• 제목/요약/키워드: Randomized controlled trials

검색결과 1,181건 처리시간 0.102초

Gastric Cancer in Asian American Populations: a Neglected Health Disparity

  • Taylor, Victoria M.;Ko, Linda K.;Hwang, Joo Ha;Sin, Mo-Kyung;Inadomi, John M.
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권24호
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    • pp.10565-10571
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    • 2015
  • Gastric cancer incidence rates vary dramatically by world region with East Asia having the highest rate. The Asian population of the United States (US) is growing rapidly and over 17 million Americans are of Asian descent. A majority of Chinese, Korean and Vietnamese Americans are immigrants. Americans of East and Southeast Asian descent experience marked gastric cancer disparities and the incidence rate among Korean men in the US is over five times higher than the incidence rate among non-Hispanic white men. Randomized controlled trials have provided evidence for the effectiveness of helicobacter pylori identification and eradication in preventing gastric cancer. Additionally, Japan and South Korea have both experienced improvements in gastric cancer mortality following the implementation of programs to detect early stage gastric cancers. There are currently no clear US guidelines regarding the primary and secondary prevention of gastric cancer in high-risk immigrant populations. However, it is likely that a proportion of US physicians are already recommending gastric cancer screening for Asian patients and some Asian immigrants to the US may be completing screening for gastric cancer in their native countries. Surveys of US primary care physicians and Asian American communities should be conducted to assess current provider practices and patient uptake with respect to gastric cancer prevention and control. In the absence of clinical guidelines, US health care providers who serve high-risk Asian groups could consider a shared decision-making approach to helicobacter pylori identification and eradication, as well as gastric endoscopy.

복합부위통증증후군의 침구치료 효과에 대한 연구동향 고찰 (A Review of Research on the Effects of Acupuncture and Moxibustion Treatment to Complex Regional Pain Syndromes)

  • 김호선;배영현;김해솔;서창용;김노현;양규진;이기범
    • Journal of Acupuncture Research
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    • 제33권4호
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    • pp.137-148
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    • 2016
  • Objectives : This study was performed to review articles concerning acupuncture or moxibustion treatment for Complex Regional Pain Syndromes. Methods : On-line databases including PubMed, Cochrane Library, Ovid-EMBASE, NDSL and OASIS were searched to find articles concerning acupuncture or moxibustion treatment for Complex Regional Pain Syndromes. Several overlapping articles and those not relevant to the topic were excluded, as well as review articles and commentaries. Results : 16 case reports were selected through the procedure, all of which presented successful treatment cases of Complex Regional Pain Syndromes with acupuncture and moxibustion. Most of them presented one single patient case and were published in Korea. However, almost half of them were printed in English, and had been continuously published since 2005. It was remarkable that pharmacopuncture was predominantly used to treat Complex Regional Pain Syndromes. Also, we noted that Chinese scalp acupuncture needs to be studied further as two successful cases were presented from the U.S army. Conclusion : The results show that several case reports have been published regarding Complex Regional Pain Syndromes treated with acupuncture and moxibustion. However, all of them were case reports which are given low status in Evidence-Based Medicine. We expect that a more diverse range of articles, including case control studies, cohort studies and randomized controlled trials will be performed in the near future, and that a unified outcome measure will be developed for Complex Regional Pain Syndromes.

소아의 난치성 신증후군의 한약 치료에 대한 최신 임상연구 동향 (Review of Clinical Research for Herbal Medicine Treatment on Refractory Nephrotic Syndrome in Children)

