• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.923-926
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• 2012

The aim of this study was to investigate the early outcome of Endostar combined with chemoradiotherapy for advanced cervical cancer. Fifty-two cases (FIGO IIb to IVa) were divided randomly into two groups, receiving chemoradiotherapy alone (CRT group) and Endostar combined with chemoradiotherapy (CRT+E group). For the patients in the CRT+E group, Endostar was administered daily with the dosage of 7.5 $mg/m^2$, and cisplatin was administered weekly with the dosage of 20 $mg/m^2$ during the radiation. The regimens lasted for 4 weeks with no difference in chemoradiotherapy between the two groups. The early outcome complete remission rate was 73.1%, partial remission rate was 23.1% and the total response rate was 96.2% in CRT+E group, a significant improvement on the 34.6%, 42.3% and 76.9%, respectively, in the CRT group. One year survive rates were 100% and 84.6% in the CRT+E group and CRT groups, the difference being significant. Endostar combined with chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and adverse effects were not encountered.

• Journal of Radiation Protection and Research
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• 제40권2호
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• pp.92-100
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• 2015

경수로 사용후핵연료 건식 중간저장시설의 방사선영향평가 효율성 개선을 목적으로 '선원항 지정방법에 따른 민감도 평가', '2-Step 계산'기법 개발 및 '냉각기간 이득효과' 적용에 따른 방사선 영향평가를 수행하였다. 본 연구에서는 저장건물의 용기배열 순서에 따라 순차적으로 선원항을 지정하여 직접선량에 미치는 민감도를 평가하였으며, 차폐건물 외벽에서의 방사선량은 내벽과 인접한 최근접 2개 열에 의한 영향이 지배적임을 확인하였다. 또한, 저장시설에 차폐 건물이 도입될 경우, 막대한 전산해석 시간을 감소시키기 위해 '2-Step 계산'기법을 수립하여 평가한 결과는 절반가량의 해석시간으로 직접(1-Step) 계산결과와 유사한 결과를 도출하였다. 마지막으로, 저장시설에 순차적으로 저장되는 저장용기의 보관기간을 사용후핵연료의 실제 냉각기간을 적용하면 건물 외벽에서의 방사선량이 냉각기간을 모두 동일하게 설정한 계산값에 비해 40% 정도 낮게 평가됨을 확인하였다. 본 연구는 중간저장시설의 방사선 영향평가를 위한 몬테칼로 차폐해석 방법의 효율성을 향상시키고자 수행되었으며, 좀 더 다양한 사례에 대한 평가를 통하여 신뢰성을 향상시킨다면 저장시설의 설계 및 부지경계 기준설정에 활용할 수 있을 것이다.

• Radiation Oncology Journal
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• 제3권2호
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• pp.153-157
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• 1985

X선의 생물체에 대한 효과는 뢴트겐이 X-선을 발견한 이래 산발적으로 보고되어 왔으나 원폭의 인류사용을 계기로 하여 급격히 진행되어 왔다. 여러 가지 동물을 사용하여 수많은 연구가 계속되어 왔으나 그 중에서도 혈액상에 관한 변화는 근래에까지도 계속되고 있다. 저자들은 잡종 백서를 사용하여 방사선에 가장 감수성이 예민한 부위인 전복부에 고식적인 분할조사를 실시하여 체중과 혈액상의 변화를 분석하였고 이 결과를 토대로 하여 화학요법등과의 병합 치료에서 혈액상의 변화를 비교할 수 있는 기본자료로 이용하고자 한다.

• Journal of Korean Neurosurgical Society
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• 제30권5호
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• pp.561-566
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• 2001

Objective : The purpose of this study are to evaluate the effectiveness of Gamma Knife radiosurgery(GKS) as a treatment of craniopharyngioma and to investigate the proper dose planning technique in GKS for craniopharyngioma. Method : Between May 1992 and March 1999, seven Gamma Knife radiosurgical procedures were done for residual tumor mass of 6 patients with craniopharyngioma after microsurgical resection. Conventional radiation therapy was not performed. In this study, their clinical, radiological and radiosurgical data were analyzed and the radiation dosage to the optic pathway, hypothalamus, pituitary stalk, and cavernous sinus were calculated and correlation with clinical outcome was evaluated. The mean follow-up period was 33.5 months(12.3-55.2 months). Result : The mean tumor volume was 4.4cc(0.4-18.0cc) and the maximum radiation dose ranged from 14 to 32 Gy(mean 20.9Gy). The radiation was given with isodose curve, 50-90% and the marginal dose varied within 8-22.4Gy(mean 12.7Gy). The mean number of isocenter was 4.3(1-12). The tumor was well controlled in all cases. In 5 of 7 cases, the size of tumor decreased to 10-50% of pre-GKS volume and remaining two showed no volume change. The mean dose to optic pathway was 5.7Gy(5.1-11.2Gy) and there were no complications. Conclusion : GKS seems to be effective for control of craniopharyngioma as an adjuvant treatment after microsurgical resection and even suboptimal dose for tumor margin is considered to be enough for tumor control. It is safe with careful dose planning to protect surrounding important structures, especially optic pathway. We believe conventional radiation therapy should be avoided because it has limitation for dose planning of additional treatments such as radiosurgery or intracystic instillation of radioisotope in case of recurrence.

