• Molecular & Cellular Toxicology
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• 제5권2호
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• pp.165-171
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• 2009

Biomarkers indicating past exposure to radiation have not yet been entirely satisfactory. In this study, we validated several genes reported as radiation response genes, as biomarkers to detect past exposure to radiation in occupationally exposed workers, especially workers in the medical field. A total of 54 radiation workers in hospital were investigated for radiation exposure dose. Their average radiation dose of recent one year was 1.09 mSv ($\pm$1.63) with a 10.63 mSv ($\pm$12.91) cumulative dose. The results of the multiple regression analysis for the various variables indicate that the Hsc70 (P=0.0292) and ORAL (P=0.0045) may be candidate biomarkers for the recent 1 year radiation exposure in radiation workers, whereas AEN (P=0.0334) and PGAMI (P=0.0003) might be for cumulative exposure.

• 한국임상수의학회지
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• 제21권3호
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• pp.286-290
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• 2004

Cytogenetic and hematological analysis was performed in peripheral blood of pig in the vicinity of Yeonggwang nuclear power station and control area. The frequency of micronuclei (MN) in peripheral blood lymphocytes from pig was used as a biomarker of radiobiological effects resulting from exposure to environmental radiation. An estimated dose of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the swine lymphocytes exposed in vitro to radiation over the range from 0 Gy to 4 Gy. MN rates in lymphocytes of pig from Yeonggwang nuclear power station and control area were 10.60/1,000 and 11.10/1,000, respectively. There were no significant differences in MN frequencies and hematological values in pig between Yeonggwang and control area. The study indicates that the MN assay in lymphocyte of pig is a rapid, sensitive and accurate method that can be used to monitor a large population exposed to radiation.

• 한국소음진동공학회논문집
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• 제21권4호
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• pp.374-383
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• 2011

A numerical model based on a mode method coupling beams and a rectangular plate is proposed to estimate radiation characteristics of an edge-clamped rectangular plate. The radiation efficiency and radiation power in the audio frequency range including the critical frequency can be predicted. The proposed model is rather simple and straightforward and gives reliable results comparing to the previous studies. The estimated radiation characteristics are compared to those of the pinned condition plates and also to those based on the formulae proposed by Maidanik. The radiation efficiency of the clamped plate seems a little higher than that of the pinned plate in the frequency range of corner and edge modes. It is explicitly shown that the power as well as efficiency at high frequencies is not influenced by these edge boundary conditions.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2005년도 춘계학술발표회
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• pp.323-324
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• 2005

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2005년도 춘계학술발표회
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• pp.325-326
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• 2005

• 한국소음진동공학회논문집
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• 제24권11호
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• pp.876-882
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• 2014

This study investigates an efficient method to estimate the total acoustic radiation power of submerged circular cylindrical structures. Since the acoustic radiation power of submerged vehicles can be changed during the operation, the estimation for its monitoring onboard is required to accomplish the missions. The total acoustic radiation power is estimated using the measured velocity and the calculated radiation efficiency of the surface which consists of submerged rectangular plate elements. Experiments are carried out to validate the estimation approach. Comparisons of the estimation results with the measurements show that they are in a good agreement for the mid-high frequency range and match well for the cases of different excitation locations which correspond to the different operation modes of underwater vehicles as well. Therefore, this estimation method can be applied effectively to the development of the radiated noise monitoring-system.

• Communications for Statistical Applications and Methods
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• 제29권6호
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• pp.709-719
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• 2022

Recently, as the importance of environmental protection has emerged, interest in new and renewable energy is also increasing worldwide. In particular, the solar energy sector accounts for the highest production rate among new and renewable energy in Korea due to its infinite resources, easy installation and maintenance, and eco-friendly characteristics such as low noise emission levels and less pollutants during power generation. However, although climate prediction is essential since solar power is affected by weather and climate change, solar radiation, which is closely related to solar power, is not currently forecasted by the Korea Meteorological Administration. Solar radiation prediction can be the basis for establishing a reasonable new and renewable energy operation plan, and it is very important because it can be used not only in solar power but also in other fields such as power consumption prediction. Therefore, this study was conducted for the purpose of improving the accuracy of solar radiation. Solar radiation was predicted by a total of three weather variables, temperature, humidity, and cloudiness, and solar radiation outside the atmosphere, and the results were compared using various models. The CatBoost model was best obtained by fitting and comparing the Boosting series (XGB, CatBoost) and RNN series (Simple RNN, LSTM, GRU) models. In addition, the results were further improved through Time series cross-validation.

