• Molecules and Cells
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• v.43 no.5
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• pp.438-447
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• 2020

The aim of this study was to explore the role of IL-6-miR-210 in the regulation of Tregs function and atrial fibrosis in atrial fibrillation (AF). The levels of interleukin (IL)-6 and IL-10 in AF patients were detected by using ELISA. Proportions of Treg cells were detected by fluorescence activated cell sorting analysis in AF patients. The expression of Foxp3, α-SMA, collagen I and collagen III were determined by western blot. The atrial mechanocytes were authenticated by vimentin immunostaining. The expression of miR-210 was performed by quantitative real-time polymerase chain reaction (qRT-PCR). TargetScan was used to predict potential targets of miR-210. The cardiomyocyte transverse sections in AF model group were observed by H&E staining. The myocardial filaments were observed by masson staining. The level of IL-6 was highly increased while the level of IL-10 (Tregs) was significantly decreased in AF patients as compared to normal control subjects, and IL-6 suppressed Tregs function and promoted the expression of α-SMA, collagen I and collagen III. Furthermore, miR-210 regulated Tregs function by targeting Foxp3, and IL-6 promoted expression of miR-210 via regulating hypoxia inducible factor-1α (HIF-1α). IL-6-miR-210 suppresses regulatory T cell function and promotes atrial fibrosis by targeting Foxp3.

• Journal of Korean society of Dental Hygiene
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• v.19 no.2
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• pp.161-172
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• 2019

Objectives: This study aimed to analyze the correlation between oral function, oral environment, and brain cognitive function in the elderly. Methods: The subjects were 60 users of senior community center and elderly day care center. The survey was conducted from November to December 2018. Subjects were assessed by oral examination and myofunction test. Oral myofunction was measured using $IOPI^R$ and Lip de $Cum^R$. Survey data were analyzed using the statistical programs of PASW Statistics ver. 18.0. Results: Tongue muscle strength and lips muscle strength was higher in males than in females. The tongue and lip strengths were higher in the <81 years old group than the ${\geq}81$ years old group. Functional tooth analysis showed that there was a ${\geq}15$ teeth group ($40.91{\pm}7.36$) and a <15 teeth group ($32.52{\pm}7.14$). Lip muscle strength analysis showed that the ${\geq}15$ teeth group ($10.54{\pm}3.40$) was higher than the <15 teeth group ($8.20{\pm}2.41$, p<0.05). Tongue muscle strength, lumbar muscle strength, and functional tooth number were lower in the elderly subjects with mild cognitive impairment. Cognitive function was significantly correlated with functional tooth number (r=0.386, p<0.001), tongue strength (r=0.478, p<0.001), and lip strength (r=0.281, p<0.05). Tongue strength was significantly correlated with lip strength (r=0.360, p<0.001) and functional tooth number (r=0.633, p<0.001). Lip strength was significantly correlated with functional tooth number (r=0.376, p<0.001). Conclusions: These results showed that age and functional tooth number influenced oral muscle strength and that the number of functional teeth and oral muscle strength were low in the elderly with mild cognitive impairment. Oral myofunction training and oral care program are suggested to improve the quality of life of the elderly.

• Journal of applied mathematics & informatics
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• v.25 no.1_2
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• pp.495-503
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• 2007

Symmetric interpolating refinable function vectors with compact support are of interest in several applications such as signal processing, image processing and computer graphics. It is known in [13] that orthogonal interpolating refinable function vectors can not be symmetric for multiplicity r = 2 and dilation d = 2. In this paper, we shall investigate symmetric interpolating refinable function vectors with compact support for multiplicity r = 2 and dilation d = 2 by omitting orthogonality. To illustrate our theorems and results in this paper, we shall also present some examples of symmetric interpolating refinable function vectors with compact support and high order of sum rules.