• Journal of Korean Neurosurgical Society
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• 제54권3호
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• pp.175-182
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• 2013

Objective : Intracavitary injection of beta-emitting radiation source for control of cystic tumors has been tried with a benefit of localized internal radiation. The authors treated cystic brain tumor patients with Holmium-166-chitosan complex (Ho-166-chico), composed of a beta-emitting radionuclide Holmium-166 and biodegradable chit polymer, and evaluated the safety and effective measurement for response. Methods : Twenty-two patients with recurrent cystic brain tumor and/or located in a deep or eloquent area were enrolled in this pilot study. The cyst volume and wall thickness were determined on CT or MRI to assess radiological response. The activity of Ho-166-chico injected via Ommaya reservoir was prescribed to be 10-25 Gy to the cyst wall in a depth of 4 mm. Results : There was neither complications related to systemic absorption nor leakage of Ho-166-chico in all 22 patients. But, two cases of oculomotor paresis were observed in patients with recurrent craniopharyngioma. Radiological response was seen in 14 of 20 available follow-up images (70%). Seven patients of 'evident' radiological response experienced more than 25% decrease of both cyst volume and wall thickness. Another 7 patients with 'suggestive' response showed decrease of cyst volume without definitive change of the wall thickness or vice versa. All patients with benign tumors or low grade gliomas experienced symptomatic improvement. Conclusion : Ho-166-chico intracavitary radiation therapy for cystic tumor is a safe method of palliation without serious complications. The determination of both minimal effective dosage and time interval of repeated injection through phase 1 trial could improve the results in the future.

• 한국환경과학회지
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• 제15권4호
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• pp.311-317
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• 2006

The purpose of this study was to investigate Rn concentration and annual radiation exposure level in the basement and first floor. The Rn Cup monitors were placed in different environments such as shopping stage, office building, Apartment, Hospital, house in Seoul from Match 1996 to April 1997 and CR-39 films were collected every two months. The mean radon concentration in the basement of house($88.6\;Bq/m^3$) showed the highest level among the areas, while radon concentration on the first floor of house($50.5\;Bq/m^3$) showed the higher than other areas. The annual radiation exposure dose that person on the floor / in the basement of differential place in the seoul can be exposed during living was estimated from 24.11 to 87.64 mRem/yr. This radiation dose is significantly lower than 130mRem maximum radiation dosage from the radon nuclide prescribed by the ICRP, with respect to the overall average exposure of the working adult. this study indicated that possible radon sources on the first floor / in the basement areas are radon intrusion from soil gas, construction materials, or ground water leaking. Further study is needed to quantitatively assess major contributions of radon-222 and health effect to radon exposure.

• Journal of Radiation Protection and Research
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• 제37권2호
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• pp.90-95
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• 2012

Radiocaesium과 radiostrontium에 대한 벼의 흡수억제 대책으로서 K와 Ca의 동시처리 효과를 조사하기 위하여 온실 내에서 방사성 추적자 실험을 수행하였다. 흙상자에 담긴 논토양(pH 6.5의 양토)에 $^{137}Cs$와 $^{85}Sr$을 가하고 농업용 KCl과 $Ca(OH)_2$를 사용하여 K와 Ca를 처리한 다음 모내기하였다. 대조 작물체의 쌀알에 대한 $^{137}Cs$와 $^{85}Sr$의 토양-작물체전이계수(TF, $m^2\;kg^{-1}-dry$)는 각각 $7.4{\times}10^{-5}$ 및 $2.1{\times}10^{-4}$였고 볏짚의 경우에는 각각 $2.6{\times}10^{-4}$ 및 $2.2{\times}10^{-2}$였다. K와 Ca의 동시처리 수준(K/Ca, $g\;m^{-2}$)이 $^{137}Cs$의 경우 33.6/322까지, $^{85}Sr$의 경우 48.0/460까지 증가할수록 전이계수가 점점 감소하였다. 최고 감소율은 두 핵종 모두 60% 정도였다. $^{85}Sr$ 전이계수는 33.6/322 처리에서도 60% 가까이 감소하였다. 당 처리에서는 벼의 생산성도 양호하였다. 이로써 본 실험에서는 33.6/322 처리가 최적인 것으로 판단되었다. 최적 처리 수준은 각종 요인에 따라 다를 수 있으므로 차후 다양한 조건에 대한 실험이 수행될 필요가 있다.

