• Journal of Chest Surgery
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• 제32권9호
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• pp.855-857
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• 1999

흉벽의 임파관종은 전 세계적으로 매우 드물게 보고 되어있다. 본원에서는 16세의 여자환자로 우측 상부 후측방 흉벽에 반복적으로 나타나는 거대 종괴를 주소로 내원한 임파관종 환자를 치험하였다. 진단은 이학 적 검사와 흉부 핵자기공명 촬영, 동위원소 임파관 촬영술을 실시하였으며 조직검사로 확진하였다. 치료는 외과적 완전 절제를 하였으며 술후 반복적 림프액의 유출로 수술부위에 vibramycin을 주사하였다.

• Nuclear Medicine and Molecular Imaging
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• 제40권2호
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• pp.66-73
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• 2006

Monoclonal antibodies are designed to bind specifically to certain antigen, give therapeutic effect to the target and to be produced in large scale with homogeneity. The monoclonal antibodies conjugated with radionuclide can deliver therapeutic irradiation to the target, and showed successful results in certain malignancies, which is known as radioimmunotherapy. The target-to-background ratio depends on the antigen expression in the target and normal tissues, which is related to the therapeutic efficacy and toxicity in radioimmunotherapy. For the solid tumor beta-ray energy should be high, but lower beta energy is better for the hematological malignancies. I-l31 is widely used in thyroid cancer with low cost and high availability. Labeling monoclonal antibody with I-131 is relatively simple and reproducible. Some preclinical data for the I-131 labeled monoclonal antibodies including acute toxicity and efficacy are available from already published literatures in KIRAMS, physician sponsored clinical trial protocols using Rituximab, KFDA approved anti-CD20 chimeric monoclonal antibody and I-131 were approved by KFDA and currently are ongoing.

• Nuclear Engineering and Technology
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• 제4권2호
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• pp.83-89
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• 1972

중성자 선속 모니타로써 단 수명 방사성 동위원소인 $^{56}$ Mn을 이용한 새로운 비교법을 사용하여 모나자이트중에 함유된 개개 희토류원소의 함량을 중성자 방사화법으로 정량하였다. 전회토류원소를 군으로 분리하고 난 다음 중성자 조사를 하였으며 개개 희토류 원소는 양이온 교환수지통을 통하여 알파 하이드록씨 부탈산으로 구배 용출시킴으로서 분리하였다. 루데슘으로 부터 란타늄까지 14개의 희토류원소를 정량하였다.

• 한국지역지리학회지
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• 제22권2호
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• pp.439-449
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• 2016

몬순 시스템의 변화를 이해하기 위해서는 과거의 변화에 대한 정보가 절실히 필요하다. 이 연구에서는 강원도 평창에서 확보한 석순에 기록되어 있는 한반도 홀로세 중후기 고기후의 변화 특성과 몬순 변동을 확인하였다. 이를 위해 절단면의 성장성 분석과 탄소 및 산소동위원소 분석, 그리고 방사성 탄소연대측정 등을 수행하였다. 석순은 약 4580 yr BP에서 660 yr BP 사이에 생성된 것으로, 미약한 중기 청동기저온기, 철기저온기-로마온난기, 중세암흑저온기가 나타났다. 동아시아 지역에서 해당기간 확인된 몬순 약화 현상이 나타났으며, 기존 연구에 비해 다소 빨리 발생 하였을 가능성을 확인하였다.

• Nuclear Engineering and Technology
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• 제27권5호
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• pp.767-774
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• 1995

