• 한국화재소방학회논문지
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• 제34권1호
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• pp.127-134
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• 2020

임신부에서 심정지가 발생하였을 때, 가장 중요한 것은 임신부를 소생시키는 것이다. 임신부에서의 심정지는 산모와 태아를 동시에 고려해야 한다는 점 때문에 일반적인 심정지와 다른 부분이 있다. 임신부 심정지 환자에서는 태아를 분만해야 하는지를 결정하는 것은 산모와 태아 모두를 위하여 매우 중요하다. 심폐소생술이 수행되더라도 임신부 심정지 환자가 모두 소생되는 것은 아니며, 얼마나 신속하고 정확하게 심폐소생술이 시행되었느냐에 따라 환자의 생존율이 결정된다. 임신부 심정지 환자는 30세 목격당시 보호자에 의한 빠른 인지와 신속한 신고 및 목격자 심폐소생술이 이루어져 졌으며 119구급대에 의한 전문소생술이 적용되었고, 환자와 태아 모두 적절한 치료 후 6일 만에 건강하게 퇴원한 사례이다. 병원 전 단계에서 임신부 환자가 자발순환회복(Return of spontaneous circulation, ROSC)되어 이송하는 경우와 전문심장구조술을 시행 하는 경우는 매우 드물다. 임신부 심정지가 발생하여 목격자에 의한 심폐소생술과 119구급대원에 의한 전문심장소생술로 현장에서 자발순환회복되어 생존퇴원한 1례를 경험하여 문헌고찰과 함께 보고하는 바이다.

• 디지털융복합연구
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• 제11권9호
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• pp.229-238
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• 2013

병원외 심정지는 오늘날 우리나라의 중대한 보건문제로서, 환자의 퇴원 시 생존율은 3.5%이며, 이 중 1%만이 신경학적 기능을 회복하는 것으로 나타났다. 이처럼 낮은 병원외 심정지 환자의 생존율을 높이기 위해서는 병원 도착 전 환자의 자발적 순환을 회복시키는 것이 매우 중요하다. 따라서 본 연구에서는 질병관리본부의 2009년도 심정지 의무기록 조사 자료를 활용하여 병원외 심정지 환자의 자발적 순환 회복률을 향상시킬 수 있는 요인들에 대한 심층 분석을 수행하였다. 심정지 환자의 자발적 순환 회복에 영향을 미치는 요인은 의사결정나무기법을 적용하여 분석하였으며, 그 결과 도착전 CPR여부, 병원 도착전 심정지 목격여부, 심정지시 활동, 과거력(암/심장질환/뇌졸중), 심정지 발생 장소, 병원전 일반인 CPR여부, 신고~현장 도착까지 걸린 시간, 연령 등이 중요한 요인으로 밝혀졌다. 이 요인들의 조합을 통해 의사결정나무모형으로 분류된 심정지 환자는 총 16개 유형이었으며, 그 중 유형 1의 특징을 갖는 집단의 자발적 순환 회복률(29.6%)이 가장 높게 나타났다. 더불어 비공공장소에서 심정지가 발생한 환자에게 일반인이 CPR을 시행하였을 경우, 심정지 환자의 자발적 순환 회복률이 향상된 것으로 보아 지역주민들에 대한 CPR교육이 중요함을 파악할 수 있었다.

• 한국작물학회지
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• 제37권4호
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• pp.355-360
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• 1992

우리나라에서 자생하는 양하의 재배시 재식밀도와 시비량이 주요생육 형질과 수량에 미치는 영향을 구명하고자 시험한 결과는 다음과 같았다. 1. 초장은 밀식할수록 크고 소식할수록 짧았으며, 엽수와 경수는 소식할수록 증가되는 경향이었다. 2. m$^2$당 화경의 수와 중량은 재식주수가 많은 밀식구에서 증가되는 경향으로 10$\times$20cm (50주 / m$^2$)와 20$\times$20cm(25주/ m$^2$)가 m$^2$당 재식밀도수가 많아 수량이 증가되어 알맞는 재식거리로 판단된다. 3. 3요소 시용 (N:P$_2$O, : $K_2$O=15:15:15)은 무시용에 비해 초장이 크고 경수가 많아 생육이 양호하고 수량이 증가되었다.

• Tuberculosis and Respiratory Diseases
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• 제72권5호
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• pp.401-408
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• 2012

Cardiopulmonary resuscitation (CPR) is a series of life-saving actions that improve the chances of survival, following cardiac arrest. Successful resuscitation, following cardiac arrest, requires an integrated set of coordinated actions represented by the links in the Chain of Survival. The links include the following: immediate recognition of cardiac arrest and activation of the emergency response system, early CPR with an emphasis on chest compressions, rapid defibrillation, effective advanced life support, and integrated post-cardiac arrest care. The newest development in the CPR guideline is a change in the basic life support sequence of steps from "A-B-C" (Airway, Breathing, Chest compressions) to "C-A-B" (Chest compressions, Airway, Breathing) for adults. Also, "Hands-Only (compression only) CPR" is emphasized for the untrained lay rescuer. On the basis of the strength of the available evidence, there was unanimous support for continuous emphasis on high-quality CPR with compressions of adequate rate and depth, which allows for complete chest recoil, minimizing interruptions in chest compressions and avoiding excessive ventilation. High-quality CPR is the cornerstone of a system of care that can optimize outcomes beyond return of spontaneous circulation (ROSC). There is an increased emphasis on physiologic monitoring to optimize CPR quality, and to detect ROSC. A comprehensive, structured, integrated, multidisciplinary system of care should be implemented in a consistent manner for the treatment of post-cardiac arrest care patients. The return to a prior quality and functional state of health is the ultimate goal of a resuscitation system of care.

