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The Oncological Safety of Nipple-Sparing Mastectomy: A Systematic Review of the Literature with a Pooled Analysis of 12,358 Procedures

  • Headon, Hannah Louise;Kasem, Abdul;Mokbel, Kefah
    • Archives of Plastic Surgery
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    • v.43 no.4
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    • pp.328-338
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    • 2016
  • Nipple-sparing mastectomy (NSM) is increasingly popular as a procedure for the treatment of breast cancer and as a prophylactic procedure for those at high risk of developing the disease. However, it remains a controversial option due to questions regarding its oncological safety and concerns regarding locoregional recurrence. This systematic review with a pooled analysis examines the current literature regarding NSM, including locoregional recurrence and complication rates. Systematic electronic searches were conducted using the PubMed database and the Ovid database for studies reporting the indications for NSM and the subsequent outcomes. Studies between January 1970 and January 2015 (inclusive) were analysed if they met the inclusion criteria. Pooled descriptive statistics were performed. Seventy-three studies that met the inclusion criteria were included in the analysis, yielding 12,358 procedures. After a mean follow up of 38 months (range, 7.4-156 months), the overall pooled locoregional recurrence rate was 2.38%, the overall complication rate was 22.3%, and the overall incidence of nipple necrosis, either partial or total, was 5.9%. Significant heterogeneity was found among the published studies and patient selection was affected by tumour characteristics. We concluded that NSM appears to be an oncologically safe option for appropriately selected patients, with low rates of locoregional recurrence. For NSM to be performed, tumours should be peripherally located, smaller than 5 cm in diameter, located more than 2 cm away from the nipple margin, and human epidermal growth factor 2-negative. A separate histopathological examination of the subareolar tissue and exclusion of malignancy at this site is essential for safe oncological practice. Long-term follow-up studies and prospective cohort studies are required in order to determine the best reconstructive methods.

Review on the Pharmacopuncture Patent in Korea (국내 약침 특허 현황에 대한 분석연구)

  • Woo, Seong-Cheon;Kang, Jun-Chul;Kim, Song-Yi;Park, Ji-Yeun
    • Korean Journal of Acupuncture
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    • v.34 no.4
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    • pp.191-208
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    • 2017
  • Objectives : The purpose of this study was to analyze the trend of pharmacopuncture in Korean patent in order to establish database for patent technology. Methods : Electronic literature searches for Korean patents related to pharmacopuncture were performed in two electronic databases (Korea Intellectual Property Right Information Service and National Digital Science Library) to June 2017. Patents that were not Korean ones, did not use medicinal herb, only described method of manufacture, or had nothing to do with pharmacopuncture were excluded in this study. The status and application date of patents, Medicinal herb, target diseases, International Patent Classification (IPC), model of experiment and extracting methods were analyzed. Results : A total of 379 patents were retrieved. Based on our inclusion/exclusion criteria, 297 patents were excluded. Of 82 included patents, 27 patents did not include experiments using pharmacopuncture, and 9 patents were invented for treating animals such as pig or calf. In IPC analysis, Bee Venom, Panax (ginseng), Angelica, and Paeoniaceae were used frequently. Musculoskeletal diseases were the most targeted diseases followed by nervous diseases. For extracting, hot water extraction, distillation extraction, and solvent extraction using alcohol, ethanol, or methanol for solvent were commonly used. Conclusions : These data are useful for inventing new patent and extending range of pharmacopuncture in clinical use, however, more systematically analyzed patent studies and pharmacopuncture-related studies for new application on various diseases are needed in further studies.

Design and Implementation of Spatial Characterization System using Density-Based Clustering (밀도 클러스터링을 이용한 공간 특성화 시스템 설계 및 구현)

  • You Jae-Hyun;Park Tae-Su;Ahn Chan-Min;Park Sang-Ho;Hong Jun-Sik;Lee Ju-Hong
    • Journal of the Korea Society of Computer and Information
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    • v.11 no.2 s.40
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    • pp.43-52
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    • 2006
  • LRecently, with increasing interest in ubiquitous computing, knowledge discovery method is needed with consideration of the efficiency and the effectiveness of wide range and various forms of data. Spatial Characterization which extends former characterization method with consideration of spatial and non-spatial property enables to find various form of knowledge in spatial region. The previous spatial characterization methods have the problems as follows. Firstly, former study shows the problem that the result of searched knowledge is unable to perform the multiple spatial analysis. Secondly, it is unable to secure the useful knowledge search since it searches the limited spatial region which is allocated by the user. Thus, this study suggests spatial characterization which applies to density based clustering.

