Over recent years, it has become evident that the central nervous system bidirectionally interacts with the gastrointestinal tract along the gut-brain axis. A series of preclinical studies indicate that the gut microbiota can modulate central nervous system function through a multitude of physiological functions. Polyphenols are ubiquitous plant chemicals included in foods such as fruits, vegetables, tea, coffee and wine, and their consumption is directly responsible for beneficial health effects due to antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, anticancer, vasodilating, and prebiotic-like effects. There is increasing evidence that dietary polyphenol can contribute to beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury as well as in cognitive functions. In this paper, we overview the neuroprotective role of dietary polyphenols especially focusing on the neuroinflammation and neurovascular function by interaction with the gut microbiome. Polyphenol metabolites could directly act as neurotransmitters crossing the blood-brain barrier and modulating the cerebrovascular system or indirectly modulating gut microbiota. In addition, evidence suggests that dietary polyphenols are effective in preventing and managing neurological disorders, such as age-related cognitive decline and neurodegeneration, through a multitude of physiological functions. Dietary polyphenols are increasingly envisaged as a potential nutraceuticals in the prevention and treatment of neurological disorders, because they possess the ability to reduce neuroinflammation, to improve memory and cognitive function and to modulate the gut microbiota.
Kim, Kyunghun;Han, Daegun;Kim, Jungwook;Lim, Jonghun;Lee, Jongso;Kim, Hung Soo
Journal of Wetlands Research
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v.21
no.1
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pp.66-76
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2019
Recently, natural disasters such as floods and droughts are frequently occurred due to climate change and the damage is also increasing. Wetland is known to play an important role in reducing and minimizing the damage. In particular, water level variability needs to be analyzed in order to understand the various functions of wetland as well as the reduction of damage caused by natural disaster. Therefore, in this study, we fitted water level series of Upo wetland in Changnyeong, Gyeongnam province to a proper time series model and residual test was performed to confirm the appropriateness of the model. In other words, ARIMA model was constructed and its residual tests were performed using existing nonparametric statistics, BDS statistic, and Close Returns Histogram(CRH). The results of residual tests were compared and especially, we showed the applicability of CRH to analyze the residuals of time series model. As a result, CRH produced not only accurate randomness test result, but also produced result in a simple calculation process compared to the other methods. Therefore, we have shown that CRH and BDS statistic can be effective tools for analyzing residual in time series model.
Park, Chailinn;Ju, Se-Jong;Park, Wongyu;Kim, Hyun-Woo;Lee, Soo Rin;Park, Jeong-Ho
Ocean and Polar Research
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v.40
no.4
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pp.213-222
/
2018
We investigated seasonal variations in the abundance of the adults and the resting eggs of copepods to understand the role of copepod resting eggs for maintaining their population inhabiting the coastal area of Dadaepo, Korea. Adults and resting eggs of copepods were collected bi-monthly with a conical net (45 cm mouth diameter, $330{\mu}m$ mesh size) and van Veen grab ($0.1m^2$ area), respectively, from October 2016 to September 2017. The species of resting eggs were identified using mtCOI gene. The mean abundance of copepods was highest in October ($3686{\pm}1190inds{\cdot}m^{-3}$) and lowest in January ($176{\pm}60inds{\cdot}m^{-3}$) with the dominance of Paracalanus parvus s.l.. Among copepod producing resting eggs, Acartia omorii and Centropages abdominalis were dominant. The mean abundance of resting eggs was the highest in July ($9148{\pm}6787eggs{\cdot}m^{-2}$) and the lowest in October ($530{\pm}348eggs{\cdot}m^{-2}$). Most of the collected resting eggs were identified as A. omorii's. The mean abundances of A. omorii adults and resting eggs were highest in July, and both abundances fluctuated in a similar pattern except in September. In September, A. omorii adults were observed in a state of low abundance, while their resting eggs occurred in a state of high abundance. These results suggest that A. omorii maintain their population by producing a large quantity of resting eggs, particularly diapause eggs, before the seawater temperature rises. These eggs would hatch and be newly recruited to their population when the environmental condition becomes favorable.
