• Proceedings of the Korean Society of Life Science Conference
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• 2000.12a
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• pp.39-43
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• 2000

HBV는 인체에 감염하여 간염, 간경변 및 간암을 유발하는 hepadnaviruses의 일종으로써 임상적으로 매우 중요한 바이러스이다. 그러나 이 바이러스에 의한 간암(HCC)의 발생 메커니즘은 아직 불확실하다. 최근에는 HBV의 X 단백질(HBx)이 간암 발생에 중요한 역할을 수행하는 것으로 보고되고 있다. HBx 단백질은 전사 활성인자(transcriptional activator)로써 숙주세포의 유전자발현에 영향을 미치어 세포증식 및 분화에 영향을 줄 수 있다. 본 연구에서는 HBx 단백질이 NIH 3T3 cell의 증식 및 형질전환에 미치는 영향을 조사하였다. HBx 단백질을 발현하는 세포주는 정상세포에 비하여 증식 속도가 2배 정도 빠르며, soft agar assay 결과에 의하면 대조군과 비교하여 더 많은 수의 colony를 형성하였다. 또한, 이들 HBx 발현 세포들은 접촉 저해 능력을 상실하여 HBx가 세포 형질 전환 능력을 가짐을 알수 있다 또한 HBx 발현 세포주에 있어서 p21의 RNA 및 protein수준이 정상세포에 비하여 낮으므로 HBx에 의한 증식 촉진 및 세포 형질 전환이 p21을 매개하여 이루어 짐을 알 수 있었다. HBx에 의한 p21 유전자의 발현 감소는 p21의 전사 수준에서 이루어지며 이는 p53-비의존적 경로에 의하여 이루어졌다.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.30 no.3
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• pp.150-160
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• 1994

Drift gillnet fishery for neon flying squid in the North pacific was one of the major pelagic fisheries of Korea until 1992, its annual catch was 79, 000M/T as average during 1988-1992, but moratoriumed since 1993 according to the decision of UN. Therefore, for the developing of the new fishing gear for the squid, the seven types of rip hook by automatic squid jigging machine were experimented by the korean research vessel Pusan 851 (G/T 1.126, 2.600 PS) in the North Pacific (38 $^{\circ}$30'-43 $^{\circ}$N, 152 $^{\circ}$E-178 $^{\circ}$W) from July 6. 1993 to August 31. 1993. The investigation on catch rate, dropout rate, and catch condition of the rip hooks related to the fishing lamp power for aggregating the squid were carried out during the period. The results obtained are as follows: The composition of catch by automatic squid jigging machine was 83.9% for neon flying squid. 15.5% for boreopacific gonate squid. 0.6% for boreal clubhook squid, and 0.01% for luminous flying squid. The catch rate of neon flying squid was 94.6% in 13.6-18.3$^{\circ}C$ of surface water temperature and 5.4% in others. The higher catch rate of neon flying squid was made in the range 13.6-18.3$^{\circ}C$ of temperature at the surface and about 1$0^{\circ}C$ of temperature at the 100m layer. The CPUE of neon flying squid in the 13.6-18.3$^{\circ}C$ of surface water temperature was ranged 0.8-11.8kg (8.7kg as average). The mantle length and body weight of neon flying squid caught in the experiment were ranged 18.3-51.3 cm, 140-3, 980g and mean mantle length and mean body weight were 29.4cm, 972g respectively. The catch rate of neon flying squid was the highest at dawn with a value of 25.0% of the total catch. The body weight of neon flying squid caught by the D type hooks was 1.7 times more than that of the A type hooks. The dropout rate of neon flying squid caught by the seven types hooks was 7.9-57.5% (19.0% as average), and dropout rate of the D type hooks was 7.9% with 2.7 times decrease than that of the A type hooks. The catch efficiency of small sized neon flying squid in case of using on-off switch method on fishing lamp in 15 minutes intervals was 2.6 times higher than that of the on-switch method with same fishing lamp power.

