• Journal of Korean society of Dental Hygiene
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• v.21 no.4
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• pp.337-348
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• 2021

Objectives: To determine the usefulness of MiriChek^TM Oral Bacter as compared to traditional clinical methods in the periodontal assessment of dogs with and without periodontitis. Methods: In this study, 61 dogs were clinically examined using the MiriChek^TM Oral Bacter test kit, and information regarding breed, age (months), sex, weight, presence of disease, and periodontitis stage was recorded. The test used a sample of supragingival plaque from the upper left premolar of the dogs. Results: This study included 30 and 31 dogs with and without periodontitis, respectively. Periodontitis was more common in older dogs than in younger dogs. The average positive and negative sensitivity rates of the MiriChek^TM Oral Bacter test kit were 73.3% and 80.7%, respectively, and were both strongly correlated with the severity of periodontitis. Conclusions: The findings of this study encourage the use of new diagnostic assist test kits, such as MiriChek^TM Oral Bacter, for appropriately detecting and diagnosing periodontal disease in dogs.

• Journal of the Korean Society for information Management
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• v.39 no.1
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• pp.91-117
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• 2022

The number of depressed patients in Korea and around the world is rapidly increasing every year. However, most of the mentally ill patients are not aware that they are suffering from the disease, so adequate treatment is not being performed. If depressive symptoms are neglected, it can lead to suicide, anxiety, and other psychological problems. Therefore, early detection and treatment of depression are very important in improving mental health. To improve this problem, this study presented a deep learning-based depression tendency model using Korean social media text. After collecting data from Naver KonwledgeiN, Naver Blog, Hidoc, and Twitter, DSM-5 major depressive disorder diagnosis criteria were used to classify and annotate classes according to the number of depressive symptoms. Afterwards, TF-IDF analysis and simultaneous word analysis were performed to examine the characteristics of each class of the corpus constructed. In addition, word embedding, dictionary-based sentiment analysis, and LDA topic modeling were performed to generate a depression tendency classification model using various text features. Through this, the embedded text, sentiment score, and topic number for each document were calculated and used as text features. As a result, it was confirmed that the highest accuracy rate of 83.28% was achieved when the depression tendency was classified based on the KorBERT algorithm by combining both the emotional score and the topic of the document with the embedded text. This study establishes a classification model for Korean depression trends with improved performance using various text features, and detects potential depressive patients early among Korean online community users, enabling rapid treatment and prevention, thereby enabling the mental health of Korean society. It is significant in that it can help in promotion.

• Analytical Science and Technology
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• v.20 no.4
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• pp.347-354
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• 2007

A simple and rapid high-performance liquid chromatography assay for the determination of residual novobiocin levels in bovine, porcine, chicken, flatfish and japanese eel muscle has been developed and validated. The separation condition for HPLC/UV was optimized with phenyl hexyl ($4.6{\times}150mm$, $5{\mu}m$) column with 10 mM monobasic sodium phosphate buffer (pH 2.5)/acetonitrile (50/50, v/v) as the mobile phase at a flow rate of 1.0 mL/min and detection wavelength was set at 254 nm. Residues were extracted from tissue by blending with methanol and lipid materials were removed with n-hexane. Then, the methanol extract was evaporated to dryness under a nitrogen stream, reconstituted in the mobile phase. Aliquot of the organic extract was decanted and filtered through $0.45{\mu}m$ syringe filter. The $20{\mu}L$ of the resulting solution was injected into the HPLC system. The calibration ranges were $0.5{\sim}5{\mu}g/g$ and calibration curves were linear with coefficients of correlation better than 0.95. The limits of quantification were $0.5{\mu}g/g$ for all muscles. The recoveries of bovine, porcine, chicken, flatfish and japaneseel muscles were 99.8%, 102.4%, 91.0%, 104.0% and 93.0%, respectively. The procedures were validated according to the CODEX guideline, determining specificity, linearity, accuracy, precision, quantitation limit and recovery.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.417-426
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• 2023

