• Title/Summary/Keyword: Randomized Clinical Trials

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Effects of Sling Exercise on Balance and Gait in Patients with Stroke: Meta-Analysis of Studies in Korea

  • Cho, Woonsu;Lee, Seongjin;Kim, Byeonggeun
    • Journal of International Academy of Physical Therapy Research
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    • v.11 no.3
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    • pp.2164-2172
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    • 2020
  • Background: Stroke patients have multiple disorders, but most have problems with balance and gait. Post-stroke rehabilitation exercise has been shown to be very important for functional recovery. Objectives: To systematically review and meta-analyze the effects of sling exercise (SE) on patients with stroke in studies published in Korea. Design: Meta-analysis. Methods: Five databases, namely, RISS, KISS, NDSL, DBpia and Earticle, were used to collect articles on vibration. Keywords such as "Stroke," "Hemiplegia," "Sling," and "Sling Exercise" were used in the search for published articles. Interventions and comparisons were SE and other exercise (OE). Outcome measures were berg balance scale (BBS) and timed up and go (TUG). Consequently, eight studies were selected in the second screening using meta-analyses. Results: Based on the results of the meta-analysis, SE was effective for BBS in the comparison of SE and OE [2.71, 95% CI (1.42, 4.01)]. It was effective for TUG in the comparison of SE and OE [-1.89, 95% CI (-3.01, -0.77)]. Conclusion: Based on eight limited studies, SE improved BBS and TUG over OE, suggesting improved stroke balance and gait. Therefore, more studies and large-scale sample randomized controlled trials are needed to confirm clinical application.

Sleep in Menopause (폐경과 수면)

  • Lim, Weon-Jeong
    • Sleep Medicine and Psychophysiology
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    • v.9 no.2
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    • pp.96-99
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    • 2002
  • Menopause, the cessation of menstruation caused by the decline in estrogen production, occurs in 95% of women between 40 and 60 years. Sleep disturbance is a frequent complaint during the perimenopause period. In contrast to premenopausla women, menopausal women experience more reduction in the total sleep hours and report more sleep disturbances, such as insomnia, noctiria and sleep disordered breathing. But the prevalence, etiology and treatment of sleep disturbances in menopause are still controversal. So further investigations are required to elucidate the factors that account for the differences in sleep disturbance between premenopausal and postmenopausal women. There are suggestive data that estrogen and progesterone deficiency may increase the susceptibility for sleep disorder in menopause. Furthermore, there are suggestive evidence from observational studies and a limited number of randomized, controlled trials that hormone replacement therapy after menopause improves sleep. However, the clinical relevance of hormone replacement therapy is unproved. So the overall benefit of hormonal replacement in postmenopausal women with sleep related disorders should be individualized to avoid potential side effects. Several studies evaluated the role of melatonin, because this hormone has effects on core body temperature & insomnia. But the exact dosage and the effects of long-term use of melatonin are unclear. So, caution is indicated in melatonin administration.

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Analysis of Studies on Hand Massage Published in Korea: On the Effects of Sleep, Pain, Anxiety and Depression (국내 학술지에 발표된 손 마사지 중재 논문 분석: 수면, 통증, 우울, 불안에 미치는 효과를 중심으로)

  • Kim, In-Ja;Cho, Yu-Na
    • The Korean Journal of Rehabilitation Nursing
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    • v.15 no.1
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    • pp.47-53
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    • 2012
  • Purpose: To identify the feasibility and provide the direction for future studies regarding hand massage, studies on hand massage published in Korea were analyzed. Methods: Using the key word of hand massage, 23 studies which identified the effects on sleep, pain, anxiety and depression were found. They were analyzed on research tendency and effects. Research tendency was analyzed in terms of published year, methods, study design, sample characteristics, and outcome variables. Effects were analyzed with hypothesis testing and effect size. Results: Among 23 studies, 60%(14 studies) were about hand massage and others (9 studies) were about aroma hand massage. The most prominent outcome variables were physiological and cognitive/emotional ones. To improve sleep, hand massage over 60 minutes was necessary while pain and anxiety were improved in the studies which less than 10 minutes hand massage was applied. Aroma hand massage was more effective than hand massage. Effect size for anxiety and depression was larger than those of sleep and pain. Conclusion: Hand massage and aroma hand massage are recommended to improve anxiety and depression as an independent nursing intervention. More randomized clinical trials are necessary to increase the validity and identify the effects of hand massage on sleep, pain, anxiety and depression.

