• Journal of the Korean Society of Radiology
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• v.82 no.1
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• pp.274-277
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• 2021

Perineal involvement by metastatic renal cell carcinoma (RCC) is very rare, and there are only few reports on its radiological findings in the literature. Here, we present a case of a 76-year old female who presented with perineal pain caused by metastatic clear cell RCC. We discuss the radiological changes of the tumor before and after targeted therapy.

• 한국도로학회:학술대회논문집
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• 2009.11a
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• pp.97-100
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• 2009

• Journal of Chest Surgery
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• v.41 no.3
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• pp.386-389
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• 2008

Lung parenchyma is a common organ for metastases of extrathoracic tumors, but endobronchial metastasis is very rare. In this report, we present a case of endobronchial metastases from renal cell carcinoma (RCC), and this was managed by performing operative resection. A 63-year-old man presented with frequent dry cough; he had previously undergone left nephrectomy and postoperative chemotherapy for grade 2 RCC eight years ago. Computed tomography and bronchoscopy showed an endobronchial tumor from the left lower lobe bronchus to the second carina, and this mass was diagnosed as a necrotic tissue with chronic inflammation at biopsy. During the operation, the mass was revealed to be a metastatic renal cell carcinoma on the frozen section diagnosis and there was no mucosal invasion on the resection margin of the left lower lobe bronchus. We performed lobectomy of the left lower lobe with systemic dissection of the mediastinal lymph nodes. The final histopathologic diagnosis of the endobrochial mass was metastatic RCC and any mediastinal lymph node metastasis was not found. The patient was discharged on postoperative day 10 without any postoperative complications.

• Proceedings of KOSOMES biannual meeting
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• 2004.05b
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• pp.1-6
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• 2004

This paper suggests an evaluation of risk level for damage of marine accidents in SRRs. Qualitative analyses in words is sometimes priorior to quantative analyses in numeric symbols. This paper intoduces a concept of fuzzy theory with the plenty of related literature review and AHP in the Korean SRRs of RCC and RSC. The methodology of this paper is max . min composition of fuzzy extensive principle, defuzzifiation is centroid of gravity methods. At the result, the evaluation of risk level is especially over Serious for smarine accident of Taean, Gunsan, Mokpo, Yosu, Tongyoung, Busan SRR. This paper recommends that many Rescue Vessels and Equipments need to the reduction of risk level about those.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.535-538
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• 2016

Background: Cyclooxygenase 2 (COX-2) is important as an enzyme in the pathway leading to the production of prostaglandin E2 (PGE2) and arachidonic acid. This pathway is known to play a role in inflammation, tumor growth, invasiveness and metastasis, inhibition of apoptosis and angiogenesis. Inhibition of COX-2 has been shown to be a promising antitumor and antiangiogenic strategy in several tumor types, including renal cell carcinoma (RCC). Therefore, we decided to evaluate the immunohistochemical expression of this marker and its association with several clinicopathological characteristics in a series of cases. Materials and Methods: COX-2 expression was examined immunohistochemically in tumor tissues obtained from 96 patients who underwent radical (94 cases) or partial (2 cases) nephrectomy. Correlations between COX-2 expression and clinicopathologic findings including pathologic stage, nuclear grade and other indicator of prognosis were examined. Results: Of 96 tumors, 20.9% were positive for COX-2 expression. A correlation was found between COX-2 expression and tumor histological subtype (P=0.03).The papillary subtype showed maximum expression of this marker (43.8%) and the clear subtype minimum (14.7%). There were also possible links between COX-2 expression and pathologic stage, nuclear grade and nodal involvement but the results were not statistically significant (P=0.8, P= 0.14 and P=0.06, respectively). No correlation was found between COX2 expression and patient age, gender, tumor size, metastasis or survival. Conclusions: In our study, COX-2 expression was correlated with the histological subtype of RCC. Additional research is required to determine the link between COX-2 expression and prognosis and also evaluation of probable effectiveness of COX-2 inhibitor drugs in treatment of RCC patients.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7497-7500
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• 2013

Background: This study concerns clinical characteristics and survival of renal cell carcinoma (RCC) patients in University Malaya Medical Centre (UMMC), as well as the prognostic significance of presenting symptoms. Materials and Methods: The clinical characteristics, presenting symptoms and survival of RCC patients (n=151) treated at UMMC from 2003-2012 were analysed. Symptoms evaluated were macrohaematuria, flank pain, palpable abdominal mass, fever, lethargy, loss of weight, anaemia, elevated ALP, hypoalbuminemia and thrombocytosis. Univariate and multivariate Cox regression analyses were performed to determine the prognostic significance of these presenting symptoms. Kaplan Meier and log rank tests were employed for survival analysis. Results: The 2002 TNM staging was a prognostic factor (p<0.001) but Fuhrman grading was not significantly correlated with survival (p=0.088). At presentation, 76.8% of the patients were symptomatic. Generally, symptomatic tumours had a worse survival prognosis compared to asymptomatic cases (p=0.009; HR 4.74). All symptoms significantly affect disease specific survival except frank haematuria and loin pain on univariate Cox regression analysis. On multivariate analysis adjusted for stage, only clinically palpable abdominal mass remained statistically significant (p=0.027). The mean tumour size of palpable abdominal masses, $9.5{\pm}4.3cm$, was larger than non palpable masses, $5.3{\pm}2.7cm$ (p<0.001). Conclusions: This is the first report which includes survival information of RCC patients from Malaysia. Here the TNM stage and a palpable abdominal mass were independent predictors for survival. Further investigations using a multicentre cohort to analyse mortality and survival rates may aid in improving management of these patients.

