• Title/Summary/Keyword: R&D outcomes

검색결과 213건 처리시간 0.025초

국내 바이오산업의 지역별 분포특성과 혁신 활동 성과에 관한 연구: 수도권과 비수도권 지역을 중심으로 (A Study on the Regional Distribution Characteristics and Innovation Activity Performance of Bio-Industry in Korea: Focusing on Metropolitan and Non-metropolitan Areas)

  • 유민정;류규하
    • 대한의용생체공학회:의공학회지
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    • 제44권4호
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    • pp.225-241
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    • 2023
  • The study empirically analyzed the differences in industry distribution and innovation activity performance in the metropolitan and non-metropolitan areas of Korea's bio companies, which are highlighted as future growth engines. The main innovation activities of the bio industry, which are focused on science and technology and expressed with high uncertainty, were analyzed, centering on human resources, technology cooperation, and investment promotion. As a result of the analysis, the biomedical industry in the metropolitan area was found to have a high proportion, and bio foods, bio-based chemicals, and energy industries in the non-metropolitan area, respectively. Moreover, the innovation activity performances differed between the two regions. In particular, the notable characteristics included human resources, investment promotion, and technical cooperation with medical institutions in the metropolitan area with a high proportion of biomedical industries, and technology personnel exchange and cooperation with private research institutions in the non-metropolitan area, which has a high proportion of bio foods, bio-based chemicals, and energy industries. This study is significant in that it is the first study to compare and analyze the performance of innovative activities based on the distribution of industries in the bio-industry, focusing on human resources, technology cooperation, and investment promotion. In addition, after investigating the distribution status and competitiveness of the domestic bio-industry by region, it will analyze the status and characteristics of the domestic bio-industry and present policy implications to implement relevant promotion policy more efficiently.

Internet search analytics for shoulder arthroplasty: what questions are patients asking?

  • Johnathon R. McCormick;Matthew C. Kruchten;Nabil Mehta;Dhanur Damodar;Nolan S. Horner;Kyle D. Carey;Gregory P. Nicholson;Nikhil N. Verma;Grant E. Garrigues
    • Clinics in Shoulder and Elbow
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    • 제26권1호
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    • pp.55-63
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    • 2023
  • Background: Common questions about shoulder arthroplasty (SA) searched online by patients and the quality of this content are unknown. The purpose of this study is to uncover questions SA patients search online and determine types and quality of webpages encountered. Methods: The "People also ask" section of Google Search was queried to return 900 questions and associated webpages for general, anatomic, and reverse SA. Questions and webpages were categorized using the Rothwell classification of questions and assessed for quality using the Journal of the American Medical Association (JAMA) benchmark criteria. Results: According to Rothwell classification, the composition of questions was fact (54.0%), value (24.7%), and policy (21.3%). The most common webpage categories were medical practice (24.6%), academic (23.2%), and medical information sites (14.4%). Journal articles represented 8.9% of results. The average JAMA score for all webpages was 1.69. Journals had the highest average JAMA score (3.91), while medical practice sites had the lowest (0.89). The most common question was, "How long does it take to recover from shoulder replacement?" Conclusions: The most common questions SA patients ask online involve specific postoperative activities and the timeline of recovery. Most information is from low-quality, non-peer-reviewed websites, highlighting the need for improvement in online resources. By understanding the questions patients are asking online, surgeons can tailor preoperative education to common patient concerns and improve postoperative outcomes. Level of evidence: IV.

The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial

  • Jihyun Yoon;Byoungjin Park;Kyung-Won Hong;Dong-Hyuk Jung
    • Journal of Ginseng Research
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    • 제47권6호
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    • pp.766-772
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    • 2023
  • Background: Korean Red Ginseng (KRG) is an effective anti-stress treatment. In this study, we investigated the therapeutic potential effects of KRG on relieving stress in a general population using transcriptome analysis. Methods: We conducted an 8-week clinical pilot study on 90 healthy men who reported stress. The study was completed by 43 participants in the KRG group and 44 participants in the placebo group. Participants were randomized 1:1 to the KRG and placebo groups. We evaluated the stress by stress response inventory (SRI) at baseline and 8 weeks. The main outcomes were changes in the levels of neurotransmitters (NTs) and NT-related gene expression. NTs were analyzed using automated (GC) content, and levels of gene expression were measured by reads per kilobase of transcript per million mapped reads (RPKM). Results: The KRG group showed significantly preserved epinephrine decrease compared with placebo group at 8 weeks (changes in epinephrine, KRG vs. placebo; -1623.2 ± 46101.5 vs. -35116.3 ± 86288.2, p = 0012). Among subjects who higher SRI score, meaning stress increased compared to baseline, the KRG group showed a smaller decrease in serotonin than the placebo group (changes in serotonin, KRG vs. placebo; -2627.5 ± 5859.1 vs, -8087.4 ± 7162.4, p = 0.005) and a smaller increase in cortisol than the placebo group (changes in cortisol, KRG vs. placebo; 1912.7 ± 10097.75 vs. 8046.2 ± 8050.6 , p = 0.019) in subgroup analysis. Transcriptome findings indicated that KRG intake affects gene expression related with metabolism of choline, adrenalin, and monoamine. Conclusion: These findings suggest that KRG has beneficial effects on the amelioration of stress response in NTs, and this effect is more prominent in stressful situations. Further clinical studies are required to confirm the anti-stress effect of KRG.

