• Title/Summary/Keyword: Randomized Clinical Trials

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Muscle Energy Technique for Neck Pain: Systematic Review (경추통에 대한 근 에너지 기법의 효과: 체계적 문헌고찰)

  • Son, Bu-Kyung;Yoo, Hyo-Jeong;Geum, Ji-Hye;Lee, Jung-Han;Ha, Won-Bae
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.15 no.1
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    • pp.49-64
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    • 2020
  • Objectives : The purpose of this study was to provide a clinical evidence base for the effectiveness of the muscle energy technique (MET) for cervicalgia. Methods : We conducted a search of 10 electronic databases up to April 2019. Randomized controlled trials (RCTs) that performed the MET for cervicalgia were included. The risk of bias was assessed using the Cochrane risk of bias (RoB) tool. Results : Six RCTs met the inclusion criteria. The literature review of these studies showed favorable results for the use of the MET in comparison to other manual medicines. Conclusions : In 6 RCTs, we found that the MET was effective in cervicalgia treatment. However, most of the included studies had an unclear risk of bias. Therefore, well-designed RCTs are necessary to obtain a higher evidence level of the MET use in cervicalgia.

Meta Analysis of Treatment for Stage IE~IIE Extranodal Natural Killer /T Cell Lymphomas in China

  • Li, Hui;Wang, Chun-Sen;Wang, Xiao-Dong
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.2297-2302
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    • 2014
  • Objective: To evaluate early treatment for extranodal natural killer/T cell lymphoma (ENK/TCL) in China and provide reference for clinical treatment of these patients. Methods: Computer-based retrieval was performed in PubMed, CNKI, CBM, VIP and WanFang Data to search for randomized controlled trials (RCTs) of treatment for early ENK/TCL, and a meta-analysis was conducted with RevMan 5.0 software. Results: A total of 11 RCTs, including 871 patients, were selected, of which the first radiotherapy had a higher complete response (CR) than the first chemotherapy [OR=14.16, 95%CI (8.68, 23.10), P<0.00001] and CR was not different between combined treatment group and radiotherapy group [OR=1.86, 95%CI (0.47, 3.58), P=0.61], but long-term survival rate was higher with combined treatment[OR=1.88, 95%CI (1.09, 3.19), P=0.02]. No difference in survival rate was observed between radio-chemotherapy and chemo-radiotherapy groups [OR=1.11, 95%CI (0.73, 1.69), P=0.63]. Conclusions: Radiotherapy is of great significance in the treatment of early ENK/TCL, but combined therapy could further enhance long-term survival rate of patients. This conclusion still requires further confirmation using RCTs with high quality and large sample size.

Multimodality Treatment for Patients with Node-Positive Prostate Cancer: the Role of Radiation Therapy

  • Ochiai, Satoru;Nomoto, Yoshihito;Kobayashi, Shigeki;Yamashita, Yasufumi;Watanabe, Yui;Toyomasu, Yutaka;Kawamura, Tomoko;Takada, Akinori;II, Noriko;Sakuma, Hajime
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.1625-1630
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    • 2016
  • Prostate cancer is the secondary most frequently diagnosed cancer in the world. Although numerous prospective randomized trial have been conducted to guide the management of patients with localized or locally advanced prostate cancer, few clinical trials targeting node-positive prostate cancer have been reported. Therefore, there are still controversies in the optimal management of node-positive prostate cancer. Recently, efficacy of multimodality treatment, including radiation therapy (RT), for such patients has been reported in several articles. The results indicate potential benefit of RT both in adjuvant therapy after prostatectomy and in definitive therapy for node-positive prostate cancer. The aim in this article was to summarize the current evidence for RT and evaluate the role in multimodality treatment for patients with node-positive prostate cancer.

Clinical Observations of Complex Therapy, including Electroacupuncture and Magnetic-acupuncture, for Treating Peripheral Facial Nerve Palsy (전기와 자기장의 침 자극을 포함한 복합치료가 말초성 안면신경마비에 미치는 영향에 대한 관찰 연구)

  • Oh, Seo Young;Lee, Hyun;Kang, Jae Hui
    • Journal of Acupuncture Research
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    • v.33 no.3
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    • pp.117-127
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    • 2016
  • Objectives : This study was performed to observe the effect of complex therapy, including electro-acupuncture and magnetic-acupuncture, on peripheral facial nerve palsy. Methods : Nine patients with peripheral facial nerve palsy were treated with acupuncture using electrical and magnetic stimulation. Acupoints in the face were stimulated with an electromagnetic field, as widely and as evenly as possible. To evaluate the effects before and after treatment we used Yanagihara's unweighted grading system, House-Brackmann scale, and Sunnybrook facial grading system and image once a week. Results : After treatment, the scores of Yanagihara's unweighted grading system, House-Brackmann scale and Sunnybrook facial grading system each improved (p-value < 0.05). Conclusion : Complex therapy using electro-acupuncture and magnetic-acupuncture might be an effective treatment to improve symptoms of peripheral facial nerve palsy. Further randomized-controlled trials are required to verify the efficacy and results of this study.

