• Clinical and Experimental Reproductive Medicine
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• 제31권3호
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• pp.183-190
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• 2004

Objectives: Methylenetetrahydrofolate reductase (MTHFR) mutation are commonly associated with hyperhomocysteinemia, and through their defects in homocysteine metabolism, they have been implicated as a risk factor for recurrent spontaneous abortion. Recent report describe that 28-bp tandem repeat polymorphism in thymidylate synthase enhancer region (TSER) that influence enzyme activity would affect plasma homocysteine level. We have investigated the relationship between TSER genotype and plasma homocysteine level in 54 patients with recurrent spontaneous abortion. Methods: Plasma homocysteine level was measured by fluorescent polarizing immunoassay. MTHFR mutation (C677T and A1298C) was identified by PCR-restriction fragment length polymorphism assay and TSER mutation was analyzed by PCR method. The data were analyzed using the program SAS 8.2 for Windows. Results: Total homocysteine level was significantly higher in MTHFR 677TT genotype ($9.80{\pm}3.87{\mu}mol/L$) than MTHFR 677CC genotype ($8.14{\pm}1.74{\mu}mol/L$) in Korean patients with unexplained recurrent spontaneous abortion (p=0.0143). However, the plasma homocysteine level was not significantly different in the MTHFR 1298AA ($8.42{\pm}2.65{\mu}mol/L$) and 1298CC ($6.09{\pm}0.32{\mu}mol/L$; p=0.2058) and, TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and 3R3R ($8.05{\pm}2.81{\mu}mol/L$; p=0.9319) mutant genotypes, respectively. In this study, we found the combination effects of TSER and MTHFR C677T genotypes. Plasma homocysteine levels were the highest ($11.47{\pm}4.66{\mu}mol/L$) in individuals with TSER 3R3R ($8.05{\pm}2.81{\mu}mol/L$) and MTHFR 677TT ($9.80{\pm}3.87{\mu}mol/L$) genotypes. Individuals with a combination of both TSER 2R2R/2R3R and MTHFR 677CC/CT genotypes ($7.69{\pm}1.77{\mu}mol/L$) had lower plasma homocysteine levels than TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and MTHR 677CC ($8.14{\pm}1.74{\mu}mol/L$) genotypes, respectively. The effect of MTHFR polymorphism in the homocysteine metabolism appears to be stronger than that of TSER polymorphism. Conclusion: Although statistically not significant, we found the elevated level of plasma homocysteine in combined genotypes with TSER and MTHFR (C677T and A1298C) in Korean patients with unexplained habitual abortion. In this study, we reported the possibility that TSER polymorphism is a genetic determinant of plasma homocysteine levels in the Korean patients as well as MTHFR C677T polymorphism. A large prospective study is needed to verify our findings.

• 한국전자파학회논문지
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• 제28권7호
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• pp.571-575
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• 2017

논문은 $0.13{\mu}m$ TSMC CMOS 공정을 이용한 위상 배열 안테나의 C-대역 양방향 T/R 칩셋에 관한 연구이다. 위상 배열 안테나의 필수 부품인 T/R 칩셋은 6 비트 위상변위기, 6 비트 가변 감쇄기, 양방향 증폭기로 구성하였다. 위상 변위기의 경우 정밀한 빔 조향을 위해서 $5.625^{\circ}$의 간격으로 최대 $354^{\circ}$까지 제어가 가능하며, 측엽 레벨을 제어하기 위한 가변 감쇄기는 0.5 dB 간격으로 최대 31.5 dB까지 감쇄가 가능하다. 또한, 1.2 V의 안정적인 전원공급을 위한 LDO(Low Drop Output) 레귤레이터와 디지털 회로의 제어가 간편하도록 SPI(Serial Peripheral Interface)를 집적화 하였으며, 칩 크기는 패드를 포함하여 $2.5{\times}1.5mm^2$이다.

