• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2006년도 추계학술발표회
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• pp.253-258
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• 2006

본 연구는 우리나라 RCC/RSC의 효율성을 2개의 입력변수와 5개의 출력변수를 자료를 토대로 퍼지 DEA를 이용하여 측정 평가하였다. 특히, 본 연구에서는 해양사고 발생자료 뿐만 아니라 환경스트레스치에 의한 잠재적 해양사고 발생가능 자료도 고려하여 운영효율성을 분석하였다. 한편, 현실자료에는 수많은 애매성이 존재하기 때문에 본 연구에서는 DEA법에 퍼지이론을 이용한 퍼지 DEA 법을 이용하였다. 이 퍼지 DEA법은 ${\alpha}-cut$ 을 기반으로 한 크리습 선형계획문제로 변환된 것으로 입/출력 변수를 삼각형 퍼지수로 하여 해를 산출하는 방법을 제안하였고, 제안된 퍼지 DEA를 이용하여 퍼지 RCC/RSC의 순위를 결정하였다. ${\alpha}-cut$를 0.5 로 하여 효율성을 산출한 결과 YS, BS, MP, TS, JJ, PH, US, IC, SC, DH, GS, TA, WD RCC/RSC 순으로 효율성 이 높게 나타났다. 따라서 효율성이 비교적 낮게 평가된TA, WD RCC/RSC는 효율성이 높은 준거집단을 참조하여 벤치마킹을 해야할 필요가 있다.

• Molecules and Cells
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• 제38권7호
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• pp.624-629
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• 2015

Since the emergence of proteomics methods, many proteins specific for renal cell carcinoma (RCC) have been identified. Despite their usefulness for the specific diagnosis of RCC, such proteins do not provide spatial information on the diseased tissue. Therefore, the identification of cancer-specific proteins that include information on their specific location is needed. Recently, matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) based imaging mass spectrometry (IMS) has emerged as a new tool for the analysis of spatial distribution as well as identification of either proteins or small molecules in tissues. In this report, surgical tissue sections of papillary RCC were analyzed using MALDI-IMS. Statistical analysis revealed several discriminative cancer-specific m/z-species between normal and diseased tissues. Among these m/z-species, two particular proteins, S100A11 and ferritin light chain, which are specific for papillary RCC cancer regions, were successfully identified using LC-MS/MS following protein extraction from independent RCC samples. The expressions of S100A11 and ferritin light chain were further validated by immunohistochemistry of human tissues and tissue microarrays (TMAs) of RCC. In conclusion, MALDI-IMS followed by LC-MS/MS analysis in human tissue identified that S100A11 and ferritin light chain are differentially expressed proteins in papillary RCC cancer regions.

• 대한기계학회논문집A
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• 제37권5호
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• pp.631-640
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• 2013

본 논문에서는 R6 코드와 RCC-MR A16 코드에서 원주방향 균열 배관에 대해 제시하는 1,2 차 복합 하중하에서 J-적분 계산법에 대한 정량적인 비교를 하였다. 균열의 형상, 균열의 깊이, 2 차 하중의 크기 변수에 대한 유한요소 해석을 수행 하였고 유한요소 해석 결과를 이용해 각 코드의 J-적분 평가법에 대한 정량적인 비교를 하였다. R6 코드는 $L_r=1$ 부근에서 보수적으로 평가 되었으며 RCC-MR A16 코드의 경우 기계하중이 작은 영역에서 보수적으로 평가되었다. 이와 같은 결과를 토대로 본 논문에서는 원주방향 균열이 있는 배관에 대하여 각 코드의 J-적분 계산을 보완할 수 있는 방법을 제시하였다. 그 결과로 보완된 J-적분 계산이 유한요소해석 결과와 잘 일치하는 것을 확인 하였다.

• 제어로봇시스템학회논문지
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• 제13권9호
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• pp.910-914
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• 2007

In this paper, an experimental study is performed to adjust position of compliance center of Elastomer Shear Pad Remote Center Compliance (ESP RCC) device, which is used on precise peg in hole process. In the study, variation of the lateral/axial stiffness of the ESP is proposed as a control parameter to adjust the position of compliance center of the ESP RCC. The variation of the stiffness of the ESP is achieved by controlling the shear stress of the ESP. To control the shear stress of the ESP, position of top side of the ESP is changed while remaining bottom side of the ESP is fixed on the RCC plate. To evaluate effect of the proposed idea, stiffness variations of the ESP on various shear stresses are measured, and variation of the compliance center is measured with the ESP RCC that can control the position of compliance center by using the shear stress. The measured data shows unique characteristics that have not been shown in other types of ESP VRCCs.

