• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3419-3423
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• 2015

Background: Liposarcoma of the spermatic cord is rare and frequently misdiagnosed. The standard therapeutic approach has been radical inguinal orchiectomy with wide local resection of surrounding soft tissues. The current trend of organ preservation in the treatment of several cancers has started to evolve. Herein we present our testis-sparing surgery experience in the treatment of spermatic cord liposarcoma and a pooled analysis on this topic. Materials and Methods: Clinical information from patient receiving organ-sparing surgery was described. Clinical studies evaluating this issue were identified by using a predefined search strategy, e.g., Pubmed database with no restriction on date of published papers. The literature search used the following terms: epidemiology, surgery, chemotherapy, radiotherapy, testis sparing surgery, spermatic cord sarcomas/liposarcomas. Results: Patient received a complete excision of the lesion, preserving the spermatic cord and the testis. The final pathological report showed a well differentiated liposarcoma with negative surgical margins and no signs of local invasion. After 2-year of follow-up, there was no evidence of local recurrence. Since the first case reported in 1952, a total of about 200 well-documented spermatic cord liposarcoma cases have been published in English literature. Among these patients, only three instances were reported to have received an organ-sparing surgery in the treatment of spermatic cord liposarcoma. Conclusions: Radical inguinal orchiectomy and resection of the tumor with a negative microscopic margin is the recommended treatment for liposarcoma of the spermatic cord. But for small, especially well-differentiated, lesions, testis-sparing surgery might be a good option if an adequate negative surgical margin is assured.

• Clinical and Experimental Reproductive Medicine
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• 제45권1호
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• pp.44-47
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• 2018

Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a patient who had previously undergone successful contralateral orchiectomy and whose sperm was preserved by onco-testicular sperm extraction. A 35-year-old patient presented with swelling of his right scrotum that had lasted for 1 month. His medical history included a contralateral orchiectomy during childhood. Ultrasonography revealed a mosaic echoic area in his scrotum, suggesting a testicular tumor. The lesion was palpated within the normal testicular tissue along its edge and semen analysis showed azoospermia. Radical inguinal orchiectomy and onco-testicular sperm extraction were performed simultaneously. Motile spermatozoa were extracted from normal seminiferous tubules under microscopy and were frozen. Eventual intracytoplasmic sperm injection using the frozen spermatozoa is planned. Onco-testicular sperm extraction is an important fertility preservation method in patients with bilateral testicular tumors or a history of a previous contralateral orchiectomy.

• Korean Journal of Radiology
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• 제2권2호
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• pp.117-120
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• 2001

We report a case of adult granulosa cell tumor arising in the scrotal tunics. The patient was a 34-year-old man who presented with right scrotal swelling, first noticed four months previously. Under the initial clinical impression of epididymo-orchitis, antibiotic treatment was instituted but there was no response. The paratesticular nodules revealed by ultrasound and magnetic resonance imaging mimicked intratesticular lesion, and radical orchiectomy was performed. Although several cases of adult testicular granulosa cell tumor, have been reported, the occurrence of this entity in the paratesticular area has not, as far as we are aware, been previously described.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.231-234
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• 2021

We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)-encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.

• Journal of Yeungnam Medical Science
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• 제20권1호
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• pp.85-91
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• 2003

Malignant fibrous histiocytoma (MFH) of the spermatic cord represents an uncommon location for the most common soft tissue tumor in adults. MFH of the spermatic cord is extremely rare. No case report has been described in the Korean literature. We report a case of malignant fibrous histiocytoma, myxoid type, arising from left spermatic cord. A 77-year-old male presented with a painless left upper scrotal mass for 5 months. Simple mass excision was performed for a diagnosis. Grossly, the mass closely contacted with the left spermatic cord. Since a myxoid type of malignant fibrous histiocytoma was diagnosed from histopathological findings, left radical orchiectomy with high ligation of the spermatic cord was performed additionally. There were no evidence of local recurrence or metastasis at 6 months after surgery.

• Journal of Yeungnam Medical Science
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• 제2권1호
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• pp.293-297
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• 1985

저자들은 최근 50세 남자 환자에서 병리조직학적으로 증명된 정상피종과 태아성 암으로 구성된 결합종양 1예를 경험하였기에 문헌 고찰과 아울러 보고하는 바이다.

• Radiation Oncology Journal
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• 제27권2호
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• pp.49-54
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• 2009

목 적: 제 1 병기 성인 고환 정상피종 환자에 대한 임상적 고찰과 함께 근치적 고환절제술 후 보조적 방사선 치료와 고환절제술 단독치료의 결과를 후향적으로 분석 비교하고자 하였다. 대상 및 방법: 1996년 1월부터 2005년 9월까지 삼성서울병원에서 제 1 병기 정상피종으로 진단을 받은 환자 32명의 순수 정상피종(pure seminoma) 환자를 대상으로 하였다. 근치적 고환절제술 후 22명은 보조적 방사선 치료를 시행하였고, 10명은 추가치료 없이 종양표지자와 복부골반 전산화단층촬영을 이용한 정기적 추적관찰을 행하였다. 방사선 치료는 10~15 MV 광자선을 사용하였으며 일일치료선량 1.8~2 Gy로 총 24~30.6 Gy (중앙값, 25.2 Gy)를 대동맥주위림프절(L1~L5)에 이문조사하였다. 전체 추적관찰기간은 근치적 고환절제술 시행일을 기준으로 24~155개월(중앙값, 96개월)이었다. 결 과: 환자의 연령은 22~58세(중앙값 34세)였고, 임상적으로 진단 전 주증상은 음낭 종괴 및 불편감이 대부분이었다. 이중 2명에서 잠복고환의 병력이 있었으며, 병리적으로 32명 중 23명에서 정상피종에 관내배아세포종(intratubular germ cell neoplasia)이 동반되어 있었다. 술후 보조적 방사선 치료를 시행한 군은 분석시점에 모든 환자가 무병상태로 100%의 국소제어율 및 생존율을 보였다. 술후 추적관찰만을 시행한 군은 10명 중 1명에서 좌측 대동맥주위 림프절에 재발하여 구제 항암화학요법 후 완전관해되었으며 국소제어율 88.9%, 생존율 100%를 보였다. 결 론: 제 1 병기 정상피종에서 근치적 고환절제술 후 보조적 방사선 치료를 시행한 군과 추적관찰만을 시행한 군간에 생존율의 차이는 없었다. 환자수가 적고 추적관찰기간이 짧기는 하지만 재발 후 항암화학요법으로 구제가 잘 되고, 방사선 치료시 이차암의 가능성이 있음을 고려한다면 정기적인 추적관찰이 가능한 환자에서 수술 후 방사선 치료를 생략할 수도 있겠다.