• Title/Summary/Keyword: Randomized Order

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Review on Clinical Study of Oriental Medical Treatment for Cancer in Korea (국내 한의학 암치료 임상연구 논문에 대한 고찰)

  • Kim, Jong-Han;Park, Dong-Suk;Kim, Yong-Suk;Lee, Jae-Dong
    • Journal of Acupuncture Research
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    • v.29 no.3
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    • pp.19-28
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    • 2012
  • Objectives : The aim of this study is to evaluate present clinical evidence of oriental medical treatment for cancer in Korea. Method : A search was performed in the Korean Studies Information, Korea Institute of Science and Technology Information, KoreaMed, Oriental Medicine Advanced Searching Integrated System, National Assembly Library, RISS4u, DBPIA, and Oasis using the keyword 'cancer', 'leukemia', 'malignant tumor', 'lymphoma', 'multiple myeloma', 'melanoma'. The search period spanned between Jan 1, 1980~June 30, 2011 and the results were analyzed and evaluated according to the publication date, journal, method of treatment, type of study, and the primary outcome. Randomized clinical trials (RCTs) and Non randomized clinical trial(NRCT) were reviewed separately. Result : The results yielded 133 trials during the period of Jan 1, 1980~June 30, 2011. Most of the trials were concerned with lung cancer and 94 of the trials were simple case studies or case series studies. 61 trials used herbal Formula/herbal medicine as the primary method of treatment. A total of 4 RCTs existed compared to only one NRCT. Conclusion : The use of oriental medicine for the treatment of cancer is gaining popularity in the field of medical scientific research. However most of the studies that have been published up to date are mostly case studies or case series studies, and RCT/NRCT are rare. In order to provide appropriate evidence regarding the effectiveness of oriental medicine in the treatment of cancer, more rigorous and well-designed studies are warranted.

A Review of Clinical Studies about Acupuncture Therapy for Whiplash Associated Disorder (교통사고로 인한 편타 손상의 침 치료에 대한 임상연구의 국내외 동향)

  • Jeon, Jun-Young;Yoo, Duk-Joo;Maeng, Tae-Ho;Shim, Jae-Woo;Cho, Woo-Young;Kim, Hyungsuk;Lim, Woong-jin;Lee, Jong-soo
    • Journal of Korean Medicine Rehabilitation
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    • v.25 no.4
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    • pp.47-54
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    • 2015
  • Objectives This study aimed to research current trends of acupuncture treatment of whiplash associated disorder (WAD). Methods Clinical studies about acupuncture therapy on WAD were searched in 7 databases. The included studies were classified according to their publication dates, methods, interventions, outcome measures. Interventions were analyzed by accompanied intervention, acupoint, acupuncture retaining time and treatment period. Results 14 articles were included. The number of studies on acupuncture for WAD shows increasing tendency since 1990. The included studies consist of 6 randomized controlled trials (RCTs), 2 non-randomized controlled trials (nRCTs), 2 cohort studies, 1 before and after study, 1 case study and 2 case reports. Most studies used visual analogue scale (VAS) as primary outcome. Conclusions This review demonstrates that further clinical studies need to be carried out under the formal clinical practice guidelines of acupuncture therapy for WAD in order to support clinical treatment objectively.

A Combined Random Scalar Multiplication Algorithm Resistant to Power Analysis on Elliptic Curves (전력분석 공격에 대응하는 타원곡선 상의 결합 난수 스칼라 곱셈 알고리즘)

  • Jung, Seok Won
    • Journal of Internet of Things and Convergence
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    • v.6 no.2
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    • pp.25-29
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    • 2020
  • The elliptic curve crypto-algorithm is widely used in authentication for IoT environment, since it has small key size and low communication overhead compare to the RSA public key algorithm. If the scalar multiplication, a core operation of the elliptic curve crypto-algorithm, is not implemented securely, attackers can find the secret key to use simple power analysis or differential power analysis. In this paper, an elliptic curve scalar multiplication algorithm using a randomized scalar and an elliptic curve point blinding is suggested. It is resistant to power analysis but does not significantly reduce efficiency. Given a random r and an elliptic curve random point R, the elliptic scalar multiplication kP = u(P+R)-vR is calculated by using the regular variant Shamir's double ladder algorithm, where l+20-bit u≡rn+k(modn) and v≡rn-k(modn) using 2lP=∓cP for the case of the order n=2l±c.

