• 한국의학물리학회지:의학물리
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• 제32권2호
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• pp.25-39
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• 2021

Brachytherapy, along with external beam radiation therapy (EBRT), is an essential and effective radiation treatment process. In brachytherapy, in contrast to EBRT, the radiation source is radioisotopes. Because these isotopes can be positioned inside or near the tumor, it is possible to protect other organs around the tumor while delivering an extremely high-dose of treatment to the tumor. Brachytherapy has a long history of more than 100 years. In the early 1900s, the radioisotopes used for brachytherapy were only radium or radon isotopes extracted from nature. Over time, however, various radioisotopes have been artificially produced. As radioisotopes have high radioactivity and miniature size, the application of brachytherapy has expanded to high-dose-rate brachytherapy. Recently, advanced treatment techniques used in EBRT, such as image guidance and intensity modulation techniques, have been applied to brachytherapy. Three-dimensional images, such as ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography are used for accurate delineation of treatment targets and normal organs. Intensity-modulated brachytherapy is anticipated to be performed in the near future, and it is anticipated that the treatment outcomes of applicable cancers will be greatly improved by this treatment's excellent dose delivery characteristics.

• 환경생물
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• 제20권4호
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• pp.277-286
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• 2002

An increase in the overall biological effect under the combined action of ionizing radiation with another inactivating agent can be explained in two ways. One is the supposition that synergism may attribute to a reduced cellular capacity of damn-ge repair after the combined action. The other is the hypothesis that synergism may be related to an additional lethal or potentially lethal damage that arises from the interaction of sublesions induced by both agents. These sublesions ave considered to be in-effective when each agent is applied separately. Based on this hypothesis, a simple mathematical model was established. The model can predict the greatest value of the synergistic effect, and the dependence of synergy on the intensity of agents applied, as well. This paper deals with the model validation and the peculiarity of simultaneous action of various factors with radiation on biological systems such as bacteriophage, bacterial spores, yeast and mammalian cells. The common rules of the synergism aye as follows. (1) For any constant rate of exposure, the synergy can be observed only within a certain temperature range. The temperature range which synergistically increases the effects of radiation is shifted to the lower temperature fer thermosensitive objects. Inside this range, there is a specific temperature that maximizes the synergistic effect. (2) A decrease in the exposure rate results in a decrease of this specific temperature to achieve the greatest synergy and vice versa. For a constant temperature at which the irradiation occurs, synergy can be observed within a certain dose rate range. Inside this range an optimal intensity of the physical agent may be indicated, which maximizes the synergy. As the exposure temperature reduces, the optimal intensity decreases and vice versa. (3) The recovery rate after combined action is decelerated due to an increased number of irreversible damages. The probability of recovery is independent of the exposure temperature for yeast cells irradiated with ionizing or UV radiation. Chemical inhibitors of cell recovery act through the formation of irreversible damage but not via damaging the recovery process itself.

• 대한방사선기술학회지:방사선기술과학
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• 제42권2호
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• pp.137-143
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• 2019

The aim of this study was analyzed the setup error of breast cancer patients in intensity modulated radiation therapy(IMRT) with deep inspiration breath holding(DIBH) and was analyzed the dose distribution due to setup error. A total of 45 breast cancer cases were performed a retrospective clinical analysis of setup error. In addition, the re-treatment planning was carried by shifting the setup error from the isocenter at the treatment. Based on this, the dose distribution of PTV and OARs was compared and analyzed. The 3D error for small breast group and medium breast group and large breast group were 3.1 mm and 3.7 mm and 4.1 mm, respectively. The difference between the groups was statistically significant(P=0.003). DVH results showed HI, CI for the PTV difference between standard treatment plan and re-treatment plan of 14.4%, 4%. The difference in $D_5$ and $V_{20}$ of the ipsilateral lung was 5.6%, 13% respectively. The difference in $D_5$ and $V_5$ of the heart of right breast cancer patients was 6.8%, 8% respectively. The difference in $D_5$, $V_{20}$ of the heart of left breast cancer patients was 7.2%, 23.5% respectively. In this study, there was a significant association between breast size and significant setup error in breast cancer patients with DIBH. In addition, it was found that the dose distribution of the PTV and OARs varied according to the setup error.