Journal of the Society of Cosmetic Scientists of Korea
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v.44
no.4
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pp.455-463
/
2018
Skin elasticity has been known to be influenced by the change of dermal components such as collagen, elastic fiber, and glycosaminoglycans. However, it is unclear whether the uppermost epidermis may affect the mechanical characteristics of elasticity. In present study we tried to find the role of stratum corneum when determining the elastic property under skin bioengineering measurement with $Cutometer^{(R)}$. A total of 10 healthy volunteers aged 25-40 years were investigated by the parameters reflecting the skin elasticity from face and volar forearm. Within various ranges of suction pressure, R0 (=Uf), R7 (=Ur/Uf) and R8 (=Ua) were obtained to explore the depth-associated elasticity. In addition, these parameters were re-measured after the skin was fully hydrated. As results, we found that the measurement of depth-associated elasticity was possible as using various suction pressure. And the R7 parameter was significantly lower from face than those from forearm in before hydration (p < 0.05). Also, we found that the hydration of stratum corneum could affect skin elasticity. Especially, the R7 parameter at 300 mbar suction pressure of face skin showed significantly increased values than that of before hydration (p < 0.05). Interestingly, measured data from the face before and after hydration manifested relatively higher variation than from the forearm. These results suggest that it is possible to evaluate the skin elasticity considering the changes of stratum corneum and epidermis by using various suction pressure and skin hydration.
Collaboration works on R&D project have many characteristics in interoranizational relationships. There are many variables on explaining the their relationships. In the previous study, I chose some relevant variables and some hypotheses. Base on service marketing theories and relationship marketing perspective I suggest 5 hypotheses. Independent variables are fairness and quality, and dependent variable is loyalty. And trust are treated as the intervening variable between the independent variables and dependent variable. To test the research model and some hypothesis empirically, I collected the data using the questionnaire. Sample size was 448, it was enough to analyze statistically. Data were analysed using the SPSS and AMOS. In the previous study, H1($fairness{\rightarrow}trust$), H2($quality{\rightarrow}trust$), H5($trust{\rightarrow}loyalty$) were accepted, but H3 and H4 were rejected. The reason H3($fairness{\rightarrow}loyalty$) and H4($quality{\rightarrow}loyalty$) were not accepted might be attributed to the fact that trust was the mediating variable between fairness and loyalty, quality and loyalty. Specific research methodologies and statistical findings from AMOS were referred in the previous study(Jeong 2018). In this study, I suggested some hypotheses on the mediating role trust between fairness and loyalty and service quality and loyalty. Using the PROCESS-macro, I found that trust was the mediating variable between fairness and loyalty as well as service quality and loyalty. This research is the complementary and extended study from previous research.
The purpose of this study is to analyze college students' perception of national natural heritages, including natural monumentsand scenic sites, in comparison with the similar concepts of national parks and eco-landscape preservation areas, to suggest managerial implications to enhance competitiveness. The first objective of this study is to measure their attitude toward traveling each type of natural heritage and to rate the relative importance of the four types of heritages in terms of preservation. Natural monuments were perceived as the most strongly preserved type, while scenic sites were perceived as the least strongly preserved type. The second objective is to conduct a correspondence analysis to match the concepts of four types of natural heritages with 10 tourist attractions representing the types. It was found that college students have difficulty appropriately identifying the types of 10 tourist attractions. In addition, multi-dimensional scaling (MDS) was implemented to identify the similarities and differences of the four types of natural heritages and to produce a positioning map matching the four types of natural heritages with the six attributes representing each type as a tourist attraction. Natural monuments were perceived very differently from scenic sites and not very differently from eco-landscape preservation areas. There were a few associations between the four types of natural heritages and the six tourism attributes, implying that little effort is made to promote and position each type of natural heritage in terms of tourism. In conclusion, a public awareness program is required to enhance the brand image of natural monuments and scenic sites in comparison to national parks and eco-landscape preservation areas. In addition, local residents who live near the natural heritages should be bolstered to play a managerial role as supporters and contents providers for sustainability.
This study aims to investigate the original position, the writer of signboard handwriting and the period of Wibongmun and Joyangru in order to restore Wibongmun and Joyangru which have been designated as tangible cultural properties (有形文化財). They also have to be moved in the Gangwon Provincial Office. Wibongmun and Joyangru were established as government offices in chuncheon(春川官衙) and they were used as attached buildings in Chunceon (春川離宮) in 1890. Wibongmun was moved to Gangwon Provincial Office 5 times and Joyangru was moved twice. In order to move them back to the original place, by using the topographic map made by the Japanese Government-General in Korea, we find out Joyangru was located in the exit of Gangwon Provincial Office and greenhouse and we also figure out Wibongmun was located in the garden. While we study historical evidence on handwriting, we also find out the handwriting of Joyangmun was written by Songhaong (松下翁) Jo, Yun-Hyeong (曺允亨). Especially, Joyangru had played a role as a government office and it may be called 'Joyangru' after reconstructing 'Joyangmun' when attached buildings were established. Through this study, we found that the first period and reason of establishing Wibongmun and Joyangru was at least before 1788. Through this study, we can find the period of both and its historic meaning more clearly.
