• Korean Chemical Engineering Research
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• 제58권2호
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• pp.257-265
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• 2020

Densities (ρ) for binary mixtures of ethanol (1) + diisopropyl ether (DIPE) or cyclohexane or alkane (C₆-C₉) (2) were measured at 298.15 K, 308.15 K and 318.15 K. The excess molar volume (V^E_m) of binary mixtures was calculated using ρ data and correlated with Redlich-Kister polynomial equation. The V^E_m values for binary mixtures of ethanol (1) + cyclohexane or n-alkane (C₆-C₉) (2) were positive, whereas for ethanol (1) + DIPE (2) these were negative. The magnitude of V^E_m values follows the order: cyclohexane > n-nonane > n-octane > n-heptane > n-hexane > DIPE. The V^E_m values have been interpreted qualitatively and also quantitatively in terms of Flory-Treszczanowicz-Benson (FTB) model and Prigogine-Flory-Patterson (PFP) theory. The values V^E_m predicted using FTB model agree well with experimental V^E_m values at all mole fractions. But the PFP theory describes well V^E_m data in ethanol-rich region (x₁ > 0.5) for all binary mixtures and is able to predict the sign of V^E_m vs x₁ curve for ethanol-lean region (x₁ < 0.5) except for ethanol (1) + nonane (2) mixtures.

• Journal of Gastric Cancer
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• 제23권2호
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• pp.289-302
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• 2023

Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM-) LM at baseline. Materials and Methods: Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM-: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM-: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan-Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM- subgroups was analyzed using the Cox regression model with reported interaction P-values. Results: The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM- (OS HR, 0.71 [LM+] vs. 0.88 [LM-]; PFS HR, 0.47 [LM+] vs. 0.76 [LM-]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions: RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2007년도 학술발표회 논문집
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• pp.1407-1411
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• 2007

현재까지 우리나라에서 주로 사용되고 있는 2차원 흐름 해석모형은 미연방 도로국(U.S. Federal Highway Administration)과 연계하여 Brigham Young University에서 개발된 SMS(Surface-Water Modeling System) 모형이다. SMS모형 중 이송 확산 모형으로는 RMA-4가 포함되나 이 모형은 최신 수치기법을 반영하지 못하는 등의 문제점들로 인해 실제 물리적 현상 모의에 있어서 한계를 가지고 있다. 따라서 물리적 현상에 대한 적절한 모의를 위한 개선과정을 통하여 RAM4가 개발되었다. 본 연구에서는 현장실측 자료를 바탕으로 RMA-4와의 모의결과 비교를 통하여 오염 확산 해석모형인 RAM4의 적용성을 검증하고자 하였다. RAM4와 RMA-4 모의에 있어서 격자구성과 경계조건은 동일하게 설정하였으며, 유량조건은 평수량과 갈수량으로 선정하였다. 각각의 유량시 수위조건이 틀려지므로 각 유량조건에 대한 격자구성을 달리하였다. 모의구간은 낙동강 본류의 수산대교에서 삼랑진 철교까지의 약 13km 구간을 대상으로 하였다. 모의 구간내에는 밀양-하남 하수처리장이 상류 좌안측에 위치하고 있고, 만곡, 단면의 축소 및 확대, 하중도, 합류 등의 지형학적 특징들이 비교적 짧은 구간에 나타나고 있어 모형의 검증에 적합하다고 판단된다.

• 한국군사과학기술학회지
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• 제11권2호
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• pp.23-31
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• 2008

The configuration model of a ballute type RAID(Ram Air Inflated Decelerator) for reducing the high speed and high revolution of smart submuntion is designed and tested. Three dimensional incompressible turbulent flow computational fluid dynamic analysis for the assembly of ballute and submunition is performed and pressure distribution, velocity, and drag around the assembly is calculated. Aerodynamic characteristics of the ballute assembly such as air flow inside and outside of the ballute and pressure distribution is clearly shown and it's drag coefficient is computed. Trajectory analysis of the submunition is performed and is in good agreement with the descending trajectory data of experimental model tested.

