• Title/Summary/Keyword: R600a

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Performance Investigation of Solar-Heating Ocean Thermal Energy Conversion (SH-OTEC) in Korea (태양열 이용 해양온도차발전시스템의 성능 예측)

  • Nguyen, Van Hap;Lee, Geun Sik
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.37 no.1
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    • pp.43-49
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    • 2013
  • The use of ocean thermal energy conversion (OTEC) to generate electricity is one of the methods proposed to utilize renewable energy and to protect the environment. In this study, simulations were performed to investigate the effect of weather conditions in the Ulsan region, Korea, on the efficiency of a solar-heating OTEC (SH-OTEC) system. This system utilizes solar thermal energy as the secondary heat source. Various working fluids were also simulated to select one that is suitable for this system. The results showed that R152A, R600, and R600A, in that order, were the most suitable working fluids. The effective area of the solar collector for a $20^{\circ}C$ increase in the collector outlet temperature fluctuated from 50 to $97m^2$ owing to the change in the monthly average solar gain. The annual average efficiency of the SH-OTEC increases to 6.23%, compared to that of a typical conventional OTEC, which is 2-4%.

Treatment of Vemurafenib-Resistant SKMEL-28 Melanoma Cells with Paclitaxel

  • Nguyen, Dinh Thang;Phan, Tuan Nghia;Kumasaka, Mayuko Y.;Yajima, Ichiro;Kato, Masashi
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.2
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    • pp.699-705
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    • 2015
  • Vemurafenib has recently been used as drug for treatment of melanomas with $BRAF^{V600E}$ mutation. Unfortunately, treatment with only vemurafenib has not been sufficiently effective, with recurrence after a short period. In this study, three vemurafenib-resistant $BRAF^{V600E}$ melanoma cell lines, $A375P^R$, $A375M^R$ and SKMEL-$28^R$, were established from the original A375P, A375M and SKMEL-28 cell lines. Examination of the molecular mechanisms showed that the phosphorylation levels of MEK and ERK, which play key roles in the RAS/RAF/MEK/ERK signaling pathway, were reduced in these three cell lines, with increased phosphorylation levels of pAKTs limited to SKMEL-$28^R$ cells. Treatment of SKMEL-$28^R$ cells with 100 nM paclitaxel resulted in increased apoptosis and decreased cellular proliferation, invasion and colony formation via reduction of expression levels of EGFR and pAKTs. Moreover, vemurafenib-induced pAKTs in SKMEL-$28^R$ were decreased by treatment with an AKT inhibitor, MK-2206. Taken together, our results revealed that resistance mechanisms of $BRAF^{V600E}$-mutation melanoma cells to vemurafenib depended on the cell type. Our results suggested that paclitaxel should be considered as a drug in combination with vemurafenib to treat melanoma cells.

The application of hydrocarbon refrigerants in a hermetic reciprocating compressor for low back pressure conditions (저온용 밀폐형 왕복동 압축기에서 탄화수소계 냉매 적용)

  • 김기문;박희용
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.10 no.6
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    • pp.683-694
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    • 1998
  • The application of hydrocarbon refrigerants in a hermetic reciprocating compressor for refrigerator is investigated. The selected refrigerants are isobutane(R600a), propane(R290), R12, binary mixture of R600a/R290, and OS-21CII. Both theoretical and experimental investigations have been performed for the selected refrigerants. The test results of hydrocarbon refrigerants have been compared to the traditional refrigerant(R12). The results show that hydrocarbon refrigerants(HC-Blend, OS-21C II) are very good alternatives in the refrigeration system for R12.

