• Journal of Pharmacopuncture
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• v.22 no.2
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• pp.115-121
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• 2019

Objectives: The objective of this study was to evaluate antidiabetic activity of Chaturmukha rasa based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase. Methods: Chaturmukha rasa was prepared as per Ayurvedic formulary. Antidiabetic activity was measured in experimentally streptozotocin induced rats. The dose was taken as 45 mg/kg, i.p. The antidiabetic activity of Chaturmukha rasa was compared Triphala Kwatha, a marketed formulation. Further In vitro $\acute{\alpha}$- Amylase Inhibitory Assay, In vitro salivary amylase Inhibitory Assay, In vitro ${\alpha}-Glucosidase$ Inhibitory Assay and In vitro Sucrase Inhibitory Assay was performed with respect to Chaturmukha rasa. The IC50 value was calculated for all the above activity. Results: Streptozotocin with Acarbose showed significant decrease in blood glucose level whereas streptozotocin with Triphala kwatha showed more decrease in blood glucose level than Streptozotocin with Acarbose. The combination of Streptozotocin + Triphala kwatha + Chaturmukha rasa showed a significant decrease in blood glucose level on 21st day. In vitro $\acute{\alpha}$- Amylase Inhibitory Assay the Chaturmukha rasa showed IC50 value $495.94{\mu}l$ when compared with Acarbose $427.33{\mu}l$, respectively. In the ${\alpha}-Glucosidase$ Inhibitory Assay Chaturmukha rasa showed IC50 value $70.93{\mu}l$ when compared with Acarbose $102.28{\mu}l$, respectively. In vitro Sucrase Inhibitory Assay Chaturmukha rasa showed IC50 value $415.4{\mu}l$ when compared with Acarbose $371.43{\mu}l$, respectively. Conclusion: This study supports that Chaturmukha rasa may inhibit diabetes by inhibition of salivary amylase or alpha Glucosidase or sucrase. This may be the mechanism by which Chaturmukha rasa inhibits diabetes. Further this study supports the usage of Chaturmukha rasa for the management of diabetes.

• Journal of Pharmacopuncture
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• v.25 no.4
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• pp.354-363
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• 2022

Objectives: This study aimed to assess the adverse effects of Rasaraj Rasa tablets after repeated oral administration for 180 days in Wistar rats. Methods: Wistar rats were divided into five groups, of which three were treated with 54, 162, and 270 mg/kg body weight of Rasaraj Rasa, respectively, which correspond to one, three, and five times the proposed human therapeutic dose, for 180 days consecutively. The fifth group (satellite) also received 270 mg/kg body weight of Rasaraj Rasa for 180 days. Body weight and food intake were measured weekly. At the end of the study, all rats were sacrificed, and their blood, serum, and organs were collected and examined using hematology, serum biochemistry, gross pathology, and histopathology tests. In contrast, the satellite group was kept for 4 weeks after treatment. Results: No significant treatment-related toxicological findings were observed in the clinical features, body weight, laboratory findings, and pathological findings of the high-dose treated groups, when compared to those of the control group. Conclusion: The no-observed-adverse-effect-level for Rasaraj Rasa in Wistar rats is set at 270 mg/kg body weight.

• Neonatal Medicine
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• v.25 no.3
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• pp.126-130
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• 2018

Parkes Weber syndrome is a rare congenital vascular anomaly, related to the RAS p21 protein activator 1 (RASA1) gene. It is characterized by capillary cutaneous malformations, bony and soft tissue hyperplasia, and multiple arteriovenous fistulas throughout the affected upper or lower extremity. These arteriovenous fistulas can be associated with life-threatening complications such as bleeding, thrombosis, and high output heart failure. In this report, we present a neonate who had a disproportionately hypertrophied left upper limb with port-wine stain, dystrophy of the left humerus, and hypertrophy of the left clavicle on X-ray, and arteriovenous malformation and massive dilatation of the left subclavian artery on magnetic resonance angiography. Exome sequencing analysis revealed a novel heterozygous splicing mutation (c.1776+2T>A) in the RASA1 gene. To the best of our knowledge, this report is the first case of RASA1-related Parkes Weber syndrome in Korea.

• Advances in Traditional Medicine
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• v.3 no.2
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• pp.63-71
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• 2003

The psycho-pharmacological effect of BRHAT VATACHINTAMANI RASA (BVC) an Ayurvedic preparation was investigated, both in animal and clinical models. It was observed that BVC possess a sedative or quitening effect in that it significantly decreased the spontaneous motor activity, and also lowered the exploratory behavior of the amphetamine treated animals. This was further evident by increase in climbing out time and taming effect on animal in isolation induced aggression test. Apart from very high dose it seems have little effect on pentobarbital sleeping time and narcotic analgesic test. The drug BVC increases performance of the animal in forced locomotor test. The effect of VATACHINTAMANI RASA on clinical study was not significant.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.01a
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• pp.245-247
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• 2021

최근 코로나 19로 인하여 온라인 강의가 증가하고 있으며 이를 활용한 학습 분석에 대한 연구가 활발히 진행되고 있다. 본 논문에서는 학습 분석 중 학습 결과에 영향을 미칠 수 있는 학습 활동 데이터를 수집하여 학습 결과를 예측하는 모델을 설계하고자 한다. 예측 모델은 기계학습을 이용하며 이전 학기의 학습 결과 데이터를 학습시켜 학습 결과에 영향을 미치는 학습 활동 데이터를 도출한다. 도출된 데이터를 이용하여 차후 학습자의 학습 결과를 예측한다. 학습 결과를 예측하기 위한 모델로 딥러닝의 DNN을 활용한다. 향후 연구로는 예측한 결과를 바탕으로 학습자의 학습 동기 부여와 학습 지도 방향을 정하는 것이다.