On the thermal buckling response of FG Beams using a logarithmic HSDT and Ritz method

  • Kadda Bouhadjeb;Abdelhakim Kaci;Fouad Bourada;Abdelmoumen Anis Bousahla;Abdelouahed Tounsi;Mohammed A. Al-Osta;S.R. Mahmoud;Farouk Yahia Addou
    • Geomechanics and Engineering
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    • 제37권5호
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    • pp.453-465
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    • 2024
  • This paper presents a logarithmic shear deformation theory to study the thermal buckling response of power-law FG one-dimensional structures in thermal conditions with different boundary conditions. It is assumed that the functionally graded material and thermal properties are supposed to vary smoothly according to a contentious function across the vertical direction of the beams. A P-FG type function is employed to describe the volume fraction of material and thermal properties of the graded (1D) beam. The Ritz model is employed to solve the thermal buckling problems in immovable boundary conditions. The outcomes of the stability analysis of FG beams with temperature-dependent and independent properties are presented. The effects of the thermal loading are considered with three forms of rising: nonlinear, linear and uniform. Numerical results are obtained employing the present logarithmic theory and are verified by comparisons with the other models to check the accuracy of the developed theory. A parametric study was conducted to investigate the effects of various parameters on the critical thermal stability of P-FG beams. These parameters included support type, temperature fields, material distributions, side-to-thickness ratios, and temperature dependency.

저인산혈성 구루병에 대한 임상적 고찰 (Clinical Study of Hypophosphatemic Rickets)

  • 이창진;조희연;강주형;신충호;하일수;정해일;양세원;최용
    • Childhood Kidney Diseases
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    • 제8권2호
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    • pp.195-204
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    • 2004
  • 목적: 저인산혈성 구루병 환아의 임상상, 각종 혈액화학 검사 수치 및 방사선 검사 소견, 치료에 대한 반응 등을 살피고 효과적인 치료에 도움이 되는 정보를 얻고자 본 연구를 시행하였다. 방법: 1983년 7월부터 2004년 2월까지 서울대학교병원 소아과에서 저인산혈성 구루병으로 진단받고 내과적인 치료를 받은 환아들의 의무기록지를 후향적으로 분석하였다. 결과: 대상환자는 56명이었고, 남녀의 비는 1:3 이었다 주소는 대부분 하지만곡과 저신장이었고, 혼자 걷기 시작하면서 발견된 경우가 가장 많았다. 진단시 평균연령은 5년 2개월 이었으며 12개월 이전에 진단 받은 경우는 없었다. 14명(25%)에서 가족력이 있었다. 진단받은 연령과 신장의 표준편차 점수는 통계적으로 의미있는 음의 상관관계가 있었다(r=-0.47, p=0.005). 생화학적 검사에서 정상 혈청 칼슘, 혈청 인의 저하, alkaline phosphatase의 상승, 세뇨관에서 인산 재흡수의 감소 및 정상 범위의 $1,25(OH)_2D_3$ 치를 보였다. 방사선 검사는 구루병에 합당하였다. 치료제로 Joulie 용액과 비타민 D 대사체를 복용하였다. 치료를 시작한 후 혈청 인과 alkaline phosphatase는 통계적으로 의미있는(P<0.05) 호전을 보였고, 방사선 검사는 구루병의 치유를 보였으나, 신장 표준편차 점수는 의미있는 변화를 보이지 않았다(.p=0.224). 치료의 부작용으로 신석회화(34%), 부갑상선호르몬의 상승(77%), 고칼슘뇨증(45%) 등이 발생하였다. 16명이 절골술을 통한 변형의 교정을 시행하였고, 그 중 4명은 하지연장을 함께 시행하였다. 결론: 증상의 시작과 진단 사이에는 수 년간의 지연이 있었다 조기치료가 환자의 예후에 가장 중요하므로, 가족력이 있는 경우 증상 발현 이전에 생화학적 검사로 조기 진단 및 치료를 하도록 해야 한다. 치료 중에는 정기적인 모니터링과 용량의 조절을 통해 합병증에 대처해야 한다.