방사성 동위원소 추적자를 포함한 모의폐기물의 시험소각을 통하여 $^{60}$Co, $^{54}$Mn 및 $^{137}$Cs의 소각공정에서의 거동을 고찰하였다. 공정 내에서 비휘발성 방사성 핵종들인 $^{60}$Co 및 $^{54}$Mn의 거동은 입자상 물질의 거동과 유사하였다. $^{60}$Co 및 $^{54}$Mn의 제염계수(DF) 는 각각 4.7$\times$$10^{5}$ 및 6.2$\times$$10^{5}$ 이었다. 반휘발성인 핵종의 거동은 소각온도의 의존성을 보여주었다. 반휘발성 $^{137}$Cs의 제염계수는 85$0^{\circ}C$ 및 $700^{\circ}C$ 의 다른 소각온도에서 각각 2.8$\times$$10^3$, 2.6$\times$$10^4$이었다. 원자력 발전소(NPS) 고리 3, 4호 기에서 운반된 건조 방사성폐기물(DAW)에 대한 시험소각도 실시하였다. 폐기물에 포함된 총 베타 /감마 방사능에 대한 제염계수가 1.1$\times$$10^{5}$ 이었다. 앞의 추적자 시험의 결과 및 건조 고체폐기물 내 핵종분포에 기준을 둔 예상제염계수보다 다소 높은 값을 보였다. 굴뚝에서의 배출농도는 0.019 Bq /N $m^3$으로 기체상 배출물에 대한 최대허용농도(MPC)를 만족시킬 수 있었다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.243-244
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• 2013

Over the past 15 years, several groups have incorporated radio-frequency quadrupole (RFQ) based instruments before the accelerator in accelerator mass spectrometry (AMS) systems for ion-gas interactions at low kinetic energy (＜40 eV). Most AMS systems arebased on a tandem accelerator, which requires negative ions at injection. Typically, AMS sensitivity abundance ratios for radioactive-to-stable isotope are limited to Xr/Xs ＞10^-15, and the range of isotopes that can be analyzed is limited because of theneed to produce rather large negative ion beams and the presence of atomic isobaric interferences after stripping. The potential of using low-kinetic energy ion-gas interactions for isobar suppression before the accelerator has been demonstrated for several negative ion isobar systems with a prototype RFQ system incorporated into the AMS system at IsoTrace Laboratory, Canada (Ontario, Toronto). Requisite for any such RFQ system applied to very rare isotope analysis is large transmission of the analyte ion. This requires proper phase-space matching between the RFQ acceptance and the ion beam phase space (e.g. 35 keV, ${\varphi}3mm$, +-35 mrad), and the ability to control the average ion energy during interactions with the gas. A segmented RFQ instrument is currently being designed at Korea Institute for Science and Technology (한국과학기술연구원, KIST). It will consist of: a) an initial static voltage electrode deceleration region, to lower the ion energy from 35 keV down to ＜40 eV at injection into the first RFQ segment; b) the segmented quadrupole ion-gas interaction region; c) a static voltage electrode re-acceleration region for ion injection into a tandem accelerator. Design considerations and modeling will be discussed. This system should greatly lower the detection limits of the 6 MV AMS system currently being commissioned at KIST. As an example, current detection sensitivity of 41Ca/Ca is limited to the order of 10^-15 while the 41Ca/Ca abundance in modern samples is typically 41Ca/Ca~10^-14 - 10^-15. The major atomic isobaric interference in AMS is 41K. Proof-of-principal work at IsoTrace Lab. has demonstrated that a properly designed system can achieve a relative suppression of KF3-/41CaF3- ＞4 orders of magnitude while maintaining very high transmission of the 41CaF3- ion. This would lower the 41Ca detection limits of the KIST AMS system to at least 41Ca/Ca~10^-19. As Ca is found in bones and shells, this would potentially allow direct dating of valuable anthropological archives and archives relevant to our understanding of the most pronounced climate change events over the past million years that cannot be directly dated with the presently accessible isotopes.

• 대한핵의학회지
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• 제3권1호
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• pp.41-49
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• 1969

742 cases of thyroid diseases treated at Radio-isotope Clinic, Seoul National University Hospital since October 1965 through July 1968 were analyzed. The patients were classified according to eye findings, as to Infiltrative, Non-infiltrative and No ophthalmopathy. Correlations between ophthalmological findings and symptoms, BMR values and $^{131}I$ uptake rate as well as response to medical treatment were carefully reviewed. Results obtained were as follows: 1. Among goitrous patients 44.5% with infiltrative ophthalmopathy, 24.1% with non-infiltrative ophthalmopathy totaling 68.6% of patients with one or more eye findings were found. Exophthalmos (44%) and visual disturbances (44%) comprised the highest incidence among eye signs. Most frequent eye symptoms were lid swelling (17.1%). 2. Female patients were predominant(91%). 3. Of cases with hyperthyroidism, after treatment with antithyroid drugs and radio-iodine therapy, general symptoms were improved in over 74%, whereas ophthalmopathy was not changed and in some cases the eye signs were aggravated. This tendency was more apparent in infiltrative ophthalmopathy. 4. Significant correlations between exophthalmos, BMR values and $^{131}I$ uptake rate were found. Among the patients of same degree of exophthalmos, BMR values and $^{131}I$ uptake rate showed the highest in non-infiltrative ophthalmopathy, moderate in infiltrative ophthalmopathy and the lowest in no ophthalmopathy.

