• 제목/요약/키워드: Randomized Clinical Trials

검색결과 951건 처리시간 0.025초

Multimodality Treatment for Patients with Node-Positive Prostate Cancer: the Role of Radiation Therapy

  • Ochiai, Satoru;Nomoto, Yoshihito;Kobayashi, Shigeki;Yamashita, Yasufumi;Watanabe, Yui;Toyomasu, Yutaka;Kawamura, Tomoko;Takada, Akinori;II, Noriko;Sakuma, Hajime
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권4호
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    • pp.1625-1630
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    • 2016
  • Prostate cancer is the secondary most frequently diagnosed cancer in the world. Although numerous prospective randomized trial have been conducted to guide the management of patients with localized or locally advanced prostate cancer, few clinical trials targeting node-positive prostate cancer have been reported. Therefore, there are still controversies in the optimal management of node-positive prostate cancer. Recently, efficacy of multimodality treatment, including radiation therapy (RT), for such patients has been reported in several articles. The results indicate potential benefit of RT both in adjuvant therapy after prostatectomy and in definitive therapy for node-positive prostate cancer. The aim in this article was to summarize the current evidence for RT and evaluate the role in multimodality treatment for patients with node-positive prostate cancer.

전기와 자기장의 침 자극을 포함한 복합치료가 말초성 안면신경마비에 미치는 영향에 대한 관찰 연구 (Clinical Observations of Complex Therapy, including Electroacupuncture and Magnetic-acupuncture, for Treating Peripheral Facial Nerve Palsy)

  • 오서영;이현;강재희
    • Journal of Acupuncture Research
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    • 제33권3호
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    • pp.117-127
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    • 2016
  • Objectives : This study was performed to observe the effect of complex therapy, including electro-acupuncture and magnetic-acupuncture, on peripheral facial nerve palsy. Methods : Nine patients with peripheral facial nerve palsy were treated with acupuncture using electrical and magnetic stimulation. Acupoints in the face were stimulated with an electromagnetic field, as widely and as evenly as possible. To evaluate the effects before and after treatment we used Yanagihara's unweighted grading system, House-Brackmann scale, and Sunnybrook facial grading system and image once a week. Results : After treatment, the scores of Yanagihara's unweighted grading system, House-Brackmann scale and Sunnybrook facial grading system each improved (p-value < 0.05). Conclusion : Complex therapy using electro-acupuncture and magnetic-acupuncture might be an effective treatment to improve symptoms of peripheral facial nerve palsy. Further randomized-controlled trials are required to verify the efficacy and results of this study.

Respiratory support with heated humidified high flow nasal cannula in preterm infants

  • Jeon, Ga Won
    • Clinical and Experimental Pediatrics
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    • 제59권10호
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    • pp.389-394
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    • 2016
  • The incidence of bronchopulmonary dysplasia (BPD) has not decreased over the last decade. The most important way to decrease BPD is by weaning the patient from the ventilator as soon as possible in order to reduce ventilator-induced lung injury that underlies BPD, and by using a noninvasive ventilator (NIV). Use of a heated, humidified, high flow nasal cannula (HHHFNC), which is the most recently introduced NIV mode for respiratory support in preterm infants, is rapidly increasing in many neonatal intensive care units due to the technical ease of use without sealing, and the attending physician's preference compared to other NIV modes. A number of studies have shown that nasal breakdown and neonatal complications were lower when using a HHHFNC than when using nasal continuous positive airway pressure (nCPAP), or nasal intermittent positive pressure ventilation. The rates of extubation failure during respiratory support were not different between patients who used HHHFNC and nCPAP. However, data from the use of HHHFNC as the initial respiratory support "after birth", particularly in extremely preterm infants, are lacking. Although the HHHFNC is efficacious and safe, large randomized controlled trials are needed before the HHHFNC can be considered an NIV standard, particularly for extremely preterm infants.

