• Journal of Periodontal and Implant Science
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• v.33 no.3
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• pp.359-372
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• 2003

Among objectives of periodontal therapy. the principal one is the morphological and functional reconstruction of lost periodontal supporting tissues. This includes de novo formation of connective tissue attachment and the regrowth of alveolar bone. The use of enamel matrix derivative(EMD) may be a suitable means of regeneration new periodontal attachment in the infrabony defects. Implant used to replace lost tooth but, implantitis occurred after installation. The purpose of this study was to investigate the effects of EMD on differentiation and growth of osteoblast in titanium disc. Twentyfive millimeter diameter and 1mm thick Ti disc which was coated 25, 50, 100, 200${\mu}g$/ml of EMD(Emdogain(R)) used as experimental group, 25, 50, 100, 200ng/d of rhBMP-2 as positive control group, and no coat as negative control group. A human osteosarcoma cell line Saos-2 was cultured in Ti disc and cell proliferation and Alkaline phosphatase (ALP) activity were measured at 1 and 6 days. PCR was performed at 2 and 8 hours. Semi-quantitative RT-PCR for mRNA expressions of various osteoblastic differentiation markers -type I collagen, ALP, osteopontin, and bone sialoprotein - were performed at appropriate concentrations based upon the results of MTT and ALP assay. Cultured cell-disc complexes were prepared for scanning electron microscopy (SEM) at 2 hour. Data were analyzed using Mann-Whitney and repeated- measures 1-way analysis of variance(SPSS software version 10,SPSS. Chicago. IL). After culture, there was more osteoblast in EMD100${\mu}g$/ml than in EMD50, 200${\mu}g$/ml on day 6. There was significant difference in experimental and positive control group compared control group, as times go by(1 and 6 days). Alkaline phosphatase activity was different significantly in EMD100, 200${\mu}g$/ml and BMP100, 200${\mu}g$/ml on day 6. The results of reverse transcriptase-polymerase chain reaction (RT-PCR) showed that expression of mRNA for ALPase, collagen type I, osteopontin. hone sialoprotein and BMP-2 was detected at 2 hour and 8 hour in EMI 200${\mu}g$/ml subgroup and BMP100ng/ml subgroup. The results of this study suggest that application of enamel matrix derivative on osteoblast attached to titanium surface facilitate the expression of bone specific protein and the differentiation and growth of osteoblast.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.554-560
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• 2020

In the manufacturing process of flat panel displays, a high-precision planar motion stage is used to position a specimen. Stages of this type typically use frictionless linear motors and air bearings, and laser interferometers. Real-time dynamic correction of the yaw motion error is very important because the inevitable yaw motion error of the stage means a change in the specimen orientation. Gantry control is generally used to compensate for yaw motion errors. Flexure units that allow rotational motion are applied to the stage to apply this method to a stage using an air-bearing guide. This paper proposes a method to improve the constant speed motion performance of a H-type XY stage equipped with air bearing and flexure units. When applying the gantry control to the stage, including the flexure units, the cause of the mutual ripple generated from the linear motors is analyzed, and adaptive learning control is proposed to compensate for the mutual ripple. A simulation was performed to verify the proposed method. The speed ripple was reduced to approximately the 22 % level. The ripple reduction was verified by simulating the stage state where yaw motion error occurs.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.7
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• pp.854-867
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• 2014

In the circumstance that high oil price state is continued over the world, the investment in crude oil development by oil major is a trend of increasing. Recently the number of delivered drill-ship for 5 years has been sharply increased all over the world and about twice than that of past 30 years. As addition to the increase of the drill-ship demand, the operation of drill-ships which is delivered recently is about 3,000 meters, ultra deep sea, on average and the work area is expending. Accordingly the drilling system including the size and length of pipe for drilling has been bigger and bigger and the power supply equipment for operation system also has large capacity. Unlike merchant vessel, high power and high voltage of diesel generators are required for drill-ship for which the demand for V-type 320 bore of diesel generator has increased. It is on the raised that the importance of lubrication oil cleaning for diesel generator on drill-ship which has longer time for construction, and also long term low load operation is unavoidable during commissioning of equipments. Recently it was reported that engine crankpin was damaged due to the hard contact caused by the abnormal wear down(Cam wear) on crankpin and bearing. The same pattern of wear down was found through the inspection on series vessels and the other vessel under commissioning. The purpose of this paper is to analyze of the wear mechanism based on the observation and theories and objective research from actual cases and to prepare the counter measures to avoid foreseeable damage when the lubricating oil is not properly cleaned.

