• Title/Summary/Keyword: Randomized Clinical Trials

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CTG and restoration in treatment of gingival recession associated with a cervical lesion: report of three cases (치경부 병소를 포함한 치은 퇴축 치료에 있어 결체 조직 이식과 수복 치료를 이용한 임상증례)

  • Kim, Eun-Suk;Park, Jin-Woo;Suh, Jo-Young;Lee, Jae-Mok
    • Journal of Periodontal and Implant Science
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    • v.39 no.4
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    • pp.437-441
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    • 2009
  • Purpose: The purpose of this report is to show three cases treated by an intergrated periodontal and restorative dentistry approach. Methods: Three patients with Miller Class Ⅰgingiva recessions associated with cervical lesions were enrolled for treatment. Two patients received a connective tissue graft and resin modified glass ionomer, and one patient was treated with a connective tissue graft, resin restoration. Keratinized gingiva and relative gingival recession were measured. Results: The mean reduction of relative gingival recession was 3.7 mm, and the mean keratinized gingiva increase was 2.5 mm. The percentage of root coverage was 80% in average. No signs of gingival inflammation or bleeding on probing were seen. The patients were satisfied with the final esthetics and had no more dentin hypersensitivity. Conclusions: This report indicates that teeth with Miller ClassⅠ gingival recession associated with cervical lesions can be successfully treated by a connective tissue graft combined with restorative dentistry. However, longitudinal randomized controlled clinical trials must be performed to support this approach.

Chuna Manual Therapy for Rheumatoid Arthritis : A Systematic Review and Meta-analysis (류마티스 관절염에 대한 추나요법의 효과 : 체계적 문헌고찰과 메타분석)

  • Heo, In;Han, In-Sik;Cha, Yun-Yeop
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.13 no.1
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    • pp.1-10
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    • 2018
  • Objectives: To evaluate the evidence supporting the effectiveness of Chuna manual therapy for rheumatoid arthritis. Methods: We conducted a search across 9 electronic databases to find all randomized controlled clinical trials (RCTs) that used Chuna manual therapy as a treatment for rheumatoid arthritis. The methodological quality of each RCT was assessed using the Cochrane risk of bias tool. Results: Our inclusion criteria were met by 5 RCTs. The meta-analysis showed positive results for the use of Chuna manual therapy combined with oriental usual care (UC) in terms of the efficacy rate, pain, and duration of morning stiffness when compared to western UC. Positive results were also obtained in terms of the efficacy rate, when Chuna manual therapy combined with medication was compared to medication treatments alone. Conclusions: Our systematic review found encouraging, but limited evidence of Chuna manual therapy for rheumatoid arthritis. However, to obtain stronger evidence without the drawbacks of trial design and the quality of studies, we recommend a comparative research to test the effectiveness of Chuna manual therapy.

Effects of Postpartum Exercise on Mental Health (산후운동이 산욕부의 정신건강에 미치는 영향)

  • Lee, Sun-Ok;Kim, Mi-Ok;Ahn, Suk-Hee;Cho, Young-Ran
    • Women's Health Nursing
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    • v.10 no.1
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    • pp.15-22
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    • 2004
  • Purpose: This study was to examine the effect of postpartum exercise on mental health. Mental health comprises a 9 symptom dimension of Somatization, Obsessive-Compulsive, Interpersonal Sensitivity, Depression, Anxiety, Hostility, Phobic anxiety, Paranoid Ideation, and Psychoticism. Method: A non-equivalent pre-test, post-test control group study was conducted. Fifty-two puerperal women who were admitted to a postpartum ward of a mother-baby clinic in Pusan were recruited; 26 women were assigned to the experimental group and 26 women to the control group. Postpartum exercise was applied to the experimental group from postpartum day 3 for a period of 8 weeks while no exercise program was applied to the control group. Mental health with SCL-90-R was measured before and after exercise. Data was analyzed using mean, $x^2$-test, t-test, and ANOVA by SPSS 10.0. Result: The mental health status in the exercise group did not show a statistically significant decrease when compared to that of the control group. Conclusion: There is no effect of postpartum exercise on women's mental health during the first 8 weeks of the postpartum period. Further studies are needed for randomized clinical trials with a larger sample size.