  • 장은하;민상연;김장현
    • 대한한방소아과학회지
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    • 제34권3호
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    • pp.1-17
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    • 2020
  • Objectives The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in refractory nephrotic syndrome (RNS). Methods We searched the randomized controlled trials (RCTs) with herbal medicine treatment on RNS from the Pubmed, CNKI, OASIS, NDSL, J-stage, and CiNii. The demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study. Results 11 RCT studies were selected and analyzed. The children in the control group were given western medicine therapy, and the treatment group was given herbal medicine along with the same western medicine of the control group. The most commonly used herbal medicines were the prescriptions to treat 'Kidney Deficiency with Blood Stasis (腎虛兼瘀血)' which composed of 'Promoting blood circulation (化瘀)', 'Diuresis-inducing (利水)', or 'Heating Yang (溫陽)' medicine based on 'Replenishing Kidney or Spleen (補腎, 補脾)' medicine. In the treatment group, proteinuria and serum lipid was significantly decreased, serum albumin was significantly increased, and total effective rate was significantly higher than the control group. Hypercoagulation and relapse rate was also significantly reduced. Adverse events were significantly lower in the treatment group. Conclusions Herbal medicine treatment on pediatric RNS can be suggested as a new treatment for children who have less response to the conventional therapy. It can also supplement the limitations of the western medicine by reducing adverse events from the steroids and immuno-suppressive agents, and lower the relapse rate as well.

Treatment of refractory IgA vasculitis with dapsone: a systematic review

  • Lee, Keum Hwa;Hong, Sung Hwi;Jun, Jinhae;Jo, Youngheun;Jo, Woogyeong;Choi, Dayeon;Joo, Jeongho;Jung, Guhyun;Ahn, Sunghee;Kronbichler, Andreas;Eisenhut, Michael;Shin, Jae Il
    • Clinical and Experimental Pediatrics
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    • 제63권5호
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    • pp.158-163
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    • 2020
  • IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved 13 articles published until June 14, 2018. The most common clinical feature was a palpable rash (100% of patients), followed by joint pain (69.2%). Treatment response within 1-2 days was observed in 6 of 26 patients (23.1%) versus within 3-7 days in 17 patients (65.4%). Relapse after treatment discontinuation was reported in 17 patients (65.4%) but not in 3 patients (11.5 %). Four of the 26 patients (15.4%) reported adverse effects of dapsone including arthralgia (7.7%), rash (7.7%), and dapsone hypersensitivity syndrome (3.8%). Our findings suggest that dapsone may affect refractory IgA vasculitis. Multicenter randomized placebo-controlled trials are necessary to determine the standard dosage of dapsone at initial or tapering of treatment in IgA vasculitis patients and evaluate whether dapsone has a significant benefit versus steroids or other medications.

치매환자의 두침(頭鍼)치료에 대한 최신 임상연구 동향 -CAJ (China Academic Journals: 중국기간전문수거고(中国期刊全文数据库))의 2001~2011년 검색을 통하여- (The Current State of Clinical Studies on Scalp Acupuncture - Treatment for Dementia-by Search for China Literature published from 2001 to 2011 in CAJ(China Academic Journals) -)

  • 이고은;박장호;양현덕;허은정;전원경;류영수;강형원
    • 동의신경정신과학회지
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    • 제23권2호
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    • pp.13-32
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    • 2012
  • Objectives : The purpose of this study was to obtain some knowledge concerning the scalp acupuncture treatment on patients with dementia for the future practice and research from clinical studies in China. Methods : The literatures were searched using the data base-China Academic Journals(CAJ) (2001-2011). Results : We found out 1 case study, and 17 randomized controlled trials(RCT) which met the inclusion criteria in most studies. There were 3 types of scalp acupuncture-applying method, cho-si scalp acupuncture(焦氏頭鍼法), combination of using ordinary acupoints(正經鍼) and extraordinary acupoints(經外寄穴), standard method of scalp acupuncture(標準頭鍼法). The often used acupoints are Yundongqu(運動區), Ganjuequ(感覺區), Yuntingqu(暈聽區), Zuyunganqu(足運感區), Sishencong (HN23), Baihui(GV20), Shenting(GV24), Fengchi(GB20), Dingnieqianxiexian(MS6), and Dingniehouxiexian(MS7). Conclusions : There were significant improvements on the scalp acupuncture-treated groups, compared to the control groups(western medication group or other acupuncture treatment group). Results of this study could be used for future studies concerning the scalp acupuncture for dementia.