• 대한수학회논문집
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• 제9권3호
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• pp.687-700
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• 1994

Throughout this paper we will let H denote the complete Heyting algebra ($H, \vee, \wedge, *$) with order reversing involution *. 0 and 1 denote the supermum and the infimum of $\emptyset$, respectively. Given any set X, any element of $H^X$ is called H-fuzzy set (or, simply f.set) in X and will be denoted by small Greek letters, such as $\mu, \nu, \rho, \sigma$. $H^X$ inherits a structure of H with order reversing involution in natural way, by definding $\vee, \wedge, *$ pointwise (sam notations of H are usual). If $f$ is a map from a set X to a set Y and $\mu \in H^Y$, then $f^{-1}(\mu)$ is the f.set in X defined by f^{-1}(\mu)(x) = \mu(f(x))$. Also for $\sigma \in H^X, f(\sigma)$ is the f.set in Y defined by $f(\sigma)(y) = sup{\sigma(x) : f(x) = y}$ ([4]). A preorder R on a set X is reflexive and transitive relation on X, the pair (X,R) is called preordered set. A map $f$ from a preordered set (X, R) to another one (Y,T) is said to be preorder preserving (inverting) if for $x,y \in X, xRy$ implies $f(x)T f(y) (resp. f(y)Tf(x))$. For the terminology and notation, we refer to [10, 11, 13] for category theory and [7] for H-fuzzy semitopogenous spaces.

• 천문학회지
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• 제29권spc1호
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• pp.151-154
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• 1996

We examine the observations of large-scale magnetic fields in the Universe. We begin at the largest scale with clusters of galaxies and work our way down through galaxies and finally to the Milky Way. on which we concentrate in detail. We examine the observations of the Galactic magnetic field, and their interpretation, under the philosophy that the Galactic magnetic field is like that in other spiral galaxies. We use pulsar data. diffuse Galactic synchrotron emission, and starlight polarization data to discuss the Galaxy's global magnetic configuration and the uniform ($B_u$), random ($B_r$), and total ($B_t$) components of the field strength. We find disagreement among conclusions derived from the various data sets and argue that the pulsar data are not the best indicator for large-scale Galactic field. Near the Solar circle, we find that the azimuthal average of $B_t$ is 4.2$\mu$G and we adopt $B_u\~$2.2 and $B_r\~3.6{\mu}G$. $B_t$ is higher in spiral arms, reaching $\~5.9{\mu}G$. $B_t$ is higher for smaller $R_{Gal}$, reaching $\~8.0{\mu}G$ for $R_{Gal}$ = 4.0 kpc. The pattern of field lines is not concentric circles but spirals. The inclination of the magnetic spiral may be smaller than that of the Galaxy's spiral arms if our sample, which refers primarily to the interarm region near the Sun, is representative. However, it is not inconceivable that the local field lines follow the Galaxy's spiral pattern, as is observed in external galaxies.

• Structural Engineering and Mechanics
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• 제60권6호
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• pp.1021-1038
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• 2016

Considerable part of reinforced concrete building has suffered from destructive earthquakes in Turkey. This situation makes necessary to determine nonlinear behavior and seismic performance of existing RC buildings. Inelastic response of buildings to static and dynamic actions should be determined by considering both flexural plastic hinges and brittle shear hinges. However, shear capacities of members are generally neglected due to time saving issues and convergence problems and only flexural response of buildings are considered in performance assessment studies. On the other hand, recent earthquakes showed that the performance of older buildings is mostly controlled by shear capacities of members rather than flexure. Demand estimation is as important as capacity estimation for the reliable performance prediction in existing RC buildings. Demand estimation methods based on strength reduction factor (R), ductility (${\mu}$), and period (T) parameters ($R-{\mu}-T$) and damping dependent demand formulations are widely discussed and studied by various researchers. Adopted form of $R-{\mu}-T$ based demand estimation method presented in Eurocode 8 and Turkish Earthquake Code-2007 and damping based Capacity Spectrum Method presented in ATC-40 document are the typical examples of these two different approaches. In this study, eight different existing RC buildings, constructed before and after Turkish Earthquake Code-1998, are selected. Capacity curves of selected buildings are obtained with and without considering the brittle shear capacities of members. Seismic drift demands occurred in buildings are determined by using both $R-{\mu}-T$ and damping based estimation methods. Results have shown that not only capacity estimation methods but also demand estimation approaches affect the performance of buildings notably. It is concluded that including or excluding the shear capacity of members in nonlinear modeling of existing buildings significantly affects the strength and deformation capacities and hence the performance of buildings.

