• Title/Summary/Keyword: RN

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Comparative Study of Toxic Effects of Anatase and Rutile Type Nanosized Titanium Dioxide Particles in vivo and in vitro

  • Numano, Takamasa;Xu, Jiegou;Futakuchi, Mitsuru;Fukamachi, Katsumi;Alexander, David B.;Furukawa, Fumio;Kanno, Jun;Hirose, Akihiko;Tsuda, Hiroyuki;Suzui, Masumi
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.2
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    • pp.929-935
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    • 2014
  • Two types of nanosized titanium dioxide, anatase ($anTiO_2$) and rutile ($rnTiO_2$), are widely used in industry, commercial products and biosystems. $TiO_2$ has been evaluated as a Group 2B carcinogen. Previous reports indicated that $anTiO_2$ is less toxic than $rnTiO_2$, however, under ultraviolet irradiation $anTiO_2$ is more toxic than $rnTiO_2$ in vitro because of differences in their crystal structures. In the present study, we compared the in vivo and in vitro toxic effects induced by $anTiO_2$ and $rnTiO_2$. Female SD rats were treated with $500{\mu}g/ml$ of $anTiO_2$ or $rnTiO_2$ suspensions by intra-pulmonary spraying 8 times over a two week period. In the lung, treatment with $anTiO_2$ or $rnTiO_2$ increased alveolar macrophage numbers and levels of 8-hydroxydeoxyguanosine (8-OHdG); these increases tended to be lower in the $anTiO_2$ treated group compared to the $rnTiO_2$ treated group. Expression of $MIP1{\alpha}$ mRNA and protein in lung tissues treated with $anTiO_2$ and $rnTiO_2$ was also significantly up-regulated, with $MIP1{\alpha}$ mRNA and protein expression significantly lower in the $anTiO_2$ group than in the $rnTiO_2$ group. In cell culture of primary alveolar macrophages (PAM) treated with $anTiO_2$ and $rnTiO_2$, expression of $MIP1{\alpha}$ mRNA in the PAM and protein in the culture media was significantly higher than in control cultures. Similarly to the in vivo results, $MIP1{\alpha}$ mRNA and protein expression was significantly lower in the $anTiO_2$ treated cultures compared to the $rnTiO_2$ treated cultures. Furthermore, conditioned cell culture media from PAM cultures treated with $anTiO_2$ had less effect on A549 cell proliferation compared to conditioned media from cultures treated with $rnTiO_2$. However, no significant difference was found in the toxicological effects on cell viability of ultra violet irradiated $anTiO_2$ and $rnTiO_2$. In conclusion, our results indicate that $anTiO_2$ is less potent in induction of alveolar macrophage infiltration, 8-OHdG and $MIP1{\alpha}$ expression in the lung, and growth stimulation of A549 cells in vitro than $rnTiO_2$.

Performance Ratio of Crystalline Si and Triple Junction a-Si Thin Film Photovoltaic Modules for the Application to BIPVs

  • Cha, Hae-Lim;Ko, Jae-Woo;Lim, Jong-Rok;Kim, David-Kwangsoon;Ahn, Hyung-Keun
    • Transactions on Electrical and Electronic Materials
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    • v.18 no.1
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    • pp.30-34
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    • 2017
  • The building integrated photovoltaic system (BIPV) attracts attention with regard to the future of the photovoltaic (PV) industry. It is because one of the promising national and civilian projects in the country. Since land area is limited, there is considerable interest in BIPV systems with a variety of angles and shapes of PV panels. It is therefore expected to be one of the major fields for the PV industry in the future. Since the irradiation is different from each installation angle, the output can be predicted by the angles. This is critical for a PV system to be operated at maximum power and use an efficient design. The development characteristics of tilted angles based on data results obtained via long-term monitoring need to be analyzed. The ratio of the theoretically available and actual outputs is compared with the installation angles of each PV module to provide a suitable PV system for the user.

