• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.21-27
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• 2019

R-404A, which is used widely in small-scale ice makers, is scheduled to be phased out because of its high global warming potential. In this study, drop-in tests were conducted using R-448A and R-449A, which replace R-404A, to modify the outdoor air and supply water temperatures. The results showed that the daily ice production rate of R-404A was 5.3% higher than that of R-448A and 4.2% higher than that of R-449A. This was attributed to the larger vapor density of R-404A, which resulted in a larger mass flow rate in the system. Between R-448A and R-449A, R-448A yielded a larger amount of ice at low air and water temperatures, whereas R-449A yielded a larger amount of ice at high air and water temperatures. The daily power consumption of R-404A was approximately 10% larger than those of R-448A and R-449A. The resulting COPs of R-448A and R-449A was similar, only 3.0% larger than that of R-404A. The literature survey showed that the condensation or evaporation data of R-448A or R-449A are very limited, and research on this issue is recommended.

• BMB Reports
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• v.53 no.5
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• pp.254-259
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• 2020

Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy-associated 4B (ATG4B) expression, which subsequently reduced the autophagy of T-cell lymphoma cells. Mechanistically, miR-449a decreased ATG4B protein level by binding to its mRNA 3'UTR, thus reducing the mRNA stability. In addition, studies with nude mice showed that miR-449a significantly inhibited lymphoma characteristics in vivo. In conclusion, our results demonstrated that the "miR-449a/ATG4B/autophagy" pathway played a vital role in the malignancy of T-cell lymphoma, suggesting a novel therapeutic target.

• Journal of the Korean Mathematical Society
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• v.48 no.3
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• pp.449-464
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• 2011

We show that, if R is a graded Noetherian ring and I is a proper ideal of R generated by n homogeneous elements, then any prime ideal of R minimal over I has h-height ${\leq}$ n, and that if R is a graded Noetherian domain with h-dim R ${\leq}$ 2, then the integral closure R' of R is also a graded Noetherian domain with h-dim R' ${\leq}$ 2. We also present a short improved proof of the result that, if R is a graded Noetherian domain, then the integral closure of R is a graded Krull domain.

• Asian-Australasian Journal of Animal Sciences
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• v.2 no.3
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• pp.449-451
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• 1989

• Structural Engineering and Mechanics
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• v.12 no.4
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• pp.449-457
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• 2001

In the design of industrial chimneys and towers, structural engineers must assume a level of the inherent damping in the structures. In order to better estimate the dynamic response of those structures, actual damping was measured from wind-induced vibration signals of chimneys and towers and its characteristics with respect to the response levels, the structural systems, and the wind direction were discussed. Damping ratio and natural frequency for three chimneys and two towers were calculated using random decrement technique.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.2
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• pp.449-454
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• 2010

In this paper, flow characteristics of R600a in an adiabatic capillary tube were investigated employing the homogeneous flow model. The model is based on fundamental equations of mass, energy and momentum which are solved simultaneously. Two friction factors(Churchill) and viscosity(McAdams) are comparatively used to investigate the flow characteristics. Thermodynamic and transport properties of R600a are calculated employing EES property code. Flow characteristics analysis of R600a in an adiabatic capillary tube is presented to offer the basic design data for the operating parameters. The operating parameters considered in this study include condensation temperature, evaporation temperature, subcooling degree and inner diameter tube of the adiabatic capillary tube. The main results were summarized as follows: condensation and evaporation temperature, inlet subcooling degree and inner diameter tube of an adiabatic capillary tube using R600a have an effect on length of an adiabatic capillary tube. The length of an adiabatic capillary tube using R600a is expressed to the correlation shown in Eq. (15).

• Communications of the Korean Mathematical Society
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• v.18 no.3
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• pp.449-457
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• 2003

On the setting of the upper half-space of the Euclidean space $R^{n}$, we show that to each weighted harmonic Bergman function $u\;\epsilon\;b^p_{\alpha}$, there corresponds a unique conjugate system ($upsilon$_1,…, $upsilon_{n-1}$) of u satisfying $upsilon_j{\epsilon}\;b^p_{\alpha}$ with an appropriate norm bound.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09a
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• pp.448-449
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• 2005

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.449-458
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• 2019

Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.

• Journal of Power Electronics
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• v.11 no.4
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• pp.449-455
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• 2011

Electric drive vehicles (EDV) have received much attention recently because of their environmental and energy benefits. In an EDV, the motor drive system directly influences the performance of the propulsion system. However, the available DC voltage is limited, which limits the maximum speed of the motors. At high speeds, the inverter voltage increases if the square wave (SW) voltage (six-step operation) is used. Although conventional direct torque control (DTC) has several advantages, it cannot work in the six-step mode required in high-speed applications. In this paper, a single-mode seamless DTC for AC motors is proposed. In this scheme, the trajectory of the reference flux changes continuously between circular and hexagonal paths. Therefore, the armature voltage changes smoothly from a high-frequency switching pattern to a square wave pattern without torque discontinuity. In addition, because multi-mode controllers are not used, implementation is more straightforward. Simulation results show the voltage pattern changes smoothly when the motor speed changes, and consequently, torque control without torque discontinuity is possible in the field weakening area even with a six-step voltage pattern.