The Effects of Maitland Thoracic Mobilization Method on Cervical Alignment and Muscle Activity in Adult with Forward Head Posture

  • Kim, Dajeong;An, Hojung;Kim, Nyeonjun;Kim, Ayeon;Hong, Geurin;Kim, Soonhee
    • Journal of International Academy of Physical Therapy Research
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    • v.11 no.3
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    • pp.2119-2125
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    • 2020
  • Background: Adults with forward head posture (FHP) often suffer from thoracic hyperkyphosis and thoracic dysfunction, and including reduction of the craniovertebral angle (CV angle) and tightening of the superficial neck muscles. In order to treat thoracic dysfunction, interventions aimed at improving thoracic mobility are necessary. Objectives: To examine the effects of maitland manual mobilization therapy on the thoracic spine in adults with FHP. Design: Single-blind randomized controlled trial. Methods: Thirty adults with FHP who met the selection criteria were randomized to the thoracic multiple joint mobilization (TMJM; n=15) group and the thoracic general joint mobilization (TGJM; n=15) group. Joint mobilizations were performed for 23 minutes a day for 4 weeks continuously, two times per week. Outcome measures were ImageJ, BTS FREE EMG 1000, neck disability Index (NDI). Results: Although changes in the left sternocleidomastoid muscle activity and NDI scores over time between the two groups differed, other variables were noted only changes observed over time. Muscle activity in the right sternocleidomastoid increased again in the TGJM group post-intervention and 2 weeks after the end of the experiment, but changes in other variables were retained or improved, confirming the lasting effects of thoracic joint mobilization. Conclusion: Thoracic multiple joint mobilization may be recommended as a more effective intervention for adults with FHP.

Research Trends of Traditional Chinese Medicine Containing Haematitum in the Neuropsychiatric Clinical Scene (대자석의 중의 신경정신과 임상연구 현황)

  • Jung, Jin-Hyeong;Choi, Yun-Hee;Kim, Tae-Heon;Kim, Bo-Kyung
    • Journal of Oriental Neuropsychiatry
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    • v.25 no.4
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    • pp.401-410
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    • 2014
  • Objectives: This study was intended to review the research trends of treating neuropsychiatric diseases and symptoms with Traditional Chinese Medicine containing Haematitum. Methods: Articles were obtained through the CNKI (China National Knowledge Infrastructure) by searching with 'Haematitum' as the main key word, and supportive words related with neuropsychiatric diseases and symptoms were selected. There were 61 articles related to clinical fields, which were then classified according to study design. Results: The 61 articles were categorized into the following types of study design: 3 randomized controlled trials, 1 quasi-randomized trial, 3 simple-designed clinical trials, and 54 case studies. Decoctions containing Haematitum were used to treat diseases and symptoms such as vertigo, headache, stroke, epilepsy, neurosis, globus hystericus, fishbilepoisoning, insomnia, mania, post-traumatic brain syndrome, and kinesia. All articles reported a good rate of effectiveness. There was no poor responsiveness regarding the effects of Haematitum in 9 studies, but it was not mentioned in the other 52 studies. Decoctions self-prepared by the authors were used in 28 studies. Modified Seonbokdeja-tang, modified Banhabeakchulcheonma-tang, modified Ondam-tang were used in that order of frequency. The daily dosage of Haematitum provided was 0.2~6 g in powder, and 9~60 g in decoction. Conclusions: Decoctions containing Haematitum are used restrictively in the neuropsychiatric clinical scene. While there were no reports of poor responsiveness of the effects of Haematitum, more research is needed to confirm its clinical stability.

