• Korean Journal of Clinical Pharmacy
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• v.33 no.1
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• pp.43-50
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• 2023

Background and Objective: With the advancement of cancer treatments and increased life expectancy, managing breakthrough cancer pain (BTcP) is essential to improve the quality of life for cancer patients. This study aimed to compare the major rapid onset opioids in Korea based on their characteristics and costs to determine the best option for each patient. Methods: Based on sales information from IQVIA-MIDAS, sublingual fentanyl tablet (SLF), fentanyl buccal tablet (FBT), and oral transmucosal fentanyl citrate (OTFC) were selected as the top three drugs for the treatment of BTcP in Korea, considering them the most comparable drugs. The cost and cost-pain relief ratio of the drugs for short-term (1 month) and long-term (1 year) treatment were compared and the ease of administration based on various factors, including pharmacokinetics, onset of action, and administration procedures were evaluated. Results: SLF was evaluated as the best overall in terms of rapid onset of action, ease of administration, and drug cost and also had the highest market share. SLF had the lowest cost pain relief ratio for both the initial and supplemental treatment for the 1-month pain intensity difference 15 (PID15) ratio. However, for the 1-month PID30 ratio, SLF was not superior to OTFC or FBT. The longer the breakthrough cancer pain duration, the more cost-effective the other rapid onset opioids. Conclusion: The rapid onset opioids that fit the patient's breakthrough cancer pain pattern have the best cost-effectiveness.

• Journal of the Korean GEO-environmental Society
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• v.24 no.5
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• pp.21-28
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• 2023

In this paper, an experimental study was conducted to present the properties of rapid hardening composite mat, and a numerical analysis was carried out to analyze the slope protection effect of the mats based on ground conditions, rainfall, slope gradient and soil height. As a result, the application of rapid hardening composite mat increased the slope safety factor in all conditions, and the increase rate of safety factor showed an average of 40% increase both in dry and rainy seasons. Through these research findings, the protective effect of the rapid hardening composite mat on sloping surfaces has been proven, and it is suggested that the rapid hardening composite mat is suitable for application in areas where slope failure or collapse is expected.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.6
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• pp.1194-1202
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• 2012

Remotely sensed satellite images can be applied to monitor and obtain land surface information on inaccessible areas. We classified paddy field area in North Korea based on on-screen digitization with visual interpretation using 291 RapidEye satellite images covering the whole country. Criteria for paddy field classification based on RapidEye imagery acquired at different time of rice growth period was defined. Darker colored fields with regular shape in the images with false color composite from early May to late June were detected as rice fields. From early July to late September, it was hard to discriminate rice canopy from other type of vegetation including upland crops, grass, and forest in the image. Regular form of readjusted rice field in the plains and uniform texture when compared with surrounding vegetation. Paddy fields classified from RapidEye imagery were mapped and the areas were calculated by administrative district, province or city. Sixty six percent of paddy fields ($3,521km^2$) were distributed in the west coastal regions including Pyeongannam-do, Pyeonganbuk-do, and Hwanghaenam-do. The paddy field areas classified from RapidEye images showed less than 1% of difference from the paddy field areas of North Korea reported by FAO/WFP (Food and Agriculture Organization/World Food Programme).

• Journal of Korean Society of Environmental Engineers
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• v.28 no.12
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• pp.1274-1279
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• 2006

The formation characteristics of $BDOC_{rapid}$ and $BDOC_{slow}$ with different ozone dosages for 3 different kinds of waters from Maeri raw water in the down stream of Nakdong river, Hoidong reservoir water in Busan City and treated Maeri raw water(sand filtered) has been investigated in this study. The ozone dosages for producing maximum $BDOC_{total}$ in the Maeri raw water, Hoidong reservoir water and sand filtered water of Maeri were 0.9, 1.1 and 1.4 $mgO_3$/mgDOC respectively. It could be concluded that the ozone dosages for formations of maximum $BDOC_{total}$ were determined by characteristics of water. The ozone dosages for producing maximum $BDOC_{rapid}$ in the Maeri raw water, Hoidong reservoir water and sand filtered water of Maeri were 0.9, 0.9 and 1.0 $mgO_3$/mgDOC respectively that were same or lower than the used ozone dosages for producing maximum $BDOC_{total}$. $BDOC_{slow}$ was being formated and increased continuously with the higher ozone dosages which were the used ozone dosages for maximum formation of $BDOC_{total}$ and $BDOC_{rapid}$. For the best results of a pre-treatment of biofiltration, the optimum ozone dosage ranges in formation of $BDOC_{rapid}/BDOC_{total}$ were $0.6{\sim}1.0\;mgO_3$/mgDOC that were lower than the ozone dosage ranges of $0.9{\sim}1.4\;mgO_3$/mgDOC for the maximum formation $BDOC_{total}$. The reported results indicated that the best and effective ways from economic and technical points of view to determine the optimum ozone dosages of the pretreatment of biofilteration process were investigating and classifying BDOC.

