• Biotechnology and Bioprocess Engineering:BBE
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• 제7권3호
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• pp.121-129
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• 2002

Existing methods for optimization of sequences by random mutagenesis generate libraries with a small number of mostly deleterious mutations, resulting in libraries containing a large fraction of non-functional clones that explore only a small part of sequence space. Large numbers of clones need to be screened to find the rare mutants with improvements. Library display formats are useful to screen very large libraries but impose screening limitations that limit the value of this approach for most commercial applications. By contrast, in both classical breeding and in DNA shuffling, natural diversity is permutated by homologous recombination, generating libraries of very high quality, from which improved clones can be identified with a small number of complex screens. Given that this small number of screens can be performed under the conditions of actual use of the product, commercially relevant improvements can be reliably obtained.

• Journal of Chest Surgery
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• 제10권1호
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• pp.44-48
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• 1977

Benign hyperplasia of hilar lymph glands is rare. Most of the lesions were intrathoracic cavity. The lesions were discovered most often on routine roentgenograms of the chest or because. of pressure symptoms or the presence of a palpable mass if outside the thorax. Diagnosis is. made after removal of gland, a procedure which may also have therapeutic value. They have been divided into 2 histol0gic types: the hyaline-vascular lesions, which were, most numerous, were characterized by small hyaline-vascular follicles and interfollicular capillary proliferation ;the plasma cell lesions were characterized by large follicles with! intervening sheets of plasma cells. We experienced one case of benign hyperplasia of lymph gland in left hilum, which were. most numerous, characterized by small hyaline-vascular follicles and interfollicular capillary proliferation-hyaline-vascular type. This 29 years old male patient was treated by right upper lobectomy with excision of lesion. The postoperative courses was uneventful.

• Radiation Oncology Journal
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• 제5권1호
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• pp.43-47
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• 1987

척수의 원발성 흑색종양은 매우 희귀한 것으로 알려져 있다. 이러한 종양의 가장 유효한 치료로서는 가능한 종양을 완전히 제거하는 것이며, 수술 후에 방사선치료를 같이 병행하고 있으나 증례가 적어서 방사선치료의 효과는 아직 잘 알려져 있지 많다. 치료 후 2년 생존율은 $16\%$ 이하로 극히 저조하며, 대부분이 1연 내에 사망하는 아주 예후가 나쁜 종양으로 보고되고 있다.

• 한국병원경영학회지
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• 제21권3호
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• pp.53-64
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• 2016

The study empirically examines the classic hypothesis on resource-based view(RBV) theory, which is the possible relationship between competitive advantage and performance. For the study, we have surveyed 198 hospital administrators in Korea. By testing the hypotheses at conceptual level, a more robust approach, we found that (1) if a hospital possesses and exploits resources and capabilities that are both valuable and rare, it will attain a competitive advantage, and (2) the attaintment of such advantage will enable the hospital to improve its performance. The results may be interest to both academics and practitioners. From an academic standpoint, the study more accurately captures the dynamics of the theory by pairing resources-capabilities as opposed to individual resources or capabilities. From a practitioner perspective, it is suggested that hospital managers need no necessarily seek out novel resources and capabilities, but rather develop novel ways in which to combine those resources and capabilities to which they do have access.

• 한국공간구조학회논문집
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• 제15권3호
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• pp.77-83
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• 2015

The cases of conducting the vibration measurement using the mobile phone with regard to the building's horizontal vibration are very rare in Korea and foreign countries. Therefore, this study analyzed the horizontal vibration nature of the building using the mobile phone targeting 5 tall buildings, and reviewed about the applicability of the mobile phone vibration measuring instrument through the comparison/verification with the data of the existing vibration measuring instrument. The peak of the measured time series waveform was measured clearly and it showed a similar value to the existing natural frequency.