Effect of Vitamin D on Muscular Strength in Postmenopausal Women: A Meta-Analysis (비타민D 보충 요법이 폐경 후 여성 근력에 미치는 효과: 메타분석)

  • Kang, Purum;Kim, Jeehyoung;Kim, Myung Jin
    • Journal of Korean Biological Nursing Science
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    • v.21 no.4
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    • pp.239-248
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    • 2019
  • Purpose: Postmenopausal women are a unique population with high risk for the degeneration of muscle. The aim of the present meta-analysis was to accurately evaluate the effects of vitamin D on muscular strength in postmenopausal women. Methods: A review was conducted using electronic databases, including PubMed, EMBASE, Ovid Medline, CINAHL complete, and the Cochrane Library from inception through 19 March 2019. Included studies were selected by two independent reviewers. The meta-analysis were performed using Review Manager 5.3 software. Results: A total of nine randomized controlled clinical trials were included in this review. Vitamin D interventions led to no changes in the upper limb muscle strength (mean difference -0.16, 95% CI: -1.09 to 0.77), lower body muscle strength (standard mean difference 0.08, 95% CI: -0.11 to 0.26), and back/hip muscle strength (standard mean difference 0.06, 95% CI: -0.05 to 0.17). Conclusion: Pooled results from eight studies indicated that supplementation of vitamin D did not increase muscle strength in postmenopausal women. Apparently, the present review suggests that supplementation of vitamin D alone had no didn't show any beneficial effects on muscle strength in postmenopausal women.

Reviewing Research on the Application of Intranasal Phototherapy in Allergic Rhinitis (알레르기 비염의 비강 내 광치료에 관한 논문 경향 분석)

  • Lee, Dong-Hyo;Kim, Nam-Kwen;Song, Jung-Mo
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.1
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    • pp.99-116
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    • 2014
  • Objective : The purpose of this study is to analyze research trends on the effects of intranasal phototherapy on allergic rhinitis. Methods : We searched potentially relevant studies using electronic databases, such as PubMed, OASIS, KMbase, and RISS. Our review of clinical research in allergic rhinitis was restricted to an analysis of papers published within the last 5 years. Independent reviewers extracted data using a standardized form. Results : In total, twenty four studies were included. Eleven studies were analyzed, and five randomized trials were identified. They suggested to be effective and no serious side-effects. Conclusions : Intranasal phototherapy can be effectively used as an alternative to the treatment of allergic rhinitis. Further studies are needed on this topic in order to demonstrate the effectiveness clearly.

Brachytherapy in Coronary Artery Disease (관상동맥질환의 방사성동위원소 치료)

  • Song, Ho-Chun
    • Nuclear Medicine and Molecular Imaging
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    • v.40 no.2
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    • pp.113-119
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    • 2006
  • Coronary artery disease is a loading cause of morbidity and mortality across the world. Percutaneous coronary intervention has become the major technique of revascularization. However, restenosis remains a major limitation of this procedure. Recently the need for repeat intervention due to restenosis, the most vexing long-term failure of percutaneous coronary intervention, has been significantly reduced owing to the introduction of two major advances, intracoronary brachytherapy and the drug-eluting stents. Intracoronary brachytherapy has been employed in recent years to prevent restenosis lesions with effective results, principally in in-stent restenosis. Restenosis is generally considered as au excessive form of normal wound healing divided up in precesses: elastic recoil, neointimal hyperplasia, and negative vascular remodeling. Restenosis has previously been regarded as a proliferative process in which neointimal thickening, mediated by a cascade of inflammatory mediators and other factors, is the key factor. Ionizing radiation has been shown to decrease the proliferative response to injury in animal models of restenosis. Subsequently, several randomized, double blind trials have demonstrated that intracoronary brachytherapy can reduce the rates of both angiographic restenosis and clinical event rates in patients undergoing percutaneous coronary intervention for in stent restenosis. Some problems, such as late thrombosis and edge restenosis, have been identified as limiting factors of this technique. Brachytherapy is a promising method of preventing and treating coronary artery restenosis.