• Journal of Ginseng Research
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• v.43 no.2
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• pp.282-290
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• 2019

Background: Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects. However, the effect of G-Rg3 on mast cell-mediated allergic inflammation has not been investigated. Method: The antiallergic effects of G-Rg3 on allergic inflammation were evaluated using the human and rat mast cell lines HMC-1 and RBL-2H3. Antiallergic effects of G-Rg3 were detected by measuring cyclic adenosine monophosphate (cAMP), detecting calcium influx, and using real-time reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay, Western blotting, and in vivo experiments. Results: G-Rg3 decreased histamine release from activated mast cells by enhancing cAMP levels and calcium influx. Proinflammatory cytokine production was suppressed by G-Rg3 treatment via regulation of the mitogen-activated protein kinases/nuclear factor-kappa B and receptor-interacting protein kinase 2 (RIP2)/caspase-1 signaling pathway in mast cells. Moreover, G-Rg3 protected mice against the IgE-mediated passive cutaneous anaphylaxis reaction and compound 48/80-induced anaphylactic shock. Conclusion: G-Rg3 may serve as an alternative therapeutic agent for improving allergic inflammatory disorders.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.142-149
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• 2019

In this study, the past erosion history and current status in the CHUNG-UI beach of Eulwang-dong, Jung-gu, Incheon-Si, South Korea were investigated and analyzed the wave with wave-induced current to investigate the causes of coastal erosion. As a result, the significant wave height ($H_{1/3}$) was in the range of 0.07~1.57 m and the mean value was 0.21 m. The maximum wave height ($H_{max}$) was in the range of 0.02-4.76m and the mean value was 0.27m. The vertical wave height and cycles were estimated through numerical model experiments of wave transformation. The 50-year frequency design wave height ranged from 0.82m to 3.75m. As a result of the experiment of wave-induced current, wave-induced current in the CHUNG-UI beach was decreased after the installation of the Detached breakwater and the Jetty. On the other hand, when the crest elevation was increased up to 5 m, there was no significant change, but when the crest elevation was increased to 8m, strong wave-induced current occurred around the submerged breakwaters due to lowered depth of water. In addition, the main erosion of the CHUNG-UI beach is due to the intensive invasion of the wave characteristics coming from the outer sea into the white sandy beach. The deformation of the wave centered on the front of the sandy beach caused additional longshore currents flowing parallel to the sandy beach and rip currents in the transverse direction, thus confirming that the longshore sediment was moved out of the front and out of the sea. The results of this study can be used as preliminary data for the recovery of the sand and the selection of efficient erosion prevention facilities.

• Journal of Satellite, Information and Communications
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• v.9 no.3
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• pp.59-63
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• 2014

This paper describes the basic principles of 3D broadcast system and proposes new 3D broadcast technology that reduces the amount of data by applying CS(Compressed Sensing). Differences between Sampling theory and the CS technology concept were described. Recently proposed CS algorithm AMP(Approximate Message Passing) and CoSaMP(Compressive Sampling Matched Pursuit) were described. This paper compared an accuracy between two algorithms and a calculation time that image data compressed and restored by these algorithms. As result determines a low complexity algorithm for 3D broadcast system.

• Journal of The Korean Society of Agricultural Engineers
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• v.54 no.6
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• pp.151-158
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• 2012

This study will not only prove experimental dynamic properties which are classified to slump, compressed strength, bending strength and toughness index blast-furnace cement concrete with polypropylene (PP) fiber that refer properties and volume of it, but also establish a basic data in order to use PP fiber reinforced blast-furnace cement concrete. The slump didn't changed by PP fiber volume $5kgf/m^3$ because of flexibility of fiber in despite of loose mixing. The reason why the slump decreased steadily by PP fiber volume $3kgf/m^3$ was rising contact surface of water. The compressed strength indicated a range of 19.49~26.32 MPa. The tensile strength indicated a range of 2.10~2.44 MPa. The bending strength was stronger about 3~16 % in case of mixing with PP fiber volume than normal concrete. The flexure strength indicated a range of 4.30~4.83 MPa. The toughness indicated a range of $0{\sim}19.88N{\cdot}mm$ and was stronger about 6.7 times in case of PP fiber volume $9kg/m^3$ than PP fiber volume $1kg/m^3$. The pavement with PP fiber volume over such a fixed quantity in the roads of a respectable amount load can have a effect to prevent not only resistance against clack but also rip off failures.