• Radiation Oncology Journal
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• 제33권2호
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• pp.109-116
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• 2015

Purpose: To analyze prognostic factors for locoregional recurrence (LRR), distant metastasis (DM), and overall survival (OS) in cervical cancer patients who underwent radical hysterectomy followed by postoperative radiotherapy (PORT) in a single institute. Materials and Methods: Clinicopathologic data of 135 patients with clinical stage IA2 to IIA2 cervical cancer treated with PORT from 2001 to 2012 were reviewed, retrospectively. Postoperative parametrial resection margin (PRM) and vaginal resection margin (VRM) were investigated separately. The median treatment dosage of external beam radiotherapy (EBRT) to the whole pelvis was 50.4 Gy in 1.8 Gy/fraction. High-dose-rate vaginal brachytherapy after EBRT was given to patients with positive or close VRMs. Concurrent platinum-based chemoradiotherapy (CCRT) was administered to 73 patients with positive resection margin, lymph node (LN) metastasis, or direct extension of parametrium. Kaplan-Meier method and log-rank test were used for analyzing LRR, DM, and OS; Cox regression was applied to analyze prognostic factors. Results: The 5-year disease-free survival was 79% and 5-year OS was 91%. In univariate analysis, positive or close PRM, LN metastasis, direct extension of parametrium, lymphovascular invasion, histology of adenocarcinoma, and chemotherapy were related with more DM and poor OS. In multivariate analysis, PRM and LN metastasis remained independent prognostic factors for OS. Conclusion: PORT after radical hysterectomy in uterine cervical cancer showed excellent OS in this study. Positive or close PRM after radical hysterectomy in uterine cervical cancer correlates with poor prognosis even with CCRT. Therefore, additional treatments to improve local control such as radiation boosting need to be considered.

• Radiation Oncology Journal
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• 제32권1호
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• pp.7-13
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• 2014

Purpose: To evaluate the results of postoperative radiotherapy in patients with extra-hepatic bile duct cancer (EHBDC) and identify the prognostic factors for local control and survival. Materials and Methods: Between January 2001 and December 2010, we retrospectively reviewed the cases of 70 patients with EHBDC who had undergone curative resection and received postoperative radiotherapy. The median radiation dose was 50.4 Gy (range, 41.4 to 54 Gy). The resection margin status was R0 in 30 patients (42.9%), R1 in 25 patients (35.7%), and R2 in 15 patients (21.4%). Results: The 5-year rates of overall survival (OS), event-free survival (EFS), and locoregional control (LRC) for all patients were 42.9%, 38.3%, and 61.2%, respectively. The major pattern of failure was distant relapses (33 patients, 47.1%). A multivariate analysis showed that the postradiotherapy CA19-9 level, radiation dose (${\geq}50$ Gy), R2 resection margins, perineural invasion, and T stage were the significant prognostic factors for OS, EFS, and LRC. OS was not significantly different between the patients receiving R0 and R1 resections, but was significantly lower among those receiving R2 resection (54.6%, 56.1%, and 7.1% for R0, R1, and R2 resections, respectively). Conclusion: In patients with EHBDC who had undergone curative resection, a postoperative radiotherapy dose less than 50 Gy was suboptimal for OS and LRC. Higher radiation doses may be needed to obtain better LRC. Further investigation of novel therapy or palliative treatment should be considered for patients receiving R2 resection.

• 한국식품영양과학회지
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• 제40권5호
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• pp.712-716
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• 2011

본 연구에서는 해조류에 대한 방사선의 영향 평가에 관하여 알아보기 위하여 감마선 조사된 미역귀로부터 추출된 조다당의 추출수율 및 미백활성에 관하여 관찰하였다. 미백활성은 melanin 합성에 중요하게 작용하는 tyrosinase 억제활성과 melanocyte의 melanin 생성 억제능을 평가하였다. 실험 결과, 방사선의 조사는 선량 의존적으로 조다당의 추출수율을 증가시키고, tyrosinase 억제 활성 및 ${\alpha}$-MSH로 melanin을 과생성 시킨 B16BL6 melanoma 세포내 melanin 생성 억제 활성을 유지시켜 주는 것으로 나타났다. 이러한 결과로 미루어 보아 감마선의 조사는 미백활성을 갖는 미역귀 조다당을 얻기 위한 효과적인 방법이며, 미백 산업 분야에서도 효과적으로 이용될 수 있을 것으로 사료된다.