• Biomedical Engineering Letters
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• 제8권4호
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• pp.383-392
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• 2018

For prompt gamma ray imaging for biomedical applications and environmental radiation monitoring, we propose herein a multiple-scattering Compton camera (MSCC). MSCC consists of three or more semiconductor layers with good energy resolution, and has potential for simultaneous detection and differentiation of multiple radio-isotopes based on the measured energies, as well as three-dimensional (3D) imaging of the radio-isotope distribution. In this study, we developed an analytic simulator and a 3D image generator for a MSCC, including the physical models of the radiation source emission and detection processes that can be utilized for geometry and performance prediction prior to the construction of a real system. The analytic simulator for a MSCC records coincidence detections of successive interactions in multiple detector layers. In the successive interaction processes, the emission direction of the incident gamma ray, the scattering angle, and the changed traveling path after the Compton scattering interaction in each detector, were determined by a conical surface uniform random number generator (RNG), and by a Klein-Nishina RNG. The 3D image generator has two functions: the recovery of the initial source energy spectrum and the 3D spatial distribution of the source. We evaluated the analytic simulator and image generator with two different energetic point radiation sources (Cs-137 and Co-60) and with an MSCC comprising three detector layers. The recovered initial energies of the incident radiations were well differentiated from the generated MSCC events. Correspondingly, we could obtain a multi-tracer image that combined the two differentiated images. The developed analytic simulator in this study emulated the randomness of the detection process of a multiple-scattering Compton camera, including the inherent degradation factors of the detectors, such as the limited spatial and energy resolutions. The Doppler-broadening effect owing to the momentum distribution of electrons in Compton scattering was not considered in the detection process because most interested isotopes for biomedical and environmental applications have high energies that are less sensitive to Doppler broadening. The analytic simulator and image generator for MSCC can be utilized to determine the optimal geometrical parameters, such as the distances between detectors and detector size, thus affecting the imaging performance of the Compton camera prior to the development of a real system.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.262-262
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• 2012

A multi-purpose cyclotron, MC50 has been operated to provide multi-ions of proton, deuteron and alpha at Korea Institute of Radiological and Medical Sciences (KIRAMS). Neutron is also produced through the (p,n) nuclear process with a Be target. However, a wide spectrum of current of ions is requested by beam users for carrying their various application fields. Therefore a simulation study is requested on the design of an axial injection system for high current proton and alpha beam extraction for radio-isotope productions and scientific researches. The purpose of this study is seeking a relatively simple method for the MC50 having higher alpha beam capability and also improving proton and deuteron beams currently used. We are considering two possibilities to improve the internal ion source and to install a new external axial injection system. The external injection system will be consisted of an Einzel lens, a steering magnet, a buncher, and a glazer lens placed in front of an inflector, which is located at the center of the main magnet.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2203-2205
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• 2003

KIRAMS-13, the first medical cyclotron developed by domestic technique, is used to produce radio-isotope such as $^{18}F$ whose life time is relatively short through test operation. For high-power operation of charged particle accelerators, the power coupler must withstand enormous stresses due to charging induced by high RF power passing through. High-power RF testing with peak power in excess of 30kW has been performed on prototype power coupler for KIRAMS-13 normal conducting cavities. CST MICROWAVE STUDIO(CST MWS) is used for fundamental RF Design, and power coupler is manufactured according to fundamental power coupler design requisite. The qualification of the couplers has occurred for the time being only in a limited set of conditions as the available RF system and control instrumentation are under improvement.