The TRPM4 gene encodes a Ca²⁺-activated monovalent cation channel called transient receptor potential melastatin 4 (TRPM4) that is expressed in various tissues. Dysregulation or abnormal expression of TRPM4 has been linked to a range of diseases. We introduced the hemagglutinin (HA) tag into the extracellular S6 loop of TRPM4, resulting in an HA-tagged version called TRPM4-HA. This TRPM4-HA was developed to investigate the purification, localization, and function of TRPM4 in different physiological and pathological conditions. TRPM4-HA was successfully expressed in the intact cell membrane and exhibited similar electrophysiological properties, such as the current-voltage relationship, rapid desensitization, and current size, compared to the wild-type TRPM4. The presence of the TRPM4 inhibitor 9-phenanthrol did not affect these properties. Furthermore, a wound-healing assay showed that TRPM4-HA induced cell proliferation and migration, similar to the native TRPM4. Co-expression of protein tyrosine phosphatase, non-receptor type 6 (PTPN6 or SHP1) with TRPM4-HA led to the translocation of TRPM4-HA to the cytosol. To investigate the interaction between PTPN6 and tyrosine residues of TRPM4 in enhancing channel activity, we generated four mutants in which tyrosine (Y) residues were substituted with phenylalanine (F) at the N-terminus of TRPM4. The YF mutants displayed properties and functions similar to TRPM4-HA, except for the Y256F mutant, which showed resistance to 9-phenanthrol, suggesting that Y256 may be involved in the binding site for 9-phenanthrol. Overall, the creation of HA-tagged TRPM4 provides researchers with a valuable tool to study the role of TRPM4 in different conditions and its potential interactions with other proteins, such as PTPN6.

• Journal of the Korean Institute of Gas
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• v.27 no.3
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• pp.77-83
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• 2023

Energy consumption is increased by rapid industrialization. As a result, climate change is accelerating due to the increase in CO₂ concentration in the atmosphere. Therefore, a shift in the energy paradigm is required. Hydrogen is in the spotlight as a part of that. Currently 95% of hydrogen is fossil fuel-based reforming hydrogen which is accompanied by CO₂ emissions. This is called gray hydrogen, if the CO₂ is captured and emission of CO₂ is reduced, it can be converted into blue hydrogen. There are 3 technologies to capture CO₂: absorption, adsorption and membrane technology. In order to select CO₂ capture technology, the analysis of the exhaust gas should be carried out. The concentration of CO₂ in the flue gas from the hydrogen production process is higher than 20%if water is removed as well as the emission scale is classified as small and medium. So, the application of the membrane technology is more advantageous than the absorption. In addition, if LNG cold energy can be used for low temperature CO₂ capture system, the CO₂/N₂ selectivity of the membrane is higher than room temperature CO₂ capture and enabling an efficient CO₂ capture process. In this study, we will analyze the flue gas from hydrogen production process and discuss suitable CO₂ capture technology for it.

• Korean Journal of Agricultural and Forest Meteorology
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• v.25 no.3
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• pp.182-196
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• 2023

Accurate and timely estimation of crop yields is crucial for various purposes, including global food security planning and agricultural policy development. Remote sensing techniques, particularly using vegetation indices (VIs), have show n promise in monitoring and predicting crop conditions. However, traditional VIs such as the normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) have limitations in capturing rapid changes in vegetation photosynthesis and may not accurately represent crop productivity. An alternative vegetation index, the near-infrared reflectance of vegetation (NIRv), has been proposed as a better predictor of crop yield due to its strong correlation with gross primary productivity (GPP) and its ability to untangle confounding effects in canopies. In this study, we investigated the potential of NIRv in estimating crop yield, specifically for corn and soybean crops in major crop-producing regions in 14 states of the United States. Our results demonstrated a significant correlation between the peak value of NIRv and crop yield/area for both corn and soybean. The correlation w as slightly stronger for soybean than for corn. Moreover, most of the target states exhibited a notable relationship between NIRv peak and yield, with consistent slopes across different states. Furthermore, we observed a distinct pattern in the yearly data, where most values were closely clustered together. However, the year 2012 stood out as an outlier in several states, suggesting unique crop conditions during that period. Based on the established relationships between NIRv peak and yield, we predicted crop yield data for 2022 and evaluated the accuracy of the predictions using the Root Mean Square Percentage Error (RMSPE). Our findings indicate the potential of NIRv peak in estimating crop yield at the county level, with varying accuracy across different counties.

• Computers and Concrete
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• v.33 no.5
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• pp.497-507
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• 2024