Electrical Acupuncture Combined Bee Venom Therapy for Pain and Disability Induced Intervertebral Herniated Disc of L-spine;A Pilot Study

  • Kwon, Young-Dal
    • 동의생리병리학회지
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    • 제22권3호
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    • pp.703-707
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    • 2008
  • To examine the efficacy of electrical acupuncture combined bee venom in controlling low back with leg pain induced Herniated Intervertebral Disc (HIVD). 13 patients (men 8, women 5; age $41.30\;{\pm}\;17.27$) diagnosed as HIVD by CT or MRI had low back and leg pain as a chief complaint and diseases such as spinal tumor, infection and fracture were excluded. They were treated by electrical acupuncture (8 Hz) combined bee venom therapy three times a week in Wonkwang University Hospital, and pain intensity with VAS and functioning with Roland-Morris Disability Qestionnaire(RDQ) were measured at the baseline(B), and 4 weeks after treatment. The data were analyzed with Wilcoxon signed ranks test(SPSS12.0) and the level set for statistical significance was P<0.05. The pain was significantly reduced by two combined treatments (=0.002;$B7.69{\pm}2.06$,4Wks$4.70{\pm}2.72$). The function was also significantly improved by both treatments(=0.001;$B12.15{\pm}6.85$,4Wks$6.85{\pm}5.15$). The results suggest that a combination of acupuncture and bee venom therapy may be beneficial for low back pain from HIVD. In future, randomized clinical trials including follow-up are needed to examine the effects of these therapies.

운동요법으로서 태극권이 혈압에 미치는 영향 : 신속 체계적 고찰 (Effect of Tai Chi as Therapeutic Exercise on Blood Pressure : Rapid Systematic Review)

  • 황의형;허광호;이금산
    • 한방재활의학과학회지
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    • 제23권1호
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    • pp.101-113
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    • 2013
  • Objectives : The purpose of this study is to systematically analyze the effect of Tai Chi as therapeutic exercise on depressing blood pressure. Methods : We reviewed articles published in the PubMed, Chinese Academic Journals(CAJ) and five Korean databases. The searching keywords were "Tai chi AND blood pressure" and "Tai chi AND hypertension". We evaluated the quality with Cochrane risk of bias tool. Results : In the 114 articles searched, 7 randomized controlled clinical trials were selected. Yang(楊) style Tai chi, exercising over 30 minutes a time and over three times a week, had an effect on decreasing blood pressure. However, Wu(吳) style Tai chi was not effective in decreasing blood pressure. Conclusions : Usual exercises for hypertension patients should be performed in the form of moderate exercises intensity for 10-26 weeks by 30-60 minute a time, over 3 times a week. The study of Tai Chi on blood pressure needs to follow this criteria in the future.

여성 복압성 요실금에 대한 뜸 치료의 효과 : 체계적 문헌 고찰 (The Efficacy of Moxibustion for Female Stress Urinary Incontinence: a Systematic Review)

  • 박혜린;조희근
    • 대한한방부인과학회지
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    • 제33권4호
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    • pp.1-22
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    • 2020
  • Objectives: The purpose of this review is to evaluate the efficacy of moxibustion for stress urinary incontinence (SUI) in women. Methods: For relevant randomized controlled trials (RCTs), we searched the following databases from their inception to September 1, 2020: The Cochrane Library, PubMed, EMBASE, Chinese National Knowledge Infrastructure Database (CNKI), Koreanstudies Information Service System (KISS), Research Information Sharing Service (RISS), and National Digital Science Library (NDSL). The key search terms were 'stress urinary incontinence' and 'moxibustion'. Data extraction and assessment of risk of bias were conducted by two authors independently. Results: A total of 11 RCTs were finally included in this systematic review. In all studies, moxibustion treatment was applied as an adjuvant therapy to the conventional treatment, and the most common conventional treatment was pelvic floor muscle training (PFMT). The treatment group (conventional treatment plus moxibustion) showed statistically more significant effect than the control group (conventional treatment only) in various evaluation indicators including urinary incontinence frequency, 1 hour urine pad test, quality of life, the clinical efficacy rate, and pelvic muscle strength. Conclusions: In this study, we investigated the efficacy of moxibustion as an adjuvant therapy for female SUI patients. Further studies are needed to supplement the safety of moxibustion and the evaluation of moxibustion dose.

임신 중 한의학 관련 보완대체의학 활용 연구 동향 분석을 통한 한방 산과학의 활성화 방안 연구 (2000년대 연구를 중심으로) (A Review of the Study on Complementary and Alternative Medicine in Obstetrics)

  • 이윤재;황덕상;이창훈;이경섭
    • 대한한의학회지
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    • 제30권1호
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    • pp.137-149
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    • 2009
  • Objectives: Pregnant women could have various diseases, but the treatment of medication has the limitation that could cause fetal injury. So pregnant women have used complementary and alternative medicine in the world, but korean medicine had not been actively studied on obstetrics. This study is to investigate efficacy and safety of complementary and alternative medicine on obstetrics. Methods: We searched for papers which had pregnancy, obstetrics, complementary medicine, acupuncture and herb in the pubmed since 2000. Results: 41 papers were found. Acupuncture have the efficacy and safety on nausea, pelvic pain in pregnancy and breech presentation. Complementary alternative medicine had been studied as randomized controlled trial at various diseases in obstetric. But the method were without coordination, results were different from methods. So more clinical trials about complementary and alternative medicine would be needed. Massage and acupressure would be helpful for pregnant mood complaint. Conclusion: Complementary and alternative medicine has been proved as efficacy and safety in obstetrics, so complementary and alternative medicine would be helpful method in pregnant women. For making guidelines on complementary and alternative medicine treatment during pregnancy, more research will be needed.

