• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.86-87
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• 2002

Recent technological innovations in the drug discovery process such as combinatorial synthesis and high throughput screening have led to the identification of an increasingly large number of compounds at the hits-to-leads stage. Therefore, rapid and precise pharmacokinetic/metabolic screening is essential to enhance the tractability of selected leads and to minimize the risk of failure in the later stages of drug development. (omitted)

• 대한교통학회:학술대회논문집
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• 대한교통학회 1998년도 제33회 학술발표회
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• pp.39-73
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• 1998

• 교통기술과정책
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• 제7권4호
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• pp.57-65
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• 2010

• Bulletin of the Korean Chemical Society
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• 제17권7호
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• pp.575-577
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• 1996

• 한국지리정보학회지
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• 제15권4호
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• pp.26-41
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• 2012

지구온난화와 함께 홍수와 가뭄 등 기후변화에 대비하기 위해서는 경지현황에 대한 신속하고 정확한 정보를 바탕으로 농업생산량을 효율적으로 관리, 예측, 대비하는 것이 필요하다. 본 연구는 시 도 규모 이상의 넓은 지역을 대상으로 농촌지역 토지피복도 제작을 지원할 수 있는 영상분류 알고리즘 개발을 목표로 객체기반 영상분석기법의 활용가능성과 한계를 검토해 보았다. 추가적인 공간자료의 사용이 최소화된 상태에서 다중시기 RapidEye 위성영상의 분광정보 활용가능성을 테스트해 보고자 하였으며, 사례연구지인 김제지역 일대($1,300km^2$)에 대한 토지피복 분류 정확도는 80.3%로 양호하게 나타났다. 분석에 사용된 RapidEye의 6.5m 공간해상도는 대체로 작은 규모로 경작되는 우리나라 경지의 공간적 특성 추출이 가능하다는 것을 보여주었으며, 객체기반의 영상분석 기법은 분석가의 전문지식을 분류과정에서 다양한 방법으로 구현해냄으로써 영상정보 활용의 최적화를 꾀할 수 있음을 보여주었다. 또한, 기개발된 영상분류 알고리즘을 저장하고, 분석목적에 맞게 세부 변수들을 조정하여 다른 지역 또는 다른 영상에 응용할 수 있다는 장점이 있다. 하지만, 객체기반 영상분류의 근간이 되는 영상분할 과정은 정량적으로 명확히 설명되지 않는 경우가 많아 분석자의 경험과 전문지식을 바탕으로 최선의 결과를 도출하는 것이 요구된다.

• 농업과학연구
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• 제39권1호
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• pp.97-110
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• 2012

This study was carried out for safety evaluation, the practical application and improvement of design method of the agricultural reservoir embankment according to backside extension. Seepage analysis, slope stability analysis and finite element analysis were performed for steady state and transient conditions. Also, the pore water pressure, seepage quantity, safety factor and stress-strain behavior according to high water level and rapid drawdown were compared and analyzed. The pore water pressure at contact region between backside extension and old embankment was kept high after rapid drawdown. Therefore, backside extension is recommended that design method is required to be improved and reinforced more than the others raising embankment. The hydraulic gradients before and after backside extension showed high value at the base of the core, but they showed stable state at the upstream slope and downstream slope. The seepage quantity per 1 day and the leakage per 100 m for the steady state and transient conditions appeared to be safe against the piping. The safety factor of slope stability showed high at the steady state, and transient conditions did not show differences depending on the rapid drawdown. The safety factor was appeared high at the upstream slope before backside extension and downstream slope after extension. The excess pore water pressure for steady state and transient conditions showed negative(-) at the upstream slope, it was small at the downstream slope. The mean effective stress (p') showed high at the base of the core and to be wild distribution after the extension. The displacement after extension showed 0.02-0.06 m in the upstream slope, the maximum shear strain after extension was smaller than that before extension.