Respiratory support with heated humidified high flow nasal cannula in preterm infants

  • Jeon, Ga Won
    • Clinical and Experimental Pediatrics
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    • v.59 no.10
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    • pp.389-394
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    • 2016
  • The incidence of bronchopulmonary dysplasia (BPD) has not decreased over the last decade. The most important way to decrease BPD is by weaning the patient from the ventilator as soon as possible in order to reduce ventilator-induced lung injury that underlies BPD, and by using a noninvasive ventilator (NIV). Use of a heated, humidified, high flow nasal cannula (HHHFNC), which is the most recently introduced NIV mode for respiratory support in preterm infants, is rapidly increasing in many neonatal intensive care units due to the technical ease of use without sealing, and the attending physician's preference compared to other NIV modes. A number of studies have shown that nasal breakdown and neonatal complications were lower when using a HHHFNC than when using nasal continuous positive airway pressure (nCPAP), or nasal intermittent positive pressure ventilation. The rates of extubation failure during respiratory support were not different between patients who used HHHFNC and nCPAP. However, data from the use of HHHFNC as the initial respiratory support "after birth", particularly in extremely preterm infants, are lacking. Although the HHHFNC is efficacious and safe, large randomized controlled trials are needed before the HHHFNC can be considered an NIV standard, particularly for extremely preterm infants.

Electrical Acupuncture Combined Bee Venom Therapy for Pain and Disability Induced Intervertebral Herniated Disc of L-spine;A Pilot Study

  • Kwon, Young-Dal
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.3
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    • pp.703-707
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    • 2008
  • To examine the efficacy of electrical acupuncture combined bee venom in controlling low back with leg pain induced Herniated Intervertebral Disc (HIVD). 13 patients (men 8, women 5; age $41.30\;{\pm}\;17.27$) diagnosed as HIVD by CT or MRI had low back and leg pain as a chief complaint and diseases such as spinal tumor, infection and fracture were excluded. They were treated by electrical acupuncture (8 Hz) combined bee venom therapy three times a week in Wonkwang University Hospital, and pain intensity with VAS and functioning with Roland-Morris Disability Qestionnaire(RDQ) were measured at the baseline(B), and 4 weeks after treatment. The data were analyzed with Wilcoxon signed ranks test(SPSS12.0) and the level set for statistical significance was P<0.05. The pain was significantly reduced by two combined treatments (=0.002;$B7.69{\pm}2.06$,4Wks$4.70{\pm}2.72$). The function was also significantly improved by both treatments(=0.001;$B12.15{\pm}6.85$,4Wks$6.85{\pm}5.15$). The results suggest that a combination of acupuncture and bee venom therapy may be beneficial for low back pain from HIVD. In future, randomized clinical trials including follow-up are needed to examine the effects of these therapies.

Effect of Tai Chi as Therapeutic Exercise on Blood Pressure : Rapid Systematic Review (운동요법으로서 태극권이 혈압에 미치는 영향 : 신속 체계적 고찰)

  • Hwang, Eui-Hyoung;Heo, Kwang-Ho;Lee, Guem-San
    • Journal of Korean Medicine Rehabilitation
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    • v.23 no.1
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    • pp.101-113
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    • 2013
  • Objectives : The purpose of this study is to systematically analyze the effect of Tai Chi as therapeutic exercise on depressing blood pressure. Methods : We reviewed articles published in the PubMed, Chinese Academic Journals(CAJ) and five Korean databases. The searching keywords were "Tai chi AND blood pressure" and "Tai chi AND hypertension". We evaluated the quality with Cochrane risk of bias tool. Results : In the 114 articles searched, 7 randomized controlled clinical trials were selected. Yang(楊) style Tai chi, exercising over 30 minutes a time and over three times a week, had an effect on decreasing blood pressure. However, Wu(吳) style Tai chi was not effective in decreasing blood pressure. Conclusions : Usual exercises for hypertension patients should be performed in the form of moderate exercises intensity for 10-26 weeks by 30-60 minute a time, over 3 times a week. The study of Tai Chi on blood pressure needs to follow this criteria in the future.

