• 제목/요약/키워드: RHO

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Studies on the Chemical Constituents from the Seeds of Zizyphus jujuba var. inermis

  • Lee, Nam Kyung;Shin, Hyun Jung;Kim, Wan-Seok;In, Gyo;Han, Chang Kyun
    • Natural Product Sciences
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    • 제23권4호
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    • pp.258-264
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    • 2017
  • This study analyzed the seeds of Zizyphus jujuba var. inermis commonly used as a remedy in traditional Chinese medicine, in order to determine its various biologically active compounds. Through process 3-pentadecylcatechol, ${\rho}$-menth-8-ene, and ${\gamma}$-bisabolene were isolated and identified for the first time which are urushiol, monoterpenoidal, and sesquiterpenoidal compounds, respectively. Also, found were another sesquiterpenoidal compounds, vomifoliol, and four steroidal compounds, ${\beta}$-sitosterol, stigmasterol, stigmasta-5,23-dien-$3{\beta}$-ol, and stigmast-4-en-3-one. In addition, fourteen triterpenoidal compounds were isolated and identified. These were lupeol, betulinic acid, betulinaldehyde, alphitolic acid, 3-O-cis-${\rho}$-coumaroyl-alphitolic acid, 3-O-trans-${\rho}$-coumaroyl-alphitolic acid, 2-O-cis-${\rho}$-coumaroyl-alphitolic acid, 2-O-trans-${\rho}$-coumaroyl-alphitolic acid, zizyberanalic acid, ceanothic acid, oleanolic acid, maslinic acid, 3-O-cis-${\rho}$-coumaroyl-maslinic acid, and 3-O-trans-${\rho}$-coumaroyl-maslinic acid. The structures were identified by comparing of the spectroscopic experiments, NMR and MS, and then compared that reported data, respectively. Three extracts of water, methanol, and chloroform from the seeds showed a weak anti-proliferative effect, anti-microbial activity, and anti-oxidant effect, respectively.

EC-MBR 공정의 MLSS, 전류밀도 및 접촉시간이 막 오염 감소에 미치는 영향 모델링 (Modeling of the effect of current density and contact time on membrane fouling reduction in EC-MBR at different MLSS concentration)

  • 김완규;장인성
    • 상하수도학회지
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    • 제33권2호
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    • pp.111-119
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    • 2019
  • Electro-coagulation process has been gained an attention recently because it could overcome the membrane fouling problems in MBR(Membrane bio-reactor). Effect of the key operational parameters in electro-coagulation, current density(${\rho}_i$) and contact time(t) on membrane fouling reduction was investigated in this study. A kinetic model for ${\rho}_i$ and t required to reduce the membrane fouling was suggested under different MLSS(mixed liquor suspended solids) concentration. Total 48 batch type experiments of electro-coagulations under different sets of current densities(2.5, 6, 12 and $24A/m^2$), contact times(0, 2, 6 and 12 hr) and MLSS concentration(4500, 6500 and 8500mg/L) were carried out. After each electro-coagulation under different conditions, a series of membrane filtration was performed to get information on how much of membrane fouling was reduced. The membrane fouling decreased as the ${\rho}_i$ and t increased but as MLSS decreased. Total fouling resistances, Rt (=Rc+Rf) were calculated and compared to those of the controls (Ro), which were obtained from the experiments without electro-coagulation. A kinetic approach for the fouling reduction rate (Rt/Ro) was carried out and three equations under different MLSS concentration were suggested: i) ${\rho}_i^{0.39}t=3.5$ (MLSS=4500 mg/L), ii) ${\rho}_i^{0.46}t=7.0$ (MLSS=6500 mg/L), iii) ${\rho}_i^{0.74}t=10.5$ (MLSS=8500 mg/L). These equations state that the product of ${\rho}_i$ and t needed to reduce the fouling in certain amounts (in this study, 10% of fouling reduction) is always constant.

