• Journal of Korea Multimedia Society
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• v.20 no.3
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• pp.511-519
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• 2017

This Paper introduces the design and communication method between PLC (Programmable Logic Controller) and Arduino based on MODBUS Protocol. MODBUS connection can be established in a new or existing system very easily, therefore we used this protocol in our proposed system. In the field of automatic devices, multi-function serial port such as RS232, RS422, RS485, and so on creates a great convenience to the developer. This proposed system used RS485 as a key mediator for data exchanging on a connected network. We also believe that it will reduce the development cost in various automated industry because this system can be reused or can be implemented any such PLC installed machines. RS485 is used as a communication interface between PLC (as a slave) and Arduino (as a master), through which a reliable network is created for safe and fast communication. Furthermore, RS485 allows multiple devices(up to 32) to communicate at half duplex on a single pair of wires and provides a long connectivity area (up to 1200 meters) as compare to other device, which makes it a user-friendly for various devices in the automated industry. Moreover, Arduino can play as a mediator by connecting third party device and setup a communication network with PLC.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.11
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• pp.4659-4664
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• 2015

Background: ABC proteins are one key type of transport superfamilies which undertake majority of drug transport, which affect the osteosarcoma response to chemotherapeutics. Previous studies have suggested the association between ABC polymorphisms and osteosarcoma response. However, the results of previous studies remain controversial. Therefore, we perform a meta-analysis to get a more precise estimation of this association. The association between ABC polymorphisms and osteosarcoma response was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Three polymorphisms of ABC including ABCB1 rs1128503, ABCC3 rs4148416 and ABCC2 rs717620 polymorphism were investigated. Overall, significant association was observed between ABCC3 rs4148416 polymorphism and osteosarcoma response under allele contrast (T vs. C: OR=1.73, 95%CI=1.09-2.74, P=0.019), homozygote comparison (TT vs. CC: OR=2.00, 95%CI=1.25-3.23, P=0.004), recessive genetic model (TT vs. TC/CC: OR=1.80, 95%CI=1.14-2.84, P=0.011) and dominant genetic model (TT/TC vs. CC: OR=1.70, 95%CI=1.20-2.42, P=0.003). Moreover, significant association was also observed in Caucasian population rather than Asian population for ABCB1 rs1128503 polymorphism. We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3051-3056
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• 2013

Background: Genetic aberrations of DNA repair enzymes are known to be common events associated with different cancer entities. The aim of the present study was to analyze genetic associations of rs1805404 (Asp81Asp) and rs1805414 (Ala284Ala) in the PARP1 gene with the risk of breast cancer in Saudi Arabia. Materials and Methods: These two SNP's were analyzed in a primary study group of breast cancer patients and healthy control subjects. Genotypes were determined by TaqMan SNP testing and analyzed using Chi-square or t test and logistic regression analysis with SPSS16.0 software. Results and Conclusions: Results showed that rs1805414 was associated with a significantly increased susceptibility to breast cancer, significant risk being observed for the TC, CC and TC+CC genotypes. In conclusion PARP1 rs1805414 SNP polymorphisms may be involved in the etiology of breast cancer in the Saudi population. In contrast, PARP1 rs1805404 did not show any significant association in overall in breast cancer samples when compared to healthy controls. Confirmation of our findings in larger populations of different ethnicities may provide evidence for a role of the PARP1 gene in breast carcinoma developnment.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6273-6276
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• 2012

