• 대한후두음성언어의학회지
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• 제11권1호
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• pp.5-11
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• 2000

Background and Objectives : Tongue-tie, or partial ankyloglossia, is manifested by an abnormally short and thick lingual frenulum. Degree of tongue-tie varies from the mild to the rare, severe and its treatment of choice is frenulotomy. Theoretically tongue-tie can affect expression of alveolar sounds. The purpose of this study is to evaluate the degree of articulation problem and to evaluate the efficacy of frenulotomy itself on alveolar sounds in tongue-tie patients. Materials and Methods : Prospectively, the authors performed preoperative and postoperative speech evaluation using picture consonants test for tongue-tie patients. Percentage of consonants correct(PCC), mean value of each alveolar phoneme depends on articulation site were evaluated. for exclusion of other articulatory improving factors except of frenulotomy itself, postoperative picture consonants test was performed 1 month after surgery. Results : Preoperative speech evaluation was performed to 37(male 21, female 16) patients and postoperative speech evaluation was performed to 17(male 9, female 8) patients, the other 20 patients were follow-up loss. Low PCC was observed in tongue-tie patients and PCC of female was higher an at of male in 2-4 years old patients. Overall PCC was improved after frenulotomy. Preoperative mean value of liquids and fricatives was lower than the other alveolar phonemes(p＜0.05) and it was improved postoperatively(p＜0.05). Conclusion : Frenulotomy itself can improve the articulation of liquids and fricatives on short follow-up. Speech therapy would be needful for improvement of the other alveolar phonemes.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7443-7447
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• 2014

Aim: Little is known about the genetic associations with Basal cell carcinoma (BCC) risk in non-Caucasian populations, in which BCC is rare, as in Korea. We here conducted a pilot genome-wide association study (GWAS) in 12 patients and 48 standard controls. Method: A total of 263,511 SNPs were analyzed with the Illumina HumanOmni1 Quad v1.0 DNA Analysis BeadChip for cases and Korean HapMap 570K for controls. Results: SNP-based analyses, based on the allele genetic model with adjustment for sex and age showed suggestive associations with BCC risk for 6 SNPs with a P-value (P < 0.0005). However, these associations were not statistically significant after Bonferroni correction: rs1040503, rs2216491, rs13407683, rs4751072, rs9891263, and rs1368474. In addition, results from gene-based analyses showed suggestive associations with BCC risk for 33 candidate genes with a P-value (P <0.0005). Consistent with previous GWAS and replication studies in Caucasian populations, PADI6, RHOU and SLC45A2 were identified as having null associations with BCC (P > 0.05), likely due to the smaller sample size. Conclusions: Although this was a small-scale negative study, to our knowledge, we have conducted the first GWAS for BCC risk in an Asian population. Further large studies in non-Caucasian populations are required to achieve statistical significance and confirm these findings.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2711-2715
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• 2013

Background: Cancer of the gallbladder is a relatively rare neoplasm with a poor prognosis. The exact mechanisms of its genesis are not known and very little information is available on molecular events leading to labeling this as an orphan cancer. Materials and Methods: In this prospective case control study we evaluated the expression of p16, pRb and cyclin D1 by immunohistochemistry to study the G1-S cell-cycle check point and its possible role in gallbladder carcinogenesis. A total of 25 patients with gallbladder carcinoma (group I), 25 with cholelithiasis (group II) and 10 normal controls. were enrolled Results: Cyclin D1 expression was seen in 10 (40%) patients each with carcinoma and cholelithiasis while only in 2 (20%) of the normal gallbladders but differences were not statistically significant (p value=0.488). p16 was expressed in 12% patients of carcinoma of the gallbladder and 28% of cholelithiasis, however this difference was not statistically significant (p value=0.095). Retinoblastoma protein was found to be expressed in 50% of normal gallbladders and 6 (24%) of carcinoma and 8 (32%) of gallstones. The present study failed to demonstrate any conclusive role of cyclin D1/RB/ p16 pathway in carcinoma of the gallbladder. Conclusions: The positive relation observed between tumor metastasis and cyclinD1 expression and p16 with nodal metastasis suggested that higher cyclin D1/p16 expression may act as a predictive biomarker for aggressive behavior of gallbladder malignancies.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1107-1110
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• 2013

