• 기술혁신학회지
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• 제17권3호
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• pp.449-466
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• 2014

그동안 기업의 R&D 투자와 기술혁신 성과의 관계에 관해 여러 연구가 있었다. 하지만 지식생산과정에 수반되는 기업의 의사결정 과정은 효과적으로 분석에 반영되지 못하였다. 특히 기업의 특허성과를 분석함에 있어 포와송모형의 한계에 대응해 최근 연구는 음이항모형을 적용해 극복하고자 했지만 기업의 선택과정을 분석하는데는 한계가 있다. 본 논문은 특허권 정보에 내재된 기업체의 의사결정 과정을 보다 효과적으로 반영하는 실증모형을 제시하고, 사업체조사 결과를 적용해 분석하였다. 특히 기업의 대표적 R&D 성과인 특허에 주목하여 특허 출원건수의 결정과정을 살펴보았다. 분석 결과, 과산포의 존재를 확인할 수 있었고, 허들모형과 일반적인 음이항모형의 결과에 유의한 차이가 있음을 제시하였다. 더불어 Wald-검정을 통해 허들의 설정이 타당하였고, 기업의 특허성과 분석에 있어서 기업의 선택과정을 고려할 필요가 있음을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4969-4976
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• 2014

Background: miR-152 is involved in the genesis and development of several malignancies. However, its role in HCC has not been fully clarified. The aim of this study was to investigate the clinicopathological significance of miR-152 and its effect on the malignant phenotype of HCC cells. Methods: miR-152 expression was detected using real-time quantitative RT-PCR in 89 pairs of HCC formalin-fixed paraffin-embedded and their adjacent tissues. Functionally, in vitro effects and mechanisms of action of miR-152 on proliferation, viability, caspase activity, apoptosis and motility were explored in HepG2, HepB3 and SNU449 cells, as assessed by spectrophotometry, fluorimetry, fluorescence microscopy, wound-healing and Western blotting, respectively. Results: miR-152 expression in HCC was downregulated remarkably compared to that in adjacent hepatic tissues. miR-152 levels in groups of advanced clinical stage, larger tumor size and positive HBV infection, were significantly lower than in other groups. A miR-152 mimic could suppress cell growth, inhibit cell motility and increase caspase activity and apoptosis in HCC cell lines. Furthermore, Western blotting showed that the miR-152 mimic downregulated Wnt-1, DNMT1, ERK1/2, AKT and TNFRS6B signaling. Intriguingly, inverse correlation of TNFRF6B and miR-152 expression was found in HCC and bioinformatics confirmed that TNFRF6B might be a target of miR-152. Conclusions: Underexpression of miR-152 plays a vital role in hepatocarcinogenesis and lack of miR-152 is related to the progression of HCC through deregulation of cell proliferation, motility and apoptosis. miR-152 may act as a tumor suppressor miRNA by also targeting TNFRSF6B and is therefore a potential candidate biomarker for HCC diagnosis, prognosis and molecular therapy.

• 열처리공학회지
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• 제34권6호
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• pp.272-280
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• 2021

The influence of acetylene flow rates on the carburizing behavior of an AISI 4115 steel in 1 ton-class mass production-type vacuum carburizing furnace has been studied through microstructure, carbon concentration, hardness analyses. The AISI 4115 steels were carburized with various flow rates (20, 32.7, 60 l/min) and locations in the furnace (top, center, bottom) at 950℃. The acetylene flow rate played an important role in controlling the carburizing properties of carburized samples, such as effective case depth and uniformity carburizing according to location in the furnace. At an acetylene flow rate of 20 l/min, the carburized samples had a shallow average hardened layer (0.645 mm) compared to the target hardening depth (1 mm) due to low carbon flux and spatial uniformity of carburization (17.8%) in the furnace. At a flow rate of 60 l/min, the carburized samples showed an average hardened layer (1.449 mm) deeper than the target hardening depth and had the spatial uniformity of carburization (98.8%). In particular, at a flow rate of 32.7 l/min, the carburized samples had an average hardened layer (1.13 mm) close to the target hardening depth and had the highest carburizing uniformity (99.1%). As a result, an appropriate flow rate of 32.7 l/min was derived to satisfy the target hardening depth and to have spatial uniform hardened layer in the furnace.

