• BMB Reports
• /
• 제53권4호
• /
• pp.223-228
• /
• 2020

Dysregulation of histone deacetylase 6 (HDAC6) can lead to the pathologic states and result in the development of various diseases including cancers and inflammatory diseases. The objective of this study was to elucidate the regulatory role of microRNA-22 (miR-22) in HDAC6-mediated expression of pro-inflammatory cytokines in lipopolysaccharide (LPS)-stimulated macrophages. LPS stimulation induced HDAC6 expression, but suppressed miR-22 expression in macrophages, suggesting possible correlation between HDAC6 and miR-22. Luciferase reporter assays revealed that 3'UTR of HDAC6 was a bona fide target site of miR-22. Transfection of miR-22 mimic significantly inhibited LPS-induced HDAC6 expression, while miR-22 inhibitor further increased LPS-induced HDAC6 expression. LPS-induced activation of NF-κB and AP-1 was inhibited by miR-22 mimic, but further increased by miR-22 inhibitor. LPS-induced expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 was inhibited by miR-22 mimic, but further increased by miR-22 inhibitor. Taken together, these data provide evidence that miR-22 can downregulate LPS-induced expression of pro-inflammatory cytokines via suppression of NF-κB and AP-1 axis by targeting HDAC6 in macrophages.

• Journal of Advanced Marine Engineering and Technology
• /
• 제22권2호
• /
• pp.210-218
• /
• 1998

Experimental results for forced convection condensationof Refrigerant-22 and ternary Refrigerant-407c(HFC-32/125/134a 23/25/52 wt%) considered as a substitute R-22 inside horizontal micor-fin tubes are presented. The test section was horizontal double-tubed counterflow condenser with a length 4000 mm micro-fin tube having 9.53 mm OD., 0.2 mm fin height and 60 fins. The refrigerants R-22 and R-407c were cooled by a coolant circulated in a surrounding annulus. The range of parameters of mass velocity was varied from 102.1 to 301.0kg/($\textrm{m}^{2}.s$) with inlet quality 1.0. Both refrigerant R-22 and its alternative refrigerant R-407c were tested within the same range of parameters. At the given experimental conditions for R-22 and R-407c the pressure drops for R-407c were considerably higher than those for R-22 at micro-fin tubes. Over the mass velocity range tested the PF(penalty factor)was lower than the increasing ratio of heat transfer area by fins. Based on the data correlation was proposed for predicting the frictional pressure drops for R-22 and R-407c for a duration of condensation inside a horizontal micro-fin tube.

• Journal of Advanced Marine Engineering and Technology
• /
• 제32권4호
• /
• pp.542-549
• /
• 2008

The evaporation heat transfer coefficient and pressure drop of R-22 and R-407C in a horizontal copper tube were investigated experimentally. The main components of the refrigerant loop are a receiver, a compressor, a mass flow meter, a condenser and a double pipe type evaporator (test section). The test section consists of a smooth copper tube of 6.4 mm inner diameter. The refrigerant mass fluxes were varied from 100 to $300\;kg/m^2s$ and the saturation temperature of evaporator were $5^{\circ}C$. The evaporation heat transfer coefficients of R-22 and R-407C increase with the increase of mass flux and vapor quality. The evaporation heat transfer coefficients of R-22 is about $5.68{\times}46.6%$ higher than that of R-407C. The evaporation pressure drop of R-22 and R-407C increase with the increase of mass flux. The pressure drop of R-22 is similar to that of R-407C. In comparison with test results and existing correlations, correlations failed to predict the evaporation heat transfer coefficient of R-22 and R-407C. therefore, it is necessary to develope reliable and accurate predictions determining the evaporation heat transfer coefficient of R-22 and R-407C in a horizontal tube.

• Archives of Pharmacal Research
• /
• 제15권4호
• /
• pp.374-375
• /
• 1992

The marine sterol (22R, 23R)-methylenecholesterol 1 has been synthesized from readily available C-22 steroidal ester 2 utilizing an intermolecular acyclic ester enolate alkylation as the key step.

• 동력기계공학회지
• /
• 제12권4호
• /
• pp.26-31
• /
• 2008

The evaporation heat transfer coefficient and pressure drop of R-22 and R-407C in a small diameter copper tube were investigated experimentally. The main components of the refrigerant loop are a receiver, a compressor, a mass flow mete, a condense and a double pipe type evaporate (test section). The test section consists of a smooth copper tube of 4.3 mm inner diameter. The refrigerant mass fluxes were varied from 100 to $300[kg/m^{2}s]$ and the saturation temperature of evaporator were $5[^{\circ}C]$. The evaporation heat transfer coefficients of R-22 and R-407C increase with the Increase in mass flux and vapor quality. The evaporation heat transfer coefficient of R-22 is about $7.3\sim47.1%$ higher than that of R-407C. The evaporation pressure drop of R-22 and R-407C increase with the increase of mass flux. The pressure drop of R-22 is about $8\sim20%$ higher than that of R-407C.