The Efficacy of Moxibustion for Female Stress Urinary Incontinence: a Systematic Review (여성 복압성 요실금에 대한 뜸 치료의 효과 : 체계적 문헌 고찰)

  • Park, Hye-Rin;Jo, Hee-Geun
    • The Journal of Korean Obstetrics and Gynecology
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    • v.33 no.4
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    • pp.1-22
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    • 2020
  • Objectives: The purpose of this review is to evaluate the efficacy of moxibustion for stress urinary incontinence (SUI) in women. Methods: For relevant randomized controlled trials (RCTs), we searched the following databases from their inception to September 1, 2020: The Cochrane Library, PubMed, EMBASE, Chinese National Knowledge Infrastructure Database (CNKI), Koreanstudies Information Service System (KISS), Research Information Sharing Service (RISS), and National Digital Science Library (NDSL). The key search terms were 'stress urinary incontinence' and 'moxibustion'. Data extraction and assessment of risk of bias were conducted by two authors independently. Results: A total of 11 RCTs were finally included in this systematic review. In all studies, moxibustion treatment was applied as an adjuvant therapy to the conventional treatment, and the most common conventional treatment was pelvic floor muscle training (PFMT). The treatment group (conventional treatment plus moxibustion) showed statistically more significant effect than the control group (conventional treatment only) in various evaluation indicators including urinary incontinence frequency, 1 hour urine pad test, quality of life, the clinical efficacy rate, and pelvic muscle strength. Conclusions: In this study, we investigated the efficacy of moxibustion as an adjuvant therapy for female SUI patients. Further studies are needed to supplement the safety of moxibustion and the evaluation of moxibustion dose.

A Review of the Study on Complementary and Alternative Medicine in Obstetrics (임신 중 한의학 관련 보완대체의학 활용 연구 동향 분석을 통한 한방 산과학의 활성화 방안 연구 (2000년대 연구를 중심으로))

  • Lee, Yoon-Jae;Hwang, Deok-Sang;Lee, Chang-Hoon;Lee, Kyung-Sub
    • The Journal of Korean Medicine
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    • v.30 no.1
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    • pp.137-149
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    • 2009
  • Objectives: Pregnant women could have various diseases, but the treatment of medication has the limitation that could cause fetal injury. So pregnant women have used complementary and alternative medicine in the world, but korean medicine had not been actively studied on obstetrics. This study is to investigate efficacy and safety of complementary and alternative medicine on obstetrics. Methods: We searched for papers which had pregnancy, obstetrics, complementary medicine, acupuncture and herb in the pubmed since 2000. Results: 41 papers were found. Acupuncture have the efficacy and safety on nausea, pelvic pain in pregnancy and breech presentation. Complementary alternative medicine had been studied as randomized controlled trial at various diseases in obstetric. But the method were without coordination, results were different from methods. So more clinical trials about complementary and alternative medicine would be needed. Massage and acupressure would be helpful for pregnant mood complaint. Conclusion: Complementary and alternative medicine has been proved as efficacy and safety in obstetrics, so complementary and alternative medicine would be helpful method in pregnant women. For making guidelines on complementary and alternative medicine treatment during pregnancy, more research will be needed.

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Literature Review of Korean Medicine Studies for Fibromyalgia Syndrome (FMS) (섬유근통 증후군의 한의학적 연구에 대한 문헌 조사: 국내 논문을 대상으로)

  • Lee, Jung-Min
    • Journal of Korean Medicine Rehabilitation
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    • v.27 no.2
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    • pp.55-66
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    • 2017
  • Objectives This study aimed to review studies in Korean medicine for fibromyalgia syndrome (FMS). Methods We conducted search across 3 electronic databases (Korean traditional knowledge portal, RISS, Oasis) to find studies for FMS in Korean medicine. Studies of Korean medicine for FMS were included and analysed. Results 15 studies were included. 2 studies were reviews and 13 studies were case reports. Total numbers of patients in case studies were 15. In case studies, acupuncture (100%), herbal medicine (76.9%), Korean physical therapy (69.2%), pharmacopuncture (53.8%), Chuna (46.1%) and moxibustion (30.7%) etc. were used. BL23 in acupuncture and CV12 in moxibustion were most frequently used. Gamisoyo-san in herbal medicine and visual analogue scale (VAS) in outcome measure were most frequently used. Conclusions This systematic review found encouraging but limited evidence of Korean medicine for FMS. I expect various trials such as randomized clinical trial or animal experimentation and more case reports. And systemic review for FMS in other national journals is needed.