Background/Aim: Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide association study (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotide polymorphisms (SNPs) with PCa has remained tobe clarified in men in Northern China. This study aimed to explore the loci associated with PCa risk in a Northern Chinese population. Methods: Blood samples and clinical information of 289 PCa patients and 288 controls from Beijing and Tianjin were collected. All risk SNPs were genotyped using polymerase chain reaction (PCR)-high resolution melting curve technology and gene sequencing. Associations between PCa and clinical covariates (age at diagnosis, prostate-specific antigen [PSA], Gleason score, tumor stage, and level of aggressiveness) and frequencies of alleles and genotypes of these SNPs were analyzed using genetic statistics. Results: Among the candidate SNPs, 11p15 (rs7127900, A) was associated with PCa risk (P = 0.02, odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.09-2.46). Genotypes showed differences between cases and controls on 11p15 (rs7127900, A), 11q13 (rs7931342, T), and HNF1B (rs4430796, A) (P = 0.03, P = 0.01, and P = 0.04, respectively). The genotype TG on 11q13 (rs7931342, T) was positively associated with an increased Gleason score (P = 0.04, OR = 2.15, 95% CI = 1.02-4.55). Patients carrying TG on 17q24 (rs1859962, G) were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44, 95% CI = 0.21-0.92) while those with AG on HNF1B (rs4430796, A) were more likely to have PSA increase (P = 0.002). Conclusion: Our study suggests that 11p15 (rs7127900, A) could be a susceptibility locus associated with PCa in Northern Chinese. Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.

• Journal of Life Science
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• v.29 no.7
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• pp.800-808
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• 2019

Charcot-Marie-Tooth disease (CMT) is a group of rare peripheral neuropathies characterized by progressive muscle weakness and atrophy and areflexia in the upper and lower extremities. The most common subtype of CMT is CMT1A, which is caused by a tandem duplication of the PMP22 gene in the 17p12 region. Patients with CMT1A show a loose genotype-phenotype correlation, which suggests the existence of secondary genetic or association factors. Recently, polymorphisms of rs71428439 (n.83A>G) and rs2292832 (n.86T>C) in the MIR149 have been reported to be associated with late onset and mild phenotypic CMT1A severity. The aim of this study was to examine the intrafamilial heterogeneities of clinical phenotypes according to the genotypes of these two SNPs in MIR149. For this study, we selected 6 large CMT1A families who showed a wide range of phenotypic variation. This study suggested that both SNPs were related to the onset age and severity in the dominant model. In particular, the AG+GG (n.83A>G) and TC+CC genotypes (n.86T>C) were associated to late onset and mild symptoms. Motor nerve conduction velocity (MNCV) was not related to the MIR149 genotypes. These results were consistent with the previous studies. Therefore, we suggest that the rs71428439 and rs2292832 variants in MIR149 may serve as genetic modifiers of CMT1A intrafamilial phenotypic heterogeneity, as they have a role in the unrelated patients. This is the first study to show an association using large families with variable clinical CMT1A phenotypes. The results will be helpful in the molecular diagnosis and treatment of patients with CMT1A.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.3
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• pp.323-328
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• 2019

Tuberculosis, a chronic bacterial infection caused by Mycobacterium tuberculosis (MTB), differs in its status latency and activity because of the characteristics of MTB, immune status of the host, and genetic susceptibility. The host defense mechanism against MTB is caused mainly by interactions between macrophages, T cells, and dendritic cells. CD44 is expressed in activated T cells when infected with MTB and regulates lymphocyte migration. In addition, CD44 mediates leukocyte adhesion to the ECM and plays a role in attracting macrophages and $CD4^+$ T cells to the lungs. Therefore, genetic polymorphism of the CD44 gene will inhibit the host cell immune mechanisms against MTB. This study examined whether the genetic polymorphism of the CD44 gene affects the susceptibility of tuberculosis. A total of 237 SNPs corresponding to the CD44 genes were analyzed using the genotype data of 443 tuberculosis cases and 3,228 healthy controls from the Korean Association Resource (KARE). Of these, 17 SNPs showed a significant association with the tuberculosis case. The most significant SNP was rs75137824 (OR=0.231, CI: 1.51~3.56, $P=1.3{\times}10^{-4}$). In addition, rs10488809, one of the 17 significant SNPs, is important for the tuberculosis outbreak can bind to the JUND and FOS transcription factors and can affect CD44 gene expression. This study suggests that polymorphism of the CD44 gene modulates the host susceptibility to tuberculosis in a variety of ways, resulting in differences in the status of tuberculosis.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.1
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• pp.69-76
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• 2018

