• Korean Journal of Veterinary Research
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• v.29 no.4
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• pp.461-467
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• 1989

The activity of lactate dehydrogenase in plasma and various tissues(skeletal muscle, cardiac muscle, liver, lung, kidney and spleen) of Korean native cattle in a Chonju abattoir, the Breeding Stock Farm and Animal Farm of Chonbuk University was determined by using ultra violet method. Using polyacrylamide gel electrophoresis, the lactate dehydrogenase isoenzyme distrimution of plasma and various tissues in Korean native cattle was studied. The plasma lactate dehydrogenase activity of Korean native cattle was $554.80{\pm}92.70IU/l$ and the lactate dehydrogenase activity of male plasma was $543.96{\pm}97.89IU/l$, which was lower than that of female plasma, $579.19{\pm}78.09IU/l$. The plasma lactate dehydrogenase activity of calf was $557.31{\pm}110.27IU/l$ and was no significantly different from that of adult Korean native cattle. But the range of calf lactate dehydrogenase activity was larger than that of adult Korean native cattle. In tissues, the lactate dehydrogenase activity was decreased in order of lung, kidney, spleen, liver, heart and skeletal muscle. The lung had the greatest activity and the skeletal muscle had the least. Lactate dehydrogenase isoenzymes in plasma and tissues were found to have a characteristic distribution and quantitative isoenzyme patterns. In plasma, the LDH1 usually had the greatest activity and other isoenzymes showed a decreasing tendency in order of LDH2, LDH3, LDH4 and LDH5. The distribution of lactate dehydrogenase isoenzymes had a wide variation in tissues. But the distribution of LDH isoenzymes in plasma was similar to that in kidney, and also cardiac muscle and spleen had similar pattern in LDH isoenzymes distribution.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.5
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• pp.765-771
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• 2001

Elastic-plastic fracture toughness JIC can be used a s an effective design criterion in elastic-plastic fracture mechanics. Among the JIC test methods approved by ASTM, unloading compliance method was used in this study. In order to examine the relationship between fracture behavior of JIC test and AE signals, the post processing of AE signals has been carried out by Short Time Fourier Transform(STFT), one of the time-frequency analysis methods. The objective of this study is to evaluate the application of characterization of AE signals for unloading compliance method of JIC test. As a result of time-frequency analysis, we could extract the AE from the raw signal and analyze the frequencies in AE signal at the same time. AE signal generated by elastic-plastic fracture of material has some different aspects at elastic and plastic ranges, or the first portion of crack growth by fracture. First of all, increased energy recorded and detected by using AE count method increase rapidly from the start of ductile fracture. The variation of main frequency range with time-frequency analysis method could be confirmed. We could know fracture behavior of interior material by examination AE characteristics generated in real-time when elastic-plastic fracture occurred in material under loading.

• Korean Journal of Materials Research
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• v.20 no.5
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• pp.278-288
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• 2010

High Pressure High Temperature (HPHT) treatment can significantly change the color of diamonds. We studied the variation of the optical properties according to the nitrogen arrangement in natural brown diamonds of various types (type IaAB, type IaB, type IaA > B, type IaA < B, IaA = B) after HPHT treatment. The diamonds with different arrangements of nitrogen were annealed at temperatures in the range $1700-1800^{\circ}C$ under a stabilizing pressure of 5 GPa. HPHT treated samples were analyzed using UV-Vis-NIR, FT-IR, and PL spectroscopy. The absorption and luminescence spectra were measured to compare the variations of nitrogen arrangement in the natural brown diamonds before and after HPHT treatment. After HPHT treatment, the brown coloration in all types of diamonds was reduced and a decrease in the peaks related to the A-aggregate of nitrogen was more predominant than the B-aggregate. Furthermore, the peaks related to N3 (415.4 nm), H4 (496.4 nm), and platelet decreased and the peaks related to H3 (503.2 nm) and G-band increased after HPHT treatment. In conclusion, spectroscopic analysis of natural brown diamonds after HPHT treatment showed that a yellow color was produced by absorption in the H3 centers and a green color was generated by interaction between absorptions of the H3 and H2 centers.