A Preliminary Study on Soil-Gas 222Rn Concentrations Depending on Different Bedrock Geology (기반암에 따른 토양가스 222Rn농도의 분포에 관한 기초연구)

  • Je, Hyun-Kuk;Kang, Chigu;Chon, Hyo-Taek
    • Economic and Environmental Geology
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    • v.31 no.5
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    • pp.415-424
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    • 1998
  • In order to investigate soil-gas $^{222}Rn$ concentrations, Kwanak Campus (Seoul National University), Boeun (Choong-buk) and Gapyung (Kyonggi) areas were selected and classified depending on their base rock types. Radon risk indices of these study areas decrease in the order of Gapyung>Kwanak Campus>Boeun areas, and in the order of rock type as banded gneiss>granite gneiss>granite>black slate-shale>mica schist>shale-lirnestone>phyllite-schist. Radon emanating trends with water content and grain size of soils were assessed by modified Morse 3 min. method. Radon emanation increases with the increase of water content in soils which is lower than 6~16 wt.%, and decreases in the range of higher than 6-16 wt. %. It shows that Rn emanation increases with the decrease of soil grain size. Radioactivity analysis of radionuclides of 238U series in some soil samples shows that radioactive disequilibrium state between $^{226}Ra$ and $^{238}U$ exists owing to different geochemical behavior of each radionuclide, and, it is necessary to carry out radioactive isotope geochemical approach for soil-gas $^{222}Rn$ study.

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The Comparative Analysis of Rn-222 in Water for Public Supply Pump Houses of Ulaanbaatar City

  • Oyunchimeg, Ts.;Khuukhenkhuu, G.;Norov, N,
    • Progress in Medical Physics
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    • v.14 no.1
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    • pp.51-53
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    • 2003
  • The results of the measured specific activities of Rn-222 in water for public water supply pump houses (wells) of Ulaanbaatar City, Mongolia using the HP-Ge gamma-spectrometer, are described. The average of the specific radioactivies for the Rn-222 were for the station “Centre” 82.59 Bq/l, station “Combinat” 91.35 Bq/l and station “Makh” 158.25 Bq/l, respectively.

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A multistage wavelength division multiplexed passive optical network (다단 분기 파장분할 다중방식 수동형 광가입자망)

  • Park, Kun-Youl;Park, Jae-Hyoung;Kim, Geun-Young;Kim, Jin-Hee
    • 한국정보통신설비학회:학술대회논문집
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    • 2008.08a
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    • pp.112-115
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    • 2008
  • The multistage wavelength division multiplexed passive optical network (WDM-PON) with multiple remote nodes (RN) can accommodate widely spread subscribers efficiently and it increases the channel usage. We implemented a multistage RN using band add-drop filters and it was applied to a wavelength-locked Fabry-Petor laser diode based gigabit WDM-PON.

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Evaluation of Radioactive Stack Air Effluents from the Advanced Fuel Science Building at KAERI (한국원자력연구원 새빛연료과학동 굴뚝방출 방사능 평가)

  • Chang, S.Y.;Kim, B.H.
    • Journal of Radiation Protection and Research
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    • v.33 no.3
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    • pp.121-126
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    • 2008
  • Radioactivities of the stack air effluents from the Advance Fuel Science Building (AFSB) at KAERI have been investigated and evaluated. In this AFSB, nuclear fuels for the HANARO research reactor have been fabricated and the advanced nuclear fuels have been studied. A stack air monitoring system has been continuously operating to monitor the stack air effluents from the facility to protect the environment. As the results of the periodical radioactivity measurement and both the gamma and alpha spectrometry for the millipore filters taken from the stack air monitor from January until March 2008, a trace amount of primordial $^{40}K$ and the short-lived decay products of natural borne $^{222}Rn$ and $^{220}Rn$ have been detected. However, the radioactivities have rapidly decayed to the level below the Minimum Detectable Activity (MDA) of the counting system. Therefore, it was evaluated that no uranium isotopes have been released to the atmosphere from the stack of the AFSB at KAERI.