• 방사선산업학회지
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• 제10권1호
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• pp.7-12
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• 2016

Ikaros, a transcription factor containing zinc-finger motif, has known as a critical regulator of hematopoiesis in immune system. Ikaros protein modulates the transcription of target genes via binding to the regulatory elements of the genes promoters. However the regulatory function of Ikaros in other organelle except nuclear remains to be determined. This study explored radiation-induced modulatory function of Ikaros in cytoplasm. The results showed that Ikaros protein lost its DNA binding ability after LDIR (low-dose ionizing radiation) exposure. Cell fractionation and Western blot analysis showed that Ikaros protein was translocated into cytoplasm from nuclear by LDIR. This was confirmed by immunofluorescence assay. We identified Autotaxin as a novel protein which potentially interacts with Ikaros through in vitro protein-binding screening. Co-immunoprecipitation assay revealed that Ikaros and Autotaxin are able to bind each other. Autotaxin is a crucial enzyme generating lysophosphatidic acid (LPA), a phospholipid mediator, which has potential regulatory effects on immune cell growth and motility. Our results indicate that LDIR potentially regulates immune system via protein-protein interaction of Ikaros and Autotaxin.

• Journal of Radiation Protection and Research
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• 제46권1호
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• pp.14-23
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• 2021

Background: For radiological protection and control, the International Commission on Radiological Protection (ICRP) provides the nominal risk coefficients related to radiation exposure, which can be extrapolated using the excess relative risk and excess absolute risk obtained from the Life Span Study of atomic bomb survivors in Hiroshima and Nagasaki with the dose and dose-rate effectiveness factor (DDREF). Materials and Methods: Since it is impossible to directly estimate the radiation risk at doses less than approximately 100 mSv only from epidemiological knowledge and data, support from radiation biology is absolutely imperative, and thus, several national and international bodies have advocated the importance of bridging knowledge between biology and epidemiology. Because of the accident at the Tokyo Electric Power Company (TEPCO)'s Fukushima Daiichi Nuclear Power Station in 2011, the exposure of the public to radiation has become a major concern and it was considered that the estimation of radiation risk should be more realistic to cope with the prevailing radiation exposure situation. Results and Discussion: To discuss the issues from wide aspects related to radiological protection, and to realize bridging knowledge between biology and epidemiology, we have established a research group to develop low-dose and low-dose-rate radiation risk estimation methodology, with the permission of the Japan Health Physics Society. Conclusion: The aim of the research group was to clarify the current situation and issues related to the risk estimation of low-dose and low-dose-rate radiation exposure from the viewpoints of different research fields, such as epidemiology, biology, modeling, and dosimetry, to identify a future strategy and roadmap to elucidate a more realistic estimation of risk against low-dose and low-dose-rate radiation exposure.

• Journal of Radiation Protection and Research
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• 제34권3호
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• pp.151-154
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• 2009

방사선비상계획은 기술적 대응과 행정적 대응으로 분류 가능하다. 본고는 국내원전 방사선비상계획을 행정적 대응의 관점에서 검토하고 개선방안을 제시하였다. 검토한 분야는 비상조직의 구성, 비상조직 발족기준, 비상요원 선정, 방사선비상계획서의 분량이다. 또한 현행 방사능방재훈련 방법의 한계를 설명하고 이에 대한 개선방안도 제시하였다. 모쪼록 여기에 제시된 개선방안이 국내 원전 방사선비상계획과 방사능방재훈련에 적용되어 보다 유용한 비상계획이 수립되고, 실질적인 방사능방재훈련이 되는 계기가 되기를 기대한다.