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영산강 및 섬진강 수계 중 농약 분포 조사 (Monitoring of Pesticides in the Yeongsan and Seomjin River Basin)

  • 이영준;최정희;김상돈;정희정;이형진;심재한
    • 한국환경농학회지
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    • 제34권4호
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    • pp.274-281
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    • 2015
  • 영산강과 섬진강의 지천을 중심으로 총 22개 지점에서 4회에 걸쳐 농약(aldicarb, carbaryl, carbofuran, chlorpyrifos, 2,4-D, MCPA, methomyl, metolachlor, molinate)의 실태조사를 수행하였다. 하천수 시료에서 농약을 추출하기 위해 Oasis HLB 카트리지를 사용하였고 LC/ MS/MS를 이용하여 분석하였다. 시험법은 matrix-matched 내부표준검량곡선과 방법검출한계, 정량한계, 정확도, 정밀도, 회수율 등으로 정도관리를 수행하였다. 각 화합물의 방법검출한계는 모든 화합물이 국립환경과학원에서 제안하는 GV/10을 만족하였다. 모든 화합물의 상관계수(r2)는 0.9965- 0.9999로써 직선성이 매우 높았고 정확도와 정밀도는 각각 89.4-113.6%와 3.1-14.0%로써 매우 양호함을 알 수 있었으며 평균 회수율은 90.8-106.2%로 매우 우수하였다. Aldicarb를 제외한 모든 성분이 검출되었고, 특히 carbofuran과 metolachlor의 검출농도와 빈도가 높았는데 이들의 광범위한 적용 범위에 따른 많은 사용량에 기인한 것으로 판단되었다. 2,4-D와 MCPA는 1(5월), 2차(7월) 시료에서만 검출되었는데 이는 두 농약의 사용 적기와 일치하였다. Methomyl과 molinate는 사용 금지된 농약이었으나 일부 지역에서 검출되었고 이는 두 농약이 불법적으로 사용되었거나 과거에 사용되어 수계로 유입, 저질에 흡착된 일부분이 지금까지 용출되어 검출되었을 것으로 판단되었다. 영산강 및 섬진강 수계의 많은 하천수 시료에서 농약이 검출되었고 그 원인이 영농활동 중 농약의 사용이라고 단정할 수 없으나, 영산강과 섬진강 수계 인근의 주된 산업활동이 농업활동이고 농약의 주된 사용이 영농활동에 이루어지며 검출된 농약이 농작물에 대한 약제의 사용 시기와 부합하는 것을 미루어 보아 영산강과 섬진강 유역 농경지에서 사용된 농약이 수계로 유입되어 비점오염원으로 작용하는 것으로 판단되었다. 따라서 수생태계 보존을 위하여 농약에 대한 수질기준 설정이 절실히 요구되었고, 이를 위해 보다 많은 실태조사 결과의 축적과 꾸준한 연구 수행이 필요한 것으로 판단되었다.

관절염 여성의 신체적 불편과 산후조리 경험정도와의 관계 연구 (A Study on the Relationship between the Present Physical Symptom Distress and Experience of Sanhujori, the Traditional Postpartal Care in Korea - Centered on Women of arthritis -)