• 대한전기학회논문지:시스템및제어부문D
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• 제54권4호
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• pp.274-283
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• 2005

Coronary Perfusion Pressure(CPP) is known for the most important parameter related to the Return of Spontaneous Circulation (ROSC), however, clinically measuring CPP is difficult either invasive or non-invaisive method. En this paper, we analyze the correlation between the extracted parameter from VF ECG wave and the CPP with the statistical method, and predict CPP value using the extracted parameters within significance level. the extracted parameters are median frequency(MF), peak frequency(PF), average segment amplitude(ASA), MSA(maximum segment amplitude), Two parameters, MF, and ASA are selected in order to predict CPP value with general regression neural network, and then we evaluated the agreement statistics between the simulated CPP and the measured CPP. In conclusion, the mean and variance of the difference between the simulated CPP and the measured CPP are 8.9716±1.3526 mmHg, and standard deviation 6.4815 mmHg with one hundred-times training and test results. the simulated CPP and the measured CPP are agreed with the overall accuracy $90.68\%$ and kappa coefficient $81.14\%$ as a discriminant parameter of ROSC.

• 한국미생물·생명공학회지
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• 제50권2호
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• pp.193-201
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• 2022

Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) are major causes of hospital- and community-acquired infections. The treatment of biofilm-related infections caused by these bacteria is a global healthcare challenge. Therefore, the development of alternative therapeutics is required. An essential oil extracted from Curcuma zedoaria (CZ) Rosc, also known as white turmeric, has been reported to possess various antimicrobial activities. In the present study, we evaluated the antibiofilm activities of an ethanolic extract of the CZ rhizome against MRSA and MSSA. The results showed that the CZ extract with the highest sub-minimum inhibitory concentration (sub-MIC), 1/2 MIC (0.312 mg/ml), significantly inhibited biofilm production by up to 80-90% in both tested strains. Subsequently, we evaluated the ability of the CZ extract to prevent cell-surface attachment to a 96-well plate and extracellular DNA (eDNA) release from the biofilm. The CZ extract demonstrated an inhibitory effect on bacterial attachment and eDNA release from the biofilm biomass. The CZ extract may inhibit biofilm formation by preventing eDNA release and cell-surface attachment. Therefore, this CZ extract is a potential candidate for the development of alternative treatments for biofilm-associated MRSA and MSSA infections.

• Journal of Chest Surgery
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• 제48권5호
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• pp.318-327
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• 2015

Background: With improvements in cardiopulmonary resuscitation (CPR) techniques, the quality and the effectiveness of CPR have been established; nevertheless, the survival rate after cardiac arrest still remains poor. Recently, many reports have shown good outcomes in cases where extracorporeal membrane oxygenation (ECMO) was used during prolonged CPR. Accordingly, we attempted to evaluate the impact of extracorporeal cardiopulmonary resuscitation (ECPR) on the survival of patients who experienced a prolonged cardiac arrest and compared it with that of conventional CPR (CCPR). Methods: Between March 2009 and April 2014, CPR, including both in-hospital and out-of-hospital CPR, was carried out in 955 patients. The ECPR group, counted from the start of the ECPR program in March 2010, included 81 patients in total, and the CCPR group consisted of 874 patients. All data were retrospectively collected from the patients' medical records. Results: The return of spontaneous circulation (ROSC) rate was 2.24 times better in CPR of in-hospital cardiac arrest (IHCA) patients than in CPR of out-of-hospital CA (OHCA) patients (p=0.0012). For every 1-minute increase in the CPR duration, the ROSC rate decreased by 1% (p=0.0228). Further, for every 10-year decrease in the age, the rate of survival discharge increased by 31%. The CPR of IHCA patients showed a 2.49 times higher survival discharge rate than the CPR of OHCA patients (p=0.03). For every 1-minute increase in the CPR duration, the rate of survival discharge was decreased by 4%. ECPR showed superiority in terms of the survival discharge in the univariate analysis, although with no statistical significance in the multivariate analysis. Conclusion: The survival discharge rate of the ECPR group was comparable to that of the CCPR group. As the CPR duration increased, the survival discharge and the ROSC rate decreased. Therefore, a continuous effort to reduce the time for the decision of ECMO initiation and ECMO team activation is necessary, particularly during the CPR of relatively young patients and IHCA patients.

