• Natural Product Sciences
• /
• 제7권2호
• /
• pp.45-48
• /
• 2001

The antioxidative effect of the extracts from the leaves and fruits of Acer ginnala against free radicals was studied by two different methods using DPPH radical-generating system, and hydroxyl radical-generating system $(Cu^{++}/H_2O_2\;system)$ which induces DNA strand breaking. Compared with well known antioxidative plants, green tea, Scutellaria baicalensis, the Acer ginnala extracts showed excellent radical-scavenging activity in DPPH radical-generating system and inhibited effectively hydroxyl radical induced-DNA strand breaking in a concentration-dependent manner in $Cu^{++}/H_2O_2$ system whereas the green tea extract stimulated the strand breaking at a low concentration. These results suggest that he extracts from the leaves and fruits of Acer ginnula could be good antioxidative agents.

• 한국군사과학기술학회지
• /
• 제13권6호
• /
• pp.1113-1120
• /
• 2010

In this paper, we have proposed Architecture Development methodology which can connect both operational view and system view. The Functional Architecture can connect both user and developer, and it is located between Activity analysis and System analysis. We suggest the new architecture methodology using the Functional Architecture and it provides effect to analyze the connection between user(military) and developer(enterprise) in Defence R&D and the new Architecture with the feedback analyze activity on a point of system view and the new architecture make the functional architecture.

• Bulletin of the Korean Chemical Society
• /
• 제33권7호
• /
• pp.2365-2368
• /
• 2012

The $11{\beta}$-hydroxysteroid dehydrogenase type 1 ($11{\beta}$-HSD1) enzyme is involved in modulation of glucocorticoid activity within target tissues. This enzyme may contribute to obesity and/or metabolic disease through its action in adipose or liver tissue. Inhibition of $11{\beta}$-HSD1 has major therapeutic potential for glucocorticoid-associated diseases, including obesity, diabetes (wound healing), and muscle atrophy. To develop such therapeutics, we performed a pharmacophore-based virtual screening (VS) for identification of novel $11{\beta}$-HSD1 inhibitors and found that the VS hit compounds show potent inhibition of $11{\beta}$-HSD1 enzyme activity. Further, we present a binding model for active compounds. The proposed pharmacophore may serve as a useful guideline for future design of new chemical entities as $11{\beta}$-HSD1-targeted antidiabetic agents.

• Natural Product Sciences
• /
• 제22권1호
• /
• pp.35-40
• /
• 2016

The first study on chemical constituents and biological activities of Clausena lansium (Lour.) Skeels (Rutaceae) growing in Vietnam has been done. Phytochemical investigation of n-hexane extract led to the isolation of five compounds: dihydroindicolactone (1), 8-geranyloxy psoralen (2), imperatorin (3), heraclenol (4) and indicolactone (5), in which this is the first report on the presence of dihydroindicolactone (1). Their structures were elucidated based on LC/MS/NMR hyphenated techniques as well as comparison with those of literature data. The n-hexane extract and its subfractions, ethanol 95% extract and several isolated compounds were evaluated for antifungal activity.

• Natural Product Sciences
• /
• 제11권2호
• /
• pp.63-66
• /
• 2005

A rare flavonol glycoside identified as $eupalitin-3-O-{\beta}-D-glucoside$ (I) was isolated from Tephrosia spinosa (Leguminosae) and its anti-inflammatory activity was evaluated against carrageenin induced paw edema. The compound exhibited significant activity when compared to the standard drug indomethacin.

• 한국식품영양학회지
• /
• 제22권2호
• /
• pp.302-307
• /
• 2009

The present study was designed to clarify the antidiabetic activity and mechanism of Dioscorea rhizome in diabetic db/db mice. Mice were administered Dioscorea rhizome and rosiglitazone orally for 7 weeks and the effects of these compounds on fasting blood glucose, glucose tolerance and intestinal disaccharidase activity in db/db mice were evaluated. The fasting serum glucose of the D. rhizome treated group was reduced when compared with that of the db/db control group. In addition, the disaccharidase activities in homogenates of the proximal, middle and distal segment of the small intestine were significantly decreased response to D. rhizome treatment, especially in the middle segment. These results suggest that D. rhizome decreases blood glucose via a decrease in the activity of disaccharidase in the mucosa of the middle region of the small intestine in db/db mice.

