% fish oil, compared with control animals fed a 20% lipid diet without fish oil for 4 weeks. The results were as follows: kidney weights were significantly higher in fish oil-fed rats compared to control rats. Plasma levels of total lipid, total cholesterol, and triglyceride markedly increased, with aging and LDL-cholesterol showing a significantly lower level in fish oil-fed rats than control rats. The urinary protein and glomerular filtration rate (GFR) increased with aging. GFR was higher in fish oil-fed rats. However, urinary protein was the same in the two groups. Renal medulla thromboxane B$_2$(TXB$_2$)tended to be lower in fish oil-fed 19-month-old rats. Urinary TXB$_2$and PGE$_2$were found to be higher proteinuria. Light microscopic examination showed interstitial inflammation, tubular atrophy, interstitial fibrosis and glomerular mesangium increase. Although glomerular sclerosis increased with aging, fish oil in the diet had no effect on histological changes. In conclusion, plasma lipid, urinary protein excretion and renal histological change showed a significant increase with aging. The reduction of TXB$_2$in the medulla and increase of GFR caused by fish oil indicated n-3 fatty acid could affect renal function in line with the hypolipidemic effect.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.5
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• pp.1001-1010
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• 2001

In TLM method, Discrete Green's function ABC have been used when improved the exactness of analyzing in wide frequency band. But this technology has a complicated process to apply absorbing boundary, which means it needs additional numerical analyzing process to obtain discrete Green's function data. so, In this paper, we propose new Green's absorbing layer for simple process to apply absorbing boundary. newly proposed Green's absorbing layer is produced by applying of loss operation, loading discrete Green's function with attenuation. A state of optimum absorbing would be obtained by relation between increasing rate of loss, attenuation constant and length of green's absorbing layer. and then Analysts of waveguide BPF is carried out using Green's absorbing layer within state of optimum absorbing, then this result is in corrective agreement with the result applying traditional discrete Green's function ABC.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2009.04a
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• pp.15-17
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• 2009

The line simplification method based on the turning function is studied in this paper for conversion of ground plan data to geospatial data to update the digital map. This method eliminate vertices effectively by estimating the length and the angle between the vertices based on the turning function which is useful to express the shape of linear feature. As the result, this method shows high shape similarity, high elimination rate of vertices and 100% of satisfaction degree to the drawing rules. Thus this line simplification method is judged to be effective in updating the digital map with ground plans.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.50 no.11
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• pp.532-540
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• 2001

In this paper, we propose a probabilistic tabu search strategy for function optimization. It is composed of two procedures, one is Basic search procedure that plays a role in local search, and the other is Restarting procedure that enables to diversify search region. In basic search procedure, we use Belief space and Near region to create neighbors. Belief space is made of high-rank neighbors to effectively restrict searching space, so it can improve searching time and local or global searching capability. When a solution is converged in a local area, Restarting procedure works to search other regions. In this time, we use Probabilistic Tabu Strategy(PTS) to adjust parameters such as a reducing rate, initial searching region etc., which makes enhance the performance of searching ability in various problems. In order to show the usefulness of the proposed method, the PTS is applied to the minimization problems such as De Jong functions, Ackley function, and Griewank functions etc., the results are compared with those of GA or EP.

• YAKHAK HOEJI
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• v.45 no.2
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• pp.205-213
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• 2001

The dopaminergic receptors were consisted of two distinct subtypes, $D_1$and $D_2$, each having different function. The present study was attempted to investigate the effects of R(-)-2,10,11-trihydroxy-N-n-propylnoraporphine (TNPA), a dopamine $D_2$receptor agonist, on renal function in dog. TNPA (5.0~15.0 $\mu$g/kg), when given into the vein, produced a dose-dependently antidiuresis along with the decrease in osmolar clearance ( $C_{osm}$) and urinary excretion of sodium and potassium ( $E_{Na}$ , and $E_{K}$). It also increased reabsorption rates of sodium and potassium in renal tubules ( $R_{Na}$ , $R_{K}$) without any changes in glomerular filtration rate (GFR), renal plasma flow (RPF) and free water clearance ( $C_{H2o}$). TNPA (0.5~1.5 $\mu$g/kg/min) infused into a renal artery decreased urine flow both in the experimental and the control kidneys. TNPA (1.5~5.0 $\mu$g/kg) administered via the carotid artery also greatly exhibited antidiuresis even at intravenously ineffective doses. Changes of renal function by TNPA given into both the renal artery and the carotid artery were almost the same aspect to those induced by intravenous TNPA. These results obtained from the present study suggest that TNPA produces antidiuresis by increasing the reabsorption rates of electrolytes in renal tubules, mainly distal tubule, through changing of central function.unction.

• Journal of Microbiology and Biotechnology
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• v.19 no.6
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• pp.610-615
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• 2009

As a provirus, polydnavirus has a segmented DNA genome on chromosome(s) of host wasp. It contains several genes in each segment that presumably play critical roles in regulating physiological processes of target insect parasitized by the wasp. A cysteine-rich protein 1 (CRP1) is present in the polydnavirus Cotesia plutellae bracovirus (CpBV) genome, but its expression and physiological function in Plutella xylostella parasitized by the viral host C. plutellae is not known. This CpBV-CRP1 encoding 189 amino acids with a putative signal peptide (20 residues) was persistently expressed in parasitized P. xylostella with gradual decrease at the late parasitization period. Expression of CpBV-CRP1 was tissue-specific in the fat body/epidermis and hemocyte, but not in the gut. Its physiological function was analyzed by inducing transient expression of a CpBV segment containing CpBV-CRP1 and its promoter, which caused significant reduction in hemocyte -spreading and delayed larval development. When the treated larvae were co-injected with double-stranded RNA of CpBV-CRP1, the expression of CpBV-CRP1 disappeared, whereas other genes encoded in the CpBV segment was expressed. These co-injected larvae significantly recovered the hemocyte-spreading capacity and larval development rate. This study reports that CpBV-CRP1 is expressed in P. xylostella parasitized by C. plutellae and its physiological function is to alter the host immune and developmental processes.