• Journal of Korea Multimedia Society
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• v.23 no.9
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• pp.1139-1146
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• 2020

Recently, as e-learning technology advances, interaction and data exchange between lecturers and learners have become very important. In addition, accuracy of data delivery and efficiency of system implementation should be ensured. Considering these aspects, SignalR is the most suitable communication method for constructing an audience response system in e-learning. Existing audience response systems require separate wireless devices and have problems with system compatibility. SignalR, on the other hand, is capable of operating in all environments including PC programs, web, Android, and iOS, and has an advantage of being easy to develop applications. As such, SignalR is widely used in chatting functions for small scale, real-time communication system, and it has never been used to implement an audience response system. Thus, for the first time in this paper, an audience response system using SignalR was proposed and an experiment was conducted on whether it was applicable at the e-learning education field. Therefore, from the results fo an experiment, a variety of e-learning environments can be built through the audience response system using SignalR proposed in this paper.

• BMB Reports
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• v.51 no.9
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• pp.456-461
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• 2018

Chemoresistance is a major barrier to successful cisplatin-based chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.4
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• pp.528-538
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• 1985

A R-S-S-R three dimensional mechanism is designed for crank-rocker type through the optimization technique. The nonlinear kinematic equation of the mechanism is formulated by adopting the concept of structural error and precision points. Taking this equation as an objective function, the required mechanism is optimally synthesized by the Fletcher-Davidon-Powell's method of optimization techniques. The structural errors due to the various positions of precision points are compared, and the results from the use of two penalty functions suggested respectively by Fiacco-McCormick and by Powell are also compared on their effectiveness. The mobility of the optimally designed mechanism is checked for the possibility of its motion, and when a mechanism is optimally designed, it is strongly suggested that the mobility must be checked on the designed mechanism.

• YAKHAK HOEJI
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• v.45 no.4
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• pp.339-346
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• 2001

A new oxygenated monoterpene (4) was isolated from the methanol extract of the aerial part of Erechtites hieracifolia together with six known components, a dimethylheptane (1), three ionone derivatives (2, 3 and 7) and two phenylpropanoids (5 and 6). Their structures were identified by means of physico-chemical and spectral data to be (2E, 5E)-6-hydroxy-2,6-dimethylhepta-2,4-dienal (1), 3(R)-hydroxy-5,6-epoxy-$\beta$-ionone (2), 3(R)-hydroxy-5,6-epoxy-7-ionol (3), (3E, 6E)-3,7-dimethylocta-3,5-dien-1,2,7-triol(4), 2-hydroxy-4-(2-propenyl)phenyl-$\beta$-D-glucopyranoside (5), 2-methoxy-4-(2-propenyl)phenyl -$\beta$-D-glucopyra-noside (6) and (6R, 9R)-3-oxo-$\beta$-ionol-$\alpha$-D -glucopyranoside (7).

• Asian Journal of Innovation and Policy
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• v.9 no.3
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• pp.281-307
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• 2020

A variety of approaches are being applied to improve the existing ex-ante evaluation by expert panels in publicly funded R&D. While the objective evaluation criteria are constantly being improved to screen and select the superior projects, alternative approaches such as random prioritization and logical modeling are also underway to overcome the conservative bias of reviewers and to secure disruptive innovation. This study intends to find critical implications for ex-ante evaluation of public R&D system from the comparison of Indonesia and Korea. For the comparative analysis, literature review and expert in-depth interviews are conducted on the national R&D system and the selection evaluation process. In Korea, the selection criteria of projects are legally promulgated for establishing an objective evaluation system, and at the program level, the major considerations in the planning process are specified by Presidential Decree. On the other hand, while Indonesia conducts R&D in 47 strategic fields largely by public research institutes (PRI) based on the non-competitive government contributions. This study draws out implications of institutionalizing the planning process at the level of program, and of increasing the ratio of contract-based competitive funding at the level of project in the national R&D portfolio.

• Advances in aircraft and spacecraft science
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• v.9 no.1
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• pp.69-93
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• 2022

Reduced graphene oxide (rGO) is one of the derivatives of graphene, which has drawn some experimental research interests in recent years however, numerical research studying the mechanical behaviors of composites made of rGO has not been taken into consideration yet. The objective of this research is to investigate the buckling, and free vibration of functionally graded reduced graphene oxide reinforced nanocomposite (FG rGORC) plates employing isogeometric analysis (IGA). The effective Young's modulus of rGORC is determined based onthe Halpin-Tsai model. Four different FG distribution types of rGO are considered varying across plate thickness. Besides, the refined plate theory is used based on Reddy's third-order function. To capture the size effect, modified couple stress theory (MCST) is employed. A comprehensive study is provided examining the effect of various parameters including rGO weight fraction, FG distribution types, boundary conditions, material length scale parameter, etc. Our obtained results show that the addition of only 1% of uniformly distributed rGO into epoxy plates leads to the fundamental frequency and critical buckling load 18% and 39% higher than those of pure epoxy plates, respectively.

• Journal of Advanced Marine Engineering and Technology
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• v.29 no.5
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• pp.533-539
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• 2005

Experimental results are presented for heat transfer and pressure gradients of HCs refrigerants R-290, R-600a, R-1270 and HCFC refrigerant R-22 during evaporating inside horizontal double pipe heat exchangers. Two tubes with a tube diameter of 12.70mm and 9.52mm are used for this investigation. Hydrocarbon refrigerants have higher pressure drop than R-22 in 12.7mm and 9.52mm. The results from the investigation can be used in the design of heat transfer exchangers using hydrocarbons as the refrigerant for the air-conditioning systems.

• Natural Product Sciences
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• v.16 no.4
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• pp.207-210
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• 2010

Phytochemical investigation of Salvia plebeia resulted in the isolation of nine compounds. Their structures were determined to be 6-methoxynaringenin (1), 6-methoxynaringenin-7-O-$\beta$-D-glucoside (2), hispidulin (3), homoplantaginin (4), nepetin (5), nepitrin (6), 6-hydroxyluteolin (7), caffeic acid (8) and rosmarinic acid (9) by spectroscopic analyses. 6-Methoxynaringenin (1), 6-hydroxyluteolin (7) and rosmarinic acid (9) were isolated from this plant for the first time.

• Korean Journal of Crystallography
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• v.12 no.2
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• pp.88-91
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• 2001

The complex [NiL₃]Cl₂·3H₂O (1) (L=trans-1,2-diaminocyclohexane) has been synthesized and characterized by X-ray crystallography. The compound 1 crystallizes in the cubic space group P2₁3, with a=13.830(1) Å, V=2645.9(2) ų, Z=4, R₁(wR₂) for 1500 observed reflections of [I> 2σ(I)] was 0.0766 (0.2068).

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.1154-1157
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• 2006

Organic thin-film transistors (OTFTs) based on a semiconducting polymer have been fabricated using an organic patterning methodology. Laser assisted lift-off (LALO) technique, ablating selectively the hydrophobic layer by an excimer laser, was used for producing a semiconducting polymer channel in the OTFT with high resolution. The selective wettability of a semiconducting polymer, poly (9-9-dioctylfluorene-co-bithiophene) (F8T2), dissolved in a polar solvent was found to define precisely the pattering resolution of the active channel. It is demonstrated that in the F8T2 TFTs fabricated using the LALO technique and is applicable for the larger area display.