This paper studies the Turbo Codes, the concatenation of Turbo Codes and Reed-Solomon (RS) codes on Orthogonal frequency-division multiplexing (OFDM) in digital communication channel, and then analysis the performances of the new concatenated Forward Error Correct (FEC) scheme applied to an OFDM system based on the digital terrestrial video broadcasting (DVB-T) scheme. We compared the results with the standard DVB-T convolutional codes performances on Additive White Gaussian Noise (AWGN) channels. The simulation results shown that by employing turbo codes with only a few numbers of iterations, the performances of the overall system can be improved significantly. These results will be obtained by applying an appropriate interleaver technique in the concatenated FEC procedure.

• Korean Journal of Microbiology
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• v.54 no.3
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• pp.305-307
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• 2018

The whole genome sequencing using PacBio RS II platform was performed for a marine bacterium Pseudoalteromonas donghaensis $HJ51^T$ isolated from East Sea of Korea. As a result, three assembled contigs consisting of a chromosome (size of 3,646,857 bp, and G + C content of 41.8%) and two plasmids (size of 842,855 bp and 244,204 bp, and G + C content of 41.3% and 40.4%, respectively) were obtained. The genome included 4,083 protein coding genes and 127 RNA genes. This result could be used for gene sources of biopolymers degradation and the development as a new host with secretion system similar to Escherichia coli.

• IE interfaces
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• v.12 no.4
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• pp.575-585
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• 1999

This study develops and operating software for a model plant. The model plant consists of an AS/RS system, two machining centers, an assembly line, and supplementary material handling equipments. Devices of each component are connected with the IBS RT24 DIO 16/16-T I/O module. Each I/O module communicates digital signals with the INTERBUS controller board via SUB-D 9 Connector cable. This study is a previous stage for developing an educational CIM software. Petri Nets is used for modelling the storage/retrieval of the AS/RS system, the flow of workpieces and the assembly line for parts. The operating software is coded with Microsoft Visual $C^{++}$ 5.0 and Interbus Library which is a software driver for the controller board. The operating software can be run on a MS Windows 95. Microsoft Access is used for the implementation of databases for BOM, AS/RS, and parts.

• Proceedings of the Korea Society for Simulation Conference
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• 2000.04a
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• pp.25-29
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• 2000

핸드오프 영역내에 정해진 RSS(Radio signal strength)에서 핸드오프를 시행하는 기존의 정적 핸드오프방식은 셀룰러 네트워크에서 제어신호가 증가하여 전송지연을 유발한다. 그러므로 핸드오프 수를 줄이는 방안으로 SPPQ(Signal Prediction Priority Queuing)에 기반한 동적 핸드오프를 제안한다.SPPQ는 RSS에 근거하여 선형적으로 핸드오프의 가능성을 예측한 후, 핸드오프 순서를 결정하는 알고리즘이다. 이 때 실제 속도와 호의 위치 분포는 일정하다고 가정하고 RSS에 대한 $\Delta$RSS(신호 세기의 증감)을 이용한다. SPPQ는 핸드오프 결정을 위해 선형적으로 RSS를 예측하며, 시간 구간에서 구한 시그널 평균을 사용한다. 그리고 두 개의 가장 최근 평균 RSS 측정값에 의해 표현되는 선형 방정식이 시간 축과 만나는 교차점을 핸드오프 예상시점으로 결정한다. 이때 각 핸드오프 후보 단말들의 threshold는 다르게 줄 수 있으며 그에 따라 우선순위를 결정한다. 이 우선순위를 기본으로 하여, 핑퐁효과로 인한 불필요한 핸드오프를 줄일 수 있도록 표본화 시간 $\Delta$t만큼 핸드오프를 낮춰 SPPQ의 성능을 높인다.