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WEATHER CHARACTERISTICS AT OBSERVATORY CANDIDATE SITES IN WEST TIBET

  • SASAKI, TOSHIYUKI;NAOE, HIROAKI;UTSUMI, YOSUKE;WANG, HONGSHUAI;YAO, YONGQIANG;YOSHIDA, MICHITOSHI;OHSHIMA, NORIO;MIKAMI, YOSHITAKA;OKADA, NORIO;KOYANO, HISASHI;SEKIGUCHI, KAZUHIRO;ANDO, HIROYASU;LIU, LIYONG;LIU, CAI-PIN;KAIFU, NORIO
    • Publications of The Korean Astronomical Society
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    • v.30 no.2
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    • pp.699-701
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    • 2015
  • The high plateaus in west China may provide suitable sites for astronomical observations with the institute's middle-range telescopes and possibly with larger telescopes. Under China-Japan collaborations for site survey in west China, we have been conducting searches for good sites and monitoring their characteristics over several years. As recent results of our site survey show, sites in west Tibet are revealed with a high possibility of good astronomical observations. Weather characteristics at Gar in Ali, Tibet, show its high clear-sky ratios, especially in winter, comparable to Mauna Kea, Hawaii. But it has some wind problem in winter, where stronger wind speeds, over 20m/sec, occur frequently even though the sky is clear. To find calmer sites, we have conducted numerical simulations for the Ali area using the Japan Meteorological Agency NonHydrostatic Model. We have found another site, named ZoZo Hill, near Gar. We will continue to monitor the Gar site to clarify weather characteristics over the whole year and hopefully start to negotiate for site monitoring at ZoZo Hill this year.

A Case Study on the Usage of Mobile Banking Service (농협의 모바일 뱅킹 서비스 사례)

  • Kim, Byung-Gon
    • Journal of Information Technology Applications and Management
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    • v.17 no.2
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    • pp.207-223
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    • 2010
  • Mobile banking is a subset of electronic banking which underlies not only the determinants of the banking business but also the special conditions of mobile commerce. Nowadays wireless networks are being evolved and diversified. In this situation The wireless e-commerce is in the limelight on new profits of Carriers. Especially from current year when Carriers in domestic plans to provide the services using 2.5G networks the service providers choose wireless e-commerce as the main parts of wireless internet strategy and will provide a various of services. Because of this situation, the importance of mobile billing service is being emphasized. This paper searches the definition and service types of mobile banking, and suggests status and prospects of domestic mobile banking. We suggest the basic direction, the stage of development and functions of services by analyzing the cases of Nonghyup's. Finally we derive the critical factors from those and suggest the effect of introduction and the direction of development. From the customer perspective, mobile banking has many strengths. For example, it allows that all customers access banking service at anytime, anywhere more easily than telephone banking or pc banking. And it reduces the time and the effort for using the service. It enables the company to make a business against global customers. On the other hand, from the company perspective, it has a lot of potential that affect market share and reduce the costs of human and material resources which used to operate and support branches. However, it needs many efforts to reach at the stage of completion. And We will have to solve the problems that develop many contents, expend the range of services and raise the service convenience.

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Simulation System Design and Development for Analysis of the Search Strategy for Underwater Targets (수중 표적 탐색전술 분석용 시뮬레이션 시스템 설계 및 개발)

  • Park, Young-Man;Shin, Seoung-Chul
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.12
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    • pp.2753-2758
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    • 2009
  • The Navy is trying to develop a sonar-operation strategy that efficiently searches for underwater targets. To develop an efficient sonar-operation strategy, a simulation system, which can analyze the efficiency of various operation strategies, is needed. The simulation executes the strategical operation by collecting information of sea environment, destroyer, sonar, and target. Also, it should be able to provide diverse information according to its progression. In this study, the simulation system that can evaluate and analyze the effectiveness of the search strategy for underwater targets in different environments was designed and developed. The simulation system was developed, utilizing the sonar equation and the lateral-range-curve, and it portrays many patterns of realistic movements of a target. This system will contribute to developing and improving efficient sonar-operation strategies to find underwater targets in the future.

A study on online WOM search behavior based on shopping orientation (의복쇼핑성향에 따른 온라인 구전 정보탐색행동에 관한 연구)

  • Lee, Angie;Rhee, YoungJu
    • Journal of the Korea Fashion and Costume Design Association
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    • v.20 no.4
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    • pp.57-71
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    • 2018
  • Since consumers have become more comfortable with providing and receiving information online, 'online word of mouth' has been gaining consideration as one of the major information sources. Also, the shopping orientation of consumers has been proven to be an important determinant of consumer behavior. Therefore, the study investigated the differences in online WOM behavior based on shopping orientation. Hedonic, loyal, and syntonic styles were the types of shopping orientation considered, and the study focused on information retrieval tendencies, the motivation of online WOM search, searching online WOM sources, and the contents for the online WOM behavior. The research conducted an off-line survey targeting females in their twenties. The total number of data sets used in the empirical study was 125, and these were analyzed by SPSS 20.0: factors analysis, Cronbach's ${\alpha}$, k-means cluster, ANOVA, Duncan's multiple range test, Kruskal-Wallis, Mann-Whitney, and Bonferroni correction. The participants were divided into 3 kinds of shopping orientation groups named 'trend-pursuit', 'passive', and 'loyal'. As a result, there were significant differences in online WOM behavior discovered between the groups. Firstly, the 'trend-pursuit' group had the highest number of ongoing searches while the 'loyal' group had the highest number of pre-purchase search. Secondly, the 'trend-pursuit' and 'loyal' groups both had the motivations of online WOM search, hedonic and utility, whereas the 'passive' group had the lowest motivations for both motivations. Thirdly, the 'loyal' group frequently referred to reviews on shopping malls as online WOM sources. The research provided a better understanding of the online WOM behavior of present consumers and suggests that fashion related corporations map out marketing strategies with the understanding of these behaviors.

