• Journal of Acupuncture Research
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• v.31 no.1
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• pp.121-130
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• 2014

Objectives : I investigated whether bee venom inhibit cell growth through enhancement of death receptor expressions in the human lung cancer cells, NCI-H460. Methods : Bee venom(1-5 ${\mu}g/ml$) inhibited the growth of NCI-H460 lung cancer cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of TNF-R1, TNF-R2, FAS, death receptors(DR) 3, 4, 5 and 6 was increased in the cells. Expression of DR downstream pro-apoptotic proteins including Caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-kB were inhibited by treatment with bee venom in NCI-H460 cells through TNF response change led by TNF-R1 and TNF-R2. Conclusions : These results suggest that bee venom should exert anti-tumor effect through induction of apoptotic cell death in NCI-H460 human lung cancer cells via enhancement of death receptor expression, and that bee venom could be a promising agent for preventing and treating lung cancer.

• Science of Emotion and Sensibility
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• v.16 no.2
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• pp.195-206
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• 2013

The main causes of traffic accidents while driving a car is of the driver's visual distraction. In this study, the color sensitivity of the information projected on the windshield were evaluated for HUD (Head Up Display) system which helps the driver's eyes on the road while driving. The driving Information were projected $9^{\circ}$ downward from front sight $0^{\circ}$ under lab's fluorescent lights, LED floorlights and the TV had having 25 [lux] illumination when driving at night environment and 100,000 [lux] of daylight environment. Munsell color hue of the basic five colors (R, Y, G, B, P) and the color of traffic lights YR, W were the color of the seven characters, each character were outlined by White, Gray except for W. Total of 19 experimental stimuli was shown in the environment of day and night driving for asking visibility information of color, fatigue, preferences, and evaluate the degree of interference. The results came out that the bright Y and G color is visibility significantly for daylight. Second, with the outline of the text, the color of the outline works as a background for luminance contrast effects and affects visibility. Third, without the outline, the glass in front of the vehicle acts as the background and the luminance contrast of characters achieve greater brightness and visibility. The luminance contrast between the stimuli and background should be considered for increasing color visibility for driving information which is an important factor for HUD commercialization.

• ALGAE
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• v.38 no.2
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• pp.93-110
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• 2023

Progress in phylogenomic analysis has led to a considerable re-evaluation of former cyanobacterial system, with many new taxa being established at different nomenclatural levels. The family Geminocystaceae is among cyanobacterial taxa recently described on the basis of polyphasic approach. Within this family, there are six genera: Geminocystis, Cyanobacterium, Geminobacterium, Annamia, Picocyanobacterium, and Microcrocis. The genus Geminocystis previously encompassed two species: G. herdmanii and G. papuanica. Herein, a new species G. urbisnovae was proposed under the provision of the International Code of Nomenclature for algae, fungi, and plants (ICN). Polyphasic analysis was performed for five strains from the CALU culture collection (St. Petersburg State University, Russian Federation), and they were assigned to the genus Geminocystis in accordance with high 16S rRNA gene similarity to existing species, as well as because of proximity to these species on the phylogenetic trees reconstructed with RaxML and Bayes methods. Plausibility of their assignment to a separate species of the genus Geminocystis was substantiated with smaller cell size; stenohaline freshwater ecotype; capability to complementary chromatic adaptation of second type (CA2); distinct 16S rRNA gene clustering; sequences and folding of D1-D1' and B box domains of the 16S-23S internal transcribed spacer region. The second objective pursued by this communication was to provide a survey of the family Geminocystaceae. The overall assessment was that, despite attention of many researchers, this cyanobacterial family has been understudied and, especially in the case of the crucially important genus Cyanobacterium, taxonomically problematic.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2007.05a
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• pp.85-88
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• 2007

A number of R, G and B LEDs for reference color temperature mixing ratio of RGB was determined by the theory of RGB mixing as a baseline. Once the number of LEDs was determined the objective color temperature from baseline has been achieved by the control the RGB duty ratio. And a practical prototype of 50W floodlighting adjusted by the above algorithm. The micro controller was developed with control algorithm for RGB duty ratio to obtain the objective color temperature. Detailed experiments to optimize algorithm of duty ratio and color temperature will be discussed in this paper as well.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.27 no.10
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• pp.653-656
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• 2014

