• 응용통계연구
• /
• 제29권5호
• /
• pp.897-906
• /
• 2016

본 연구에서는 민감한 변수와 변환된 변수로 구성된 Bar-Lev 등 (2004)의 승법모형에 무관한 양적변수를 새롭게 추가한 승법 무관양적속성 확률화응답모형을 제안하였다. 그리고 무관한 양적변수에 대한 정보를 알 때와 모를 때로 구분하여 민감한 양적속성 추정에 대한 이론적 체계를 마련하고자 하였다. 또한 제안한 승법 무관양적속성 확률화응답모형과 기존의 승법모형인 Eichhorn-Hayre 모형, Bar-Lev 등의 모형, 그리고 Gjestvang-Singh 모형과의 관계를 살펴보았고, Bar-Lev 등의 모형과의 효율성을 비교하였다. 그 결과, 기존의 승법모형들이 제안한 승법 무관양적 속성 확률화응답모형의 특별한 경우임을 확인할 수 있었고, 제안한 모형과 Bar-Lev 등의 모형과의 효율성을 수치적으로 비교한 결과 $C_x({\sigma}_x/{\mu}_x)$값이 작을수록 그리고 $C_z({\sigma}_z/{\mu}_z)$값이 클수록 제안한 승법 무관양적속성 확률 화응답모형이 Bar-Lev 등의 모형보다 효율성이 좋게 나타남을 알 수 있었다. 그리고 제안한 승법 무관양적속성 모형은 $p_1=p$값이 커질수록 또한 ${\mu}_z=1$일 때 보다 ${\mu}_z=0.5$일 때가 더 효율적인 것으로 나타났다.

• 한국산업정보학회논문지
• /
• 제20권4호
• /
• pp.1-9
• /
• 2015

본 연구에서는 다속성 의사결정(MADM)과 게임 이론을 결합하여 무선 자원의 이용효율을 향상시키는 호 수락제어 방법을 제시한다. 다속성 의사결정 방법으로 그레이 관계분석(GRA), 단순부가가중치법(SAW), TOPSIS들을 이용하였는데, 이 방법들은 서로 다른 서비스 품질(QoS)을 갖는 서비스들이 선호하는 대상 네트워크들의 선호도를 계산할 것이다. 이 선호도 값들을 이용한 효용함수를 바탕으로, 사용자가 요구하는 서비스 중에서 서비스 제공자들에게 적합한 서비스를 선택할 수 있도록 비협력적 게임이 진행된다. 요청되는 모든 서비스가 선택될 때까지 게임은 반복적으로 진행되며, 각 단계에서 내쉬균형을 이루는 서비스가 선택되도록 하였다. 서로 다른 특성을 갖는 4개의 무선 랜(WLAN) 시스템 중에서 임의의 2개의 네트워크가 중첩하여 존재하는 경우들을 각각 분석한 결과, 모든 다속성 의사결정 방법들은 서비스 제공자가 얻는 최대 보수의 차이는 있었으나 게임의 각 단계에서 동일한 서비스 선택하는 결과를 얻을 수 있었다.

• 한국간담췌외과학회지
• /
• 제26권1호
• /
• pp.58-68
• /
• 2022

Backgrounds/Aims: Mechanisms for the development of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients remain unclear. The aim of the present study was to identify genes and pathways involved in the development of HBV-associated HCC. Methods: The GSE121248 gene dataset, which included 70 HCCs and 37 adjacent liver tissues, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in HCCs and adjacent liver tissues were identified. Gene ontology and Kyoto Encyclopedia of Genes and Genome pathway enrichment analyses were then performed. Results: Of 134 DEGs identified, 34 were up-regulated and 100 were down-regulated in HCCs. The 34 up-regulated DEGs were mainly involved in nuclear division, organelle fission, spindle and midbody formation, histone kinase activity, and p53 signaling pathway, whereas the 100 down-regulated DEGs were involved in steroid and hormone metabolism, collagen-coated extracellular matrix, oxidoreductase activity, and activity on paired donors, including incorporation or reduction of molecular oxygen, monooxygenase activity, and retinol metabolism. Analyses of protein-protein interaction networks with a high degree of connectivity identified significant modules containing 14 hub genes, including ANLN, ASPM, BUB1B, CCNB1, CDK1, CDKN3, ECT2, HMMR, NEK2, PBK, PRC1, RACGAP1, RRM2, and TOP2A, which were mainly associated with nuclear division, organelle fission, spindle formation, protein serine/threonine kinase activity, p53 signaling pathway, and cell cycle. Conclusions: This study identified key genes and carcinogenic pathways that play essential roles in the development of HBV-associated HCC. This may provide important information for the development of diagnostic and therapeutic targets for HCC.

• Asian-Australasian Journal of Animal Sciences
• /
• 제29권3호
• /
• pp.343-351
• /
• 2016

Although the chemical, physical, and nutritional properties of bovine milk have been extensively studied, only a few studies have attempted to characterize milk-synthesizing genes using RNA-seq data. RNA-seq data was collected from 21 Holstein samples, along with group information about milk production ability; milk yield; and protein, fat, and solid contents. Meta-analysis was employed in order to generally characterize genes related to milk production. In addition, we attempted to investigate the relationship between milk related traits, parity, and lactation period. We observed that milk fat is highly correlated with lactation period; this result indicates that this effect should be considered in the model in order to accurately detect milk production related genes. By employing our developed model, 271 genes were significantly (false discovery rate [FDR] adjusted p-value<0.1) detected as milk production related differentially expressed genes. Of these genes, five (albumin, nitric oxide synthase 3, RNA-binding region (RNP1, RRM) containing 3, secreted and transmembrane 1, and serine palmitoyltransferase, small subunit B) were technically validated using quantitative real-time polymerase chain reaction (qRT-PCR) in order to check the accuracy of RNA-seq analysis. Finally, 83 gene ontology biological processes including several blood vessel and mammary gland development related terms, were significantly detected using DAVID gene-set enrichment analysis. From these results, we observed that detected milk production related genes are highly enriched in the circulation system process and mammary gland related biological functions. In addition, we observed that detected genes including caveolin 1, mammary serum amyloid A3.2, lingual antimicrobial peptide, cathelicidin 4 (CATHL4), cathelicidin 6 (CATHL6) have been reported in other species as milk production related gene. For this reason, we concluded that our detected 271 genes would be strong candidates for determining milk production.