  • 정영미;유은광
    • 여성건강간호학회지
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    • 제5권1호
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    • pp.111-132
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    • 1999
  • This correlational descriptive study sought to define the relationship between the experience of Sanhujori, Korean tradition non-professional postpartal care after delivery and abortion and present physical symptom distress of arthritis female who visited to outpatient clinic of rheumatic internal medicine at three hospital located in Seoul, Pusan, Chongju, Korea. Data from a convenience sample of 98 women who orally agreed to be respondent were collected from September 1, 1998 to October 31, 1998 for two months by way of interview with semi-structured questionnaire. Data analysis consisted of frequency, percentage, mean, S. D., Pearson Correlation Coefficient, t-test, ANOVA and Scheffe test as a post hoc by SPSS. The results of the study were as follows ; Mean age of participants as 52.8 years and mean number of children 3.3. Mean frequency of child birth was 3.1 times per woman, 67.4% of respondents had menopause, 57.0% did not have Sunhujori after abortion. The health status implies the subjective health status women perceived, which came from the three points of view of the present, comparative with other of same age and changed after delivery. The respondents of 76.1% perceived them as unhealthy and the main sites of physical symptom distress were upper & lower extremities including knee and hand 34.8%, shoulder 26.5%, waist 22.4%. Women perceived the etiology of the arthritis as 'did Sanhujori wrongly' 36.7%, 'aging process' 24.5%, 'stress' 16.3%, 'overwork' 15.3%, 'Immunocompromize' & 'physical constitution' 7.1% respectively, 'character' 3.1%, 'genetic' 2.0%, 'malnutrition' 1.0%. The mean period of Sanhujori after delivery was 20.4 at the first child and 18.1 at the second child. The higher frequency of child birth, the shorter period of Sanhujori. For the subjective evaluation of whether the women did Sanhujori well or not, the rate of 'did Sanhujori well' was the highest rank in the first child and the rate of 'did not particularly Sanhujori well' was the highest rank in the last child. There was a significant positive correlation between physical function disability and rheumatoid arthritis symptom at the level of 1% of significance statistically(r=.406). And a positive correlation between physical function disability and Sanhubyung symptom at the level of 5% of significance statistically(r=.224). There was a significant positive correlation among rheumatoid arthritis symptom, Sanhubyung symptom and menopause symptom at the level of 1%-5% of significance statistically. Most of all, the correlation between Sanhubyung symptom and menopause symptom was the higher than others. There was a negative correlation between the present physical symptom distress and experience of Sanhujori(r=.-130), however it was not significant statistically. However, there was a positive correlation between subjective health status and experience of Sanhujori at the level of 1% of significance statistically(r=.328). In conclusion, this finding reconfirmed the positive relationship between the perceived health status and experience of Sanhujori after delivery among women of arthritis. It provides a challenge to the professional care givers to study further on the effects of Sanhuiori after abortion or delivery on the physical symptom distress from the variouis aspects through the cross-sectional and longitudinal research. The strategy for the development of the appropriate intervention for primary prevention of sequele after childbirth and quality of care for desirable health outcomes for postpartal women with considering deeply on the relationship between women's health and postapartal care.

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FEAS 프로그램 개발을 통한 방사성폐기물 처분장 종합 성능 평가(TSPA) 투명성 증진에 관한 연구 (Building Transparency on the Total System Performance Assessment of Radioactive Repository through the Development of the FEAS Program)

  • 서은진;황용수;강철형
    • 터널과지하공간
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    • 제13권4호
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    • pp.270-278
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    • 2003
  • 고준위 방사성폐기물 처분 연구 사업이 대중의 동의를 얻기 위해서는 처분 사업의 안전성에 대한 신뢰성 획득이 중요하다. 이를 위해서 투명하게 공개될 수 있는 종합성능평가(TSPA, Total System Performance Assessment)의 수행이 필요하다. 종합성능평가 수행에서 무엇을 평가할 것인가, 어떻게 평가할 것인가 그리고 각 이해 당사자들이 쉽게 이해할 수 있는 용어로 평가 결과들을 어떻게 전달할 것인가등과 같은 의견전달논의의 시발점이 된 것이 FEP(Features, Events, and Processes)시나리오 관련 연구라고 할 수 있는데 지금까지는 평가 영역 외부의 이해 당사자들이 평가 관련 상세 정보를 접하는 것이 쉽지 않은 일이었기 때문에 대부분의 경우 일방향(One-way communication) 의견 전달에 한정되어 왔다. 그러나 인터넷의 출현으로 성능 평가 등에도 쌍방향(Two-way communication) 의견 전달의 가능성이 높아지게 되었다. 본 연구에서는 FEP으로부터 AM(Assessment Methods Flow chart)까지의 형성 전 과정을 체계적으로 연결하여 웹 상에 나타내는 방법을 개발했다. 평가 관련 모든 요소들은 웹 기반 프로그램인 FEAS(FEp to Assessment through Scenario development) 내에서 시스템적 구성을 이루게 된다. 2003년부터 시작되는 연구에서는 FEAS 프로그램과 현재 개발 중에 있는 웹 기반의 품질보증(QA, Quality Assurance) 및 성능 평가(PA, Performance Assessment) 입력 자료 시스템을 하나의 시스템으로 통합하는 연구를 수행함으로써 든 이해 당사자들이 "처분장에서 생태계에 이르는 핵종들의 이동 경로에 대한 시나리오는 어떠한 것이며, 그 관계 결과들과 연구에 이용되는 실제 데이터들은 어떤 것인지"에 대해 쉽게 이해할 수 있도록 할 것이다.