• Journal of Energy Engineering
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• v.21 no.4
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• pp.339-345
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• 2012

RMembrane LNG storage tanks have been recently investigated to replace full-containment LNG storage tanks because of safety and cost aspects. Quantitative Risk Analysis (QRA) and Finite Element Method (FEM) were used to evaluate safety of membrane LNG storage tanks. In this study, structural safety evaluation results via FEM analysis showed that both membrane type and full-containment type cryogenic LNG storage tanks with 140,000 $m^3$ capacity were equivalently safe in terms of strength safety and leakage safety of a storage tank system. Also, Fault Tree Analysis (FTA) was used to improve the safety of membrane LNG storage tanks and membrane LNG tanks were modified by adding three safety equipments: impact absorber structure for the low part of the membrane, the secondary barrier to diminish the thermal stress of the corner part of the outer tank, and a pump catcher in case of falling of a pump. Consequently, the safety of the modified membrane LNG storage tanks were proved to be equivalent to that of full-containment LNG storage tanks.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.295-301
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• 2017

Botulinum neurotoxin (BoNT/A) is a neurotoxin that selectively attacks the peripheral cholinergic nerve endings. It is produced by Gram -positive, endospore-forming strict anaerobic bacteria, Clostridium botulinum. Since BoNT/A could be a biothreat agent, as well as a contaminator of food and water supplies, the development of sensitive assays for toxin detection and potent antitoxin for the treatment of intoxication is necessary. In this study, for the purpose of producing monoclonal antibodies (mAbs) that are capable of neutralizing Botulinum neurotoxin type A (BoNT/A), scFv (single-chain variable domain fragment) libraries from the rabbit antisera against BoNT/A was fused to a human IgG. The resulting recombinant scFvIgG antibody protein was expressed in stable cell lines and was purified using a protein A affinity chromatography. The efficacy of scFvIgG mAb was confirmed by ELISA and was evaluated for the neutralization of BoNT/A in vivo. Such an in vivo toxin neutralization assay was performed using mice. Although scFvIgG antibody proteins (10 ug) failed to fully protect the mice challenged with BoNT/A (100,000 $LD_{50}$), it significantly prolonged the survival time. These results suggest that scFvIgG mAb may be capable of neutralizing BoNT/A single-chain variable domain fragment.

• Journal of Advanced Navigation Technology
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• v.21 no.2
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• pp.171-178
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• 2017

In this paper, in order to verify the performance of a localization algorithm using GPS as an auxiliary sensor, the algorithm was applied to a hovering-type autonomous underwater vehicle (AUV) to perform a field test. The applied algorithm is an algorithm to improve the accumulated positional error of dead reckoning using doppler velocity logger(DVL) and tilt-compensated compass module (TCM) mounted on the AUV. GPS when surfaced helps the algorithm to estimate the position and the heading bias error of TCM for geodetic north, which makes it possible to perform dead reckoning on north-east-down (NED) coordinates. As a result of field test performing heading control, it was judged that the algorithm could improve the positional error, enhance the operational capability of AUV and contribute to the research of underwater navigation depending on a magnetic compass.

• Journal of Korea Water Resources Association
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• v.51 no.3
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• pp.195-205
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• 2018

Drought is a complex phenomenon caused by various factors which can be classified into natural and anthropogenic causes. In Korea, the natural drought typically occurs when the high pressure of the Pacific Ocean develops rapidly or becomes stronger than usual in summer, resulting in a short-lived monsoon season. Drought also can be classified into meteorological, agricultural, hydrological, and socioeconomic drought depending on the development process and consequences. Each type of droughts can influence the other drought types directly or indirectly. Drought propagation refers a phenomenon that changes from meteorological drought to agricultural or hydrological drought. In this study, the occurrence and patterns of drought propagation are evaluated. The relationship between meteorological and agricultural droughts was assessed using hydrometeorological data. We classified the types of drought into five categories to evaluate the occurrence and characteristics of drought propagation. As results, we found drought propagation did not occur or delayed until three months, depending on the type of drought. The further generalized relationship of drought propagation is expected to be used for predicting agricultural drought from the preceding meteorological drought.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.7
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• pp.957-962
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• 2002