• The Korean Journal of Archival Studies
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• no.11
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• pp.181-214
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• 2005

Metropolitan rapid transit system plays an essential role in the public transportation system of any large city, and its managing agency is usually charged with the responsibility of storing and managing the design drawings of the system. The drawings are important and historically valuable documents that must be kept permanently because they contain comprehensive data that is used to manage and maintain the system. However, no study has been performed in Korea on how well agencies are preserving and managing these records. Seoul Metropolitan Rapid Transit Corporation(SMRT) is the managing agency established by the city of Seoul to operate subway lines 5, 6, 7, and 8 more efficiently to serve its citizens. By the Act on Records Management in Public Institutions(ARMPI), SMRT should establish a records center to manage its records. Furthermore, all drawings produced by SMRT and other third party entities should be in compliance with the Act. However, SMRT, as a form of local public corporation, can establish a records center by its own way. Accordingly, the National Archives & Records Service(NARS) has very little control over SMRT. Therefore, the purpose of this study is to research and analyze the present state of storage and management of the drawings of metropolitan rapid transit in SMRT and is to find a desirable method of preservation and management for drawings of metropolitan rapid transit. In the process of the study, it was found that a records center is being considered to manage only general official documents and not to manage the drawings as required by ARMPI. SMRT does not have a records center, and the environment of management on the drawings is very poor. Although there is a plan to develop a new management system for the drawings, it will be non-compliant of ARMPI. What's happening at SMRT does not reflect the state of all other cities' metropolitan rapid transit records management systems, but the state of creation of records center of local public corporation is the almost same state as SMRT. There should be continuous education and many studies conducted in order to manage the drawings of metropolitan rapid transit efficiently by records management system. This study proposes a records center based on both professional records centers and union records centers. Although metropolitan rapid transit is constructed and managed by each local public corporation, the overall characteristics and processes of metropolitan rapid transit projects are similar in nature. In consideration of huge quantity, complexity and specialty of drawings produced and used during construction and operation of metropolitan rapid transit, and overlap of each local public corporation's effort and cost of the storage and management of the drawings, they need to be managed in a professional and united way. As an example of professional records center, there is the National Personnel Records Center(NPRC) in St. Louis, Missouri. NPRC is one of the National Archives and Records Administration's largest operations and a central repository of personnel-related records on former and present federal employees and the military. It provides extensive information to government agencies, military veterans, former federal employees, family members, as well as researchers and historians. As an example of union records center, there is the Chinese Union Dangansil. It was established by several institutions and organizations, so united management of records can be performed and human efforts and facilities can be saved. We should establish a professional and united records center which manages drawings of metropolitan rapid transit and provides service to researchers and the public as well as members of the related institutions. This study can be an impetus to improve interest on management of not only drawings of metropolitan rapid transit but also drawings of various public facilities.

• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.4
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• pp.1-14
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• 2012

A river is defined as the watercourse flowing through its channel, and the mapping tasks of a river plays an important role for the research on the topographic changes in the riparian zones and the research on the monitoring of flooding in its floodplain. However, the utilization of the ground surveying technologies is not efficient for the mapping tasks of a river due to the irregular surfaces of the riparian zones and the dynamic changes of water level of a river. Recently, the spatial information data sets are widely used for the coastal mapping tasks due to the acquisition of the topographic information without human accessibility. In this research, we tried to extract a river from the RapidEye imagery by using the ISODATA(Iterative Self_Organizing Data Analysis) classification algorithm with the two different parameters(NIR (Near Infra-Red) band and NDVI(Normalized Difference Vegetation Index)). First, the two different images(the NIR band image and the NDVI image) were generated from the RapidEye imagery. Second, the ISODATA algorithm were applied to each image and each river was generated in each image through the post-processing steps. River boundaries were also extracted from each classified image using the Sobel edge detection algorithm. Ground truths determined by the experienced expert are used for the assessment of the accuracy of an each generated river. Statistical results show that the extracted river using the NIR band has higher accuracies than the extracted river using the NDVI.