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Characteristics on Evaporating Pressure Drop of HCs Refrigerants inside a horizontal tube (수평관내 HC계 냉매의 증발 압력강하 특성)

  • Choi, Jun-Hyuk;Lee, Ho-Saeng;Kim, Jae-Dol;Yoon, Jung-In
    • Proceedings of the Korean Society of Marine Engineers Conference
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    • 2006.06a
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    • pp.63-64
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    • 2006
  • Chracteristics on evaporating pressure drop of HCs refrigerants inside a horizontal tube were studied experimentally. Experimental results were presented for pressure drops of hydrocarbon refrigerants R-290, R-600a, R-1270 and HCFC refrigerant R-22 inside a horizontal double pipe heat exchanger. Three tubes with a tube diameter of 12.70mm, 9.52mm and 6.35mm were used for this study. Hydrocarbon refrigerants showed higher evaporating pressure drop than that of R-22 in all tubes. The highest pressure drop was founded in R-600a. The highest evaporating perssure drop of all refrigerants was shown in a tube diameter of 6.35mm with same mass flux. The results can be used as the basic data for the design of heat exchanger using hydrocarbon refrigerants as an alternatives.

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Survey of Perkinsus olseni infection in Manila clam, Ruditapes philippinarum in 2009 on the west and south coast of Korea using PCR technique (PCR 기법을 이용한 2009년 우리나라 서해안과 남해안 바지락, Ruditapes philippinarum의 Perkinsus olseni 감염에 관한 보고)

  • Lee, Nam-Sil;Hwang, Jee-Youn;Choi, Dong-Lim;Park, Myoung-Ae
    • Journal of fish pathology
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    • v.23 no.2
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    • pp.145-153
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    • 2010
  • Prevalence of a protozoan parasite Perkinsus olseni in Manila clam Ruditapes philippinarum was surveyed from July to December 2009 on the west and south coast of Korea. P. olseni infection was diagnosed using two primer sets, P.olseni NTS Forward/P.olseni NTS Reverse set and PolsITS-140F/PolsITS-600R set in polymerase chain reaction(PCR). The results using PolsITS-140F and PolsITS-600R primer set was retained up to 60% at all stations from July to December, except for Padori. Especially, Goheung showed 100% prevalence from October to December. The results about comparison of the 4 station's DNA sequences which were analyzed from PCR products(457bp) using PolsITS-140F and PolsITS-600R primer set, there were only 2base differences at Sunjedo.

Expression of Sodium-Iodide Symporter Depending on Mutational Status and Lymphocytic Thyroiditis in Papillary Thyroid Carcinoma

  • Song, Young Shin;Park, Young Joo
    • International journal of thyroidology
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    • v.11 no.2
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    • pp.152-159
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    • 2018
  • Background and Objectives: Sodium-iodine symporter (NIS) is a marker for the degree of differentiation in thyroid cancer. The genetic factors or microenvironment surrounding tumors can affect transcription of NIS. In this study, we investigated the NIS mRNA expression according to mutational status and coexistent lymphocytic thyroiditis in papillary thyroid cancer (PTC). Materials and Methods: The RNA expression levels of NIS in the samples from database of The Caner Genome Atlas (TCGA; n=494) and our institute (n=125) were analyzed. Results: The PTCs with the $BRAF^{V600E}$ mutation and the coexistence of $BRAF^{V600E}$ and TERT promoter mutations showed significantly lower expression of NIS (p<0.001, respectively), and those with BRAF-like molecular subtype also had reduced expression of NIS (p<0.001). NIS expression showed a positive correlation with thyroid differentiation score (r=0.593, p<0.001) and negative correlations with expressions of genes involved in ERK signaling (r=-0.164, p<0.001) and GLUT-1 gene (r=-0.204, p<0.001). The PTCs with lymphocytic thyroiditis showed significantly higher NIS expression (p=0.013), regardless of mutational status. Conclusion: The NIS expression was reduced by the $BRAF^{V600E}$ mutation and MAPK/ERK pathway activation, but restored by the presence of lymphocytic thyroiditis.