• 한국안전학회지
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• 제24권3호
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• pp.88-95
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• 2009

Most of subway stations are located underground and the number of passengers is far more than that of designed value, therefore the risk of accident is growing bigger and serious damage is expected in case of disaster. In Korea the period of evacuation study is short and numerical and experimental data of evacuation phenomena in subway station is rare. Many egress evaluation depend on foreign commercial S/Ws which are not yet proven its availability in special case such as subway station. In this paper outflow coefficients which are essential in egress evaluation are calculated at train door, stairway and turnstile at 3 most crowed subway stations. This numerical data can be used in prediction of egress evaluation and the result of other prediction methods can be verified with these experimental data.

• 한국임상수의학회지
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• 제1권1호
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• pp.41-47
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• 1984

The author carried out bovine mastitis test by California Mastitis test(CMT) for the milk from dairy cows in the surburbs of Taejeon. In order to select prefer commercial therapeutic antibacterial agents for mastitis treatment, Staphylococcus aureus were isolated from the CMT positive milk and the strains were tested for the tolerance test to the agents. The results obtained were summarized as follows : 1. The tolerance test appeared graduate tolerance in cases with continuously repeat of therapeutic agents. 2. The antibacterial agents revealed strong tolerance were D-and E-ointments. 3. The antibacterial agents revealed suspect tolerance were A-and F-ointments and ampicillin, penicillin, kanamycin and streptomycin. 4. The antibacterial agents revealed non or rare tolerance were B-and G-ointments and chloramphenicol, erythromycin and oxytetracycline. 5, It is concluded that the use of 3-day-interval in turn with antibacterial agents selected by tolerance test may be beneficial.

• 대한기관식도과학회지
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• 제1권1호
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• pp.82-93
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• 1995

Three-dimensional reconstruction of computed tomographic image(3D CT) is a well-established imaging modality which has been investigated in various clinical settings. It is commonly performed in case of congenital or developmental abnormalities, and traumatic fracture of skull and face that requires reconstruction of osseous structure. However reporting the 3D CT in laryngeal or tracheal stenosis is rare and its results are obscure. The authors performed 3D CT in six cases of tracheal stenosis and found diagnostic value of 3D CT. A Comparision of diagnostic information obtained from plain X-ray, 2D CT and 3D CT has performed in total six cases of tracheal stenosis. Surgical treatment of the tracheal stenosis was following in these cases : tracheal end to end anastomosis In 1 case, laryngotracheal end to end anastomosis in 2 cases. 3D CT information was compared with operative finding. In two of six cases, satisfactory information was not obtained from 3D CT in evaluating an exact stenosis of trachea. Future, it will be helped in evaluating of tracheal stenosis by 3D CT.

• Investigative Magnetic Resonance Imaging
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• 제23권4호
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• pp.381-384
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• 2019

Spontaneous intracranial hypotension (SIH) can be a rare risk factor of cerebral venous thrombosis. We describe a case of isolated cortical vein thrombosis (CVT) secondary to SIH and discuss the value of susceptibility-weighted imaging for the detection of isolated CVT.

• Journal of Electrical Engineering and Technology
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• 제9권3호
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• pp.942-949
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• 2014

We studied about the rotor design change using a Ferrite ring magnet to reduce material cost in the condition of the same stator core design. However, this design direction has many weak points such as the decrease of BEMF, the low maximum output, the irreversible demagnetization characteristics of a permanent magnet and so on. In order to mitigate such disadvantages, an optimization design of the BLDC motor has been developed by changing each design parameter and by improving the electromagnetic structure. In the proposed water pump SPM BLDC motor using Ferrite magnet, the outer and inner diameter of stator is fixed to the value of the conventional IPM BLDC motor using Nd-Fe-B magnet. The design specification requirements should be satisfied with the same output power and efficiency characteristics in the same dimension. As a result of this study, the design comparison results considering driving performances and material cost are represented. Through the actual experiment with the prototype of the designed motor, the simulations results are verified.