• Korean Journal of Ecology and Environment
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• v.51 no.1
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• pp.135-147
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• 2018

In order to investigate the runoff characteristics of nonpoint source pollutants in the Lake Doam watershed, water quality and flow rate were monitored for 38-rainfall events from 2009 to 2016. The EMC values of SS, COD, TN and TP were in the range of 33~2,169, 3.5~56.9, 0.09~7.65 and $0.06{\sim}2.21mg\;L^{-1}$, respectively. As a result of analyzing the effect of rainfall factor on the nonpoint source pollutant load, EMCs of SS, COD and TP showed a statistically significant correlation with rainfall (RA) (p<0.01) and SS showed highly significant correlation with maximum rainfall intensity (MRI, R=0.48). The load ranges of SS, COD, TN and TP were 10.4~11,984.6, 1.1~724.4, 0.6~51.6 and $0.03{\sim}22.85ton\;event^{-1}$, respectively, showing large variation depending on the characteristics of rainfall events. The effect of rainfall on the load was analyzed. SS, COD and TP showed a positive correlation, but TN did not show any significant correlation. The annual load of SS was the highest with $88,645tons\;year^{-1}$ in 2011 when rainfall was the highest with 1,669 mm. The result of impact analysis of nonpoint source pollution reduction project and land-use change on runoff load showed that pollutant load significantly reduced from 2009 to 2014 but SS and TP loads were increased from 2014 to 2016 due to increase in construction area. Therefore, we suggested that nonpoint source pollution abatement plan should be continued to reduce the soil loss and pollutants during rainfall, and countermeasures to reduce nonpoint source pollution due to construction need to be established.

• YAKHAK HOEJI
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• v.52 no.2
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• pp.93-100
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• 2008

A liquid chromatographic method with tandom spectrometric detection (LC/MS/MS) for the simultaneous determination of doxifluridine and its active metabolite, 5-fluorouracil (5-FU) was developed over the concentration range of $5{\sim}2000$ ng/ml, respectively. Doxifluridine, 5-FU and internal standard, 5-chlorouracil (5-CU), were extracted from liver and intestine tissue via protein precipitation. Acetonitrile was used as the extraction solvent and the supernatant was evaporated and reconstructed in mobile phase. Optimum chromatographic separation was achieved on a Agilent Zorbax $C_{18}$ ($100\;mm{\times}2.1\;mm$, $3.5\;{\mu}m$) column with mobile phase run in isocratic with methanol : water (20 : 80, v/v). The flow rate was 0.2 ml/min with total cycle time of 5 min. The lower limit of quantification was validated at 5.0 ng/ml of liver and intestine tissue, for both doxifluridine and 5-FU, respectively. The intra-day and inter-day precision and accuracy of quality control (QC) samples were <11% coefficient of variation and <7% relative error from theoretical concentration for both analytes. In addition, the special designed stability study was performed, because the metabolism of doxifluridine occurs spontaneously even in ice bath for monkey liver. The stability of doxifluridine in liver and intestine of monkey and beagle dog was compared. It was found that bioanalytical validation could not be performed for the monkey liver; however, beagle dog's liver has relatively low speed of metabolism compared to monkey liver and instead of monkey liver, beagle dog's liver could be used for the validation. Bioanalytical validation could be performed in monkey intestine. Eventually, this developed method for liver and intestine will be useful in support of the toxicokinetic and pharmacokinetic studies of doxifluridine and 5-FU.

• Journal of The Korea Institute of Healthcare Architecture
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• v.21 no.1
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• pp.67-76
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• 2015

Purpose : The current tactile walking surface indicators have not been easily accessible to blind and vision-impaired people due to unexpected variation of walking environment and walking behavior of transportation poor. Moreover, those indicators frequently cause the inconvenience to transportation users' walking. Thus, this study aims to investigate the improvement of tactile walking surface indicators, by comparing and analyzing findings from the relevant research. Results from this study contribute to suggest the better standard criteria of tactile walking surface indicators for transportation users, especially blind and vision-impaired people, the handicapped, the child and the elderly and weak, providing the secure and convenient circumstance for walking. Method : This study presents the problems about the standard criteria of tactile walking surface indicators via the examination of finding from the past studies. For example, we examine all standard criteria, focusing on shapes, colors and qualities of materials used for Tactile Walking Surface Indicators. Then, the present study suggests the improvement of standard, which apply to the current walking environment practically and reasonably. Results : To improve the current condition of tactile walking surface indicators, the analysis on international and domestic standard criteria need to be conducted. Findings from these analyses helps to suggest the better criteria for the interval between projecting points of tactile walking surface indicators, effective perceived range of walking road, and the brightness contrast between tactile walking surface indicators and finishing materials. Implication : The suggested standard criteria of tactile walking surface indicators need to be tested by transportation users, and the practical instructions of establishing tactile walking surface indicators should also be developed.