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섬유근통 증후군의 한의학적 연구에 대한 문헌 조사: 국내 논문을 대상으로 (Literature Review of Korean Medicine Studies for Fibromyalgia Syndrome (FMS))

  • 이정민
    • 한방재활의학과학회지
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    • 제27권2호
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    • pp.55-66
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    • 2017
  • Objectives This study aimed to review studies in Korean medicine for fibromyalgia syndrome (FMS). Methods We conducted search across 3 electronic databases (Korean traditional knowledge portal, RISS, Oasis) to find studies for FMS in Korean medicine. Studies of Korean medicine for FMS were included and analysed. Results 15 studies were included. 2 studies were reviews and 13 studies were case reports. Total numbers of patients in case studies were 15. In case studies, acupuncture (100%), herbal medicine (76.9%), Korean physical therapy (69.2%), pharmacopuncture (53.8%), Chuna (46.1%) and moxibustion (30.7%) etc. were used. BL23 in acupuncture and CV12 in moxibustion were most frequently used. Gamisoyo-san in herbal medicine and visual analogue scale (VAS) in outcome measure were most frequently used. Conclusions This systematic review found encouraging but limited evidence of Korean medicine for FMS. I expect various trials such as randomized clinical trial or animal experimentation and more case reports. And systemic review for FMS in other national journals is needed.

치경부 병소를 포함한 치은 퇴축 치료에 있어 결체 조직 이식과 수복 치료를 이용한 임상증례 (CTG and restoration in treatment of gingival recession associated with a cervical lesion: report of three cases)

  • 김은숙;박진우;서조영;이재목
    • Journal of Periodontal and Implant Science
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    • 제39권4호
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    • pp.437-441
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    • 2009
  • Purpose: The purpose of this report is to show three cases treated by an intergrated periodontal and restorative dentistry approach. Methods: Three patients with Miller Class Ⅰgingiva recessions associated with cervical lesions were enrolled for treatment. Two patients received a connective tissue graft and resin modified glass ionomer, and one patient was treated with a connective tissue graft, resin restoration. Keratinized gingiva and relative gingival recession were measured. Results: The mean reduction of relative gingival recession was 3.7 mm, and the mean keratinized gingiva increase was 2.5 mm. The percentage of root coverage was 80% in average. No signs of gingival inflammation or bleeding on probing were seen. The patients were satisfied with the final esthetics and had no more dentin hypersensitivity. Conclusions: This report indicates that teeth with Miller ClassⅠ gingival recession associated with cervical lesions can be successfully treated by a connective tissue graft combined with restorative dentistry. However, longitudinal randomized controlled clinical trials must be performed to support this approach.

류마티스 관절염에 대한 추나요법의 효과 : 체계적 문헌고찰과 메타분석 (Chuna Manual Therapy for Rheumatoid Arthritis : A Systematic Review and Meta-analysis)

  • 허인;한인식;차윤엽
    • 척추신경추나의학회지
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    • 제13권1호
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    • pp.1-10
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    • 2018
  • Objectives: To evaluate the evidence supporting the effectiveness of Chuna manual therapy for rheumatoid arthritis. Methods: We conducted a search across 9 electronic databases to find all randomized controlled clinical trials (RCTs) that used Chuna manual therapy as a treatment for rheumatoid arthritis. The methodological quality of each RCT was assessed using the Cochrane risk of bias tool. Results: Our inclusion criteria were met by 5 RCTs. The meta-analysis showed positive results for the use of Chuna manual therapy combined with oriental usual care (UC) in terms of the efficacy rate, pain, and duration of morning stiffness when compared to western UC. Positive results were also obtained in terms of the efficacy rate, when Chuna manual therapy combined with medication was compared to medication treatments alone. Conclusions: Our systematic review found encouraging, but limited evidence of Chuna manual therapy for rheumatoid arthritis. However, to obtain stronger evidence without the drawbacks of trial design and the quality of studies, we recommend a comparative research to test the effectiveness of Chuna manual therapy.