• Korean Journal of Mathematics
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• v.22 no.1
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• pp.181-206
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• 2014

Let $R={\bigoplus}_{\alpha{\in}\Gamma}R_{\alpha}$ be a graded integral domain graded by an arbitrary grading torsionless monoid ${\Gamma}$, and ⋆ be a semistar operation on R. In this paper we define and study the graded integral domain analogue of ⋆-Nagata and Kronecker function rings of R with respect to ⋆. We say that R is a graded Pr$\ddot{u}$fer ⋆-multiplication domain if each nonzero finitely generated homogeneous ideal of R is ⋆$_f$-invertible. Using ⋆-Nagata and Kronecker function rings, we give several different equivalent conditions for R to be a graded Pr$\ddot{u}$fer ⋆-multiplication domain. In particular we give new characterizations for a graded integral domain, to be a $P{\upsilon}MD$.

• Journal of the Korean Mathematical Society
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• v.34 no.3
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• pp.581-598
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• 1997

This paper is concerned with the impulsive control problem $$ \dot{x}(t) = f(t, x) + g(t, x)\dot{u}(t), t \in [0, T], x(0) = \overline{x}, $$ where u is a possibly discontinuous control function of bounded variation, $f : R \times R^n \mapsto R^n$ is a bounded and Lipschitz continuous function, and $g : R \times R^n \mapsto R^n$ is continuously differentiable w.r.t. the variable x and satisfies $\mid$g(t,\cdot) - g(s,\cdot)$\mid$ \leq \phi(t) - \phi(s)$, for some increasing function $\phi$ and every s < t. We show that the map $u \mapsto x_u$ is Lipschitz continuous when u ranges in the set of step functions whose total variations are uniformly bounded, where $x_u$ is the solution of the impulsive control system corresponding to u. We also define the generalized solution of the impulsive control system corresponding to a measurable control functin of bounded variation.

• Journal of Veterinary Clinics
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• v.9 no.1
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• pp.333-366
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• 1992

Safety of recombinant porcine somatotropin administration on pig was studied using 32 Landrace x Yorkshire crossbred pigs. The starting body weight ranged from 55.5kg to 65.3kg. Eight pigs were allotted to each low dose group of sustained releasing rPST(SL), high dose group of sustained releasing rPST(SH), daily injection group of rPST(DI), and control group(C). Pigs in SL group and SH group were injected subcutaneously twice in 3 week-interval with 1000$\mu\textrm{g}$ and 2000$\mu\textrm{g}$ of sustained releasing rPST per kg body weight, respectively. Pigs in DI group were injected intramuscularly with 100$\mu\textrm{g}$ of rPST everyday for 6 weeks. Blood was collected from anterior vena cava just before the first treatment, and at four weeks and six weeks of experiment. Hematological parameters and blood chemical parameters indicating liver function, kidney function, electrolyte metabolism, mineral metabolism and lipid metabolism were determined. Necropsy and urinalysis were performed after final blood collection. The results were summarized as follows, and it is concluded that rPST administration does not affect pig health negatively. 1. rPST administration did not affect kidney function as manisfested by BUN, creatinine and urinalysis. 2. rPST administration did not affect liver function as manisfested by total protein, albumin, serum AST activity serum ALT activity serum ALP activity, serum LDH activity, serum GGT activity and serum SDH activity. 3. rPST administration did not affect skeletal muscle, cardiac muscle and brain as manifasted by serum AST activity and serum LDH activity. 4. rPST administration increased blood glucose level within normal range. 5. rPST administration did not affect lipid metabolism as manisfested by triglyceride, cholesterol, and phospholipid concentrati on. 6. rPst administration dia not affect mineral metabolism as manisfested by calcium, phosphorus, magnesium and iron concentration. 7. rPST administration did not affect electrolyte metabolism as manisfested by Na, K, chloride concentration. 8. rPST administration did not affect erythrocyte count, leukocyte count, thrombocyte count, and plasma fibrinogen level.