• 한국멀티미디어학회논문지
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• 제13권2호
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• pp.216-224
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• 2010

RAM 기반 신경망은 빠른 처리 속도와 하드웨어 구현의 용이성 등의 장점을 가지고 있지만 반면에 메모리의 포화 문제, 반복학습, 일반화 패턴 추출의 어려움 등의 단점도 가지고 있다. 이런 단점을 극복하기 위해 누적 다중 판별자를 가지는 3차원 뉴로 시스템(3DNS) 등이 제안되었지만 메모리 포화 문제는 해결하지는 못하였다. 본 논문에서는 메모리 포화 문제를 해결하기 위하여 적응적 가중치를 가지는 AWN (Adaptive Weight Neuron)을 사용한 적응적 가중치 누적 신경망(AWCNN)을 제안한다. 제안된 모델은 AWN으로 3DNS을 개선하여 인식률과 메모리 포화 문제 해결을 향상하였다. 제안된 시스템의 평가는 전처리 과정 없이 NIST의 MNIST에서 제공하는 자료를 이용하여 실험하였다. AWCNN은 3DNS보다 1.5%이상의 향상된 인식률을 보였고 일반화 패턴을 이용한 인식에서는 모든 입력 패턴의 교육된 것과 비슷한 성능을 얻었다.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2008년도 정기총회 및 학술발표대회
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• pp.199-202
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• 2008

It is well-known fact that tidal difference between the ebb and flow in Yellow Sea is about 9 m so that it has largest value in the world. This wide range of tide level enables Yellow Sea water to intrude into main stream of Han River. However, the study of the tidal reach of Han River has not been carried out thoroughly since North and South Koreas share this region so that topography data and physical measurement are lacking. In this study, to examine the reverse flow and dispersion behavior by tidal effect at the tidal reach of Han River, 2-D river analysis models were applied. RMA-2 was applied to calculate the horizontal velocities and water surface elevation. With the results of velocities and water depth, RAM4, which is 2-D advection-dispersion model based on FEM was simulated to analyze the horizontal transport behavior of BOD.

• 한국국방경영분석학회지
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• 제18권2호
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• pp.23-43
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• 1992

A Stochastic simulation model for optimal design and evaluation of the integrated weapon systems under the consideration of the RAM (reliability, availability and maintainability) and life cycle cost (LCC) was developped. This model is supposed to satisfy a need regarding the methodology of optimaldesign and performance evaluation for both developpers and users of weapon systems.

• Journal of the Korean Statistical Society
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• 제14권2호
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• pp.95-99
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• 1985

In this paper, Bayesian analysiss of the general linear econometric model is carried out by using a multinomal prior for the vector of unknown regression coefficents and a half-normal prior for the standard deviation of the disturbances.

• 한국정보과학회논문지:시스템및이론
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• 제27권4호
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• pp.416-419
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• 2000

G를 꼭지점들이 일반 위치에 있는 n개의 꼭지점을 갖는 볼록다각형이라 하자. 본 논문에서는 두 개의 탐조등을 G의 경계선에 배치하여 G의 내부를 모두 비추는 알고리즘을 개발하는데, 두 탐조등의 최대각을 최소화하는 것이 목적이다. 확장된 real-RAM상에서 O($n^2$) 시간 알고리즘을 제시한다

• Journal of applied mathematics & informatics
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• 제22권1_2호
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• pp.387-401
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• 2006

This paper deals with the problem of a ratio-dependent prey- predator model with combined harvesting. The existence of steady states and their stability are studied using eigenvalue analysis. Boundedness of the exploited system is examined. We derive conditions for persistence and global stability of the system. The possibility of existence of bionomic equilibria has been considered. The problem of optimal harvest policy is then solved by using Pontryagin's maximal principle.