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Effects of Sling Exercise on Balance and Gait in Patients with Stroke: Meta-Analysis of Studies in Korea

  • Cho, Woonsu;Lee, Seongjin;Kim, Byeonggeun
    • Journal of International Academy of Physical Therapy Research
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    • v.11 no.3
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    • pp.2164-2172
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    • 2020
  • Background: Stroke patients have multiple disorders, but most have problems with balance and gait. Post-stroke rehabilitation exercise has been shown to be very important for functional recovery. Objectives: To systematically review and meta-analyze the effects of sling exercise (SE) on patients with stroke in studies published in Korea. Design: Meta-analysis. Methods: Five databases, namely, RISS, KISS, NDSL, DBpia and Earticle, were used to collect articles on vibration. Keywords such as "Stroke," "Hemiplegia," "Sling," and "Sling Exercise" were used in the search for published articles. Interventions and comparisons were SE and other exercise (OE). Outcome measures were berg balance scale (BBS) and timed up and go (TUG). Consequently, eight studies were selected in the second screening using meta-analyses. Results: Based on the results of the meta-analysis, SE was effective for BBS in the comparison of SE and OE [2.71, 95% CI (1.42, 4.01)]. It was effective for TUG in the comparison of SE and OE [-1.89, 95% CI (-3.01, -0.77)]. Conclusion: Based on eight limited studies, SE improved BBS and TUG over OE, suggesting improved stroke balance and gait. Therefore, more studies and large-scale sample randomized controlled trials are needed to confirm clinical application.

Sleep in Menopause (폐경과 수면)

  • Lim, Weon-Jeong
    • Sleep Medicine and Psychophysiology
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    • v.9 no.2
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    • pp.96-99
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    • 2002
  • Menopause, the cessation of menstruation caused by the decline in estrogen production, occurs in 95% of women between 40 and 60 years. Sleep disturbance is a frequent complaint during the perimenopause period. In contrast to premenopausla women, menopausal women experience more reduction in the total sleep hours and report more sleep disturbances, such as insomnia, noctiria and sleep disordered breathing. But the prevalence, etiology and treatment of sleep disturbances in menopause are still controversal. So further investigations are required to elucidate the factors that account for the differences in sleep disturbance between premenopausal and postmenopausal women. There are suggestive data that estrogen and progesterone deficiency may increase the susceptibility for sleep disorder in menopause. Furthermore, there are suggestive evidence from observational studies and a limited number of randomized, controlled trials that hormone replacement therapy after menopause improves sleep. However, the clinical relevance of hormone replacement therapy is unproved. So the overall benefit of hormonal replacement in postmenopausal women with sleep related disorders should be individualized to avoid potential side effects. Several studies evaluated the role of melatonin, because this hormone has effects on core body temperature & insomnia. But the exact dosage and the effects of long-term use of melatonin are unclear. So, caution is indicated in melatonin administration.

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Analysis of Studies on Hand Massage Published in Korea: On the Effects of Sleep, Pain, Anxiety and Depression (국내 학술지에 발표된 손 마사지 중재 논문 분석: 수면, 통증, 우울, 불안에 미치는 효과를 중심으로)

  • Kim, In-Ja;Cho, Yu-Na
    • The Korean Journal of Rehabilitation Nursing
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    • v.15 no.1
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    • pp.47-53
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    • 2012
  • Purpose: To identify the feasibility and provide the direction for future studies regarding hand massage, studies on hand massage published in Korea were analyzed. Methods: Using the key word of hand massage, 23 studies which identified the effects on sleep, pain, anxiety and depression were found. They were analyzed on research tendency and effects. Research tendency was analyzed in terms of published year, methods, study design, sample characteristics, and outcome variables. Effects were analyzed with hypothesis testing and effect size. Results: Among 23 studies, 60%(14 studies) were about hand massage and others (9 studies) were about aroma hand massage. The most prominent outcome variables were physiological and cognitive/emotional ones. To improve sleep, hand massage over 60 minutes was necessary while pain and anxiety were improved in the studies which less than 10 minutes hand massage was applied. Aroma hand massage was more effective than hand massage. Effect size for anxiety and depression was larger than those of sleep and pain. Conclusion: Hand massage and aroma hand massage are recommended to improve anxiety and depression as an independent nursing intervention. More randomized clinical trials are necessary to increase the validity and identify the effects of hand massage on sleep, pain, anxiety and depression.

Effect of Vitamin D on Muscular Strength in Postmenopausal Women: A Meta-Analysis (비타민D 보충 요법이 폐경 후 여성 근력에 미치는 효과: 메타분석)