UNDERWATER DISTRIBUTION OF VESSEL NOISE (선박소음의 수중분포에 관한 연구)

  • PARK Jung Hee
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.10 no.4
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    • pp.227-235
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    • 1977
  • The noise pressure scattered underwater on account of the engine revolution of a pole and liner, Kwan-Ak-San(G. T. 234.96), was measured at the locations of Lat. $34^{\circ}47'N$, Long. $128^{\circ}53'E$ on the 16th of August 1976 and Lat. $34^{\circ}27'N$, Long. $128^{\circ}23'E$ on the 28th of July, 1977. The noise pressure passed through each observation point (Nos. 1 to 5), which was established at every 10m distance at circumference of outside hull was recorded when the vessel was cruising and drifted. In case of drifting, the revolution of engine was fixed at 600 r. p. m. and the noise was recorded at every 10 m distance apart from observation point No. 3 in both horizontal and vertical directions with $90^{\circ}$ toward the stern-bow line. In case of cruising, the engine was kept in a full speed at 700 r.p.m. and the sounds passed through underwater in 1 m depth were also recorded while the vessel moved back and forth. The noise pressure was analyzed with sound level meter (Bruel & Kjar 2205, measuring range 37-140 dB) at the anechoic chamber in the Institute of Marine Science, National Fisheries University of Busan. The frequency and sound waves of the noise were analyzed in the Laboratory of Navigation Instrument. From the results, the noise pressure was closely related to the engine revolution shelving that the noise pressure marked 100 dB when .400 r. p. m. and increase of 100 r. p. m. resulted in 1 dB increase in noise pressure and the maximum appeared at 600 r. p. m. (Fig.5). When the engine revolution was fixed at 700 r. p. m., the noise pressures passed through each observation point (Nos. 1 to 5) placed at circumference of out side hull were 75,78,76,74 and 68 dB, the highest at No.2, in case of keeping under way while 75,76,77,70 and 67 dB, the highest at No.3 in case of drifting respectively (Fig.5). When the vessel plyed 1,400 m distance at 700 r.p.m., the noise pressure were 67 dB at the point 0 m, 64 dB at 600m and 56 dB at 1,400m on forward while 72 at 0 m, 66 at 600 m and 57 dB at 1,400 m on backward respectively indicating the Doppler effects 5 dB at 0 m and 3 dB at 200 m(Fig.6). The noise pressures passed through the points apart 1,10,20,30,40 and 50 m depth underwater from the observation point No.7 (horizontal distance 20 m from the point No.3) were 68,75,62,59,55 and 51 dB respectively as the vessel was being drifted maintaining the engine revolution at 600 r. p. m. (Fig. 8-B) whereas the noise pressures at the observation points Nos.6,7,8,9 and 10 of 10 m depth underwater were 64,75,55,58,58 and 52 dB respectively(Fig.8-A).

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Evaporating heat transfer characteristics of R-22 alternative hydrocarbon refrigerants at heat exchanger using grooved inner tube (내면 핀관을 사용하는 열교환기에서 R-22 대체 탄화수소계 냉매의 증발 열전달 특성)

  • 홍진우;박승준;노건상;구학근;오후규
    • Journal of Advanced Marine Engineering and Technology
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    • v.24 no.4
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    • pp.414-420
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    • 2000
  • In this paper, evaporation heat transfer characteristics at a inner grooved tube were studied using a new natural refrigerants R-290, R-600a and HCFC refrigerant R-22. Experiments were performed in the inner tube with outside diameter of 12.70mm, having 75 fins with a fin height of 0.25mm. The following results were obtained from this research. On the evaporating heat transfer characteristics, the maximum increment of heat transfer coefficient was found in R-290. Average heat transfer coefficient was obtained the maximum value in R-290 and the minimum value in R-22. It reveals that the natural refrigerant can be used as a substitute for R-22. In the grooved inner tube, 70% of the increment of the heat transfer coefficient was obtained compared to the smooth tube. Comparing the heat transfer coefficient between experimental results and simulation data of other's, the Kandlikar's correlated equation was closely approximated to the author's experimental results in the smooth tube or grooved inner one.

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