• Magazine of the Korea Concrete Institute
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• v.9 no.5
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• pp.233-244
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• 1997

구조적으로 손상을 입은 구조물들에 대한 보강방법으로 강판, 카본쉬트, 아라미드섬유쉬트 등을 이용한 접착공법이 최근 들어 많이 사용되고 있으며 그 중 가장 널리 Tm이는 방법은 강판접착공법이다. 강판접착공법에 대해서는 많은 연구가 진행되어 오고 있으나, 보의 구조적 거동에 영향을 미치는 다양한 인자들의 영향이나 강성, 파괴양상등에 미치는 영향들에 대해서는 체계적인 평가가 이루어지지 않은 실정이며 특히 강판접착공법에서 파괴에 큰 영향을 미치는 박리하중에 대한 연구는 미흡한 실정이다. 따라서 본 연구에서는 일련의 철근콘크리트보부재를 대상으로 하여 주요실험변수로 선행하중의 크기, 강판의길이, 강판의 두께, 앵커볼트의 간격과 유무, 강판의 층수, 측면보강높이를 실험변수로 하여, 휨인장에 대해 강판잡착공법을 적용하여 포괄적인 실험을 수행하였다. 3등분점하중법의 실험결과를 이용하여 처짐, 인장 및 압축 철근의 변형도, 콘크리트와 강판의 변형도를 분석하였고, 이를 토대로 파괴양상과 파괴하중을 분석하였다.

• YAKHAK HOEJI
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• v.16 no.3
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• pp.137-147
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• 1972

Estrone, which is obtainable from 19-hydroxycholesterol acetate through microbial oxidation, was chemically transformed to orally active estrogens, ethynylestradiol and methylestradiol. For progestin synthesis, $5{\alpha}$-bromo-619-oxidoisoandrosterone, was harvested from the culture broth(ATCC:19170), in which $5{\alpha}$-bromo-619-oxidocholestanol, acetate was added as a carbon source. Methylestrenolone, a potent orally active progestin, was synthesized from the harvested product via several reactions. Norethindrone, a popular progestin, was also prepared from 19-norandrostenedione. 19-Norandrostenedione is also available through microbial oxidation and chemical modification of $5{\alpha}$-chlor-619-oxidocholestanol, acetate.

• Journal of Korean Society for Quality Management
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• v.23 no.4
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• pp.180-189
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• 1995

Today, as globalization continues and international trading blocks are formed, world markets are intensely competitive and abound in product variety, volume, complexity and environmental management. Specifically, green consumer's needs and expectations are changing and diversifying, resulting in a changed global environment for industry. Due to these changes, domestic companies are striving to achieve the Environmental Management System (ISO 14000) certification. This is considered a basis step in meeting the guiding principle and practice of ISO/TC 207/SC 3 resolution. In this paper, we will present three type(I, II, III) of Environmental Labelling programs to build a model for environmental management system by analysing practitioner and stakeholder. After companies establish an ISO 9000 quality system these companies should focus on improve toward their own Environmental Labelling program and continue to build ISO 14000.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2011.11a
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• pp.164-165
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• 2011

스마트폰 기술이 항만물류 산업에도 혁신적 변화를 일으키고 있다. 2010년 국토해양부는 '유무선 통합 Smart-Port' 정책을 발표하고 스마트폰과 Wibro, 3G, Wifi 등 통신망을 이용한 항만물류서비스를 통하여 항만자동화와 효율성 제고를 꾀하겠다는 계획을 발표하고 실행에 박차를 가하고 있다. 국내 항만물류 분야에서는 국토해양부의 정책에 발맞추어 다양한 형태의 항만물류 모바일 서비스를 제공하고 있다. 본 연구에서는 국내 항만물류 분야에서 도입, 사용되고 있는 스마트폰을 이용한 모바일 애플리케이션 사례를 분석하고, 활성화방안을 제시하였다.