  • Kang, Purum;Kim, Jeehyoung;Kim, Myung Jin
    • Journal of Korean Biological Nursing Science
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    • v.21 no.4
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    • pp.239-248
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    • 2019
  • Purpose: Postmenopausal women are a unique population with high risk for the degeneration of muscle. The aim of the present meta-analysis was to accurately evaluate the effects of vitamin D on muscular strength in postmenopausal women. Methods: A review was conducted using electronic databases, including PubMed, EMBASE, Ovid Medline, CINAHL complete, and the Cochrane Library from inception through 19 March 2019. Included studies were selected by two independent reviewers. The meta-analysis were performed using Review Manager 5.3 software. Results: A total of nine randomized controlled clinical trials were included in this review. Vitamin D interventions led to no changes in the upper limb muscle strength (mean difference -0.16, 95% CI: -1.09 to 0.77), lower body muscle strength (standard mean difference 0.08, 95% CI: -0.11 to 0.26), and back/hip muscle strength (standard mean difference 0.06, 95% CI: -0.05 to 0.17). Conclusion: Pooled results from eight studies indicated that supplementation of vitamin D did not increase muscle strength in postmenopausal women. Apparently, the present review suggests that supplementation of vitamin D alone had no didn't show any beneficial effects on muscle strength in postmenopausal women.

Reviewing Research on the Application of Intranasal Phototherapy in Allergic Rhinitis (알레르기 비염의 비강 내 광치료에 관한 논문 경향 분석)

  • Lee, Dong-Hyo;Kim, Nam-Kwen;Song, Jung-Mo
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.1
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    • pp.99-116
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    • 2014
  • Objective : The purpose of this study is to analyze research trends on the effects of intranasal phototherapy on allergic rhinitis. Methods : We searched potentially relevant studies using electronic databases, such as PubMed, OASIS, KMbase, and RISS. Our review of clinical research in allergic rhinitis was restricted to an analysis of papers published within the last 5 years. Independent reviewers extracted data using a standardized form. Results : In total, twenty four studies were included. Eleven studies were analyzed, and five randomized trials were identified. They suggested to be effective and no serious side-effects. Conclusions : Intranasal phototherapy can be effectively used as an alternative to the treatment of allergic rhinitis. Further studies are needed on this topic in order to demonstrate the effectiveness clearly.

Brachytherapy in Coronary Artery Disease (관상동맥질환의 방사성동위원소 치료)

  • Song, Ho-Chun
    • Nuclear Medicine and Molecular Imaging
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    • v.40 no.2
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    • pp.113-119
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    • 2006
  • Coronary artery disease is a loading cause of morbidity and mortality across the world. Percutaneous coronary intervention has become the major technique of revascularization. However, restenosis remains a major limitation of this procedure. Recently the need for repeat intervention due to restenosis, the most vexing long-term failure of percutaneous coronary intervention, has been significantly reduced owing to the introduction of two major advances, intracoronary brachytherapy and the drug-eluting stents. Intracoronary brachytherapy has been employed in recent years to prevent restenosis lesions with effective results, principally in in-stent restenosis. Restenosis is generally considered as au excessive form of normal wound healing divided up in precesses: elastic recoil, neointimal hyperplasia, and negative vascular remodeling. Restenosis has previously been regarded as a proliferative process in which neointimal thickening, mediated by a cascade of inflammatory mediators and other factors, is the key factor. Ionizing radiation has been shown to decrease the proliferative response to injury in animal models of restenosis. Subsequently, several randomized, double blind trials have demonstrated that intracoronary brachytherapy can reduce the rates of both angiographic restenosis and clinical event rates in patients undergoing percutaneous coronary intervention for in stent restenosis. Some problems, such as late thrombosis and edge restenosis, have been identified as limiting factors of this technique. Brachytherapy is a promising method of preventing and treating coronary artery restenosis.

A Meta-analysis of Intervention Studies on Cancer-related Fatigue in Korea: 1990-2010 (국내 암환자 피로에 적용한 중재효과의 메타분석: 1990-2010)

  • Oh, Pok Ja;Jung, Ji Ah
    • Journal of Korean Clinical Nursing Research
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    • v.17 no.2
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    • pp.163-175
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    • 2011
  • Purpose: This study was to analyze the characteristics and effect size of intervention studies applied to cancer-related fatigue in Korea. Methods: For meta-analysis, a total of 963 studies were retrieved from search engines. And 19 studies with a total of 721 participants published from 1990 to 2010 were selected upon their satisfaction with the inclusion criteria. Two authors independently extracted data from the selected studies and assessed the methodological quality. The data was analyzed by the RevMan 5.0 program of Cochrane library. Results: Intervention studies included 4 studies on foot-reflexo-massage (21.1%), comprehensive program (21.1%), and exercise (21.1%), respectively, 3 for hand-reflexo-massage (15.8%), and 4 for others. The effect size of the intervention studies shown higher effect size in order of exercise (d=-1.80), and foot & hand-reflexo-massage (d=-0.55). Conclusion: This study suggest that exercise can reduce the intensity of cancer-related fatigue, even though the number of intervention studies and randomized controlled trials were very few. There is limited evidence that reflexo-massage is effective in reducing cancer-related fatigue.