• Title/Summary/Keyword: Ras

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A Study about Finding Optimal Path Using HAS Dynamic Programming (RAS Dynamic Programming을 이용한 최적 경로 탐색에 관한 연구)

  • Kim, Jeong-Tae;Cho, Hyun-Chul;Lee, Kwon-Soon
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2007.12a
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    • pp.226-227
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    • 2007
  • Significant increase of container flows in marine terminals requires more efficient automatic port systems. This paper presents a novel routing and collision avoidance algorithm of linear motor based shuttle cars using random access sequence dynamic programming (RAS DP). The proposed RAS DP is accomplished online for determining optimal paths for each shuttle car.

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Roles of MAPKs in H-ras-induced Invasion and Motility

  • Kim, Mi-Sung;Lee, Eun-Jung;Kim, Hyeong-Reh;Moon, A-Ree
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.119-120
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    • 2003
  • One of the most frequent defects in human cancer is the uncontrolled activation of the ras-signaling pathways. Elevated p21 ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues. infiltration into lymphatic vessels and tumor recurrence, We demonstrate that H-ras, but not N-ras, upregulates matrix metalloproteinase(MMP)-2 expression and induces invasive phenotype in MCF10A human breast epithelial cells. (omitted)

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RAS SIGNALING IN INVASION AND MOTILITY OF MCF10A HUMAN BREAST EPITHELIAL CELLS

  • Kim, Mi-Sung;Lee, Eun-Jung;Shin, Il-Chung;Ahn, Seong-Min;Hyun Song;Kim, Hyeong-Reh-Choi;Aree Moon
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.76-77
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    • 2002
  • Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer including the degrees of invasion and tumor recurrence. Expression of H-, K-, and N-ras is regulated in a tissue-specific manner and during development, indicating that ras proteins may have different cellular functions.(omitted)

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Ras Oncogene Mutations in Urine Sediments of Patients with Bladder Cancer

  • Buyru, Nur;Tigli, Hatice;Ozcan, Faruk;Dalay, Nejat
    • BMB Reports
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    • v.36 no.4
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    • pp.399-402
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    • 2003
  • Early detection of bladder cancer is particularly important since it dramatically affects the survival rates. However, neither urinary cytology nor tumor markers that are currently used are sensitive enough for the early detection of bladder cancer or recurrent disease. The ras genes are frequently mutated in cancer. In this study, we investigated the diagnostic potential of ras mutation analysis in urinary sediments of patients with bladder cancer using a single-strand conformation polymorphism analysis and polymerase chain reaction. Mutation in codon 12 of the H-ras gene was observed in 39% of the patients. Our results indicate that this approach may significantly improve diagnostic sensitivity in detecting bladder tumors.

Reinforcement of Polyethylene Pipes with Modified Carbon Microfibers

  • Petukhova, E.S.;Savvinova, M.E.;Krasnikova, I.V.;Mishakov, I.V.;Okhlopkova, A.A.;Jeong, Dae-Yong;Cho, Jin-Ho
    • Journal of the Korean Chemical Society
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    • v.60 no.3
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    • pp.177-180
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    • 2016
  • The surface properties of carbon microfibers (CMFs) are modified by chemical deposition of carbon nanofibers via the so-called ethylene processing. CMFs and the modified CMFs (MCMFs) are investigated as reinforcement additives to fabricate polyethylene (PE) composites with enhanced mechanical characteristics. The mechanical properties of the PE-MCMF composites are found to be better and favorable for applications under harsh climatic conditions such as those in Siberia. Improved adhesive interaction between MCMFs and PE is responsible for these enhanced mechanical properties.

Structure, signaling and the drug discovery of the Ras oncogene protein

  • Han, Chang Woo;Jeong, Mi Suk;Jang, Se Bok
    • BMB Reports
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    • v.50 no.7
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    • pp.355-360
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    • 2017
  • Mutations in Ras GTPase are among the most common genetic alterations in human cancers. Despite extensive research investigating Ras proteins, their functions still remain a challenge over a long period of time. The currently available data suggests that solving the outstanding issues regarding Ras could lead to development of effective drugs that could have a significant impact on cancer treatment. Developing a better understanding of their biochemical properties or modes of action, along with improvements in their pharmacologic profiles, clinical design and scheduling will enable the development of more effective therapies.