• Clinical and Experimental Pediatrics
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• v.51 no.10
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• pp.1071-1076
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• 2008

Purpose : Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory infections in infants and young children. Early detection allows quarantining of infected inpatients to prevent nosocomial transmission and to choose a treatment. To achieve rapid reporting, to facilitate prompt antiviral therapy, and to avoid unnecessary use of antibiotics, an easy, rapid diagnostic method for RSV is needed. We evaluated a lateral flow immunochromatography (RSV Respi-Strip test) and EIA (Enzyme immuno assay) compared to RT-PCR. Methods : From April 2007 to March 2008, 112 consecutive respiratory specimens (nasopharyngeal aspirates, throat swabs, tracheal aspirates, sputum) from patients who were suffering from the clinical signs and symptoms of respiratory tract infection were enrolled in Busan. A total of 112 patients were tested with RSV Respi-Strip (Corio-BioConcept, Belgium), EIA, and RT-PCR at the same time. Results : Of the 112 specimens tested, the number of children who showed positive results at RT-PCR and Respi-Strip were 45 and 42, respectively. The Respi-Strip rapid antigen test had a sensitivity of 88% and a specificity of 94%. The positive and negative predictive values were 90% and 92%, respectively. The agreement was 83%. Conclusion : In our study, the rapid antigen test had as much sensitivity as any method for detection of RSV. The test has many advantages such as easy performance, simple interpretation, and rapid results. If the rapid antigen test is widely applied in the clinical setting, the may be useful for diagnostic and epidemiological studies of RSV infection.

• International Commerce and Information Review
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• v.16 no.5
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• pp.319-342
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• 2014

In this paper, we aim to advance our knowledge about factors influencing rapid globalization of firms in Korea. Through analysing empirically, this study focuses on the effect of technology competencies and marketing competencies and network in Korea rapid globalization. The subject of this study was foreign subsidiaries that entered in korea to expand their business overseas. This study are examined by the sample of 186 foreign subsidiaries operating in Korea. The empirical results from structural equation modeling and regression analysis. Our findings show that marketing competencies, technological competencies and network are key drivers of rapid globalization in Korea market. Meanwhile, we also find that marketing competencies related to overseas market development in B2C foreign subsidiaries and technology competencies related to overseas market development in B2B foreign subsidiaries. And it was revealed in the path analysis using AMOS model that the relevancy of the study model was higher for B2C foreign subsidiaries than B2B foreign subsidiaries and the explanatory power(statistic index) revealed to be 31.9% higher for B2C foreign subsidiaries than B2B foreign subsidiaries in the effect relation on the rapid globalization in Korea market. Company type (B2C/B2B) was revealed moderating factor on the rapid globalization. Our study confirmed that marketing, technological competencies and network of firms effects on the rapid globalization in Korea.

• Korean Journal of Microbiology
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• v.43 no.2
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• pp.91-99
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• 2007

For the detection of Human Immunodeficiency Virus (HIV), multiple and ultra-rapid real-time PCR methods were developed. The target DNA sequences were deduced from HIV-1 specific 495bp partial env gene (gi_1184090) and from HIV-2 specific 294 bp partial env gene (gi_1332355), and were synthesized by using PCR-based gene synthesis on the reason of safety. Ultra-rapid real-time PCR was performed by $Genspector^{TM}$ using microchip-based, $1\;{\mu}l$ of reaction volume with extremely short time in each 3 step in PCR. The detection including DNA-amplification and melting temperature analysis was completed inner 15 minutes. The HIV-1 specific 117 bp-long and HIV-2 specific 119 bp-long PCR products were successfully amplified from minimum of template,2.3 molecules of each env gene. This kind of real-time PCR was designated as ultra-rapid real-time PCR in this study and it could be applied not only an alternative detection method against HIV, but also other pathogens using PCR-based detection.

• Korean Journal of Microbiology
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• v.44 no.3
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• pp.203-211
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• 2008

Rapid detection-method for Shiga toxin type 1 that was produced from Shiga toxin-producing Escherichia coli (STEC) was developed by two-step ultra-rapid real-time (URRT) PCR. The specific primers were deduced from 80 bp stable region of stx type 1 (stxl) gene among various informations of STEC strains. URRT PCR is a microchip-based real-time PCR using 6 ${\mu}l$ of reaction volume with extremely short denaturation step and annealing/extension step (1 sec, 3 sec, respectively) in each cycle of PCR. Using the stx1-specific URRT PCR, 35 cycled PCR were finished in time of 6 min and 38 see, also measured 7 min and 28 see including melting temperature (Tm) analysis. The detection-limit of stxl-specific URRT-PCR was estimated until 3 colony forming units / PCR with products with stable Tm at $81.42{\pm}0.34^{\circ}C$. In the applications to various STEC strains and contaminated genomic DNAs, stx1-specific URRT-PCR were tested and shown that it would be expected an useful method for the rapid detection of stx1-coded STEC strains.