Intrahepatic cholangiocarcinoma (ICC), one of the primary liver cancers, is frequent in the northeastern part of Thailand. Surgical resection remains the best method of treatment, but patients suffering from ICC usually present at a late stage of the disease. Studies of survival and prognostic factors after surgery remain rare. The aim here was to evaluate the survival rate and factors affecting the survival of patients with intrahepatic cholangiocarcinoma after surgery. The study used a retrospective cohort design. The subjects were 73 consecutive patients with ICC, who were admitted for surgery to Srinagarind Hospital, Khon Kaen University, during the period 2005-2009. The censoring date was 31 December, 2011, data being evaluated using uni- and multivariate analyses. Postoperative survival analysis was performed by the Kaplan-Meier method, and the Cox proportional hazard model was used to identify independent prognostic factors. The total follow-up time was 99 person-years. The total number of deaths was 59, giving a mortality rate of 59 per 100 person-years. The cumulative 1-, 3-, and 5-year survival rates were 52.1%, 21.7%, and 11.2%, respectively. The median duration of survival after resection was 12.4 months. Univariate analysis revealed stage of disease, lymph node metastasis, histological type, histological grade and macroscopic classification to be statistically significant (p-value<0.05) prognostic factors. In the multivariate analysis, only macroscopic classification was statistically significant (p-value<0.05). In conclusion, macroscopic classification was the only independent factor found to be significantly associated with survival following surgical treatment of ICC.

• 유기물자원화
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• 제24권3호
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• pp.101-108
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• 2016

경기도 포천시 하수처리장에서 수처리후 탈수된 몇 가지 유기성 슬러지내 크롬과 망간 농도에 대하여 조사하였다. 또한, 슬러지 급이량 변화에 따른 줄지렁이(Eisenia fetida) 체내 크롬과 망간의 생물축적에 대하여 고찰하였다. 유기성 슬러지내의 크롬과 망간 농도는 각각 0.0~0.3 mg/kg, 3.6~17.6 mg/kg를 나타내었기에, 이러한 중금속 농도들은 지렁이 개체군에 대하여 급성독성을 유발시키지 않는 것으로 판단되었다. 그리고, 슬러지 급이량 증가에 의하여 지렁이 체내에 크롬의 생물축적이 이루어졌으나 슬러지 공급량에 비례해서 크롬 농도가 증가하지 않았으며, 일정한 농도로 유지되다가 감소하는 경향을 나타내었다. 한편, 망간에 대해서는 생물축적이 거의 일어나지 않았다. 본 실험으로부터 60 g의 슬러지를 공급하였을 때, BAF 값은 망간의 경우 0.00~0.12이었으며, 인분슬러지를 주입하였을 때 BAF 값은 크롬의 롬 경우 19.33를 나타내었다.

• 한국IT서비스학회지
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• 제2권2호
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• pp.15-29
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• 2003

This thesis suggests a R&D model for Korean SI companies who aggressively drive oversea business to overcome domestic market limitation and to become world class SI players. Even though there have been a lot of discussions on IT technologies and new business models, scientific approach to a R&D model for SI companies is rare due to its natural distinctiveness from manufacturing and general service domain. Therefore, this will be a flagship thesis to keep up our study. As business market environment gets more competitive, major Korean SI players will be confronted with much more keen competition among themselves. And as they are willing to expand their oversea market presence, they can not help struggling against global SI players. So, here we are presenting SI players the reinforcement of R&D as one of the key components to build up their own core competencies. That is, SI players have to adopt and evaluate fast changing and complicated IT technologies at the right time, and to apply them into a real business with cost-effective service delivery and operation processes internally. The ultimate purpose of all of these activities is to offer a SI company the value added business model based on its innovative technical capabilities and well refined service deliver model. For this purpose, we suggests, SI company's R&D has to play an important role of emerging technology verification/evaluation/utilization, value added business model creation, future innovation lead, standard body participation, and effective service delivery and quality system development. To become a more effective R&D organization, hybrid R&D, in which central R&D and divisional sub R&D work together, is considered as an idea model. The reliability of the R&D model for Korean SI companies', here we suggest, has been checked by SI companies R&D specialists and on-site business people.