• 기술혁신학회지
• /
• 제17권1호
• /
• pp.174-194
• /
• 2014

공동기술개발은 작금의 글로벌 과학연구에 있어서 가장 의미있는 활동 중 하나이며, 이는 기회요인과 도전과제를 동시에 지닌다. 또한 국경을 넘는 활동은 참가자들의 특징, 조직유형, 협력목적 및 동기 등에 따라 성과가 매우 다르게 나타난다. 이러한 불확실성을 감소시키고 협력연구의 성과를 증진시키기 위해서는 포괄적인 차원의 연구와 구체적인 연구가 병행될 필요가 있다. 이에 본 연구는 한국과 미국 내의 기업, 대학 및 공공연구기관이 R&D를 둘러싼 협업의 성공사례를 분석했다. 본 연구의 목적은 성공적인 기술협력의 요인을 찾아내는 것이다. 사례분석 결과 성공요인으로서 연구팀의 강력한 의지, 파트너의 적정 선정 및 역할분담, 보완적 기술과 자산, 정부의 지원 등이 도출되었다.

• 한국산학기술학회논문지
• /
• 제11권5호
• /
• pp.1829-1837
• /
• 2010

정부가 민간기업에 지출하는 연구개발비는 최근 들어 지속적으로 늘어왔다. 2008년에는 전체 공공 연구개발 지출액의 17%가 민간기업에 지원됐으며 서비스업에서 지출되는 연구비의 약 9%가 공공 연구개발비였으나 이들 지원금에 대한 평가 및 연구가 잘 이루어지고 있지 않다. 본 연구의 목적은 국내 서비스기업들의 양적 질적인 혁신활동 결과에 공공 연구개발 보조금이 어떠한 효과를 가지는지를 분석하는 것이다. 즉, 정부의 직접보조금이 서비스기업의 혁신활동을 촉진시키는지 구축시키는지를 Propensity Score Matching (PSM) 방법을 이용하여 실증 분석하는 것이다. 분석결과 정부의 보조금은 기업 최초 서비스혁신의 성과에만 통계적으로 유의한 양의 효과를 미치는 것으로 나타났으며 다른 결과지표에는 유의한 영향을 미치지 못하는 것으로 나타났다. 이는 정부의 서비스업에 대한 보조금 지급정책이 국가전체 혁신수준의 향상 및 양적인 증가에는 기여하지 못하나 기업자체의 경쟁력 강화를 위한 혁신활동은 촉진시킨다고 할 수 있다.

• 한국경영과학회지
• /
• 제40권4호
• /
• pp.19-33
• /
• 2015

Recently, interest in research and development (R&D) investment decisions have increased among Korean domestic enterprises. However, existing R&D investment studies only focused on government R&D investment policies while only a few studies investigated firm level R&D investment. Prior literatures also overlooked the feedback loop between R&D investment and firm performance. Therefore, this paper identifies a system dynamics model for R&D investment decision making in domestic electronics firms. The conceptual model is derived from R&D investment-related theories found in bodies of literature on company performance, enterprise activity, and market maturity. This study investigates the dynamic feedback between R&D activities and sales using the system dynamics model. In other words, the system dynamics model is used to explain the change in the closed feedback circulation structure in R&D investment activities including technology development, production process, and marketing that subsequently result in sales increase and re-investment into R&D from the generated revenues. There are two major results. First, a similar ratio of investment on technology development and production process derives the higher company sales. Second, regardless of market maturity, marketing investment ratio positively affects sales and R&D budget growth. This study provides a system dynamics model to find the optimal ratio for R&D investment and suggests managerial strategic implications on electronic firm R&D investment decision making under market maturity condition.

• 기술경영경제학회:학술대회논문집
• /
• 기술경영경제학회 2003년도 제23회 하계학술발표회 논문집
• /
• pp.108-115
• /
• 2003

Government R&D Project Management in Korea has had considerable difficulties because of the lack of project monitoring systems and insufficient communication. The National Program for Tera-level Nanodevices (TND Program) is a ten-year R&D program for commercialization in the area of nano technology. Collaboration and communication among the various participants such as business companies, universities, and government R&D institutes are key success factors in this R&D program. TND Program office has developed a Web-based project management system. This system consists of mostly four sub-management functions: (1) Milestones management of all R&D projects; (2) DR (Design Review) management as the mechanism for checking the performance against milestones; (3) Project activity management using the WBS (Work Breakdown Structure); (4) Budget management. Additionally, it also has many R&D supporting functions such as technology information bulletin board, community management, and visual summary of project progress and performance. This system is effective for monitoring research project as well as measuring project performance of the overall research program. This Web-based system has become the useful tool of R&D moving target mechanism and effective communication and collaboration tool. System features and adoption process of the system are also suggested.