• Korean Journal of Adult Nursing
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• v.19 no.3
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• pp.401-412
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• 2007

Purpose: The purpose of this study was to determine the relationship between assessed pain, functional status, and emotional status in elderly women with dementia. Methods: The method was a descriptive correlational design. Subjects were sampled from 75 elderly women with dementia who were resident in nursing home. and their pain, functional status(physical function, cognitive function), emotional status(depression, agitation) were measured. The collected data were analyzed for correlations between pain and functional status and for emotional status using the SPSS 11.0 statistical program. Results: The pain degree of the aged women in dementia were as follows; between 0 and 27 points, average 4.04 points, which was a possible point extent. Looking at the grades in detail items, the wry face expression was shown highest, an average of 0.84 points. The relation with cognitive function was(r=-.259, p<.025) a minus relation. And the relation with physical function was (r=.406, p<.001) a plus one. The relation with depression was (r=.462, p<.001), plus one. And (r=.592, p<.001) a plus relation was found with agitation. Conclusion: Pain is associated with impaired functional and emotional status. Major efforts are needed to improve nursing assessment and management of pain in this cognitive impaired population.

• Journal of Magnetics
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• v.19 no.2
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• pp.170-173
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• 2014

The purpose of the present study was to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) in conjunction with task oriented training, on cortical excitability and upper extremity function recovery in stroke patients. This study was conducted with 31 subjects who were diagnosed as a hemiparesis by stroke. Participants in the experimental (16 members) and control groups (15 members) received rTMS and sham rTMS, respectively, during a 10 minutes session, five days per week for four weeks, followed by task oriented training during a 30 minutes session, five days per week for four weeks. Motor cortex excitability was performed by motor evoked potential and upper limb function was evaluated by motor function test. Both groups showed a significant increment in motor function test and amplitude, latency in motor evoked potential compared to pre-intervention (p < 0.05). A significant difference in post-training gains for the motor function test, amplitude in motor evoked potential was observed between the experimental group and the control group (p < 0.05). The findings of the current study demonstrated that incorporating rTMS in task oriented training may be beneficial in improving the effects of stroke on upper extremity function recovery.

• Korean Journal of Computational Design and Engineering
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• v.12 no.3
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• pp.220-232
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• 2007

Current geometric modeling and analysis are commonly based on B-Rep modeling and a finite elements method respectively. Furthermore, it is difficult to represent an object whose material property is heterogeneous using the B-Rep method because the B-Rep is basically used for homogeneous models. In addition, meshes are required to analyze a property of a model when the finite elements method is applied. However, the process of generating meshes from B-Rep is cumbersome and sometimes difficult especially when the model is deformed as time goes by because the topology of deforming meshes are changed. To overcome those problems in modeling and analysis including homogeneous and heterogeneous materials, we suggest a unified modeling and analysis method based on implicit representation of the model using R-function which is suggested by Rvachev. For implicit modeling of an object a distance field is approximated and blended for a complex object. Using the implicit function mesh-free analysis is possible where meshes are not necessary. Generally mesh-free analysis requires heavy computational cost compared to a finite elements method. To improve the computing time of function evaluation, we utilize GPU programming. Finally, we give an example of a simple pipe design problem and show modeling and analysis process using our unified modeling and analysis method.

• Bulletin of the Korean Mathematical Society
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• v.48 no.3
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• pp.655-672
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• 2011

Let $C^r$[0,t] be the function space of the vector-valued continuous paths x : [0,t] ${\rightarrow}$ $R^r$ and define $X_t$ : $C^r$[0,t] ${\rightarrow}$ $R^{(n+1)r}$ and $Y_t$ : $C^r$[0,t] ${\rightarrow}$ $R^{nr}$ by $X_t(x)$ = (x($t_0$), x($t_1$), ..., x($t_{n-1}$), x($t_n$)) and $Y_t$(x) = (x($t_0$), x($t_1$), ..., x($t_{n-1}$)), respectively, where 0 = $t_0$ < $t_1$ < ... < $t_n$ = t. In the present paper, with the conditioning functions $X_t$ and $Y_t$, we introduce two simple formulas for the conditional expectations over $C^r$[0,t], an analogue of the r-dimensional Wiener space. We establish evaluation formulas for the analogues of the analytic Wiener and Feynman integrals for the function $G(x)=\exp{{\int}_0^t{\theta}(s,x(s))d{\eta}(s)}{\psi}(x(t))$, where ${\theta}(s,{\cdot})$ and are the Fourier-Stieltjes transforms of the complex Borel measures on ${\mathbb{R}}^r$. Using the simple formulas, we evaluate the analogues of the conditional analytic Wiener and Feynman integrals of the functional G.