• 천문학논총
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• 제8권1호
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• pp.83-104
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• 1993

In principle, both radiation and collision are capable of pumping the SiO masers. In order to check which pumping mechanism is more efficient, we calculated the rate equation for our model including the 3 vibrational slates with 7 rotational states of each vibrational slate. Through solving the radiative transfer equation with the Sovolev approximation, we estimated the line profiles from an expanding envelope for several transitions. It is found that the collision works more efficiently than the radiation for the inversion in excited vibrational stales. However in an expanding envelope model we could not get the strong line intensity as observed one because the population inversion is possible only in a small restricted region. For the enough population inversion to get type observed maser intensity. the number density of SiO and hydrogen molecules should be up to about $2{\times}10^5\;cm^{-3}$ and $1{\times}10^9\;cm^{-3}$, respectively, and the inversion should be occured in the region of no Jess than 11014cm.

• Journal of Photoscience
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• 제9권2호
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• pp.445-447
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• 2002

The compositional changes in mycosporine-like amino acids (MAAs) were investigated in the marine dinoflagellate Scrippsiella sweeneyae exposed to four different spectral compositions and five relative intensities of UV-B (280-320 nm) to UV-A (320-400 nm) + photosynthetically available radiation (PAR: 400-700 nm). Neither dose nor wavelengths of UVR significantly affected the growth rates. UVR caused a significantly increase in cell volume. Cell volume in the >280nm treatment was more than two times greater at 6.8 % of UVR intensity. Production of UVR induced MAAs was dependent on the dose of UVR. However. the induction of MAAs was related to the cell growth. Greater induction of MAAs was observed at shorter wavelengths. The composition of MAAs varied with increasing light intensity of UVR.

• Radiation Oncology Journal
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• 제37권4호
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• pp.232-248
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• 2019

Proton beams have been used for cancer treatment for more than 28 years, and several technological advancements have been made to achieve improved clinical outcomes by delivering more accurate and conformal doses to the target cancer cells while minimizing the dose to normal tissues. The state-of-the-art intensity modulated proton therapy is now prevailing as a major treatment technique in proton facilities worldwide, but still faces many challenges in being applied to the lung. Thus, in this article, the current status of proton therapy technique is reviewed and issues regarding the relevant uncertainty in proton therapy in the lung are summarized.

• 한국해양공학회지
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• 제15권4호
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• pp.53-59
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• 2001

The Primary Production of phytoplanktons produces organic matter in high concentration in eutrophicated Hakata Bay, Japan, even during the winter season in spite of low water temperature. Phytoplanktons are considered to have any biological capabilities to keep activities of photosynthesis under the unfavorable conditions, and this affects water quality of the bay. In this study, seasonal variations in primary production efficiency were predicted by using a simple box-type ecosystem model, which introduced the concept of efficiency for absorption of solar radiation energy in relation to growth of phytoplanktons under the low solar radiation intensity. According to the simulation result of primary production, it was organic pollution comes from dissolved organic carbon (DOC) throughout the year, DOC of which is originated from the primary production of phytoplanktons on biological response of the seasonal variation of ambient conditions.

• 한국해양공학회지
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• 제12권2호통권28호
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• pp.22-32
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• 1998

Many of steel structures having little internal damping consist of stiffened plates. In case that viscoelastic materials are adhered to the stiffened plates for the reduction of structure-borne noise, their effects are varied by the adhered position and dynamic characteristics of the structures as well as their material properties and adhered amount. In this paper, sound reduction effects of viscoelastic materials partially adhered to the different positions of a stiffened steel plate have been investigated by the measurement of vibratory velocity and sound intensity. The results show that optimal adherent positions of viscoelastic materials to reduce sound radiation power are the loop areas of modes.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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• pp.65-65
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• 2006

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 2007년도 추계학술대회 논문집
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• pp.210-210
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• 2007