• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.454-474
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• 2002

Vasoactive intestinal peptide (VIP) is a very potent dilatator and a nonadrenergic, noncholinergic (NANC) neurotransmitter or neuromodulator in the peripheral and the central nervous systems. The mechanisms of action of VIP were examined in aortic circular and in uterine longitudinal smooth muscle strips of the rat. The effects of sympathetic neurotransmitter were investigated in gastric and aortic circular muscle strips of the mouse and the rat. The effects of silver spike point, SSP, low frequency electrical stimulations of VIP, sympathetic neurotransmitter and $\beta$-endorphin were examined in plasma, serum and 24h urine from the healthy volunteer. In gastric smooth muscle strips from the mouse, adrenergic neurotransmitter norepinephrine was inhibitory effected, followed by caused phasic and tonic contraction to the, muscrine receptor agonist carbachol and acetylcholine, respectively. In urine from the healthy volunteer, both norepinephrine and epinephrine were significantly decreased in continue type and low frequency (3 Hz) of SSP electrical stimulations. The contractile responses to S-HT in uterine longitudinal smooth muscle strips of the rats were completely decreased by a VIP 1 $\mu$M. The contractile responses to PGF2$\alpha$ were not decreased by a VIP. In plasma and serum from the healthy volunteer, both VIP and $\beta$-endorphin were significantly increased in continue type and low frequency (3 Hz) of SSP electrical stimulations. Therefore, this study demonstrate that VIP has the capacity to relax vascular or gastric smooth muscles in part by stimulating the generation of NO, and silver spike point low frequency electrical stimulation has the capacity both to decrease sympathetic neurotransmitters and to increase VIP, $\beta$-endorphin.

• 동의생리병리학회지
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• 제22권3호
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• pp.593-599
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• 2008

This research was aimed to examine the effect of Polygoni Multiflori Radix extract on the blood pressure in spontaneous hypertensive rat (SHR) and norepinephrine - induced arterial contraction in rabbit. In order to investigate the effect of Polygoni Multiflori Radix on rabbit's contracted vascular ring detached from common carotid artery, vascular ring with intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of Polygoni Multiflori Radix-induced relaxation, Polygoni Multiflori Radix extract was infused into contracted vascular ring which had been pretreated by $N{\omega}$-nitro-L-arginine(L-NNA), Methylene blue(MB), and $Ca^{2+}$ was infused into contracted vascular ring induced by NE after treatment of Polygoni Multiflori Radix extract in $Ca^{2+}$-free solution. The results were as follows: Systolic blood pressure was significantly attenuated by administration of Polygoni Multiflori Radix. Blood flow and aldosterone were significantly decreased, but velocity and renin were not affected by Polygoni Multiflori Radix. Polygoni Multiflori Radix had an effective relaxation to the contracted vascular ring by NE in 0.03 mg/ml, 0.1 mg/ml and 0.3 mg/ml level. Polygoni Multiflori Radix had an effective relaxation to the intact endothelium vascular ring, but when endothelium was removed, vascular ring did not relax. Polygoni Multiflori Radix-induced relaxation was inhibited by the pretreatment of L-NNA and MB. Pretreatment of Polygoni Multiflori Radix extract inhibit the contraction by influx of extra-$Ca^{2+}$ in contracted vascular ring induced by NE in $Ca^{2+}$-free solution. As mentioned above, we suggest that Polygoni Multiflori Radix relaxes vascular ring through suppress influx of extra-cellular $Ca^{2+}$ by the action of nitric oxide from endothelium.

• 동의생리병리학회지
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• 제22권3호
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• pp.666-671
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• 2008

This study was undertaken to define the effect of ChungGongGo extract on norepinephrine-induced arterial contraction in rabbit. In order to investigate the effect of ChungGongGo extract on rabbit's contracted vascular ring detached from common carotid artery, vascular ring with intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of ChungGongGo extract-induced relaxation, ChungGongGo extract was infused into contracted vascular ring which had been pretreated by $N{\omega}$-nitro-L-arginine(L-NNA), Methylene blue(MB), and $Ca^{2+}$ was infused into contracted vascular ring induced by NE or KCl after treatment of ChungGongGo in $Ca^{2+}$-free solution. The results were as follows: ChungGongGo extract had an effective relaxation to the contracted vascular ring by NE in 1.0mg/ml and 0mg/ml level. ChungGongGo extract had an effective relaxation to the intact endothelium vascular ring, but when endothelium was removed, vascular ring did not relax. ChungGongGo extract-induced relaxation was inhibited by the pretreatment of L-NNA and MB. Pretreatment of ChungGongGo extract inhibit the contraction by influx of extra-$Ca^{2+}$ in contracted vascular ring induced by NE in $Ca^{2+}$-free solution. As mentioned above, we suggest that ChungGongGo relaxes vascular ring through suppress influx of extra-cellular $Ca^{2+}$ by the action of nitric oxide from endothelium.