• 분석과학
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• 제24권4호
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• pp.266-274
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• 2011

Hitachi LaChromUltra 2000U를 사용하여 역상의 초고속액체크로마토그래피 방법으로 식품 중의 PAHs 14종을 신속하게 분석하는 방법을 개발하였다. PAHs분석을 위한 방법은 solid phase extraction (SPE)법에 의한 정제 후 u-HPLC를 사용하여 형광검출기로 분석하였다. 이 분석법은 감도가 매우 좋았으며, 식품 중의 PAHs를 ${\mu}g$/kg수준에서 분석이 가능하였다. 6개의 시료를 분석한 결과 모든 시료에서 PHE가 검출되었고, 그 함량은 2.5~19.9 ${\mu}g$/kg이었다. Benzo[c]fluorine (BCL), pyrene (PYR), benzo[a]anthracene (BaA), chrysene (CHR), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF) 이 ${\mu}g$/kg이하의 농도에서 검출되었으나 그 농도는 모두 정량한계 이하이었다.

• Plant Biotechnology Reports
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• 제3권1호
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• pp.87-93
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• 2009

To determine whether pattern recognition based on metabolite fingerprinting for whole cell extracts can be used to discriminate cultivars metabolically, leaves and fruits of five commercial strawberry cultivars were subjected to Fourier transform infrared (FT-IR) spectroscopy. FT-IR spectral data from leaves were analyzed by principal component analysis (PCA) and Fisher's linear discriminant function analysis. The dendrogram based on hierarchical clustering analysis of these spectral data separated the five commercial cultivars into two major groups with originality. The first group consisted of Korean cultivars including 'Maehyang', 'Seolhyang', and 'Gumhyang', whereas in the second group, 'Ryukbo' clustered with 'Janghee', both Japanese cultivars. The results from analysis of fruits were the same as of leaves. We therefore conclude that the hierarchical dendrogram based on PCA of FT-IR data from leaves represents the most probable chemotaxonomical relationship between cultivars, enabling discrimination of cultivars in a rapid and simple manner.

• 산업기술연구
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• 제21권B호
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• pp.249-256
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• 2001

The purpose of this study was to remove the excessive air foaming which was produced in mixing the RSLMC(latex-modified concrete with rapid-setting cement) by choosing the best antifoam agent type. A series of RSLMM(latex-modified mortar with rapid-setting cement) experiments were carried out as a basic experiments for RSLMC with the main experimental variables such as antifiamer types(A, B, C, D), antifoamer contents(0, 1, 2, 3%), and latex contents(10, 15%). Air content test and compressive strength tests were carried out to measure the improved properties of RSLMM. SEM analysis, also, was carried to observe the formation of latex film. The results of RSLMM showed that the decrease of 50% air content was obtained by admixturing an antifoam agent by 1%. This made the strength enhanced and the workability be within the purposed. The best properties of compressive strengths was obtained at latex content of 15% and D antifoam agent of 1%. compressive strength increased about 32.6%. The analysis of SEM results no difference in a formation of later film.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권4호
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• pp.366-375
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• 2001

Bone shaving for surgical correction is general method in facial asymmetrical patient with fibrous dysplasia. Therefore, decision of bone shaving amount on the preoperative planning is very difficult for improvement of ideal occlusal relationship and harmonious face. Preoperative planning of facial asymmetry with fibrous dysplasia is generally confirmed by the simulation surgery based on evaluation of clinical examination, radiographic analysis and analysis of facial study model. However, the accurate postoperative results can not be predicted by this method. By using the computed tomography based RP(rapid prototyping) model, simulation of facial skeleton can be duplicated and 3-dimensional simmulation surgery can be perfomed. After fabrication of postoperative study model by preoperactive bone shaving, preoperative and postoperactive surgical index was made by omnivaccum and clear acrylic resin. Amount of bone shaving is confirmed by superimposition of surgical index at the operation. We performed the surgical correction of facial asymmetry patients with fibrous dysplasia using surgical index and prototyping model and obtained the favorable results.