건착망의 운동특성(II) -그물감이 다른 건착망의 침강특성 해석- (Characteristics on the Motion of Purse Seine(II) -An Analysis on the Sinking Characteristics of Model Purse Seine by Different Netting Material-)

  • 김석종;박정식
    • 수산해양기술연구
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    • 제31권4호
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    • pp.372-378
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    • 1995
  • 건착망의 침강 운동특성을 구명하기 위한 기초연구로서 그물감의 재료가 다른 세 종류의 건착망을 수중 총중량(60g)이 동일하게 되도록 발돌의 양을 조절하여 제작하고, 침강특성을 해석하였다. 실험에 사용한 건착망은 그물실의 직경 및 발의 길이가 같은 폴리프로피렌계(밀도 0.91g/$cm^3$) 및 폴리에스터계(밀도 1.38g/$cm^3$)의 매듭 없는 그물감을 사용하여, 뜸줄의 길이를 420cm, 그물의 폭을 86cm가 되도록 제작하고, 이 그물들을 각각 PP, PA 및 PES 그물이라고 하였다. 회유수조의 수로상에 투망장치를 설치해서 정지상태의 수중에 투망하고, 측면에 설치한 비디오 카메라를 이용하여 촬영 녹화하였다. 그리고, 그물에 표시한 측정점의 좌표를 화상해석장치로 읽고 실험치를 구하였다. 여기에는, 건착망의 수직방향의 침강운동을 나타내는 미분방정식을 구하고 Runge-Kutta-Gill법에 의한 연립 미분방정식 해법을 이용하여 수치해석을 행하였으며, 그 결과는 다음과 같다. 1. 그물 아랫자락의 침강속도는 PP 그물이 가장 빠르고, PA 및 PES 그물 순으로 늦게 나타났다. 2. 그물감의 저항계수 $K_D$는 계산결과 $K_D=0.061({\frac{\rho}{{\rho}_w}})^4$의 관계식으로 나타낼 수 있었다. 3. 그물다발의 저항계수 $C_R$은 계산결과 $C_R=0.91({\frac{\rho}{{\rho}_w}}$의 관계식으로 나타낼 수 있었다. 4. 건착망 투망후 경과시간에 따른 그물 아랫자락의 도달수심에 대한 실험치와 계산치는 매우 잘 일치하여 meas.=0.99cal.의 관계였다.

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전문대학생의 진로의식에 관한 연구 - D대학 치기공과 재학생을 중심으로 - (The research on the Career Consciousness of the College Students (revolve around D College Dental Technology Student))

  • 배봉진;이화식;박명호
    • 대한치과기공학회지
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    • 제32권4호
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    • pp.387-401
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    • 2010
  • Purpose: The work of Dental technician which is part of national dental health, is more specialized recently. This research provides fundamental data from analyzing student's career consciousness according to needs of a career education. Here is the conclusion of the analysis about student's career consciousness, that is for a right choice of career. Methods: This study did questionnaire to a dental Laboratory Technology student who locate in Taegu. Question response student number was 570 people. Response contents analyzed to 506 people except imperfect questionnaire. Data used windows sas 8.0 program and did descriptive statistical analysis. Results: There is a meaningful difference in what they want to know about an occupation according to ages. (${\rho}$ < 0.01) All ages are similar to their occupational thinking, however they who are under twenties consider working environment. Most motives of an entrance are similar, there is a meaningful difference. (${\rho}$ < 0.05) According to a grade of college, there is a meaningful difference how to obtain informations of a career. (${\rho}$ < 0.05) Sophomores and juniors obtain information from seniors or family, however freshmen obtain from the internet because of an accessibility. There is a meaningful difference of a job meaning between men and women. (${\rho}$ < 0.01) Men are working for a means of living. But women give weight to a self-development. The older they grow, the more they know about their aptitude. Selecting subjects are different choosing time & motive. According to ages and where they are from, there is a meaningful difference how much know about their aptitude. (${\rho}$ < 0.05) Older Students know more than young students. Selecting subjects are different choosing time & motive. In accordance with a grade, ages, and where they are from, there are different degrees about how much know their interests. There is a meaningful difference of a choosing major period and choosing informations. (${\rho}$ < 0.01) And also there is a meaningful difference where they are from and why they enter to College. (${\rho}$ < 0.001) In accordance with a grade, ages, and where they are from, there are different degrees about how much know their aptitude. There is a meaningful difference of a choosing major period. (${\rho}$ < 0.01) And also there is a meaningful difference why they enter to College. (${\rho}$ < 0.001) Conclusion: Although we know that a career education is very important, however lots of students select a career without their aptitude & interest & character. We need to teach a career education systematically; considering students career consciousness, with a proper career guidance, cultivating career consciousness.