• 설비공학논문집
• /
• 제16권5호
• /
• pp.444-451
• /
• 2004

Flow condensation heat transfer coefficients (HTCs) of R22, R134a, R407C, and R410A were measured on horizontal plain and microfin tubes. The experimental apparatus was composed of three main parts; a refrigerant loop, a water loop and a water/glycol loop. The test section in the refrigerant loop was made of both a plain and a microfin copper tube of 6.0∼6.16 mm inside diameter and 1.0 m length. Refrigerants were cooled by passing cold water through an annulus surrounding the test section. Tests were performed at a fixed refrigerant saturation temperature of 4$0^{\circ}C$ with mass fluxes of 100, 200, and 300 kg/m2s. Test results showed that at similar mass flux the flow condensation HTCs of R134a were similar to those of R22 for both plain and microfin tubes. On the other hand, HTCs of R407C were lower than those of R22 by 4∼16% and 16∼42% for plain and microfin tubes respectively. And HTCs of R410A were similar to those of R22 for a plain tube but lower than those of R22 by 3∼9% for a microfin tube. Heat transfer enhancement factors of a microfin tube were 1.3∼1.9.

• 설비공학논문집
• /
• 제14권7호
• /
• pp.575-583
• /
• 2002

In this study, condensation heat transfer tests were conducted in flat aluminum multi-channel tubes using R-410A, and the results are compared with those of R-22. Two internal geometries were tested; one with a smooth inner surface and the other with micro-fins. Data are presented for the following range of variables; vapor quality (0.1~0.9), mass flux (200~600 kg/$m^2$s) and heat flux (5~15 ㎾/$m^2$). Results show that the effect of surface tension drainage on the fin surface is more pronounced for R-22 than R-410A. The smaller Weber number for R-22 may be responsible. For the smooth tube, the heat transfer coefficient of R-410A is slightly larger than that of R-22. For the micro-fin tube, however, the reverse is true. Possible reasoning is provided considering the physical properties of the refrigerants. For the smooth tube, a correlation of Akers et at. type predicts the data reasonably well. For the micro-fin tube, the Yang and Webb model was modified to correlate the present data.

• Journal of Advanced Marine Engineering and Technology
• /
• 제20권3호
• /
• pp.91-100
• /
• 1996

Experimental results for forced convection condensation of non-azeotropic refrigerant mixtures inside a horizontal smooth tube are presented. The mixtures of R-22+R-134a and pure refrigerants R-22 and R-134a are used as the test fluids and a double pipe heat exchanger of 7.5mm ID and 4800mm long inside tube is used. The range of parameters are 100-300kg/h of mass flow rate, 0-1.0 of quality, and 0, 33, 50, 67, and 100 weight percent of R-22 mass fraction in the mixtures. The heat flux, vapor pressure, vapor temperature and tube wall temperature were measured. Using the data, the local and average heat transfer coefficients for the condensation have been obtained. In the same given experimental conditions, the liquid heat transfer coefficients for NARMs were considerally lower than that of the pure refrigerant of R-22 and R-134a. Local heat transfer characteristics for NARMs were different from pure refrigerant R-22 and R-134a. In some regions, local heat transfer coefficients for NARMs were increased in the following order ; Bottom$\rightarrow$Top$\rightarrow$Side. The condensation heat transfer coefficients for NARMs increased with mass velocity, heat flux, and quality, but were considerably lower than that of pure refigerant R-22 and R-134a.

• 에너지공학
• /
• 제15권4호
• /
• pp.243-249
• /
• 2006

본 실험적 연구는 슬릿휜-관열교환기의 냉매측 압력강하에 대하여 수행하였다. 응축기의 설계조건에서 미세휜관내 냉매 R22와 R134a의 압력강하에 대한 실험데이터와 앞서 제안한 상관관계식과 상호 비교하였다. 실험은 냉매 R22와 Rl34a의 응축기 입구온도 $60^{\circ}C$, 질량유속 $150{\sim}250\;kg/m^{2}s$ 범위에서 수행하였다. 공기의 유입조건은 건구온도 $35^{\circ}C$, 상대습도 40%이며, 공기유속의 범위는 $0.68{\sim}1.43\;m/s$이다. 실험결과 응축기의 과냉도 $5^{\circ}C$ 조건에서 R134a의 압력강하는 R22보다 $22{\sim}22.6%$ 높게 나타났으며, 냉매의 질량유속 $200{\sim}250\;kg/m^{2}s$의 범위에서 실험으로부터 측정한 R22와 Rl34a의 압력강하는 예측결과와 ${\pm}20%$내에 일치하였다.

• 설비공학논문집
• /
• 제16권1호
• /
• pp.42-53
• /
• 2004

An experimental study on the refrigerant-side pressure drop of slit fin-tube heat exchanger has been carried out. A comparison was made between the predictions of previously proposed empirical correlations and experimental data for the pressure drop on design conditions of condenser in micro-fin tube for R22 and its alternatives, R407C (R32/125/134a, 23/25/52 wt.％) and R410A (R32/125, 50/50 wt.％). Experiments were carried out under the conditions of inlet refrigerant temperature of 6$0^{\circ}C$ and mass fluxes varying from 150 to 250 kg/$m^2$s for R22, R407C and R410A. The inlet air conditions are dry bulb temperature of 35$^{\circ}C$, relative humidity of 40% and air velocity varying from 0.68 to 1.43 m/s. Experiments show that pressure drop for R410A and R407C were 17.8∼20.2％ and 5∼6.8％ lower than those of R22 respectively for the degree of subcooling of 5$^{\circ}C$. For the mass fluxes of 200∼250 kg/$m^2$s, the deviation between the experimental and predicted values for the pressure drop was less than $\pm$20％ for R22, R407C and R410A.