• 대한교통학회지
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• 제31권2호
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• pp.33-44
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• 2013

토지이용-교통 통합모형은 실증연구와 정책연구에 적합한 풍부하고 유연한 모형요소를 가지고 있다. 그러나 모형의 구성이 복잡한 만큼 후생함수의 정책변수에 대한 변화율 또한 통상 복잡하다. 따라서 최적 정책수단이 충족시켜야 할 1계 도함수 조건을 푸는 최적 정책수단의 수식을 명시적으로 유도하는 것이 매우 어렵고, 그 결과 수치해석적 모형은 이론연구 도구로서 활용하는데 근본적 한계를 가지고 있었다. 이 문제를 해결하고자 Yu and Rhee(2011) 및 Rhee (2012)는 이들 모형에서 목적함수인 후생함수의 정책변수에 대한 변화율을 간단한 수식으로 변환하는 방법론을 제시한 바 있다. 그러나 이들이 사용한 모형에서 교통수요는 고정된 것으로 가정하고 있어, 이들 모형 또한 교통 계획적 관점에서 보았을 때 상당한 한계를 지니고 있다. 이에 본 연구는 이들의 방법론을 교통수요가 탄력적인 토지이용-교통 모형으로 확장한다. 이 방법론을 이용하면 보다 현실적인 모습의 토지시장과 교통망이 구현된 모형에서 정책수단의 다양한 영향을 분석할 수 있게 된다. 이러한 분석은 종래에 존재하지 않았거나 있었다 하더라도 매우 제한된 범위에서 수행되었던 분석들이다.

• 동의생리병리학회지
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• 제22권1호
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• pp.131-136
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• 2008

This study was undertaken to define the effect of Polygoni cuspidatae Radix on contracted rabbit common carotid artery and its mechanism. In order to investigate the effect of Polygoni cuspidatae Radix on rabbit's contracted vascular ring detached from common carotid artery, vascular ring with intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of Polygoni cuspidatae Radix-induced relaxation, Polygoni cuspidatae Radix extract was infused into contracted vascular ring which had been pretreated by $N{\omega}-nitro-L-arginine(L-NNA)$, Methylene blue(MB), and $Ca^{2+}$ was infused into contracted vascular ring induced by NE or KCl after treatment of Polygoni cuspidatae Radix extract in $Ca^{2+}-free$ solution. The results were as follows : Polygini cuspidatae Radix had an effective relaxation to the contracted vascular ring by NE in 0.1 mg/ml and 0.3 mg/ml level. Polygini cuspidatae Radix had an effective relaxation to the intact endothelium vascular ring, but when endothelium was removed, vascular ring did not relax. Polygini cuspidatae Radix-induced relaxation was inhibited by the pretreatment of L-NNA and MB. Pretreatment of Polygini cuspidatae Radix extract inhibit the contraction by influx of $extra-Ca^{2+}$ in contracted vascular ring induced by NE or KCl in $Ca^{2+}-free$ solution. As mentioned above, we suggest that Polygini cuspidatae Radix relaxes vascular ring through suppress influx of extra-cellular $Ca^{2+}$ by the action of nitric oxide from endothelium.

• 대한지구과학교육학회지
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• 제2권1호
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• pp.80-90
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• 2009

The purpose of this study is to investigate the characteristics of the mind maps which were drawn with pencil or color pens by elementary students. For this study, 31 students of the 6th grade were selected and trained mind mapping. After training, the subjects had drawn mind maps with color pens about the ROCK for 15minutes and drew mind maps with pencil after 2days of mind mapping using color pens. In addition to activities of mind mapping, the students handed in their papers which were written one's impression of drawing two kinds of mind mapping. The results were follows: First, in central circle which was linked words connected firstly with ROCK as key word, the difference of 2kinds mind maps were little showed in the quantity and quality of the words, branches and their adequacy. Second, the mind maps using pencils had more words, branches and images than mind maps of using color pens in the whole assessment. Third, the most students suggested that the mind mapping using pencil were advantage to economy of time, retouching words and branches, also the mind mapping using pencil made the students relax the strain for drawing it because of retouching possibility. Consequently, the results of this study suggest the mind mapping using pencil has advantage effect on the purpose of gaining students' thinking abundantly and economy of time in elementary science classes.

