Radiation Effect on Body Weight and Hematological Changes of Hybrid Mice by Conventional Fraction, Large Abdominal Field Irradiation

고식적 분할조사시 전복부 조사량에 따른 잡종 백서의 체중과 혈액상의 변화에 관한 연구

Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ray. Various experimental animals were tried for radiobiological studies. 72hybrid mice with conventional faction $(15\times/week)$, large abdominal field $12\times3cm$, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about $29.7\%$ in male; $30.4\%$ in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to $40-50\%$ of pretreatment values by only 1000rad irradiation. Change of differential count was interesting; : lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed + - +++, showing no correlation with dosage. Application of our study in clinical combination therapy (radiation + chemotherapy) was discussed.

X선의 생물체에 대한 효과는 뢴트겐이 X-선을 발견한 이래 산발적으로 보고되어 왔으나 원폭의 인류사용을 계기로 하여 급격히 진행되어 왔다. 여러 가지 동물을 사용하여 수많은 연구가 계속되어 왔으나 그 중에서도 혈액상에 관한 변화는 근래에까지도 계속되고 있다. 저자들은 잡종 백서를 사용하여 방사선에 가장 감수성이 예민한 부위인 전복부에 고식적인 분할조사를 실시하여 체중과 혈액상의 변화를 분석하였고 이 결과를 토대로 하여 화학요법등과의 병합 치료에서 혈액상의 변화를 비교할 수 있는 기본자료로 이용하고자 한다.