• Journal of the Semiconductor & Display Technology
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• v.7 no.1
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• pp.1-5
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• 2008

In this paper, we fabricated pressure difference type gas flow sensor using only dry etching technology by ICP-RIE(inductive coupled plasma reactive ion etching). The sensor's structure consists of a common shear stress type piezoresistive pressure sensor with an orifice fabricated in the middle of the sensor diaphragm. Generally, structure like diaphragm is fabricated by wet etching technology using TMAH, but we fabricated diaphragm by only dry etching using ICP-RIE. To equalize the thickness of diaphragm we applied insulator($SiO_2$) layer of SOI(Si/$SiO_2$/Si-sub) wafer as delay layer of dry etching. Size of fabricated diaphragm is $1000{\times}1000{\times}7\;{\mu}m^3$ and overall chip $3000{\times}3000{\times}7\;{\mu}m^3$. We measured the variation of output voltage toward the change of gas pressure to analyze characteristics of the fabricated sensor. Sensitivity of fabricated sensor was relatively high as about 1.5mV/V kPa at 1kPa full-scale. Nonlinearity was below 0.5%F.S. Over-pressure range of the fabricated sensor is 100kPa or more.

• Journal of Magnetics
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• v.21 no.2
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• pp.183-186
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• 2016

In this study, we report on an investigation of proton radiation resistance of 410 martensitic stainless steels under 3 MeV proton with the doses ranging from $1.0{\times}10^{15}$ to $1.0{\times}10^{17}p/cm^2$ at the temperature 623 K. Vibrating sample magnetometer (VSM) and X-ray diffractometer (XRD) were used to study the variation of magnetic properties and structural damages by virtue of proton irradiation, respectively. VSM and XRD analysis revealed that the 410 martensitic stainless steels showed proton radiation resistance up to $10^{17}p/cm^2$. Proton energy degradation and flux attenuations in 410 stainless steels as a function of penetration depth were calculated by using Stopping and Range of Ions in Matter (SRIM) code. It suggested that the 410 stainless steels have the radiation resistance up to $5.2{\times}10^{-3}$ dpa which corresponds to neutron irradiation of $3.5{\times}10^{18}n/cm^2$. These results could be used to predict the maintenance period of SUS410 stainless steels in fission power plants.

• Journal of the Semiconductor & Display Technology
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• v.11 no.3
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• pp.33-37
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• 2012

Simple and high efficiency blue organic light-emitting diodes with three organic layers of N, N'-diphenyl-N,N'-bis-[4-(phenyl-m-tolylamino)-phenyl]-biphenyl-4,4'-diamine[DNTPD]/1,1-bis-(di-4-polya-minophenyl)cyclohexane[TAPC]/electron transport material [ET-137] were fabricated and their electroluminescent characteristics were evaluated according to the TAPC thickness variation in a range of $50{\sim}300{\AA}$. Electroluminescence spectra of the devices with structure of DNTPD/TAPC/ET-137 showed all the same central emission wavelengths of 455 nm under an applied voltage of 7V, which were similar with that of the device with ET-137 only. On the other hand, the electroluminescence spectra of the device with structure of DNTPD/ET-137 without TAPC layer showed double emission peaks at the wavelengths of 455 nm and 561 nm under an applied voltage of 7V. In the devices with structure of DNTPD/TAPC/ET-137, single peak blue emission was not maintained in the device with $50{\AA}$-thick TAPC above 8V by the formation of exciplex. In the device with $300{\AA}$-thick TAPC, however, single peak blue emission was maintained until 10 V. According to the thickness increase of TAPC in the fabricated devices, the current density and luminance decreased, but the luminous efficiency and roll-off characteristics were improved.

• International Journal of Precision Engineering and Manufacturing
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• v.8 no.2
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• pp.54-58
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• 2007

This paper describes an atomic force microscope (AFM)-based instrument for measuring the nanoscale cutting edge profiles of diamond cutting tools. The instrument consists of a combined AFM unit and an optical sensor to align the AFM tip with the top of the diamond cutting tool edge over a submicron range. In the optical sensor, a aser beam is emitted from a laser diode along the Y-axis and focused to a small beam spot with a diameter of approximately $10{\mu}m$ at the beam waist, which is then received by a photodiode. The top of the tool edge is first brought into the center of the beam waist by adjusting it in the X-Z-plane while monitoring the variation in the photodiode output. The cutting tool is then withdrawn and its top edge position at the beam center is recorded. The AFM tip can also be positioned at the beam center in a similar manner to align it with the top of the cutting edge. To reduce electronic noise interference on the photodiode output and thereby enhance the alignment accuracy, a technique is applied that can modulate the photodiode output to an AC signal by driving the laser diode with a sinusoidal current. Alignment experiments and edge profile measurements of a diamond cutting tool were carried out to verify the performance of the proposed system.