$Cs_3Sb$ photocathode was formed by newly developed process and successive in-situ lighting devices were fabricated in a process chamber. R, G, and B phosphors were applied on the anode plate, respectively. Major parameters such as brightness, power consumption, and efficacy were measured. The wavelength of LED excitation source was 450 nm. Both high power and low power modes were applied in the measurement. Measurement values were clearly differentiated by the voltage application modes. The measured values of each parameter was good enough to be applied for general lighting source. The results showed that $Cs_3Sb$ photocathode formed in atmospheric conditions was functioning as good as the photocathode formed in UHV conditions, and thus it could be applied to advanced lighting devices.

• Journal of Ginseng Research
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• v.47 no.6
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• pp.706-713
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• 2023

Background and objective: The ability to inhibit aggregation has been demonstrated with synthetically derived ginsenoside compounds G-Rp (1, 3, and 4) and ginsenosides naturally found in Panax ginseng 20(S)-Rg3, Rg6, F4, and Ro. Among these compounds, Rk3 (G-Rk3) from Panax ginseng needs to be further explored in order to reveal the mechanisms of action during inhibition. Methodology: Our study focused to investigate the action of G-Rk3 on agonist-stimulated human platelet aggregation, inhibition of platelet signaling molecules such as fibrinogen binding with integrin α_IIbβ₃ using flow cytometry, intracellular calcium mobilization, dense granule secretion, and thromboxane B₂ secretion. In addition, we checked the regulation of phosphorylation on PI3K/MAPK pathway, and thrombin-induced clot retraction was also observed in platelets rich plasma. Key Results: G-Rk3 significantly increased amounts of cyclic adenosine monophosphate (cAMP) and led to significant phosphorylation of cAMP-dependent kinase substrates vasodilator-stimulated phosphoprotein (VASP) and inositol 1,4,5-trisphosphate receptor (IP₃R). In the presence of G-Rk3, dense tubular system Ca²⁺ was inhibited, and platelet activity was lowered by inactivating the integrin αIIb/β₃ and reducing the binding of fibrinogen. Furthermore, the effect of G-Rk3 extended to the inhibition of MAPK and PI3K/Akt phosphorylation resulting in the reduced secretion of intracellular granules and reduced production of TXA₂. Lastly, G-Rk3 inhibited platelet aggregation and thrombus formation via fibrin clot. Conclusions and implications: These results suggest that when dealing with cardiovascular diseases brought upon by faulty aggregation among platelets or through the formation of a thrombus, the G-Rk3 compound can play a role as an effective prophylactic or therapeutic agent.

• Journal of Sensor Science and Technology
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• v.24 no.2
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• pp.113-118
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• 2015

Intravenous (IV) infusion set is one of the most common treatment methods applied to hospitalized patients. However, it is necessary to check the injection of IV solution in order to prevent patients from any possible medical injuries. In this paper, using the optical sensors to detect exhaustion of IV solution was proposed. The optical sensor is coplanar structure composed of LED and photodiode which is installed according to focal distance of the lens. These two elements detect exhaustion of IV solution at the desired point conveniently. Through the results of experiments using various wavelength of LED (R.G.B), the blue LED was selected to the optimum light source. The suggested optical sensor can detect exhaustion of IV solution by the differences in the amount of light which is caused by properties such as total reflection, refractive index and scattering. From the implementation, the detector is applicable to both containers of IV solution, glass bottle and plastic pack. And also the result shows apparent differences according to existence of IV solution even if the IV solution color and illumination were changed.