• CELLMED
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• v.10 no.1
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• pp.4.1-4.4
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• 2020

Ayurveda scholars have well described about the physio-anatomical aspect of mammary gland (Stana), physiology of lactation, importance of breast milk (Stanya) in growth and development of baby, various factors affecting the lactation and causing changes in property of milk, Galactogouge (Stanyajanana), and drugs for purification of mother milk (Stanya Shodhana). The recent studies provide evidence for above descriptions of Ayurveda. Breast milk (Stanya) is the nearly complete sole source of nourishment for infants. It has been considered as subsidiary tissue (Upadhatu) of blood plasma (Rasa Dhatu) as it is formed out of Rasa Dhatu (Plasma) and its quality and quantity gets affected by quality of nutrient fraction of food formed after complete digestion (Aahar Rasa). It provides health (Aarogya), strength and immunity (Bala) to the feeding child and gives innumerable beneficial effects like protection against not only acute infections like URTI, diarrhoea but also on chronic illnesses like CVD, metabolic disorders too. The Ayurveda description related to Mammary gland and physiology of lactation still need a better understanding for its implementation on promotion of health. Thus an attempt has been made to compile and analyze the view of Ayurveda scholars on Breast (Stana), Breast milk (Stanya) and physiological aspect of lactation as well as to draw a possible scientific understanding for the relevance.

• Journal of the Semiconductor & Display Technology
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• v.21 no.4
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• pp.14-17
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• 2022

Due to the development of IT technology and the on-going Coronavirus disease, non-face-to-face services have been activated. To overcome the inconvenience of non-face-to-face service, service providers have adopted chatbots as a way to feel like a human being. As the increasing chatbot services, chatbot builders have emerged, which can help non-developers to build them. Although its popularity has increased, its performance evaluation has not been conducted on such chatbot builders. In this paper, we implement a prototype chatbot that classifies hospital departments in the medical field using Dialogflow and Rasa, which are popular chatbot builders. By measuring the accuracy of the chatbot's classification of medical subjects, we evaluated the level of accuracy that the most used chatbot builder can have when they are used to build a chatbot service. The simulation results showed that Dialogflow had 87%, 65%, and 60%, and Rasa did 64%, 70%, and 63% in surgery dermatology, and otolaryngology, respectively.

• Food Science and Biotechnology
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• v.14 no.5
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• pp.645-650
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• 2005

To reduce ammonia-like odor in chondroitin sulfate, longnose skate (Rasa rhina) cartilage was processed by washing, autoclaving, and alkali pretreatments. Content of total volatile basic nitrogen (TVB-N), index of ammonia-like odor, of raw skate cartilage without pretreatment was 254 mg/100 g, whereas those of skate cartilage pretreated with washing and autoclaving increased to 630 and 636 mg/100 g, respectively. TVB-N of skate cartilage pretreated with sodium hydroxide sharply decreased to 15 mg/l00 g at optimal condition of 0.12 M and 3.6 volume of NaOH, as determined by surface response methodology of central composite design for optimization. Alkali pretreatment resulted in 97.6% deodorizing. Washing and autoclaving pretreatments had almost no effect on the yield of chondroitin sulfate (approximately 30%), whereas decreased to 16.0% after alkali pretreatment, showing chondroitin sulfate of skate cartilage as chondroitin sulfate C.

• Journal of Practical Engineering Education
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• v.15 no.1
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• pp.73-80
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• 2023

The advancement of online technology in the 21st century has increased online courses and web-based communication in higher education. This type of education is not limited by time or location and has made it possible to expand university campuses globally and broaden the reach of university education to the general public and students from other universities. Changes such as a decrease in the school-age population and a reorganization of the university structure have also created an opportunity to change the perception of online education. In this paper, we conducted surveys on K University students, high school seniors, and the general public to assess their satisfaction with online courses, identify areas that require massive online courses, and determine students' needs for the operation of massive online courses. The survey showed that K University students are generally satisfied with online courses. However, improvements are needed to ensure a smooth online course-taking environment, increase system uniformity, and enhance the overall online course environment. High school students have a strong preference for natural science and should be offered online courses in subjects such as mathematics and physics as prerequisites to prepare for their major classes. The general public prefers the humanities, which is evident in the purpose of the liberal arts lectures.

• Aerospace Industry
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• s.98
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• pp.36-39
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• 2008