• 한국세라믹학회지
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• 제37권7호
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• pp.705-712
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• 2000

In this study, the dispersion stability of CeO2 based complex oxide was studied, and density, porosity, and microstructure of green body were investigated using colloid surface chemistry to manufacture the Gd2O3 doped CeO2 solid electrolyte in an aqueous system. To prepare the stable slurry for slip casting, the dispersion stability was examined as a function of pH using ESA(electrokinetic sonic anplitude) analysis. The dynamic mobility of particles was enhanced with anionic and cationic dispersant were added the amount of 0.5wt% respectively, but pH value in slurries didn't move to below 6.0 because of the influence of dopants. This phenomenon also appeared in the CeO2-Y2O3 and CeO2-Sm2O3 systems, so it could be inferred that rare earth dopants such as Gd2O3, Sm2O3 and Y2O3 not only have the similar motion with changing pH in an aqueous system but also can be dissolved in the range of pH 6.0∼6.5. In CeO2-Gd2O3 system, when the anionic dispersant was added the amount of 0.5wt% and pH value in slurries was fixed at 9.5, the green body density was 4.07g/㎤, and the relative density of sintered body was 95.2%. It could be inferred from XRD analysis that Gd3+ substituted into Ce4+ site because there was no free Gd2O3 peak.

• Archives of Plastic Surgery
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• 제32권5호
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• pp.619-624
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• 2005

Patency of the radial artery plays an important role in the survival of radial forearm fasciocutaneous free flap and artery conduit of coronary artery bypass graft procedure. Even though Allens' test has been used for evaluating the patency of radial artery, the studies on the correlations between risk factors for atherosclerosis and histopathologic findings of radial arteries are rare, until now. Therefore, the authors investigated the correlations between these two factors, and tried to estimate the feasibility of the radial artery in high-risk groups for artherosclerosis. The risk factors for atherosclerosis and lipid profiles were investigated in 38 patients by history taking, physical examinations and blood analysis. And 38 cases of segments of vessel were harvested during the elevation of the flap. The degrees of vessel medial sclerosis were estimated by R values(by Kobayashi and colleagues) that is the median value between the thickness of the intima and that of the media. The measured mean R value was $0.210{\pm}0.05$. Thirty one cases belonged to Grade I(R<0.25), 7 cases belong to Grade II(0.25

• 대한영상의학회지
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• 제79권6호
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• pp.348-353
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• 2018

간의 가성 림프종은 비종양성 림프구의 절 외 과다증식에 의해 형성되는 드문 양성 종양이다. 검색한 바에 따르면 현재까지 영문으로 46예가 보고되었다. 우리는 75세 여자환자에서 과혈관성 종양으로 오인된 간의 가성 림프종 증례를 보고하고자 한다. 조직검사상 직장의 신경내분비 암종이 진단된 후 시행한 조영증강 전산화단층촬영에서 1.0 cm 크기의 경계가 불분명하고 낮은 감쇄를 보이는 결절이 간에 관찰되었다. 자기공명영상에서는 동맥 조영기에 조영 증강을 보이고, 20분 지연기 조영 영상에서 저신호 강도를 보이며, 확산강조영상에서 고신호 강도를 보였다. Fluorodeoxyglucose (이하 FDG) positron emission tomography (PET)/CT에서는 FDG의 섭취 증가를 보였다. 초음파에서는 저에코성 병변으로 관찰되었고, 초음파 유도 하 조직검사를 통하여 간의 가성 림프종으로 확진 되었다.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제25권4호
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• pp.459-475
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• 2022

등호와 동치는 초등 수학에서 가장 기본적이면서도 핵심적인 필수 개념이지만 이를 지도하는 구체적인 방안에 대한 연구는 드물다. 이에 본 연구에서는 등호 및 동치를 강조하여 지도하기 위한 교수·학습 요소(관계적 기호로서 등호의 의미 강조하기, 등식을 추론의 대상으로 다루기, 미지수가 포함된 등식 활용하기)를 중심으로 초등학교 수학 교과서를 분석하였다. 특히 본 연구에서는 2022년부터 적용된 2015 개정 3~4학년군 검정교과서 10종을 분석하여 등호 및 동치를 지도하는 방안에 대해 전반적인 경향성과 특징을 살펴보았다. 그 결과, 2015 개정 3~4학년군 검정교과서에서는 전반적으로 관계적 기호로서 등호의 의미를 강조하는 활동이 가장 많이 구현되었고, 등식을 추론의 대상으로 다루거나 미지수가 포함된 등식을 활용하는 활동은 드물었다. 분석 결과를 중심으로 초등학교 수학 교과서에서 등호 및 동치를 의미 있게 지도하는 방안에 대한 시사점을 논의하였다.