• 대한두개안면성형외과학회지
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• 제20권6호
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• pp.392-396
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• 2019

Renal cell carcinoma (RCC) represents 2% to 3% of human cancers and is aggressive, with metastatic capability. The frequent metastatic sites are lung, bone, and liver. Reports of RCC metastatic to skin, and especially scalp are rare. Here we present an 83-year-old woman who was diagnosed with RCC 19 years prior and had a metastatic scalp lesion. An 83-year-old woman presented with a red-to-purple, protruding lesion at the right parietotemporal area. Twenty-three years ago, a right renal mass was incidentally discovered on ultrasound through a routine medical examination. She underwent right nephrectomy for RCC 4 years later. Five months after nephrectomy, new lung nodules were observed. Fifteen years after nephrectomy, metastatic lesions were found in the pelvic bone. She visited dermatology department for evaluation of the new scalp lesion, a year before she first visited our department. Despite chemotherapy, the mass was gradually enlarged. She consulted the plastic surgery department for management of the metastatic RCC was successfully treated with total excision including a 1-cm safety margin, local flap, and STSG coverage. Complete healing was observed, without evidence of recurrence during a 7-month followup. Metastases to the skin are rare, but must be kept in mind because of its high metastatic ability and poor prognosis.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3109-3112
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• 2012

Background: Many studies have focused on possible associations between the glutathione S-transferase M 1 (GSTM1) null genotype and risk of renal cell carcinoma (RCC), but the impact remains unclear owing to obvious inconsistencies among the findings. The present study aimed to quantify the strength of any association in a meta-analysis. Methods: We searched the PubMed, Embase and CBM databases for studies concerning the association between the GSTM1 null genotype and risk of RCC. We estimated the summary odds ratio (OR) with its 95% confidence intervals (95% CI) to assess the association. Results: The meta-analysis showed the GSTM1 null genotype was not associated with risk of RCC overall (OR = 1.04, 95% CI 0.92-1.18, P = 0.501). For Caucasians, the GSTM1 null genotype was also not associated with risk of RCC (OR=1.02, 95% CI 0.90-1.16, P = 0.761). The cumulative meta-analyses showed a trend of no obvious association between GSTM1 null genotype and risk of RCC as information accumulated. Sensitivity analyses by omitting those studies also did not materially alter the overall combined ORs. No evidence of publication bias was observed. Conclusion: Meta-analyses of available data show that the GSTM1 null genotype is not significantly associated with risk of renal cell carcinoma.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1077-1082
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• 2013

Background: Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. We aimed to explore whether the expression of Long Non-Coding RNA (LncRNA) growth arrest-specific transcript 5 (GAS5) is associated with RCC genesis. Methods: We selected twelve clinical samples diagnosed for renal clear cell carcinoma and found that the LncRNA GAS5 transcript levels were significantly reduced relative to those in adjacent unaffected normal renal tissues. Results: In addition, expression of GAS5 was lower in the RCC cell line A498 than that in normal renal cell line HK-2. Furthermore, using functional expression cloning, we found that overexpression of GAS5 in A498 cells inhibited cell proliferation, induced cell apoptosis and arrested cell cycling. At the same time, the migration and invasion potential of A498 cells were inhibited compared to control groups. Conclusion: Our study provided the first evidence that a decrease in GAS5 expression is associated with RCC genesis and progression and overexpression of GAS5 can act as a tumor suppressor for RCC, providing a potential attractive therapeutic approach for this malignancy.

• 한국안전학회지
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• 제27권6호
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• pp.14-19
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• 2012

The Helium cooled ceramic reflector(HCCR) test blanket module(TBM) has been designed and developed to participate the ITER(International Thermonuclear Experimental Reactor) test blanket program in Korea. The TBM was one of the main objectives for developing ITER for proving the tritium self-sufficiency and the heat transfers to produce the electricity with the breeding blanket concept. Among the TBM components, the first wall(FW) was the most important component in safety since it was directly faced a high level of a heat and fast neutrons from the plasma side and could protect the others components inside TBM. In this paper, the FW has been designed through the thermo-mechanical analysis considering ITER operation conditions. With the developed simple models, the stress limit analysis based on RCC-MR code which is the nuclear power plant design codes in France was evaluated for the allowable design criteria. The results showed that the designed FW model satisfied $1.5S_m$ or $3S_m$ of the allowable stress($S_m$) in RCC-MR code at the maximum stress region in the FW.

• Annals of Coloproctology
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• 제34권6호
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• pp.280-285
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• 2018

For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

• Animal Bioscience
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• 제37권6호
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• pp.1121-1129
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• 2024

Objective: Objective of the study was to reduce heat stress in Murrah buffaloes and maintain their milk production and other vital functions during heat stress. Methods: A total of 21 dyads of calf-mother Murrah buffalo were selected for the study and equally divided in 3 treatment groups. First treatment group was restricted calf contact (RCC), second treatment group was fence line calf contact (FCC) and third treatment groups fence line calf contact and heat stress protection (FCC-HSP [time-controlled fan-fogger system] in the shed). Present study was conducted from April to mid-September 2021. Results: Maximum temperature and temperature humidity index in FCC-HSP shed were significantly (p<0.05) lower than that in FCC and RCC shed. Higher (p<0.05) mean daily milk yield in both the treatment groups FCC (10.36±0.30) and FCC-HSP (10.97±0.31) than RCC (8.29±0.41) was recorded. Though no significant difference between FCC and FCC-HSP in daily milk yield but FCC-HSP yielded 600 gm more milk than FCC. Pulse rate (PR) and respiration rate (RR) were lowest in FCC-HSP followed by FCC and RCC, respectively. Cortisol and prolactin levels were lower (p<0.05) in FCC-HSP followed by FCC and RCC, respectively. Conclusion: Hence, FCC along with heat stress ameliorative measures helped the buffaloes to be free of stress and maintain milk yield during heat stress period of the year in tropical conditions.