Nozzles from Alumina Ceramics with Submicron Structure Fabricated by Radial Pulsed Compaction

  • Kaygorodov, Anton;Rhee, Chang;Kim, Whung-Whoe;Ivanov, Viktor;Paranin, Sergey;Spirin, Alexey;Khrustov, Vladimir
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09a
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    • pp.368-369
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    • 2006
  • By means of magnetic pulsed compaction and sintering of weakly aggregated alumina based nanopowders the jet forming nozzle samples for the hydroabrasive cutting were fabricated. The ceramics was obtained from pure alumina, as well as from alumina, doped by $TiO_2$, MgO and AlMg. It was shown that the samples sintered from AlMg doped $Al_2O_3$ powder have the best mechanical properties and structural characteristics: relative density ${\sim}0.97$, channel microhardness. - 18-20 GPa, channel surface roughness ${\sim}0.7\;{\mu}m$, average crystallite size ${\sim}1\;{\mu}m$.

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A study of thermolysis of irradiated diamide-containing extraction systems with nitric acid

  • Srvortsov, I.V.;Belova, E.V.;Sokolov, I.P.;Rodin, A.V.;Stefanovsky, S.V.;Mysoedov, B.F.
    • Nuclear Engineering and Technology
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    • v.50 no.8
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    • pp.1421-1425
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    • 2018
  • The dynamics of gas release at thermal oxidation of extraction systems on the basis of diamides of dicarbonic acids in fluorinated sulphones with 14 mol/L $HNO_3$ was investigated. The effect of preirradiation of the mixtures with accelerated electrons on the kinetics of their thermolysis was determined. The mixtures were heated in an autoclave at temperatures of 170 and $200^{\circ}C$ and irradiated using an electron accelerator to absorbed doses of 0.1, 0.5, and 1.0 MGy. It has been shown that no conditions for autocatalytic oxidation at thermolysis of extraction mixtures irradiated up to a dose of 1 MGy were developed.

H$\alpha$ IMAGING AND PHOTOMETRY OF BLUE COMPACT GALAXIES WITH 6-M TELESCOPE

  • NEIZVESTNY S. I.;KNIAZEV A. YU.;LIPOVETSKY V. A.;PUSTILNIK S. A.;UGRYUMOV A. V.;KORABLINA N. B.;ISAENKO V. N.
    • Journal of The Korean Astronomical Society
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    • v.29 no.spc1
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    • pp.77-78
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    • 1996
  • We perfom a large project for complex study of Blue Compact Galaxies (BCGs) with strong star formation, which includes optical spectroscopy, BVR CCD photometry and HI 21 cm radio survey. The most interesting galaxies are studied also with HST and VLA. In the frame of this project we began the study of H$\alpha$ morphology of BCGs with 6-m telescope. We present and discuss here the results for the first 6 galaxies. We found the noticeable variety of forms for H$\alpha$ morphology comparing to broad band images: from very compact HII region in very center of stellar body (Mark 996, possible dwarf post-merger, old galaxy experiencing strong star formation burst), to very extended gas emission encompassing the whole area traced by stars (SBS 0335-052, the most probable young galaxy in formation).

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Increase of Grb2 and Ras Proteins and Expression of Growth Factors in LPS Stimulated Odontoblast-like Dental Pulp Cells

  • Jeong, Soon-Jeong;Jeong, Moon-Jin
    • Applied Microscopy
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    • v.43 no.1
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    • pp.27-33
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    • 2013
  • Inflammatory cells express the inflammatory cytokines and growth factors induced by lipopolysaccharide (LPS). Odontoblasts are located at the pulp-dentin interface and extend their cell processes far into the dentin where they are the first cells to encounter microorganisms or their products. Therefore, this study examined the expression of some growth factors related to the signal pathway, such as growth factor receptor binding protein 2 (Grb2)-Ras in odontoblast-like dental pulp cells, after a treatment with LPS. After 60 minutes, the mRNA and protein expression levels of Grb2 and Ras were higher in the LPS-treated cells than in the control cells. The level of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) mRNA expression was increased significantly to a level similar to that of Grb2 and Ras at 60 minutes. The platelet-derived growth factor-AA (PDGF-AA) mRNA level was expressed strongly in the odontoblast like dental pulp cells without an association with LPS stimulation. Scanning electron microscopy revealed many extensions of the cytoplasmic processes and the number of processes increased gradually at 30, 60 and 90 minutes after LPS stimulation. From these results VEGF and bFGF expression might be induced through the Grb2-Ras signal transduction pathway in LPS treated odontoblasts.