• Journal of Oral Medicine and Pain
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• 제16권1호
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• pp.73-84
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• 1991

저자는 연령을 추정하기 위한 기본자료를 얻기 위하여 상하악의 대구치, 소구치의 발육정도를 평가하였다. Orthopantomograph를 촬영한 722명의 3,464개 치아를 대상으로 crown-root ratio를 측정하여 발육정도를 평가하였으며, 다음과 같은 결론을 얻었다. 1. 완전히 형성된 치아의 crown-root ration에는 남녀간에 유의한 차이가 없었다. 2. 발육중인 치아의 crown-root ratio에는 좌우측간에 유의한 차이가 없었다. 3. 각 치아의 crown-root ratio를 이용한 연령추정의 회귀방정식은 다음과 같다. 남자: 여자 : 하악좌측 제 2대구치 : Y=4.599X+7.832(r=0.8337) 하악 좌측 제 2대구치 : Y=4.857X+7.429(r=0.8975) 제 1대구치 : Y=5.179X+2.324(r=0.7948) 제 1대구치 : Y=5.919X+2.018(r=0.8144) 제 2소구치 : Y=3.863X+7.432(r=0.8638) 제 2소구치 : Y=3.679X+7.275(r=0.8819) 제 1소구치 : Y=3.472X+7.120(r=0.8352) 제 1소구치 : Y=4.001X+6.544(r=0.9024) 하악우측 제 2대구치 : Y=4.447X+7.938(r=0.8045) 하악 우측 제 2대구치 : Y=4.653X+7.365(r=0.8598) 제 1대구치 : Y=5.954X+1.495(r=0.7777) 제 1대구치 : Y=5.449X+2.012(r=0.7553) 제 2소구치 : Y=3.894X+7.253(r=0.8689) 제 2소구치 : Y=3.772X+7.025(r=0.8719) 제 1소구치 : Y=4.189X+6.717(r=0.8370) 제 1소구치 : Y=4.327X+6.193(r=0.8524) 상악좌측 제 2대구치 : Y=4.430X+7.722(r=0.7538) 상악 좌측 제 2대구치 : Y=4.876X+7.606(r=0.8311) 제 1대구치 : Y=4.645X+2.886(r=0.6894) 제 1대구치 : Y=6.754X+1.891(r=0.5378) 제 2소구치 : Y=4.391X+6.686(r=0.7700) 제 2소구치 : Y=1.245X+10.575(r=0.1908) 제 1소구치 : Y=5.564X+6.037(r=0.9032) 제 1소구치 : - 상악우측 제 2대구치 : Y=4.587X+7.966(r=0.7882) 상악 우측 제 2대구치 : Y=4.454X+7.803(r=0.8443) 제 1대구치 : Y=4.047X+4.124(r=0.6352) 제 1대구치 : Y=6.336X+2.911(r=0.4688) 제 2소구치 : Y=2.920X+8.089(r=0.7277) 제 2소구치 : Y=3.105X+8.082(r=0.6381) 제 1소구치 : Y=3.264X+6.970(r=0.7292) 제 1소구치 : - 4. Orthopantomograph상의 crown-root ratio를 이용한 연령의 추정에는 상악치아들 보다 하악치아들이 더 정확하게 사용될 수 있다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2006년도 International Meeting of the Microbiological Society of Korea
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• pp.97-99
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• 2006

A chitinase-producing bacterium strain KCTC10714 was isolated from sea sand around the King Sejong Station, King George Island in Antarctica. It was identified as Sanguibacter sp., based on the biochemical properties and 16S rRNA gene sequence. KCTC10714 chitinase showed enzyme activity in broad range of temperature from 0 to $70^{\circ}C$. At $0^{\circ}C$, it showed 70.9% of relative activity in comparison with 100%. The chitinase gene of KCTC10714 was cloned using inverse PCR cloning method. KCTC10714 chitinase gene was designated as chi21702. The ORF of chi21702 consisted of 1,449 bp (482 amino acid), and contained ChtBD3 (a chitin/cellulose binding domain) and an active site for chitinase family 18.

• 한국치위생학회지
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• 제23권6호
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• pp.441-449
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• 2023

Objectives: This study was conducted to analyze the factors influencing the positive psychological capital, growth mindset, and self-leadership of dental hygienists in the Seoul and Gyeonggi regions with regard to their retention intention. The findings would serve as basic data for improving the retention intention. Methods: The methods espoused for analysis comprised independent sample t-test and ANOVA for group comparisons, Pearson's correlation analysis for examining the correlation between variables, and multiple regression analysis for identifying factors affecting retention intention. Results: Positive psychological capital was higher among those under the age of 27 and employed in dental clinics. Growth mindset was higher among those with less than three years of work experience and those working in clinics. Self-leadership was higher among those aged 28-31, and retention intention was higher among those under the age of 27 and with less than three years of work experience (p<0.05). A correlation was observed between positive psychological capital and self-leadership (r=0.760), self-leadership and retention intention (r=0.514), positive psychological capital and retention intention (r=0.505), positive psychological capital and growth mindset (r=0.337), and growth mindset and self-leadership (r=0.245) (p<0.001). Factors influencing the intention to stay at work were self-leadership (β=0.309) and positive psychological capital (β=0.242) (p<0.05). Conclusions: In order to improve dental hygienists' retention intention, it is necessary to devise strategies for improving positive psychological capital and self-leadership.

