Phytochemical Constituents from Salvia plebeia

  • Received : 2010.06.10
  • Accepted : 2010.10.25
  • Published : 2010.12.31

Abstract

Phytochemical investigation of Salvia plebeia resulted in the isolation of nine compounds. Their structures were determined to be 6-methoxynaringenin (1), 6-methoxynaringenin-7-O-$\beta$-D-glucoside (2), hispidulin (3), homoplantaginin (4), nepetin (5), nepitrin (6), 6-hydroxyluteolin (7), caffeic acid (8) and rosmarinic acid (9) by spectroscopic analyses. 6-Methoxynaringenin (1), 6-hydroxyluteolin (7) and rosmarinic acid (9) were isolated from this plant for the first time.

Keywords

References

  1. Garcia-Alvarez, M.C., Hasan, M., Michavila, A., Fernandez-Gadea, F., and Rodriguez, B., Epoxysalviacoccin, a neo-clerodane diterpenoid from Salvia plebeia. Phytochemistry 25, 272-274 (1986).
  2. Jeong, D.M., Jung, H.A., Kang, H.S., and Choi, J.S., Peroxynitrite scavengers from Phellinus linteus. Nat. Prod. Sci. 14, 1-11 (2008).
  3. Jeong, H.J., Hong, S.H., and Kim, H.M., Oriental medicines with antianaphylactic effect. Oriental Pharmacy and Experimental Medicine 4, 125-136 (2004). https://doi.org/10.3742/OPEM.2004.4.3.125
  4. Jin, Q., Han, X.H., Hwang, J.H., Hong, S.S., Park, M., Lee, C., Lee, C.H., Lee, D., Lee, M.K., and Hwang, B.Y., A new phenylbutanone glucoside from Salvia plebeian. Nat. Prod. Sci., 15, 106-109 (2009).
  5. Jin, X.F., Lu, Y.H., Wei, D.Z., and Wang, Z.T., Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 48, 100-104 (2008). https://doi.org/10.1016/j.jpba.2008.05.027
  6. Kim, S.J., Heo, M.Y., Son, K.H., and Kim, H.P., Tyrosinase inhibitory activity of 80 plant extracts (II). The J. of Applied Pharmacology 11, 5-7 (2003).
  7. Lim, J.A., Yun, B.W., and Baek, S.H., Antioxidative activity and nitrite scavenging ability of methanol extract from Salvia plebeia R. Br. Kor. J. Medicinal Crop Sci. 15, 183-188 (2007).
  8. Lu, Y., and Foo, L.Y., Polyphenolics of Salvia - a review. Phytochemistry 59, 117-140 (2002). https://doi.org/10.1016/S0031-9422(01)00415-0
  9. Nagao, T., Abe, F., Kinjo, J., and Okabe, H., Antiproliferative constituents in plants 10 flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. Biol. Pharm. Bull. 25, 875-879 (2002). https://doi.org/10.1248/bpb.25.875
  10. Plattner, R.D. and Powell, R.G., A secoisolariciresinol branched fatty diester from Salvia plebeia seed. Phytochemistry 17, 149-150 (1978). https://doi.org/10.1016/S0031-9422(00)89701-0
  11. Powell, R.G., and Plattner, R.D., Structure of a secoisolariciresinol diester from Salvia plebeia seed. Phytochemistry 15, 1963-1965 (1976). https://doi.org/10.1016/S0031-9422(00)88856-1
  12. Satake, T., Kamiya, K., Saiki, Y., Hama, T., Fujimoto, Y., Kitanaka, S., Kimura, Y., Uzawa, J., Endang, H., and Umar, M., Studies on the constituents of fruits of Helicteres isora L. Chem. Pharm. Bull. 47, 1444-1447 (1999). https://doi.org/10.1248/cpb.47.1444
  13. Weng, X.C. and Wang, W., Antioxidant activity of compounds isolated from Salvia plebeia. Food. Chem. 71, 489-493 (2000). https://doi.org/10.1016/S0308-8146(00)00191-6
  14. Wollenweber, E., Mann, K., Arriaga-Giner, F.J., Roitman, J.N., and West, J.G., Exudate flavonoids from two Australian Asteraceae, Bracteantha viscosa and Cassinia quinquefaria. Phytochemistry 33, 871-873 (1993). https://doi.org/10.1016/0031-9422(93)85293-Z
  15. Xiang, L., Chen, H.N., Xu, C.M., Zhang, S.S., and Wang, H.Y., Study on flavanoids from Salvia plebeian. Chin. Pharm. J. 43, 813-815 (2008).