Effects of Mirror-based Visual Effects on Chest Compression Quality in Cardiopulmonary Resuscitation

  • Yun, Seong-Woo
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.11
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    • pp.179-185
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    • 2019
  • In this paper, We purpose the basic data for the success of effective CPR using mirror in order to increase the quality of chest compression during CPR. The subject of this study was an experimental study based on a randomized crossover design of 28 people who completed the BLS Health Care Provider, and collected data were analyzed by SPSS Ver. 23.0 for Win statistics program. As the research methods, depth, speed, compression to relaxation ratio, arm angle and easiness during the chest compression were measured. Taken together, the results of this study showed that using a mirror-based chest compression method for chest compressions in adult CPR could make chest compressions easier, in addition, the quality of breast compression was improved by improving the posture of the rescuers, such as the average depth of compression, compression to relaxation ratio, and arm angle. However, it is necessary to confirm the feasibility of clinical application through additional studies on various environmental factors and job groups for mirror-based chest compression method.

Safety of Ojeok-san Extract Powder and Soft Extract in Healthy Male Volunteers, Single Center, Randomized Controlled, Cross-over Study (오적산 혼합단미엑스산제와 혼합단미연조엑스제의 안전성 평가를 위한 단일 기관, 무작위 배정, 교차 연구)

  • Shin, Hee-Ra;Park, Kyungtae;Yeom, Seung-Ryong;Kwon, Young-Dal
    • Journal of Korean Medicine Rehabilitation
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    • v.29 no.1
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    • pp.63-73
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    • 2019
  • Objectives The purpose of this study is to evaluate the safety of Ojeok-san extract powder and soft extract in healthy male volunteers. Methods Randomized controlled, cross over study was carried out in healthy male volunteers. Total 27 of 31 subjects meeting the inclusion criteria were enrolled and three subjects for waiting were included. To each group 12 subjects were randomly allocated by random number table. Group A took the extract powder in the first period and then took the soft extract in the second period. Group B took the medicine in the opposite order. Trial was conducted through two times of hospitalizations and all subjects had a seven-days of wash out period. Vital sign and laboratory test were checked before and after the medication. The mean difference of safety evaluation variables were analyzed by paired t-test (p<0.001) or wilcoxon signed rank test (p<0.05). The mean difference between two groups were analyzed by independent t-test (p<0.05) or Mann whitney test (p<0.05). Results As a result of all data related to vital sign and laboratory test in both group, There were no significant differences associated with the clinical trial drug between before and after the medication. And there was no adverse event associated with the clinical trial drug. Conclusions Both Ojeok-san extract powder and soft extract were found to be safe for healthy male volunteers.

Comparison of seaweed pack and mudpack as treatment for knee osteoarthritis: a prospective randomized controlled study

  • Lee, Sang Hee;Han, Ji Hoon;Lee, Sung Jae;Cho, Hwi Young;Baek, Jung Heum;Kim, Jae Gyoon
    • Physical Therapy Rehabilitation Science
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    • v.8 no.1
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    • pp.22-31
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    • 2019
  • Objective: For knee osteoarthritis (OA), there is a demand for alternative modalities in order to delay surgery and to avoid the side effects of medications. This study compared the effects of applying seaweed pack and mudpack for the treatment of knee OA. Design: Randomized controlled trial. Methods: Twenty-five patients with knee OA who satisfied the criteria were included. The patients were divided into two groups according to the treatment method: mudpack (n=12) and seaweed pack (n=13). The two groups were treated for 20 minutes, twice a day for five continuous days at the Ocean Healing Center at Wando Island, South Korea. Participants were assessed by clinical scores (Western Ontario and McMaster Universities Osteoarthritis Index, Hospital for Special Surgery Knee Score, Knee injury and Osteoarthritis Outcome Score and 36-Item Short Form Health Survey) and lab results (erythrocyte sedimentation rate, C-reactive protein, insulin-like growth factor-1 [IGF-1], tumor necrosis $factor-{\alpha}$ [$TNF-{\alpha}$]) during the follow-up period. Results: For the most part, clinical scores improved after therapy and maintained improvements for four weeks in both groups (p<0.05). In the seaweed group, $TNF-{\alpha}$ was significantly decreased at two weeks post-therapy (p<0.05). In both groups, IGF-1 was significantly increased immediately post-therapy (p<0.05). There were no statistically significant differences after therapy between the groups in clinical scores and labs. Conclusions: Seaweed packs and mudpacks had similar positive effects for knee OA. Additionally, the seaweed pack group showed decreased levels of $TNF-{\alpha}$ at two weeks post-treatment, which may explain the reduced inflammatory reaction. For rehabilitation therapy, use of seaweed packs may serve as an alternative modality for the treatment of knee OA.