단기간 귀리 추출물 섭취의 혈당 및 콜레스테롤 저하 효과 평가 (Evaluation the Effects of Short Term Intake Avena sativa Extracts on Blood Glucose and Cholesterol Level)

  • 김하나;이인수;신경숙;윤순규;이부형;윤승규;최진우;서인범
    • 한국콘텐츠학회논문지
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    • 제15권3호
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    • pp.272-279
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    • 2015
  • 최근 혈당조절에 도움이 되는 다양한 천연추출물에 대한 연구가 진행되고 있다. 귀리는 다양한 생리효능이 있는 것으로 알려져 있는데 특히 ${\beta}$ 클루칸은 체내 혈중 콜레스테롤 수치를 낮추어 심혈관 질환을 예방하고 비만과 관련된 성인병 예방에 효과를 보이는 것으로 보고되고 있다. 이에 본 연구는 상품화된 귀리 추출물로 이루어진 다운앤컨트롤(비엠제약)을 이용하여 6주간 무작위, 이중맹검, 실험군-대조군 임상 연구를 통해 혈당 및 혈중 콜레스테롤에 대한 효과를 평가한 결과, 통계학적으로 유의한 차이를 보이지는 않았지만 당화알부민은 각각 시험군에서 50.33% 감소, 대조군에서 37.91% 감소 및 중성지방은 시험군에서 7.51% 감소, 대조군에서 3.98% 증가로 상대적으로 차이를 보여 시험약의 혈당저하 효과 및 중성지방의 감소효과를 일부에서 관찰할 수 있었다.

천장관절 가동술이 신체중심 이동거리에 미치는 정도 (The effects of Sacroiliac joint mobilization on the Equilibrium Ability)

  • 공원태;한종만
    • 대한정형도수물리치료학회지
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    • 제11권1호
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    • pp.29-36
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    • 2005
  • The purpose of this study was to evaluate change of path length center of body on sacroiliac joint mobilization. The subjects were consisted of sixty healthy adult two decade(28 females. 32 males; mean aged 22.2) from 20 to 29. All subjects randomly assigned to the control group, sacroiliac joint mobilization group. sacroiliac joint mobilization group received sacroiliac joint mobilization for 2-3 minutes per day and three times a week during 3 weeks period. The study carried out to determine the change of path length center of body on sacroiliiac joint mobilization from July 1, 2004 through september 30, 2004. Active balancer(SAKAI EAB-100) was used to measure equilibrium ability. All measurements of each subjects were measured at pre-experiment and post-experiment. The results of this study were summarized as follows: 1. The WPL of control group, sacroiliac joint mobilization group was no significantly differences at pre-experiment but significantly reduced post-experiment(p<.05). The results of analyzed effects of WPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group according to pre-experiment and post-experiment(p<.05). 2. The UPL of control group, sacroiliac joint mobilization group was no significantly differences at pre-experiment but significantly reduced post-experiment(p<.05). The results of analyzed effects of UPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group according to pre-experiment and post-experiment(p<.05). Conclusionally these data suggest that a 3-week S-I joint mobilization improved equilibrium. Additional randomized controlled trials to more fully investigate treatment effects and factors that may mediate these effects are needed.

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임신 및 출산 여성의 요실금 및 대변실금 예방을 위한 케겔운동의 효과: 체계적 문헌 고찰 (Effect of Kegel Exercise to Prevent Urinary and Fecal Incontinence in Antenatal and Postnatal Women: Systematic Review)

  • 박성희;강창범;장선영;김보연
    • 대한간호학회지
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    • 제43권3호
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    • pp.420-430
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    • 2013
  • Purpose: The aim of this study was to review the literature to determine whether intensive pelvic floor muscle training during pregnancy and after delivery could prevent urinary and fecal incontinence. Methods: Randomized controlled trials (RCT) of low-risk obstetric populations who had done Kegel exercise during pregnancy and after delivery met the inclusion criteria. Articles published between 1966 and 2012 from periodicals indexed in Ovid Medline, Embase, Scopus, KoreaMed, NDSL and other databases were selected, using the following keywords: 'Kegel, pelvic floor exercise'. The Cochrane's Risk of Bias was applied to assess the internal validity of the RCT. Fourteen selected studies were analyzed by meta-analysis using RevMan 5.1. Results: Fourteen RCTs with high methodological quality, involving 6,454 women were included. They indicated that Kegel exercise significantly reduced the development of urinary and fecal incontinence from pregnancy to postpartum. Also, there was low clinical heterogeneity. Conclusion: There is some evidence that for antenatal and postnatal women, Kegel exercise can prevent urinary and fecal incontinence. Therefore, a priority task is to develop standardized Kegel exercise programs for Korean pregnant and postpartum women and make efficient use of these programs.