• Journal of Navigation and Port Research
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• v.28 no.10 s.96
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• pp.909-915
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• 2004

This paper suggests an evaluation of risk level for damage of marine accidents in SRRs. Qualitative analyses in words is sometimes priorior to quantative analyses in numeric symbols. This paper introduces a concept of fuzzy theory with the plenty of related literature riview and AHP in the Korean SRRs of RCC and RSC. The methodology of this paper is $max{\cdot}min$ composition of fuzzy extensive principle, defuzzifiation is centroid of gravity methods. At the result, the evaluation of risk level is especially over Serious for marine accident of Busan SRRs. This paper recommends that many Rescue Vessels and Equipments need to the reduction of risk level about those.

• Nuclear Engineering and Technology
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• v.38 no.3
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• pp.293-300
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• 2006

A liquid metal reactor (LMR) operated at high temperatures is subjected to both cyclic mechanical loading and thermal loading; thus, creep-fatigue is a major concern to be addressed with regard to maintaining structural integrity. The Korea Advanced Liquid Metal Reactor (KALIMER), which has a normal operating temperature of $545^{\circ}C$ and a total service life time of 60 years, is composed of various cylindrical structures, such as the reactor vessel and the reactor baffle. This study focuses on the creepfatigue crack initiation for a cylindrical Y-junction structure made of 316 stainless steel (SS), which is subjected to cyclic axial tensile loading and thermal loading at a high-temperature hold time of $545^{\circ}C$. The evaluation of the considered creep-fatigue crack initiation was carried out utilizing the ${\sigma}_d$ approach of the RCC-MR A16 guide, which is the high-temperature defect assessment procedure. This procedure is based on the total accumulated strain during the service time. To confirm the evaluated result, a high-temperature creep-fatigue structural test was performed. The test model had a circumferential through wall defect at the center of the model. The defect front of the test model was investigated after the $100^{th}$ cycle of the testing by utilizing a metallurgical inspection technique with an optical microscope, after which the test result was compared with the evaluation result. This study shows how creep-fatigue crack initiation for a high-temperature structure can be predicted with conservatism per the RCC-MR A16 guide.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3703-3708
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• 2015

Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with colorectal, lung, gastric cancer, pancreatic and metastatic renal cell carcinoma. We here evaluated whether preoperative NLR is an independent prognostic factor for non-metastatic renal cell carcinoma (RCC). Materials and Methods: Data from 327 patients who underwent curative or palliative nephrectomy were evaluated retrospectively. In preoperative blood routine examination, neutrophils and lymphocytes were obtained. The predictive value of NLR for non-metastatic RCC was analyzed. Results: The NLR of 327 patients was $2.72{\pm}2.25$. NLR <1.7 and NLR ${\geq}1.7$ were classified as low and high NLR groups, respectively. Chi-square test showed that the preoperative NLR was significantly correlated with the tumor size (P=0.025), but not with the histological subtype (P=0.095)and the pT stage (P=0.283). Overall survival (OS) and disease-free survival (DFS) were assessed using the Kaplan-Meier method. Effects of NLR on OS (P=0.007) and DFS (P=0.011) were significant. To evaluate the independent prognostic significance of NLR, multivariate COX regression models were applied and identified increased NLR as an independent prognostic factor for OS (P=0.015), and DFS (P=0.019). Conclusions: Regarding patient survival, an increased NLR represented an independent risk factor, which might reflect a higher risk for severe cardiovascular and other comorbidities. An elevated blood NLR may be a biomarker of poor OS and DFS in patients with non-metastatic RCC.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6197-6201
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• 2012

Although enhancer of zeste homolog 2 (EZH2) has been reported as an independent prognostic factor in renal cell carcinoma (RCC), little is known about the exact mechanism of EZH2 in promoting the genesis of RCC. However, several studies have shown that dysregulation of the Wnt/${\beta}$-catenin signaling pathway plays a crucial role. Therefore, we determined whether EZH2 could affect ACHN human RCC cell proliferation and invasion via the Wnt/${\beta}$-catenin pathway. In the present study, we investigated the effects of short interfering RNA (siRNA)-mediated EZH2 gene silencing on Wnt/${\beta}$-catenin signaling in ACHN cells. EZH2-siRNA markedly inhibited the proliferation and invasion capabilities of ACHN, while also reducing the expression of EZH2, Wnt3a and ${\beta}$-catenin. In contrast, cellular expression of GSK-$3{\beta}$ (glycogen synthase kinase-$3{\beta}$), an inhibitor of the Wnt/${\beta}$-catenin pathway, was conspicuously higher after transfection of EZH2 siRNA. These preliminary findings suggest EZH2 may promote proliferation and invasion of ACHN cells via action on the Wnt/${\beta}$-catenin signaling pathway.