An understanding of 'original form' plays an important role as it is the starting point of heritage conservation. This paper delineated several types of understanding on 'original form' over times, and aims at analyzing the way how such concepts has provided a platform of repair works of timber buildings in Korea over times. Conservation in Korea was initiated by the attitude of the Japanese authority during the Colonial period and 'restoring into the earliest form', which had been set in the early stage of the Japanese conservation, has strongly influenced on Korean practice during the period. Such attitude has lasted even after the independence of Korea. In Japan, however, the attitude has shifted to taking a careful decision on the alteration of the existing form during the 1930s. In addition, examination and research in the repair work became essential steps to conduct along with the publication of the report of works. In Korea there has been lack of understanding on the importance of examination and research in repair works and the publication of report of the works has not been mandatory so that it has emphasized on the 'form' in conservation aiming at 'restoring the earliest form'. Such attitude has created the problem of replacing original material during the work which should aim at preserving and maintaining heritage in Korea. Because of these circumstances in preserving the architectural cultural properties in Korea, cultural buildings had succeeded in preserving the outer appearance but there are remaining questions on preserving the original states of them. This paper has pointed out that it is necessary to set out the principles of conserving 'original condition' through further study and discussion based on the careful consideration on both the international principles and Korean context.
Kim, Hee Sook;Kim, Ji-Youn;Lee, Song Min;Park, Hye-Jung;Lee, Sang-Hyeon;Jang, Jeong Su;Lee, Mun Hyon
Microbiology and Biotechnology Letters
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v.47
no.3
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pp.390-400
/
2019
In this study, strains isolated from soil samples collected from Busan, Changwon, and Jeju Island were examined to verify their abilities of phosphate solubilization and nitrogen fixation, production of indole-3-acetic acid (IAA), siderophore, and 1-aminocylopropane-1-carboxylyic acid (ACC) deaminase in order to select strains that promote plant growth and play a role in biocontrol of pests or pathogens. According to the results of this study, most of the isolated strains were found to have ability of phosphate solubilization, nitrogen fixation, IAA production, siderophore production, and production of ACC deaminase. These isolated strains might help plant growth by directly improving absorption of nutrients essential for phosphate solubilization and nitrogen fixation. In addition, they can promote plant growth and control resistance to plant diseases through extracellular enzyme activity and antifungal activity. In addition, most of the selected strains were found to survive in various environmental conditions such as temperature, salinity, and pH. Therefore, Pseudomonas plecoglossicida ANG14, Pseudarthrobacter equi ANG28, Beijerinckia fluminensis ANG34, and Acinetobacter calcoaceticus ANG35 were finally selected through a comparative advantage analysis to suggest their potential as novel biological agents. Further studies are necessary in order to prove their efficacy as novel biological agents through formulation and optimization of effective microorganisms, their preservation period, and crop cultivation tests.
Because the service is characterized by simultaneous production and consumption, the customer must participate directly in the delivery and production process of the service. For this reason, the variable Customer Participation has aggregated many empirical results in the service marketing field. Recent research on customer participation has focused on the relationship marketing, and is empirically identifying the relevance of customer participation and relative value of relationship marketing. These findings indicate that customer participation should be understood in a relationship between customers and service firms. Using commitment velocity and customer participation velocity considering dynamic of the relationship, this study aims to re-examine the relationship between customer participation and encounter satisfaction which is the foundation of relationship formation. Multiple regression analysis and hierarchical regression analysis are used as research methods. The study found that customer participation has a direct positive effect on encounter satisfaction, and that commitment velocity and customer participation velocity also have a significant effect on encounter satisfaction. However, all assumptions that were expected to moderate the impact of customer participation on encounter satisfaction were rejected. Although the study failed to identify the moderating role, it was clear about the impact on the encounter satisfaction of commitment velocity and customer participation velocity. Applying them to a wider variety of service types provided an opportunity to identify the value of the study, and to broaden the scope of the study suing these variables.
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