• The Korean Journal of Physiology and Pharmacology
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• v.7 no.5
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• pp.289-293
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• 2003

Mutations in the NF2 tumor suppressor gene cause neurofibromatosis type 2, an autosomal dominant inherited syndrome predisposed to the multiple tumors of the nervous system. Merlin, the NF2 gene product was reported to block Ras-mediated cell transformation and represses Ras-induced expression of cyclin D1. However, the potential mechanism underlying the anti-Ras function of merlin on the cyclin D1 is still unclear. In this study, we investigated whether merlin decreases Ha-ras-induced accumulation of cyclin D1 at the transcriptional level, and demonstrated that merlin suppressed Ras-induced cyclin D1 promoter activity mediated by the cyclic AMP-responsive element (CRE) in SK-N-BE(2)C neuroblastoma cells. Furthermore, we found that merlin attenuated active Ras and forskolin-induced CRE-driven promoter activity. These results suggest that the transcriptional repression of the cyclin D1 expression by merlin may contribute to the inhibition of Ras-induced cell proliferation.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.2
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• pp.60-65
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• 2009

A highly reliable Video Transmission System (VTS) was developed in order to obtain both video and digital data simultaneously in the real time flight test situation of a flying vehicle. The VTS integrates GPS date digital telemetry data and video signals into a compact digital data package which is compressed and processed by an MPEG-2 Encoder and a modulator respectively. The modulator is composed of a specially devised Forward Error Correction processor and base band QPSK modulator. The designed VTS was verified and proved for its required functioning and performance through separate flight tests using an airplane and Rockets.

• The Journal of the Korea institute of electronic communication sciences
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• v.4 no.1
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• pp.7-13
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• 2009

Now society has been extending to ubiquitous information society under the information telecommunication facilities. So it is importance to install and design those for the core business. If there is a serious problem on the information telecommunication infra-facility, it could be seriously effected to the life of the people and the national economy. To prevent the those problems, information telecommunication infra-facilities have been installed/supervised due to the proper telecommunication specialists. In this paper, firstly invested the current supervision system and then proposed how to upgrade information telecommunication services through the proposed supervision system for the telecommunication infra-facilities.

• The Journal of the Korea institute of electronic communication sciences
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• v.4 no.2
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• pp.93-100
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• 2009

As the Internet Protocol be widely/rapidly used in packet communication, common carriers are providing the multimedia service(Both direction real-time voice, video conference, remote educational etc.)on the Internet. Also the 070 VoIP (Voice over IP) service is provided by the carriers on the packer network. In order to offer VoIP service in Korea, common carrier has to acquire the optimum level for QoS(quality of service). In this paper, we study on CODEC quality to get a higher QoS for VoIP.

• Human Ecology Research
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• v.55 no.6
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• pp.567-580
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• 2017

This study explored the influence of adolescent depression on adult media addiction by examining Bronfenbrenner's ecological perspective. The ecological perspective is a useful framework to identify the link between youths' interacting subjects in the ecological environment. It can also be used to understand adolescent problems and addiction behaviors. The current study examined the influence of parents, peers, and teachers on adult media addiction and depression with a focus on micro-systems that have the greatest influence on adolescents among various environmental systems. We analyzed 568 participants who reported exposure to adult media. SPSS 20.0 was used to conduct a descriptive analysis of the data; AMOS 19.0 was used to conduct a confirmatory factor analysis and structural equation model. The results of study are as follows. First, parental abuse and peer alienation significantly increases depression. Second, peer communication significantly decreases depression. Third, parental monitoring and parental affection significantly decreased adult media addiction. Fourth, parental abuse, peer alienation, and depression significantly increased adult media addiction. This study is meaningful in that it examines the influence of parent, peer, and teacher relationships among adolescents on adult media addiction and depression. This study can be helpful to understand adult media addiction and depression among Korean adolescents.