• 한국가정과교육학회지
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• 제3권1호
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• pp.49-59
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• 1991

The purpose of this study is to find out the influence of Home Economics learning on the recognition and attitude of middle school boy’s home life and to suggest the basic materials for the development of the Home Economics education through students’opinion of Home Economics. For this purpose, a survey was conducted in Cheong-ju area using questionaire. The subjects were 487 boys who studied Home Economics (HE group)and 480 boys who studied Technique (T group) in middle school. The statistics used for data analysis were t-test and x$^2$-test. The results of this study were as follows： 1. The recognition and attitude to home life on the general characteristics of home life； In urban area, the interests in bealth and the role of the consumers were higher than those of rural areas-on the bases of the standard of life, the middle class students had a higher interest in nutrition and food habits, the students whose father were engaged in special job had a higher interest in health and nutrition. 2. The difference of the recognition and attitude between HE & groups； In the field of food life, HE’s knowledge about the six nutrients and the basic food groups and attitude toward buying food were higher than T’s. In the field of family life and resources, HE and T accepted the importance of family life and the role of home as important, hoped to get psychological relax from home and to take the right sexual education. In the field of clothes life, HE and T had the general tendency to have their clothes in proper manner and to select their clothes for themselves, but HE took a higher interest in clothes mending and the role of clothes. 3. The opinions on Home Economics； HE answered that Home Economics was useful to them (more than 90% of HE) and that 57.1% of HE were interested in Home Economics. The order of interest among three fields were as follows： food life, clothes life, family life and resources. 71.9% of T hoped to take Home Economics course.

• 대한한의학방제학회지
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• 제10권2호
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• pp.143-158
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• 2002

The purpose of the present study is to determine the effect of Jakyakgamchotang on histamine or acetylcholine induced tracheal smooth muscle contraction in rats and guinea pigs. Guinea pig(500g, male) and Sprague Dawley rats(250g, male) were killed by $CO_2$ exposure and a segment (4-5mm) of the thoracic trachea from each rat and guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine(His) which evoked 50% of maximal response($ED_{50}$) was obtained from cumulative dose response curves for histamine($10^{-7}{\sim}10^{-4}M$). Contractions evoked by His($ED_{50}$) were inhibited significantly by Jakyakgamchotang. In guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 90.8% (p〈0.001) after $100{\mu}l/ml$ Jakyakgamchotang. In rat tracheal smooth muscle, the mean percent inhibition of acetylcholine induced contraction was 22.1% (p〈0.05) after $100{\mu}l/ml$ Jakyakgamchotang. Propranolol indomethacin and methylene blue($10^{-7}M$) slightly but significantly attenuated the inhibitory effects of Jakyakgamchotang. These results indicate that Jakyakgamchotang can relax histamine or acetylcholine induced contraction of guinea pig and rat tracheal smooth muscle.

• 한국통신학회논문지
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• 제33권12A호
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• pp.1191-1199
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• 2008

주파수 재사용도 K = 1을 사용하는 셀룰러 OFDMA 시스템에서 셀 경계 사용자의 동일 채널 간섭에 의한 수율 저하 문제를 완화하기 위한 대역 분산적 자원 할당 알고리즘을 제안하고, 이에 따른 성능 향상 효과를 분석한다. 본 논문에서 고려한 대역 분산적 자원 할당 알고리즘은 셀 내의 사용자를 경로 감쇄 순서로 내림차순으로 정렬한 후에 각 셀마다 다르게 미리 정해져 있는 자원 할당 영역부터 자원을 할당한다. 셀마다 다른 시간과 공간적인 영역에서 자원 할당을 시작하도록 되어 있으므로 셀 경계의 사용자부터 셀 중앙의 사용자들까지 셀 내 특정위치의 사용자를 특정 시간대에 배치하여 셀 경계 사용자들이 동시에 같은 자원을 사용하여 간섭이 매우 커지는 경우를 미리 방지하고 셀 내의 사용자들에게 간섭이 평준화되어 고르게 영향을 받도록 한다. 이러한 대역 분산적 자원 할당 방식을 사용하여 셀 경계 사용자의 전송률과 outage 성능이 향상되었음을 확인하였다.

• 대한한의학방제학회지
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• 제7권1호
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• pp.167-181
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• 1999

Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae, Radixi, Radix Ledeboutriellae, Rhizoma Atractylodis, Herba Ephedrae, Radix Puerariae and Radi Aconitx Bupleuri have been used in Korea for many centuries as a treatment for various disease. The purpose of the present study is to determine the effect of several herbs on norepinephrine(NE) induced blood vessel contraction in rabbits and pigs. Rabbit(2 kg, male) were killed by $CO_2$ exposure and a segment (8-10mm) of each rabbit was cut into equal segments and mounted in a tissue bath. Contractile force was measured with force displacement transducers under 2-3 g loading tension. The dose of norepinephrine(NE) which evoked 50% of maximal response $(ED_{50})$ was obtained from cumulative dose response curves for NE $(10^{-6}{\sim}10^{-3}M)$. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae and Herba Ephedrae in abdominal aorta. Contractions evoked by NE $(ED_{50})$ were inhibited significantly be Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Herba Ephedrae, Radix Puerariae and Radix Bupleuri in femoral artery. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Radix Sophorae Subprostratae, Radix Aconiti and Herba Ephedrae in renal artery. These results indicate that each herb can relax NE induced contraction of rabbit and pig blood vessel selectively, and that this relaxation relates to Gui-Gyung(歸經).