Determining Characteristics of Groundwater Inflow to the Stream in an Urban Area using Hydrogeochemical Tracers (222Rn and Major Dissolved Ions) and Microbial Community Analysis (수리지화학적 추적자(222Rn, 주요용존이온)와 미생물 군집 분석을 통한 도심 지역 하천에서의 지하수 유출 특성 평가)

  • Oh, Yong Hwa;Kim, Dong-Hun;Lee, Soo-Hyoung;Moon, Hee Sun;Cho, Soo Young
    • Journal of Soil and Groundwater Environment
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    • v.25 no.2
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    • pp.16-23
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    • 2020
  • In this work, 222Rn activity, major dissolved ions, and microbial community in ground- and surface waters were investigated to characterize groundwater inflow to the stream located in an urban area, Daejeon, Korea. The measured 222Rn activities in groundwater and stream water ranged from 136 to 231 Bq L-1 and 0.3 to 48.8 Bq L-1, respectively. The spatial distributions of 222Rn activity in the stream strongly suggested groundwater inflow to the stream. The change of geochemical composition of the stream water indicated the effect of groundwater discharge became more pronounced as the stream flows downstream. Furthermore, microbial community composition of the stream water had good similarity to that of groundwater, which is another evidence of groundwater discharge. Although groundwater inflow could not be estimated quantitatively in this study, the results can provide useful information to understand interactions between groundwater and surface water, and determine hydrological processes governing groundwater recharge and hydrogeological cycles of dissolved substances such as nutrients and trace metals.

Susceptibility for ischemic stroke in Sasang constitutional classification is associated with the interleukin-1 receptor antagonist polymorphism

  • Lee, Byung-Cheol;Ahn, Young-Min;Ahn, Se-Young;Doo, Ho-Kyung
    • Advances in Traditional Medicine
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    • v.6 no.1
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    • pp.27-33
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    • 2006
  • The Sasang constitutional medicine classifies the mankind into four constitutional types according to the individual psychological and physical traits. Differences in the Sasang constitutional medicine may be explained by the genetic factors. In order to determine the association of Sasang constitutional classification and interleukin-1 receptor antagonist (IL-1Ra) in genetic susceptibility to ischemic stroke, we classified the four constitutional types in ischemic stroke patients (n = 125) and the healthy control subjects (n = 107), and genotyped for IL-1Ra polymorphism by polymerase chain reaction (PCR) methods. The distribution of the $IL1RN^*1/IL1RN^*2$ genotype in the ischemic stroke patients was significantly different from the healthy controls (OR = 6.09; P =0.0134). And the prevalence of $IL1RN^*1/IL1RN^*2$ genotype was increased in Taeum-in ischemic stroke patients, as compared to Taeum-in healthy controls (OR = 14.71; P = 0.0144). These results suggest that $IL1RN^*1/IL1RN^*2$ genotype in Taeum-in might be associated with the increasing risk for ischemic stroke. Furthermore, this relationship could provide the basis for a new approach in the investigation of the etiology of ischemic stroke.

Principal Component Analysis and Molecular Characterization of Reniform Nematode Populations in Alabama

  • Nyaku, Seloame T.;Kantety, Ramesh V.;Cebert, Ernst;Lawrence, Kathy S.;Honger, Joseph O.;Sharma, Govind C.
    • The Plant Pathology Journal
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    • v.32 no.2
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    • pp.123-135
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    • 2016
  • U.S. cotton production is suffering from the yield loss caused by the reniform nematode (RN), Rotylenchulus reniformis. Management of this devastating pest is of utmost importance because, no upland cotton cultivar exhibits adequate resistance to RN. Nine populations of RN from distinct regions in Alabama and one population from Mississippi were studied and thirteen morphometric features were measured on 20 male and 20 female nematodes from each population. Highly correlated variables (positive) in female and male RN morphometric parameters were observed for body length (L) and distance of vulva from the lip region (V) (r = 0.7) and tail length (TL) and c' (r = 0.8), respectively. The first and second principal components for the female and male populations showed distinct clustering into three groups. These results show pattern of sub-groups within the RN populations in Alabama. A one-way ANOVA on female and male RN populations showed significant differences ($p{\leq}0.05$) among the variables. Multiple sequence alignment (MSA) of 18S rRNA sequences (421) showed lengths of 653 bp. Sites within the aligned sequences were conserved (53%), parsimony-informative (17%), singletons (28%), and indels (2%), respectively. Neighbor-Joining analysis showed intra and inter-nematodal variations within the populations as clone sequences from different nematodes irrespective of the sex of nematode isolate clustered together. Morphologically, the three groups (I, II and III) could not be distinctly associated with the molecular data from the 18S rRNA sequences. The three groups may be identified as being non-geographically contiguous.