• Culinary science and hospitality research
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• v.12 no.4 s.31
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• pp.269-283
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• 2006

To show the recognition of hand-sanitizer, we studied the answers of research questions where we got from the northern part of Seoul and Kyunggi Province. We had categorized two groups both industry-related people who work in restaurants, hygiene service shops, whole sales, government organizations, PC shops, factory-department stores and non industry-related people who work in schools, general offices for this study. 1. Hand sanitation level: Over 60% people washed hands 6 times a day. The group using water and soap was much bigger than the group using water for washing hands. For drying, people preferred wipe tissue, towels, clothes, non drying in that order. 2. Recognition of hand sanitizer and its usage experience: Most people(66.5%) did not know what hand sanitizer is, but they have positive attitude if they use this machine. 3. Place of hand sanitizer: The proper places to install were such public places as hospitals, restrooms, and restaurants. The fifties-group was the most frequently hand washing generation with over 9 times a day. 4. Comparison of recognition for hand-sanitizer by male and female: There were different results in each evaluation item by either male or female. The frequency and method of hand washing showed high in males, while females observed hand sanitization, installation requirements, installation areas, home installation, etc more than anything else.

• Genomics & Informatics
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• v.6 no.3
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• pp.136-141
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• 2008

A large number of studies have been performed to identify biomarkers that will allow efficient detection and determination of the precise status of a patient’s disease. The use of microarrays to assess biomarker status is expected to improve prediction accuracies, because a whole-genome approach is used. Despite their potential, however, patient samples can differ with respect to biomarker status when analyzed on different platforms, making it more difficult to make accurate predictions, because bias may exist between any two different experimental conditions. Because of this difficulty in experimental standardization of microarray data, it is currently difficult to utilize microarray-based gene sets in the clinic. To address this problem, we propose a method that predicts disease status using gene expression data that are transformed by their ranks, a concept that is easily applied to two datasets that are obtained using different experimental platforms. NCI and colon cancer datasets, which were assessed using both Affymetrix and cDNA microarray platforms, were used for method validation. Our results demonstrate that the proposed method is able to achieve good predictive performance for datasets that are obtained under different experimental conditions.

• Bulletin of the Korean Chemical Society
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• v.35 no.4
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• pp.1133-1138
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• 2014

Ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI- MS/MS) provides a high-speed method to screen a large number of samples for small molecules with specific properties. In this study, UPLC-ESI-MS/MS with multiple reaction monitoring (MRM) was employed to screen urinary phospholipid (PL) content for biomarkers of prostate cancer. From lists of urinary PLs structurally identified using nanoflow LC-ESI-MS/MS, 52 PL species were selected for quantitative analysis in urine samples between 22 cancer-free urologic patients as controls and 45 prostate cancer patients. Statistical treatment of data by receiver operating characteristic (ROC) analysis yielded 14 PL species that differed significantly in relative concentrations (area under curve (AUC) > 0.8) between the two groups. Among PLs present at higher levels in prostate cancer urine, phosphatidylcholines (PCs) and phosphatidylinositols (PIs) constituted the major head group PLs (3 PCs and 7 PIs). For technical reasons, PL species of low abundance may be underrepresented in data from UPLC-ESI-MS/MS performed in MRM mode. However, the proposed method enables the rapid screening of large numbers of plasma or urine samples in the search for biomarkers of human disease.

• Clinical and Experimental Reproductive Medicine
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• v.5 no.1_2
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• pp.17-26
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• 1978

The purpose of this study is to explore into the Korean Women's sexual life in terms of sexual behavior, sexual attitudes, and sexual experiences. In recent years, it has been generally recognized in both academic area and general publics that traditional norms, values, and patterns of behavior have been rapidly changing in Korea, thus being replaced by new ones. 1. The prevailing preconception that Korean women are sexwise traditional and conservative seems to be no longer true in the present days. 2. In this country, their sexual behaviors and attitudes at least within their marriage have been already westernized, being very similar to those of western women. 3. Knowledge and information of sexual matters held by Korean women prior to their marriage seems to be very limited, compared to those of western women. 4. It seems that Korean women have developed positive attitudes toward sex education practice in their family.

• Tuberculosis and Respiratory Diseases
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• v.40 no.6
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• pp.747-750
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• 1993

A 51-year-old male was admitted due to mediastinal mass. Chest PA showed a $4{\times}5$ cm sized round mass on right lower paratracheal area. The chest computerized tomogram showed cystic mass located between superior vena cava and trachea. This cystic mass was composed of variable internal architecture with Hounsfield unit(HU) from -44.4 to +25.5. The resected cystic mass revealed ectodermal, mesodermal, and endodermal structures. We report a case of anterior mediastinal cystic teratoma confirmed by open thoracotomy.