한국내 물류서비스에 드론 활용을 위한 연구 (Study on Utilization Drones in Domestic Logistics Service in Korea)

  • 강기석;전인오
    • 유통과학연구
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    • 제14권5호
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    • pp.51-57
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    • 2016
  • Purpose - In the year of 2015 and 2016, one of the items that got attention in CES was a drone. It has been 100 years since a drone emerged, but most were used for military purposes. As its use became diverse as of 2010, it got attention of the general public. In Korea, it was in 2011 that a drone was known to the public through an aerial video shooting for television program. This study tried to come up with suggestions by comparing domestic with overseas cases, and tried to consider the related technologies and systems with applying the role of drones in logistics service. Research design, data, and methodology - The overseas cases were regarded as drone's logistical purpose. The Prime Air service by US Amazon is still not commercialized and under pre-testing due to Federal Aviation Regulations, although it started in 2013. In Germany, DHL succeeded in delivering service testing which is called Parcelcopter, but it is not commercialized yet. Other than these, there are more attempts to prepare logistics service in China with Taobao, in France with Geopost's test, and in Africa. In Korea, CJ Korea Express tested delivery with a self-developed drone Results - In order to study for utilizing drones for logistics as the prerequisites, some overseas and domestic cases, which are currently considered, were reviewed. Also, the technologies and institutional requirements to commercialize drones for logistical purpose were reviewed. The reasons for using drones in logistics is to ensure the price competitiveness by reducing cost. The empirical test also will be needed because drone pilot areas are designated by ministry of land, infrastructure and transport. Conclusions - In order to utilize drones in logistics and foster the industry, this study would like to suggest the followings. First of all, size of drones for logistics needs to be fixed and their operating system should be standardized. Centralized investment resources are needed through standardization to ensure the market occupancy. Secondly, it is necessary to get the converged businesses that do research, develop and commercialize drones with the investment of private sector. Example can be found in Korea aerospace Industries. We can respond to the rapid growth of the market with intensive investing by integrating the private sector investment. Thirdly, institutional arrangements are needed to be established quickly. In the case of high-technologies like drones, institutional support often does not follow the rapid development of the technology. The problems can be found in securing drones-only airspace, creating drone-specialized pilot's license, matters related to remote controller and complementary regulations for drones in Aviation Act. If these regulations are not prepared or complemented at the right timing, technologies cannot be commercialized even though the development is completed. Fourthly, there is a need to secure the transparency regarding possible privacy and personal information protection problem while operating drones. Finally, in order to foster this new industry, government should focus on supporting R&D more in the long term than short term outcomes.

DEA 모형을 이용한 국내 대학의 기술이전 효율성 분석 (A study on the efficiency measurement of University's technology transfer by DEA model)

  • 진경미;윤병운
    • 한국산학기술학회논문지
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    • 제13권6호
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    • pp.2558-2569
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    • 2012
  • 기술 개발에 소요되는 비용이 증가하는 반면 기술 실현화를 통해 개발된 제품이나 서비스의 수명주기는 점차 짧아지고 있다. 이에 기업은 기술 혁신에 드는 비용을 절감하면서 빠르게 변화하는 시장에 대응하기 위해 개방형 혁신(open innovation)을 적극적으로 실행하고 있다. 그 중, 대학으로부터의 기술이전은 기술혁신의 대표적인 수단 중의 하나이다. 그러나 대학이 많은 자원을 연구개발에 투자하고 있음에도 투여된 자원이 가져오는 결과는 도외시 되고 있다. 따라서 현 시점에서 대학에서의 기술이전의 성과 및 효율성에 대한 연구가 요구되고 있다. 그러나, 기존 연구는 대부분 기술이전의 성과에 영향을 미치는 요인 분석에 집중되어있기 때문에 본 연구에서는 국내 소재 대학을 대상으로 대학에서의 기술이전 효율성을 분석하여 효율성 값을 토대로 대학의 유형별 효율성에 차이가 있는지를 검정하였다. 일반 대학보다 목적성이 있는 특화 대학에서 기술이전 효율성이 높은 것으로 분석되었고, 효율성 프론티어로 선정된 대학의 수 역시 특화 대학이 많았다. 대학 TLO 육성 지원 사업 참여 여부에 따른 대학에서의 기술이전의 효율성에는 유의한 차이가 없다는 점을 고려할 때, 국내에서 대학 TLO 육성 지원 사업이 성과를 내기 위해서는 시간이나 노력이 더욱 요구될 것이다. 본 연구의 대학별 효율성 분석은 향후 국내 및 국외 효율성 비교 연구와 대학의 기술이전 평가에 있어서 합리적인 측정지표를 제시할 수 있을 것으로 기대된다.