Effectiveness of whole body vibratory stimulation for fall prevention in super-aged women: a preliminary randomized trial

  • Kim, Byeong-Soo;Lim, Kang-Uk;Baek, In-Seon;Kim, Min-Kyoung;Kang, Hye-Min;Nam, Gi-Jeong;Lee, Myung-Mo
    • Physical Therapy Rehabilitation Science
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    • v.8 no.1
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    • pp.32-39
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    • 2019
  • Objective: The aim of this study is to investigate the effects of whole body vibratory stimulation on muscle strength, balance, and fall efficacy among super-aged women. Design: Randomized controlled trial. Methods: Twenty-eight super-aged women over 80 years of age were assigned to either the experimental group (n=14) and control group (n=14). The experimental group received an exercise program that used the whole body vibratory stimulation with a frequency of 30 Hz and amplitude of 3 mm, and the control group received an exercise program without vibratory stimulation. Intervention was provided for 4 weeks, 3 sessions per week, and 30 minutes per session. In order to measure lower extremity muscle strength the 30-second chair stand test (CST) was used. The Berg Balance Scale (BBS) was used to measure dynamic balance. Static balance was measured by tracking the path length, velocity, and area of the center of pressure (CoP). The Falls Efficacy Scale (FES) was used to measure the subjects' fear of falling. Results: Both the experimental and control group demonstrated statistically significant increase in muscle strength, dynamic balance, and fall efficacy (p<0.05). Only the experimental group showed significant improvements in static balance before and after the intervention (p<0.05). The experimental group showed significantly greater improvements in CST, BBS, and CoP (path length, velocity) than control group (p<0.05). Conclusions: Whole body vibratory stimulation exercise is shown to be a safe and appropriate physical therapy intervention method to enhance muscle strength, balance, and fall efficacy of super-aged women.

Why abandon Randomized MAC-Address : An Analysis of Wi-Fi Probe Request for Crowd Counting (Why abandon Randomized MAC-Address : Wi-Fi Probe Request 기반 유동인구 분석 방법)

  • Oppokhonov, Shokirkhon;Lee, Jae-Hyun;Moon, Jun-young
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.24-34
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    • 2021
  • Estimation of the presence of people in real time is extremely useful for businesses in providing better services. Many companies and researchers have attempted various researches in order to count the number of floating population in specific space. Recently, as part of smart cities and digital twins, commercialization of measuring floating populations using Wi-Fi signals has become active in the public and private sectors. This paper explains the floating population measuring system from the perspective of general consumers(non-experts) who uses current population data. Specifically, it presents a method of estimating the floating population based on MAC-address values collected from smartphones. By distinguishing Real MAC-address and Random MAC-address values, we compare the estimated number of smartphone devices and the actual number of people caught on CCTV screens to evaluate the accuracy of the proposed method. And it appeared to have a similar correlation between the two datas. As a result, we present a method of estimating the floating population based on analyzing Wi-Fi Probe Requests

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