뇌졸중 환자에서 상지 회복을 위해 컴퓨터-인간 연동을 이용한 가상현실 기반 훈련 프로그램 (Virtual Reality-based Training Program Using Computer-human Interface for Recovery of Upper Extremity Use in Stroke Patients)

  • 이경희;황기철
    • 디지털융복합연구
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    • 제14권1호
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    • pp.285-290
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    • 2016
  • 본 연구는 뇌졸중 환자의 상지 재활에 사용되는 컴퓨터-인간 연동을 이용한 가상현실 기반 훈련 프로그램 중재의 효과를 알아보고자 하였다. 2015년 2월까지 Medline 데이터베이스에서 뇌졸중 환자의 상지 재활을 위한 가상 현실 중재를 다루는 무작위 대조군 임상 연구들을 검색하였다. PEDro 스케일이 연구의 질을 사정하기 위해 사용되었다. 선정된 8개의 연구가 분석되어졌다. PEDro 스케일은 5 부터 8/10까지 다양했다. 모든 연구들은 가상현실 기반 훈련 그룹에서 상지 기능 회복에 유의한 결과를 보였다. 본 연구는 뇌졸중 환자의 상지 회복을 위해 사용되는 가상 현실 기반 훈련 프로그램의 적용이 다양하고 예측할 수 없는 실행으로 구성된 과제 지향적이고 점진적인 학습을 제공함을 통해 특히 배움에 효과가 있음을 보여주었다. 본 연구에서는 가상현실 훈련 프로그램을 뇌졸중 환자의 상지 기능 재활에 탁월한 학습 효과를 기대할 수 있으며 과제-지향과 등급화된 학습을 제공하는데 효과적이다.

천장관절가동술과 요천추부안정화 운동이 균형능력에 미치는 영향 (The Effects of Sacroiliac Joint Mobilization and Lumbopelvic Stabilizing Exercises on the Equilibrium Ability)

  • 공원태;정연우;배성수
    • The Journal of Korean Physical Therapy
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    • 제17권3호
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    • pp.285-295
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    • 2005
  • The purpose of this study was to evaluate effects of sacroiliac joint mobilization and lumbopelvic stabilizing exercises on the equilibrium ability. The subjects were consisted of ninety healthy adult two decade(43 females. 47 males; mean aged 22.1) from 20 to 29. All subjects randomly assigned to the control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group. Lumbopelvic stabilizing exercises group received lumbopelvic stabilizing exercises for 30 minutes, sacroiliac joint mobilization group received sacroiliac joint mobilization for 2-3 minutes per day and three times a week during 3 weeks period. Active balancer(SAKAI EAB-100) was used to measure equilibrium ability. All measurements of each subjects were measured at pre-experiment, after 10 days, and post-experiment. The results of this study were summarized as follows: 1. The WPL of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group was no significantly differences at pre-experiment(p>.05), but significantly reduced after 10 days and post-experiment(p<.05). The results of analyzed effects of WPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group according to pre-experiment, after 10 days, and post-experiment(p<.05). 2. The RA of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group was no significantly differences at pre-experiment(p>.05), but significantly reduced after 10 days, and post-experiment(p<.05). The results of analyzed effects of RA was significantly reduced between experiment type of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group according to pre-experiment, after 10 days, and post-experiment(p<.05). Conclusionally these data suggest that a 3-week SI joint mobilization and lumbopelvic stabilizing exercises improved equilibrium. Additional randomized controlled trials to more fully investigate treatment effects and factors that may mediate these effects are needed.

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