• BMB Reports
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• 제51권9호
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• pp.444-449
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• 2018

Acute myeloid leukemia (AML) is one of the most common hematological malignancies all around the world. MicroRNAs have been determined to contribute various cancers initiation and progression, including AML. Although microRNA-204 (miR-204) exerts anti-tumor effects in several kinds of cancers, its function in AML remains unknown. In the present study, we assessed miR-204 expression in AML blood samples and cell lines. We also investigated the effects of miR-204 on cellular function of AML cells and the underlying mechanisms of the action of miR-204. Our results showed that miR-204 expression was significantly downregulated in AML tissues and cell lines. In addition, overexpression of miR-204 induced growth inhibition and apoptosis in AML cells, including AML5, HL-60, Kasumi-1 and U937 cells. Cell cycle analysis further confirmed an augmentation in theapoptotic subG1 population by miR-204 overexpression. Mechanistically, baculoviral inhibition of apoptosis protein repeat containing 6 (BIRC6) was identified as a direct target of miR-204. Enforcing miR-204 expression increased the luciferase activity and expression of BIRC6, as well as p53 and Bax expression. Moreover, restoration of BIRC6 reversed the pro-apoptotic effects of miR-204 overexpression in AML cells. Taken together, this study demonstrates that miR-204 causes AML cell apoptosis by targeting BIRC6, suggesting miR-204 may play an anti-carcinogenic role in AML and function as a novel biomarker and therapeutic target for the treatment of this disease.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.446-449
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• 2008

Organic light emitting diodes (OLEDs) with multiple organic layers were fabricated to obtain and to evaluate an equivalent resistance and an equivalent capacitance of OLED device. The staircase voltage with an increasing period and a constant period was designed and applied to the OLED. The resistance of OLED was found to decrease from $270\;k{\Omega}$ to $2\;K{\Omega}$ as applied voltage increased after turn on. The equivalent capacitance of OLED maintained unchanged at low voltage level and deceased after showing peak value as the applied voltage increased.

• 대한화학회지
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• 제17권6호
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• pp.444-449
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• 1973

Forsythia Koreana NAKAI씨를 methanol로 추출분리하여 얻은 sapogenin 및 그 유도체들을 mass specta, ultraviolet spectra, infrared spectra, n.m.r spectra 원소분석, 정성실험으로 확인한 결과 ursolic acid임이 밝혀졌다.

• Clinical and Experimental Reproductive Medicine
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• 제33권2호
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• pp.85-95
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• 2006

목 적: CYP1B1은 자궁내막증의 발생과 관련된 에스트로겐의 대사 및 dioxin의 대사 모두와 관련이 있는 유전자로 생각하여 자궁내막증의 발생위험과 CYP1B1의 codon 119G${\rightarrow}$T, 432G${\rightarrow}$C, 449T${\rightarrow}$C, 453A${\rightarrow}$G의 유전자 다형성과의 관계에 대해서 알아보고자 하였다. 연구방법: 병리조직학적으로 자궁내막증 III기와 IV기임을 확인한 여성 199명과 대조군으로 자궁내막증 환자군과 연령이 비슷한 여성에서 양성 난소 낭종으로 수술을 시행하여 자궁내막증이 없음을 육안으로 확인한 183명을 대상으로 PCR 및 RFLP를 시행하여 CYP1B1의 codon 119G${\rightarrow}$T, 432C${\rightarrow}$G, 449T${\rightarrow}$C, 453A${\rightarrow}$G의 다형성을 조사하였다. 결 과: CYP1B1에서 $Ala^{l19}Ser$, $Va1^{432}Leu$, $Asn^{449}(T^{449}{\rightarrow}C)$, $Asn^{453}Ser$ 각각의 유전자 다형성은 그 분포와 위험도에 있어서 자궁내막증 환자와 대조군 간에 통계적으로 유의한 차이는 없었다. CYP1B1에서 앞서 밝힌 4가지 codon의 다형성을 조합한 결과 GG/CC/CC/AA의 유전자형을 갖는 여성에 비해 GG/GC+GG/TC+TT/AA의 유전자형을 갖는 경우만이 자궁내막증의 위험도가 2.056 (95% CI: 1.003-4.216)으로 유의하게 높은 것을 알 수 있었다. 결 론: 이상으로 볼 때 한국인 여성에서 중증자궁내막증 발생은 CYP1B1의 유전적 다형성과 관련이 있는 것으로 보이며, 향후 자궁내막증의 발생 기전을 밝히는데 주요한 자료가 될 것으로 본다.