In July, three trials were conducted to evaluate the best sponge type and optimum PMSG dose to be administered to sheep under the Jordanian Badia (arid) conditions. In trial 1, three flocks (n=77, n=18 and n=47 for flocks 1, 2 and 3, respectively) were administered with 40 mg fluorogestone acetate (FGA) intravaginal sponges for 12 days before receiving 600 IU of PMSG at the time of sponge removal. In trial 2, 95 ewes were assigned to 4 groups to receive 300 (n=25), 450 (n=27), 600 (n=22) or 750 (n=21) IU of PMSG following a 12 d FGA 40 mg sponge insertion period. In trial 3, 60 ewes were assigned to 3 groups (n=20) to receive either FGA 30 mg, FGA 40 mg or medroxyprogesterone acetate (MAP) 60 mg intravaginal sponges all followed by an administration of 600 IU of PMSG at sponge removal. In all trials, rams were isolated 1 day before sponge insertion and were allowed back with the ewes at sponge removal. Estrual responses and lambing data were collected. The effects of treatment, milking status and face color on estrual responses and lambing data were examined. In trial 1, greater first cycle conception rate (p<0.05), twinning rate (p<0.01) and the number of lambs born/served ewe (p<0.01) were observed in flock 2 compared with flocks 1 and 3. Neither face color nor milking status had any influence on the measured parameters (p>0.05). Despite low lambing rate in trial 2, ewes receiving 600 IU of PMSG had greater (p<0.05) number of lambs born/served ewe compared with ewes receiving 450 IU of PMSG. Regardless of PMSG dose, intervals to detected estrus occurred 10 h earlier (p<0.01) in dry than lactating ewes. Similar to trial 2, lambing rate was depressed in trial 3. The expression of estrus was advanced (p<0.05) in ewes receiving MAP 60 mg sponges compared with those receiving FGA 30 and FGA 40 mg sponges (42$\pm$3.1, 49$\pm$3.1 and 49$\pm$3.1 h post sponge removal in ewes receiving MAP 60 mg, FGA 30 mg and FGA 40 mg sponges, respectively). Other parameters were not influenced (p>0.05) by sponge type, milking status and face color. Data show that a 600 IU dose of PMSG tends to give the best lambing results. In addition, results indicate that the use 60 mg MAP sponges for estrus synchronization may be more appropriate under the Jordanian Badia conditions during late seasonal anestrus.

• Korean Journal of Environmental Agriculture
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• v.26 no.1
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• pp.85-93
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• 2007

This study aims to investigate the flora and the vegetation of Dokdo (Dongdo). The vegetation types were investigated by the Z-M school method. A total of 44 vascular plant taxa belonging to 24 families, 41 genera, 36 species, and 11 varieties are recognized in Dongdo, Dokdo. In this study, we confirmed four species, Chenopodium serotinum, Chelidonium majus var. asiaticum, Bromus japonicus, Elymus sibiricus, that had not been previously reported. The biological type of Dokdo was determined to be $Th-D_4-R_5-e(b)$ type. Two main vegetation groups which were established in a rocky area with little soil development and in a developed soil layer, along the development of soil layer have been distinguished and classified into five communities. The former was composed of 1 community; Aster spathulifolius-Sedum oryzifolium community. The latter was composed of 4 communities; Agropyron tsukusiense var. transiens community, Festuca rubra-Artemisia japonica ssp. littoricola community, Miscanthus sinensis community, and Artemisia princeps community.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.725-732
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• 2017

Weight reduction is one of the important issues in the automotive industry and the development of internal combustion engines vehicles, future vehicles, and eco-friendly vehicles for improving fuel efficiency. The objective of this study is to investigate the improvement of driving performance by weight reduction and optimum design for a formula-type self-designed on-road vehicle. This study is divided into the four steps. Firstly, the engine room was replaced and designed with a lighter engine. Secondly, an optimization study was conducted to simplify and lighten the vehicle components with the design of the frame. Thirdly, the structure design was optimized and the suspension was analyzed with the design of the frame. Finally, the design of an upright and hub with reduced weight was carried out using lighter parts. As a result, we reduced the weight of the vehicle by 48.5kg compared to the previous year (19.5%) and increased the acceleration from 6.8 s to 5.8 s.s.