H2O2 Inhibits Proliferation and Mediates Suppression of Migration via DLC1/RhoA Signaling in Cancer Cells

  • Ma, Long;Zhu, Wen-Zhen;Liu, Ting-Ting;Fu, Hui-Ling;Liu, Zhao-Jun;Yang, Bing-Wu;Song, Tai-Yu;Li, Guo-Rong
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권4호
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    • pp.1637-1642
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    • 2015
  • Background: RhoGTPase-activating proteins (RhoGAPs) regulate RhoGTPases in cells, but whether individual reactive oxygen species (ROS) regulate RhoGAPs is unknown. Our previous published papers have shown that deleted in liver cancer 1 (DLC1) inhibits cancer cell migration by its RhoGAP activity. The present study was designed to explore the role of $H_2O_2$ in regulation of DLC1. Materials and Methods: We treated cells with $H_2O_2$ for 24h and phenotypic changes were analyzed by MTT, RT-PCR, Western blotting, immunofluorescence staining and wound healing assays. Results: $H_2O_2$ downregulated cyclin D1 and cyclin E to inhibit proliferation, and upregulated BAX to induce apoptosis in MCF-7 cells. Compared with non-tumorigenic cells, $H_2O_2$ increased expression of DLC1 and reduced activity of RhoA in cancer cells. Stress fiber production and migration were also suppressed by $H_2O_2$ in MDA-MB-231 cells. Conclusions: Our study suggests that $H_2O_2$ inhibits proliferation through modulation of cell cycle and apoptosis-related genes, and inhibits migration by decreasing stress fibers via DLC1/RhoA signaling.

전기적 특성의 in-situ 측정에 의한 개질된 NR 블랜드의 가황 반응에 관한 연구 (A Study on the Vulcanization Reaction of Modified NR Blends by In-Situ Electrical Property Measurement)

  • 하기룡;서숭혁;노승백;이승현;안원술
    • Elastomers and Composites
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    • 제38권3호
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    • pp.235-242
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    • 2003
  • 이소프렌 고무(IR)로 개질된 천연고무계의 NR/CB 복합재료의 가교반응에 대하여 반응 도중의 전기적 성질 변화를 in-situ로 측정함으로서 주어진 샘플의 가교반응 특성을 연구하였다. 샘플의 전기적 성질이 가황반응이 진행되는 동안 샘플 내의 카본 블랙의 재정렬에 의해 연속적으로 변하기 때문에 샘플의 체적고유저항 값(${\rho}$)의 변화를 반응시간의 함수로 표시하였다. 이로부터, 반응온도에 따른 반응시작 안정화시간($t_i$), 최대반응속도 시간($t_p$), 및 이 때의 최대반응속도 체적고유저항값(${\rho}_p$)을 정의하여 이로부터 Arrhenius 도시를 이용한 해석을 시도하였다. 체적 고유저항값 ${\rho}$는 반응시작 전에는 ${\sim}10^8$ order의 높은 값을 보이다가 반응시작 후에 급격히 떨어지는 안정화 시간, $t_i$를 거친 후에 다시 최대반응속도를 보이는 $t_p$에서 피크를 보이며, 그 이후에는 단조 감소하여 일정한 값으로 수렴하는 것이 관찰되었다. 한편, 샘플의 반응온도가 높아질수록 $t_i$$1{\sim}2$분으로서 상대적으로 일정한 데 반하여, $t_p$는 점점 더 짧아져 $160^{\circ}C$의 반응온도에서는 3분 정도로까지 짧아지는 것이 관찰되었다. 또한 반응의 인가 주파수에 대한 변화로서, 약 1,000Hz이하의 저주파수에서는 상대적으로 낮은 활성화에너지($E_a$)값을 보였으나, 10,000Hz의 높은 측정주파수에서는 더 큰 $E_a$값을 나타냄으로서 반응온도변화에 민감함을 보여주었다.