• Korean Journal of Mathematics
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• 제25권4호
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• pp.483-494
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• 2017

In the current manuscript, we investigate the pointwise convergence of the singular integral operators involving power nonlinearity given in the following form: $$T_{\lambda}(f;x)={\int_a^b}{\sum^n_{m=1}}f^m(t)K_{{\lambda},m}(x,t)dt,\;{\lambda}{\in}{\Lambda},\;x{\in}(a,b)$$, where ${\Lambda}$ is an index set consisting of the non-negative real numbers, and $n{\geq}1$ is a finite natural number, at ${\mu}$-generalized Lebesgue points of integrable function $f{\in}L_1(a,b)$. Here, $f^m$ denotes m-th power of the function f and (a, b) stands for arbitrary bounded interval in ${\mathbb{R}}$ or ${\mathbb{R}}$ itself. We also handled the indicated problem under the assumption $f{\in}L_1({\mathbb{R}})$.

• 약학회지
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• 제42권1호
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• pp.82-88
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• 1998

The effect of hepatoprotective agents and bile acids on tumor necrosis factor-alpha, (TNF-${\alpha}$) production in murine and human macrophage cell line (RAW264.7 and U937) was inve stigated. The hepatoprotective agents including silymarin and its major component, silybin, significantly inhibited TNF-alpha production in a concentration dependent manner ($IC_50$ of silybin=67.7${\mu}g$/ml (140.3${\mu}g$M)). In differentiated U937 cells, especially, silybin showed more effective inbitory activity ($IC_50$=35.1${\mu}g$g/ml (72.7${\mu}g$M)). These results suggest that silymarin and silybin may inhibit TNF-alpha production in the process of hepatic diseases in human. However, biphenyldimethyl dicarboxylate (DDB) was not effective. In the case of bile acids, chenodeoxycholic acid (CDCA) showed a concentration dependent inhibitory effect on TNF-alpha production ($IC_50$ of CDCA= 71.5${\mu}g$g/ml (182.1${\mu}g$M)). In contrast, glycine or taurine conjugated form (G-CDCA or T-CDCA) restored to the control level or significantly increased TNF-${\alpha}$ production. And also ursodeoxycholic acid (UDCA) and its conjugated forms (G-UDCA and T-UDCA) showed a variety of patterns on TNF-${\alpha}$ production by changes of functional groups and concentration. These results also indicate that bile acids may regulate TNF-${\alpha}$ production in normal hepatic function or disease conditions.

• Journal of Radiation Protection and Research
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• 제19권2호
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• pp.121-132
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• 1994

본 연구는 대구지역의 지각 ${\gamma}$-선에 의한 조사선량율을 측정하고 그에 따른 성분별 공간선량율 및 지역적 분포 등의 환경방사선 특성을 조사하였다. ${\gamma}$-선 스펙트럼의 측정에는 $4^{'}{\phi}{\times}4^{'}$ NaI(T1) 계측기와 휴대용 다중파고분석장치를 이용하여 이 지역내의 28개 지점에서 in-situ spectrometry를 수행하였으며, 측정된 스펙트럼으로부터 조사선량율을 환산하여 지각 ${\gamma}$-선의 총선량율과 일반적으로 자연방사능의 주종이 되는 $^{40}K,\;^{238}U$ 계열 및 $^{232}Th$계열의 성분별 조사 선량율을 구하였다. 조사결과 대구지역의 지각 ${\gamma}$-선에 의한 평균조사선량율은 $9.4{\mu}R/h$였으며 지점별 분포는 $7.6{\sim}11.0{\mu}R/h$ 범위로 다소 차이를 보였다. 측정시에 수반되는 기후나 우주선 등에 따른 일 변화폭을 고려한다면 지점간의 차이는 주로 표토층의 자연방사성핵종인 $^{40}K,\;^{238}U$계열 및 $^{232}Th$ 계열의 핵종에 기인함을 알 수 있었으며, 성분별 선량율은 $^{40}K\;2.9{\sim}4.6{\mu}R/h,\;^{238}U$ 계열 $1.2{\sim}3,\;1{\mu}R/h,\;^{232}Th$ 계열 $2.5{\sim}5.0{\mu}R/h$의 분포를 나타냈다.