• 전자공학회논문지SC
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• 제44권5호
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• pp.45-54
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• 2007

시/주파수 분석은 생체 신호 처리에서 널리 사용되어왔다. 전기 생리학적 신호로부터 중요한 특징들을 추출함으로써 이 방법들은 특정 질병의 임상 병리학적 기전 해석이 가능하다. 하지만 이 방법은 신호가 안정하다는 가정 아래 적용되었으며 불안정한 시스템에서의 적용은 제한이 되어 있다. 본 연구에서는 비선형적이고 비정상적인 심실세동 심전도 파형의 분석을 위해 Hilbert-Huang 변환을 사용한 새로운 신호처리 방법을 제안하였다. Hilbert-Huang 변환은 경험모드분리법(EMD)과 힐버트 변환으로 크게 두 가지로 구성된다. Hilbert-Huang 변환은 EMD를 사용하여 각각의 특성을 지니고 있는 독립적인 내부모드함수들로 나누어지며, 힐버트 변환에 의해 순간 주파수와 크기를 구할 수 있게 된다. 이런 특성으로 신호의 국부적인 작용에 대하여 정확하게 설명할 수 있게 된다. 본 연구에서는 Hilbert-Huang 변환을 기반으로 심실세동 심전도 파형으로부터 두 종류의 파라미터(EMD-IF, EMD-FFT)를 추출하고 서포트 벡터 머신(Support Vector Machine)을 이용하여 소생성공 및 실패 여부 예측에 관하여 연구하였다. 평균적으로 민감도와 특이도는 각각 87.57%와 76.92%로 나타났다. Hilbert-Huang 변환은 더욱 정확하게 심실세동에서의 소생성공 예측을 가능하게 하였다.

• 한국발생생물학회지:발생과생식
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• 제21권1호
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• pp.47-54
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• 2017

Unlike mouse results, cloning efficiency of nuclear transfer from porcine induced pluripotent stem cells (piPSCs) is very low. The present study was performed to investigate the effect of cell cycle inhibitors on the cell cycle synchronization of piPSCs. piPSCs were generated using combination of six human transcriptional factors under stem cell culture condition. To examine the efficiency of cell cycle synchronization, piPSCs were cultured on a matrigel coated plate with stem cell media and they were treated with staurosporine (STA, 20 nM), daidzein (DAI, $100{\mu}M$), roscovitine (ROSC, $10{\mu}M$), or olomoucine (OLO, $200{\mu}M$) for 12 h. Flow Cytometry (FACs) data showed that piPSCs in control were in G1 ($37.5{\pm}0.2%$), S ($34.0{\pm}0.6%$) and G2/M ($28.5{\pm}0.4%$). The proportion of cells at G1 in DAI group was significantly higher than that in control, while STA, ROSC and OLO treatments could not block the cell cycle of piPSCs. Both of viability and apoptosis were affected by STA and ROSC treatment, but there were no significantly differences between control and DAI groups. Real-Time qPCR and FACs results revealed that DAI treatment did not affect the expression of pluripotent gene, Oct4. In case of OLO, it did not affect both of viability and apoptosis, but Oct4 expression was significantly decreased. Our results suggest that DAI could be used for synchronizing piPSCs at G1 stage and has any deleterious effect on survival and pluripotency sustaining of piPSCs.

• 한국응급구조학회지
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• 제15권3호
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• pp.57-70
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• 2011

Purpose : The purpose of this study was to reveal some factors of ROSC & survival for cardiac arrests from sport & leisure activities(CASLs). Methods : A retrospective study of the 1,341 out of hospital cardiac arrests(OHCAs) treated by EMS in Gyeonggi Provincial Fire and Disaster Headquarters from January to December in 2008 was conducted. The primary end-point was admission to emergency room. To clarify the factors through comparison of CASLs(n=58) with ROSCs & survivals(n=58), Answer Tree analysis for data mining with the CHAID algorithm was performed and alpha was set at .05. Mean, median, and percentile of time intervals, distances, and age on the 58 CASLs, 75 ROSCs, and 27 survivals(patients admitted to emergency room) were analysed. Results : Fourteen CASLs(24.1%), 41 ROSCs(54.7%), 16 survivals(59.3%) were treated with CPR within 5 min., and only 2 CASLs(3.4%), 11 ROSCs(14.7%), 10 survivals(37.0%) were treated with defilbrillation within 10 min. from arrest. If time recording from arrest to defilbrillation, the patients were classified 81.0%($X^2=9.83$, p=.005) into ROSCs & survivals. And the patients with no history, 100.0%($X^2=5.44$, p=.020). The other patients with no intention, 87.5%($X^2=7.00$, p=.024). Whereas the other patients with intention, treated with CPR after 4 min. from arrest were classified 67.2%($X^2=3.99$, p=.046) into CASLs. Conclusion : CPR within 4 minutes was the most important factor that discriminates between CASLs and ROSCs & survivals to record cardiac arrests-defilbrillation time. CPR within 4 min. from arrest, no history, and no intention were factors for improved ROSC & survival.