Design and Implementation of a Non-Face-to-Face Oriented Location-Based Service Software (비대면 지향의 위치-기반 서비스 소프트웨어 설계 및 구현)

  • Park, Hyuk Gyu;Won, Dong Hyun;Shin, Kwang Sung
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.580-581
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    • 2021
  • There are various Location-Based Services(LBS) that apply GPS technology in mobile devices such as smart-phone and tablet. In this paper, we designed non-face-to-face oriented LBS software in the reality that non-face-to-face services are increasing due to COVID-19. The proposed model searches location information for trading goods or services and utilizes information identified in real time. The proposed scheduling and priority control algorithm provides efficient service allocations and simulation was performed based on web/app to verify this. While commercialized LBS platforms focus on used goods transactions, the designed method is different in that it provides non-face-to-face services and not-direct transactions between individuals. It provides a wide range of transactions and services to users such as small business owners and franchises.

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Definition, Scope, and Applications of Physiotherapy Biofeedback: Systematic Reviews (물리치료 바이오피드백의 정의 및 범위와 활용법: 체계적 문헌고찰 )

  • Jong-Seon Oh;Kyung-Jin Lee;Seong-Gil Kim
    • Journal of the Korean Society of Physical Medicine
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    • v.18 no.4
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    • pp.109-119
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    • 2023
  • PURPOSE: The definition and scope of biofeedback are broad and lack a clear framework. Therefore, efforts are needed to clearly understand the exact range and definition of biofeedback based on the research and development conducted to date. Thus, the purpose of this study was to arrive at the definition and scope of biofeedback through a literature review and analysis of its application methods. METHODS: This study is a systematic literature review conducted to understand the various types and effects of biofeedback. International databases such as Google Scholar and PubMed were used. Domestic databases utilized for keyword searches included the Research Information Sharing Service (RISS) and the National Digital Science Library (NDSL). Quality assessment of the selected studies in the selection process was done using the Cochrane risk of bias, and the research was analyzed according to the population, intervention, control, and outcomes (PICO) format. RESULTS: Studies conducted between 2019 and 2021 were selected, with 4 papers falling under physiological classifications and 7 under biomechanical classifications. The quality assessment results showed that random sequence generation, allocation concealment, performance bias, and reporting bias were unclear. Detection bias was moderate, and attrition bias and other biases were low. Out of the 11 papers, 9 dealt with physical function outcomes, 5 with daily life activities, and 3 with mental functions. CONCLUSION: Physiological biofeedback tended to influence psychological factors more than physical functions, while biomechanical biofeedback tended to have a positive impact on physical functions.

Trends in FTA Research of Domestic and International Journal using Paper Abstract Data (초록데이터를 활용한 국내외 FTA 연구동향: 2000-2020)

  • Hee-Young Yoon;Il-Youp Kwak
    • Korea Trade Review
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    • v.45 no.5
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    • pp.37-53
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    • 2020
  • This study aims to provide the implications of research development by comparing domestic and international studies conducted on the subject of FTA. To this end, among the papers written during the period from 2000 to July 23, 2020, papers whose title is searched by FTA (Free Trade Agreement) were selected as research data. In the case of domestic research, 1,944 searches from the Korean Citation Index (KCI) and 970 from the Web of Science and SCOPUS were selected for international research, and the research trend was analyzed through keywords and abstracts. Frequency analysis and word embedding (Word2vec) were used to analyze the data and visualized using t-SNE and Scattertext. The results of the analysis are as follows. First, in the top 30 keywords of domestic and international research, 16 out of 30 were found to be the same. In domestic research, many studies have been conducted to analyze the outcomes or expected effects of countries that have concluded or discussed FTAs with Korea, on the other hand there are diverse range of study subjects in international research. Second, in the word embedding analysis, t-SNE was used to visually represent the research connection of the top 60 keywords. Finally, Scattertext was used to visually indicate which keywords were frequently used in studies from 2000 to 2010, and from 2011 to 2020. This study is the first to draw implications for academic development through abstract and keyword analysis by applying various text mining approaches to the FTA related research papers. Further in-depth research is needed, including collecting a variety of FTA related text data, comparing and analyzing FTA studies in different countries.