• 생물환경조절학회지
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• 제12권4호
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• pp.173-179
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• 2003

본 연구는 오이와 토마토의 플러그 묘 공정육묘시 발생하는 도장 억제를 위한 적생광 처리시기와 광도의 영향을 알아보기 위해 실험을 수행하였다. 일몰 휴, 야간 및 일출 전 적색광 처리시기에 의한 묘의 도장억제는 일몰 후 처리가 오이와 토마토의 초장을 각각 21.3%와 14.2%로 가장 크게 억제하였고, 경경의 굵기도 가장 두꺼웠다. 엽록소함량은 토마토에서만 일몰 후 처리된 플러스묘의 함량이 대조구에 비해 유의적으로 높게 나타났다. 적색광 초리시기에 의한 두 작물의 건물중을 보면, 대조구에 비해 지상부 건물중은 일몰 후와 일출 전 적색광 처리에 의해 유의적인 감소를 보였다. 오이와 토마토 플러그묘의 T/R율은 일몰 후 처리에서 타 처리에 비해 가장 작았으며 조ㅈ직의 충실도는 밀몰 후 처리에서 가장 크게 나타났다. 광도별 처리에 의한 초장은 오이와 토마토 플러그묘 모두에서 광도가 증가함에 따라 초장은 감소하였다. 하배출, 절간장 및 엽면적도 초장과 유사한 경향을 나타내었다. 두 작물 모두 경경과 엽록소함량 및 조직의 충실도는 광도가 증가함에 따라 증가하는 경향을 보였다. 하지만 지상부와 지하부의 건물율은 광도의 증가에 따라 감소하는 경향이 나타났으며, 오이는 2 및 8 ${\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$의 적색광 처리구에서 토마토는 8 ${\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$처리구에서 가장 낮은 T/R율을 나타내었다.

• Advances in Traditional Medicine
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• 제4권3호
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• pp.157-161
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• 2004

We showed the effects of the traditional herbal medicine, Jukyeoondam-tang (JO-T, Zhu-ru-Wen-Dan-Tang in Chinese), on ventricular arrhythmia induced by aconitine. Electrophysiological experiments with conventional microelectrode techniques revealed that JO-T potently suppressed the aconitine-induced arrhythmias in ventricular strips of the rat. In the aconitine-induced arrhythmia model of the rat, pretreatment with JO-T $(100\;{\mu}g/ml)$ completely occluded the appearance of ventricular tachyarrhythmia (VT) or ventricular fibrillation (VF) induced by aconitine. Furthermore, the aconitine-induced ventricular arrhythmia was occluded by $Na^+$ channel blocker quinidine but was not occluded by $K^+$ channel blocker glibenclamide $(3\;{\mu}mol/L)\;and\;Ca^{2+}$ channel blocker nifedipine $(10\;{\mu}mol/L)$. We also confirmed the effect of JO-T in the ischemia-reperfusion (I/R)-induced arrhythmia model of the rat. JO-T did not affect the I/R-induced arrhythmias in rats. JO-T may alleviate the risk of ventricular arrhythmias following aconitine. These results suggest that JO-T is a potent antiarrhythmic drug having a$Na^+$ channel-blocking action.