A Meta-analysis of Intervention Studies on Cancer-related Fatigue in Korea: 1990-2010 (국내 암환자 피로에 적용한 중재효과의 메타분석: 1990-2010)

  • Oh, Pok Ja;Jung, Ji Ah
    • Journal of Korean Clinical Nursing Research
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    • v.17 no.2
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    • pp.163-175
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    • 2011
  • Purpose: This study was to analyze the characteristics and effect size of intervention studies applied to cancer-related fatigue in Korea. Methods: For meta-analysis, a total of 963 studies were retrieved from search engines. And 19 studies with a total of 721 participants published from 1990 to 2010 were selected upon their satisfaction with the inclusion criteria. Two authors independently extracted data from the selected studies and assessed the methodological quality. The data was analyzed by the RevMan 5.0 program of Cochrane library. Results: Intervention studies included 4 studies on foot-reflexo-massage (21.1%), comprehensive program (21.1%), and exercise (21.1%), respectively, 3 for hand-reflexo-massage (15.8%), and 4 for others. The effect size of the intervention studies shown higher effect size in order of exercise (d=-1.80), and foot & hand-reflexo-massage (d=-0.55). Conclusion: This study suggest that exercise can reduce the intensity of cancer-related fatigue, even though the number of intervention studies and randomized controlled trials were very few. There is limited evidence that reflexo-massage is effective in reducing cancer-related fatigue.

Acupoint Sticking Therapy for Endometriosis ; Systematic Review (자궁내막증의 혈위 첩부 치료에 대한 체계적 문헌고찰)

  • Bae, Ju-Eun;Park, Kyung-Dug;Yoon, Young-Jin
    • The Journal of Korean Obstetrics and Gynecology
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    • v.32 no.3
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    • pp.162-173
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    • 2019
  • Objectives: The purpose of this review was to overview and evaluate the efficacy of acupoint sticking therapy for women with endometriosis. Methods: We searched for randomized controlled clinical trials (RCTs) using acupoint sticking therapy on endometriosis in 5 electronic databases such as EMBASE, Pubmed, and CAJ. The results of the studies were analyzed and the risk of bias was assessed by using Cochrane risk of bias tool. Results: Two RCTs were included for analysis. In the selected studies, Treatment group was higher effective cure rate than any control group. In one RCT, Acupoint sticking therapy was only used, but the other RCT was treated acupoint sticking therapy combined with acupuncture. So, Interventions in 2 studies were not same, Quantitative synthesis was impossible. Conclusion: The limitation of this review is that the number of studies included is small. However, our systematic review provides a basis for acupoint sticking therapy for endometriosis. Acupoint sticking therapy was considered as one of external treatment method for patients with endometriosis.

Chuna Manual Therapy for Cervicogenic Dizziness : A Systematic Review (경추성 현훈에 대한 추나요법의 치료 효과 : 체계적 문헌고찰)

  • Park, Na Ri;Choi, Soo Min;Yang, Doo Hwa;Woo, Chang Hoon;Ahn, Hee Duk
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.13 no.2
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    • pp.11-21
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    • 2018
  • Objectives : To evaluate the evidence for effectiveness of Chuna manual therapy, for cervicogenic dizziness Methods : We conducted a search across 6 electronic databases to find all randomized controlled clinical trials(RCTs) that discuss Chuna manual therapy till September 2018. Results : 7 RCTs were selected for our inclusion criteria. The systematic review showed positive results for using Chuna manual therapy, for treating cervicogenic dizziness. Conclusions : Our systematic review found that effectiveness Chuna manual therapy for cervicogenic dizziness. However, our systematic review had several limited evidence. We recommend an additional research to test the effectiveness of Chuna manual therapy.

Nutritional Support for Neurocritically Ill Patients (신경계 중환자의 영양 집중 치료)

  • Jeong, Hae-Bong;Park, Soo-Hyun;Ryu, Ho Geol
    • Journal of Neurocritical Care
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    • v.11 no.2
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    • pp.71-80
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    • 2018
  • Nutritional assessment and support are often overlooked in the critically ill due to other urgent priorities. Unlike oxygenation, organ dysfunction, infection, or consciousness, there is no consensus of indicators. Making it difficult to evaluate the effectiveness of an intervention. Nevertheless, appropriate nutritional support in the critically ill has been associated with less morbidity and lower mortality. But, nutritional support has been considered an adjunct, for body weight maintenance and to help patients during the inflammatory phase of illness. Thus, it has been assigned a lower priority, compared to mechanical ventilation or hemodynamic stability. Recent findings have shown that nutritional support may prevent cellular injury due to oxidative stress and help strengthen the immune response. Large-scale randomized trials and clinical guidelines have shown a shift from nutritional support to nutritional therapy, with an emphasis on the importance of protein, minerals, vitamins, and trace elements. Nutrition is also important in neurocritically ill patients. Since there are few studies or recommendations with regard to the neurocritical population, the general recommendations for nutritional support should be applied.