• Electronics and Telecommunications Trends
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• v.38 no.1
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• pp.55-64
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• 2023

Recently, preparations for 6G have led to the increasing interest in integrated or hybrid communication networks considering low-orbit satellite communication networks with terrestrial mobile communication networks. In addition, the demand for frequency allocation for new mobile services from low-orbit small satellites to provide global internet of things (IoT) services is increasing. The operation of such satellites and terrestrial mobile communication networks may inevitably cause interference in adjacent bands and the same band frequency between satellites and terrestrial systems. Focusing on the results of the recent ITU-R WP4C meeting, this study introduces the current status of frequency sharing and interference issues between satellites and terrestrial systems, and frequency allocation issues for new mobile satellite operations. Coexistence and compatibility studies with terrestrial IMT in L band and 2.6 GHz band, operated by Inmassat and India, respectively, and a new frequency allocation study (WRC-23 AI 1.18) are carried out to reflect satellite IoT demand. For the L band, technical requirements have been developed for emission from IMT devices at 1,492 MHz to 1,518 MHz to bands above 1,518 MHz. Related studies in the 2 GHz and 2.6 GHz bands are not discussed due to lack of contributions at the recent meeting. In particular, concerning the WRC-23 agenda 1.18 study on the new frequency allocation method of narrowband mobile satellite work in the Region 1 candidate band 2,010 MHz to 2,025 MHz, Region 2 candidate bands 1,695 MHz to 1,710 MHz, 3,300 MHz to 3,315 MHz, and 3,385 MHz to 3,400 MHz, ITU-R results show no new frequency allocation to narrow mobile satellite services. Given the expected various collaborations between satellites and the terrestrial component are in the future, interference issues between terrestrial IMT and mobile satellite services are similarly expected to continuously increase. Therefore, participation in related studies at ITU-R WP4C and active response to protect terrestrial IMT are necessary to protect domestic radio resources and secure additional frequencies reflecting satellite service use plans.

• Journal of Bio-Environment Control
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• v.30 no.3
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• pp.196-205
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• 2021

This research was conducted in order to analyze the difference in yield through the changes in growth and measuring the photosynthesis efficiency in cherry tomatoes. Seedlings of cherry tomato 'Nonari' were used as scion and non-grafted control, while 4 different grafted tomatoes 'Powerguard', 'T1', 'L1', and 'B.blocking' were used as rootstocks. Plants grafted onto 'B.blocking' produced the highest fruit yield (417.5 g plant^-1), whereas non-grafted plant 'Nonari' had the lowest fruit yield, (354.2 g plant^-1) at the latter period of cherry tomatoes in May. The flowering position in May, plant grafted onto 'B.blocking', showed 14-17 cm, whereas non-grafted plant 'Nonari' showed 10-14 cm. The growth strength on May 15, non-grafted plant 'Nonari', showed 8.43 mm which was the lowest value among the treatments. Grafted plants kept the growth balance until the end of the harvest that led to an increase in fruit yield, while non-grafted plant weakened the vigor earlier that led to a decrease in fruit yield. Grafted plants showed higher values of chlorophyll fluorescence variables than the values of non-grafted plant. These results indicate that grafting influenced fruit yield which was observed as maintaining growth balance for longer and an increase in photosynthesis efficiency compared to non-grafting.

• Food Science of Animal Resources
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• v.42 no.6
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• pp.915-927
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• 2022

Recently, protein-fortified milk powders are being widely consumed in Korea to prevent sarcopenia, and the demand for high-protein food powders is continuously increasing in the Korean market. However, spray-dried milk proteins have poor flowability and wettability owing to their fine particle sizes and high inter-particle cohesive forces. Fluidized bed agglomeration is widely used to improve the instant properties of food powders. This study investigated the effect of fluidized bed agglomeration on whey protein isolate (WPI)-fortified skim milk powder (SMP) at different SMP/WPI ratios. The fluidized bed process increased the particle size distribution, and agglomerated particles with grape-like structures were observed in the SEM images. As the size increased, the Carr index (CI) and Hausner ratio (HR) values of the agglomerated WPI-fortified SMP particles exhibited excellent flowability (CI: <15) and low cohesiveness (HR: <1.2). In addition, agglomerated WPI-fortified SMP particles exhibited the faster wetting time than the instant criterion (<20 s). As a result, the rheological and physical properties of the WPI-fortified SMP particles were effectively improved by fluidized bed agglomeration. However, the fluidized bed agglomeration process led to a slight change in the color properties. The CIE L^* decreased, and the CIE b^* increased because of the Maillard reaction. The apparent viscosity (η_a,10) and consistency index (K) values of the rehydrated solutions (60 g/180 mL water) increased with the increasing WPI ratio. These results may be useful for formulating protein-fortified milk powder with better instant properties.