CDMA 단말기 RF 송신단의 Traffic Rho 성능 개선에 관한 연구 (The Study on Improvement of Traffic Rho Performance in RF Transmitter of CDMA Handset)

  • 박희봉;황승훈;황금찬
    • 한국통신학회논문지
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    • 제25권4B호
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    • pp.624-628
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    • 2000
  • 본 논문에서는 CDMA 단말기의 전기적 성능에 관한 최소의 요구 사항을 명기한 IS-98B의 항목에서 CDMA 파형의 질(Waveform Quality)을 규정하는 항목인 트래픽로(Traffic Rho)가 최소 성능에 만족하지 않을 경우 CDMA 단말기에 나타나는 현상을 분석하고, CDMA단말기 디자인시 단말기 송신부의 IF(Intermediate Frequency)단에서 TX IF SAW FILTER의 매칭회로를 개선하고 송신단 전원인 3.0V -TX를 발생시키는 LDO(Low Dropout Regulator)의 노이즈 발생을 차단하여 트래픽로 문제 해결방법을 제안한다. 제안 방법을 적용한 후의 파형과 적용전의 파형을 HP8924C 와 HP8595E을 이용하여 비교하여 성능을 개선됨을 보였다.

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항만운송시스템의 분석에 관한 연구 (An Analysis of the Port Transportation System)

  • 이철영;문성혁
    • 한국항해학회지
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    • 제7권1호
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    • pp.1-32
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    • 1983
  • The delay due to congestion has recently attracted widespread attention with the analysis of over-all operation at the port. But, the complexity of the situation is evident in view of the large number of factors which impinge on the considerable end. Queueing theory is applicable to a large scale transportation system which is associated with arrivals of vessels in a large port. The attempt of this paper is to make an extensive analysis of the port transport system and its economic implications from the viewpoint that port is one of the physical distribution facilities and a kind of queueing system which includes ships and cargoes as port customer. By analyzing the real data on the Port of Pusan, it is known that this port can be represented as a set of multi-channel with identical setof Poisson arrival and Erlang service time, and also it is confirmed that the following formula is suitable to calculate the mean delay in this port, namely, $W_4={\frac{\rho}{\lambda(1-\rho)} {\frac{e_N(\rho{\cdot}N)}{D_{N-1}(\rho{\cdot}N)}$ where, ${\lambda}$: mean arrival rate $\mu$: mean servicing rate; N: number of servicing channel; ${\rho}$: utillization rate (${\lambda}/N{\mu}$) $e_N$: the Poisson function Coming to grips with the essentials of the cost of delay due to congestion, a simple ship journey cost model is adopted and the operating profit sensitivity to variation in port time is examined, and for purpose of a future development for port princing service the marginal cost is approximately calculated on the basis of queueing theory.

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Barcoding and Phylogenetic Inferences in Nine Mugilid Species (Pisces, Mugiliformes)

  • Polyakova, Neonila;Boutin, Alisa;Brykov, Vladimir
    • Animal Systematics, Evolution and Diversity
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    • 제29권4호
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    • pp.272-278
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    • 2013
  • Accurate identification of fish and fish products, from eggs to adults, is important in many areas. Grey mullets of the family Mugilidae are distributed worldwide and inhabit marine, estuarine, and freshwater environments in all tropical and temperate regions. Various Mugilid species are commercially important species in fishery and aquaculture of many countries. For the present study we have chosen two Mugilid genes with different phylogenetic signals: relatively variable mitochondrial cytochrome oxidase subunit I (COI) and conservative nuclear rhodopsin (RHO). We examined their diversity within and among 9 Mugilid species belonging to 4 genera, many of which have been examined from multiple specimens, with the goal of determining whether DNA barcoding can achieve unambiguous species recognition of Mugilid species. The data obtained showed that information based on COI sequences was diagnostic not only for species-level identification but also for recognition of intraspecific units, e.g., allopatric populations of circumtropical Mugil cephalus, or even native and acclimatized specimens of Chelon haematocheila. All RHO sequences appeared strictly species specific. Based on the data obtained, we conclude that COI, as well as RHO sequencing can be used to unambiguously identify fish species. Topologies of phylogeny based on RHO and COI sequences coincided with each other, while together they had a good phylogenetic signal.