In squat reinforced concrete walls, the displacement capacity for lateral deformation is low and the ability to resist the axial load can quickly be lost, generating collapse. This work consists of testing two squat reinforced concrete walls. One of the specimens is built with conventional detailing of reinforced concrete walls, while the second specimen is built applying an alternative design, including stirrups along the diagonal of the wall to improve its ductility. This solution differs from the detailing of beams or coupling elements that suggest building elements equivalent to columns located diagonally in the element. The dimensions of both specimens correspond to a wall with a low aspect ratio (1:1), where the height and length of the specimen are 1.4 m, with a thickness of 120 mm. The alternative wall included stirrups placed diagonally covering approximately 25% of the diagonal strut of the wall with alternative detailing. The walls were tested under a constant axial load of 0.1f'cAg and a cyclic lateral displacement was applied in the upper part of the wall. The results indicate that the lateral strength is almost identical between both specimens. On the other hand, the lateral displacement capacity increased by 25% with the alternative detailing, but it was also able to maintain the 3 complete hysteretic cycles up to a drift of 2.5%, reaching longitudinal reinforcement fracture, while the base specimen only reached the first cycle of 2% with rapid degradation due to failure of the diagonal compression strut. The alternative design also allows 46% more energy dissipation than the conventional design. A model was used to capture the global response, correctly representing the observed behavior. A parametric study with the model, varying the reinforcement amount and aspect ratio, was performed, indicating that the effectiveness of the alternative detailing can double de drift capacity for the case with a low aspect ratio (1.1) and a large longitudinal steel amount (1% in the web, 5% in the boundary), which decreases with lower amounts of longitudinal reinforcement and with the increment of aspect ratio, indicating that the alternative detailing approach is reasonable for walls with an aspect ratio up to 2, especially if the amount of longitudinal reinforcement is high.

• Journal of Dental Anesthesia and Pain Medicine
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• v.24 no.1
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• pp.19-35
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• 2024

Background: This study investigated a safe and effective bolus dose and lockout time for patient-controlled sedation (PCS) with dexmedetomidine for dental treatments. The depth of sedation, vital signs, and patient satisfaction were investigated to demonstrate safety. Methods: Thirty patients requiring dental scaling were enrolled and randomly divided into three groups based on bolus doses and lockout times: group 1 (low dose group, bolus dose 0.05 ㎍/kg, 1-minute lockout time), group 2 (middle dose group, 0.1 ㎍/kg, 1-minute), and group 3 (high dose group, 0.2 ㎍/kg, 3-minute) (n = 10 each). ECG, pulse, oxygen saturation, blood pressure, end-tidal CO₂, respiratory rate, and bispectral index scores (BIS) were measured and recorded. The study was conducted in two stages: the first involved sedation without dental treatment and the second included sedation with dental scaling. Patients were instructed to press the drug demand button every 10 s, and the process of falling asleep and waking up was repeated 1-5 times. In the second stage, during dental scaling, patients were instructed to press the drug demand button. Loss of responsiveness (LOR) was defined as failure to respond to auditory stimuli six times, determining sleep onset. Patient and dentist satisfaction were assessed before and after experimentation. Results: Thirty patients (22 males) participated in the study. Scaling was performed in 29 patients after excluding one who experienced dizziness during the first stage. The average number of drug administrations until first LOR was significantly lower in group 3 (2.8 times) than groups 1 and 2 (8.0 and 6.5 times, respectively). The time taken to reach the LOR showed no difference between groups. During the second stage, the average time required to reach the LOR during scaling was 583.4 seconds. The effect site concentrations (Ce) was significantly lower in group 1 than groups 2 and 3. In the participant survey on PCS, 8/10 in group 3 reported partial memory loss, whereas 17/20 in groups 1 and 2 recalled the procedure fully or partially. Conclusion: PCS with dexmedetomidine can provide a rapid onset of sedation, safe vital sign management, and minimal side effects, thus facilitating smooth dental sedation.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.2
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• pp.272-279
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• 2012

