• 한국산학기술학회논문지
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• 제20권1호
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• pp.21-27
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• 2019

그간 소형 제빙기에는 R-404A가 사용되어 왔으나 지구 온난화와 관련하여 대체 냉매 적용이 시급한 실정이다. 본 연구에서는 제빙기에 적용되어 온 R-404A를 대체할 R-448A와 R-449A에 대하여 drop-in test를 수행하였다. 시험은 외기 온도와 증발판에 공급되는 물 온도를 변화시키며 수행되었다. 실험 결과 R-404A의 일 평균 제빙량은 R-448A보다는 5.3%, R-449A보다는 4.2% 크게 나타났다. 이는 R-404A의 기체 밀도가 커서 냉매 순환량이 증가하기 때문으로 판단된다. 한편 R-448A와 R-449A의 제빙량을 비교하면 외기온도나 믈 온도가 낮아 제빙량이 많으면 R-448A가, 외기 온도나 물 온도가 높으면 R-449A가 우수한 성능을 보인다. 일 평균 소비 전력량은 R-448A나 R-449A보다 R-404A에서 대략 10% 크게 나타났다. 한편 성적계수의 경우 R-448A와 R-449A는 거의 동일하고 R-404A의 값보다는 3.0% 크게 나타났다. 현재 R-448A, R-449A의 증발, 응축 열전달에 대한 데이터가 부족한 실정으로 향후 이 부분에 대한 기초 연구가 필요할 것으로 판단된다.

• BMB Reports
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• 제53권5호
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• pp.254-259
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• 2020

Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy-associated 4B (ATG4B) expression, which subsequently reduced the autophagy of T-cell lymphoma cells. Mechanistically, miR-449a decreased ATG4B protein level by binding to its mRNA 3'UTR, thus reducing the mRNA stability. In addition, studies with nude mice showed that miR-449a significantly inhibited lymphoma characteristics in vivo. In conclusion, our results demonstrated that the "miR-449a/ATG4B/autophagy" pathway played a vital role in the malignancy of T-cell lymphoma, suggesting a novel therapeutic target.

• 대한수학회지
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• 제48권3호
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• pp.449-464
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• 2011

We show that, if R is a graded Noetherian ring and I is a proper ideal of R generated by n homogeneous elements, then any prime ideal of R minimal over I has h-height ${\leq}$ n, and that if R is a graded Noetherian domain with h-dim R ${\leq}$ 2, then the integral closure R' of R is also a graded Noetherian domain with h-dim R' ${\leq}$ 2. We also present a short improved proof of the result that, if R is a graded Noetherian domain, then the integral closure of R is a graded Krull domain.

• Asian-Australasian Journal of Animal Sciences
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• 제2권3호
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• pp.449-451
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• 1989

• Structural Engineering and Mechanics
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• 제12권4호
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• pp.449-457
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• 2001

In the design of industrial chimneys and towers, structural engineers must assume a level of the inherent damping in the structures. In order to better estimate the dynamic response of those structures, actual damping was measured from wind-induced vibration signals of chimneys and towers and its characteristics with respect to the response levels, the structural systems, and the wind direction were discussed. Damping ratio and natural frequency for three chimneys and two towers were calculated using random decrement technique.

• 한국산학기술학회논문지
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• 제11권2호
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• pp.449-454
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• 2010

본 논문은 균질유동모델을 적용하여 단열 모세관내 R600a의 유동 특성을 이론적으로 조사하였다. 이 모델은 시뮬레이션 해석에 필요한 기본적인 질량, 에너지, 운동량 방정식에 근거하고 있다. 또한 2개의 마찰인자와 점성계수모델을 이용하여 유동특성을 조사하였다. R600a의 열역학 및 전달 물성치는 EES 물성치 코드를 이용하여 계산하였다. 작동변수들에 대한 기초 설계자료를 제공하고자 단열 모세관내 R600a의 유동 특성을 분석하였다. 본 연구의 작동변수에는 응축온도, 증발온도, 과냉각도, 모세관의 직경이 있다. 주요 결과를 요약하면 다음과 같다. R600a용 단열 모세관내 응축온도, 증발온도, 과냉각도, 관직경은 모세관 전체길이에 영향을 준다. 즉 R600a용 모세관 전체길이는 식(15)와 같은 상관식으로 나타낸다.

• 대한수학회논문집
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• 제18권3호
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• pp.449-457
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• 2003

On the setting of the upper half-space of the Euclidean space $R^{n}$, we show that to each weighted harmonic Bergman function $u\;\epsilon\;b^p_{\alpha}$, there corresponds a unique conjugate system ($upsilon$_1,…, $upsilon_{n-1}$) of u satisfying $upsilon_j{\epsilon}\;b^p_{\alpha}$ with an appropriate norm bound.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2005년도 학술발표회(1)
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• pp.448-449
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• 2005

• The Korean Journal of Physiology and Pharmacology
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• 제23권6호
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• pp.449-458
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• 2019

Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.

• Journal of Power Electronics
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• 제11권4호
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• pp.449-455
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• 2011

Electric drive vehicles (EDV) have received much attention recently because of their environmental and energy benefits. In an EDV, the motor drive system directly influences the performance of the propulsion system. However, the available DC voltage is limited, which limits the maximum speed of the motors. At high speeds, the inverter voltage increases if the square wave (SW) voltage (six-step operation) is used. Although conventional direct torque control (DTC) has several advantages, it cannot work in the six-step mode required in high-speed applications. In this paper, a single-mode seamless DTC for AC motors is proposed. In this scheme, the trajectory of the reference flux changes continuously between circular and hexagonal paths. Therefore, the armature voltage changes smoothly from a high-frequency switching pattern to a square wave pattern without torque discontinuity. In addition, because multi-mode controllers are not used, implementation is more straightforward. Simulation results show the voltage pattern changes smoothly when the motor speed changes, and consequently, torque control without torque discontinuity is possible in the field weakening area even with a six-step voltage pattern.