In order to effectively treat livestock wastewater in constructed wetlands by natural purification method, removal velocities of pollutants under different injection methods in constructed wetlands were investigated. The removal velocities of chemical oxygen demand (COD), suspended solid (SS), T-N and T-P by continuous injection method were slightly rapid than those by intermittent injection method in full-scale livestock wastewater treatment plant. The removal velocity (K; $day^{-1}$) of COD by continuous injection method was $0.38\;d^{-1}$ for $1^{st}$ bed, $0.13\;d^{-1}$ for $2^{nd}$ bed, $0.17\;d^{-1}$ for $3^{rd}$ bed, $0.05\;d^{-1}$ for $4^{th}$ bed and $0.17\;d^{-1}$ for $5^{th}$ bed. The removal velocities (K; $day^{-1}$) of COD in $1^{st}$, $2^{nd}$, $3^{rd}$, $4^{th}$ and $5^{th}$ beds by intermittent injection method were $0.210\;d^{-1}$, $0.086\;d^{-1}$, $0.222\;d^{-1}$, $0.053\;d^{-1}$ and $0.137\;d^{-1}$, respectively. The removal velocity (K; $day^{-1}$) of SS by continuous injection method was $0.750\;d^{-1}$ for $1^{st}$ bed, $0.108\;d^{-1}$ for $2^{nd}$ bed, $0.120\;d^{-1}$ for $3^{rd}$ bed, $0.086\;d^{-1}$ for $4^{th}$ bed and $0.292\;d^{-1}$ for $5^{th}$ bed. The removal velocities (K; $day^{-1}$) of SS in $1^{st}$, $2^{nd}$, $3^{rd}$, $4^{th}$ and $5^{th}$ beds by intermittent injection method were $0.485\;d^{-1}$, $0.056\;d^{-1}$, $0.174\;d^{-1}$, $0.081\;d^{-1}$ and $0.227\;d^{-1}$, respectively. The removal velocity (K; $day^{-1}$) of T-N by continuous injection method was $0.361\;d^{-1}$ for $1^{st}$ bed, $0.121\;d^{-1}$ for $2^{nd}$ bed, $109\;d^{-1}$ for $3^{rd}$ bed, $0.047\;d^{-1}$ for $4^{th}$ bed and $0.155\;d^{-1}$ for $5^{th}$ bed. The removal velocities (K; $day^{-1}$) of T-N in $1^{st}$, $2^{nd}$, $3^{rd}$, $4^{th}$ and $5^{th}$ beds by intermittent injection method were $0.235\;d^{-1}$, $0.071\;d^{-1}$, $0.171\;d^{-1}$, $0.058\;d^{-1}$ and $0.126\;d^{-1}$, respectively. The removal velocity (K; $day^{-1}$) of T-P by continuous injection method was $0.803\;d^{-1}$ for $1^{st}$ bed, $0.084\;d^{-1}$ for $2^{nd}$ bed, $0.076\;d^{-1}$ for $3^{rd}$ bed, $0.118\;d^{-1}$ for $4^{th}$ bed and $0.301\;d^{-1}$ for $5^{th}$ bed. The removal velocities (K; $day^{-1}$) of T-P in $1^{st}$, $2^{nd}$, $3^{rd}$, $4^{th}$ and $5^{th}$ beds by intermittent injection method were $0.572\;d^{-1}$, $0.049\;d^{-1}$, $0.090\;d^{-1}$, $0.112\;d^{-1}$ and $0.222\;d^{-1}$, respectively.

• Journal of Intelligence and Information Systems
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• v.23 no.1
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• pp.143-159
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• 2017

Due to the rapid development of IT in recent years, not only personal information but also the key technologies and information leakage that companies have are becoming important issues. For the enterprise, the core technology that the company possesses is a very important part for the survival of the enterprise and for the continuous competitive advantage. Recently, there have been many cases of technical infringement. Technology leaks not only cause tremendous financial losses such as falling stock prices for companies, but they also have a negative impact on corporate reputation and delays in corporate development. In the case of SMEs, where core technology is an important part of the enterprise, compared to large corporations, the preparation for technological leakage can be seen as an indispensable factor in the existence of the enterprise. As the necessity and importance of Information Security Management (ISM) is emerging, it is necessary to check and prepare for the threat of technology infringement early in the enterprise. Nevertheless, previous studies have shown that the majority of policy alternatives are represented by about 90%. As a research method, literature analysis accounted for 76% and empirical and statistical analysis accounted for a relatively low rate of 16%. For this reason, it is necessary to study the management model and prediction model to prevent leakage of technology to meet the characteristics of SMEs. In this study, before analyzing the empirical analysis, we divided the technical characteristics from the technology value perspective and the organizational factor from the technology control point based on many previous researches related to the factors affecting the technology leakage. A total of 12 related variables were selected for the two factors, and the analysis was performed with these variables. In this study, we use three - year data of "Small and Medium Enterprise Technical Statistics Survey" conducted by the Small and Medium Business Administration. Analysis data includes 30 industries based on KSIC-based 2-digit classification, and the number of companies affected by technology leakage is 415 over 3 years. Through this data, we conducted a randomized sampling in the same industry based on the KSIC in the same year, and compared with the companies (n = 415) and the unaffected firms (n = 415) 1:1 Corresponding samples were prepared and analyzed. In this research, we will conduct an empirical analysis to search for factors influencing technology leakage, and propose an early warning system through data mining. Specifically, in this study, based on the questionnaire survey of SMEs conducted by the Small and Medium Business Administration (SME), we classified the factors that affect the technology leakage of SMEs into two factors(Technology Characteristics, Organization Characteristics). And we propose a model that informs the possibility of technical infringement by using Support Vector Machine(SVM) which is one of the various techniques of data mining based on the proven factors through statistical analysis. Unlike previous studies, this study focused on the cases of various industries in many years, and it can be pointed out that the artificial intelligence model was developed through this study. In addition, since the factors are derived empirically according to the actual leakage of SME technology leakage, it will be possible to suggest to policy makers which companies should be managed from the viewpoint of technology protection. Finally, it is expected that the early warning model on the possibility of technology leakage proposed in this study will provide an opportunity to prevent technology Leakage from the viewpoint of enterprise and government in advance.