The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effect of Dioscorea rhizome on the Activity of Intestinal Disaccharidases in Diabetic db/db mice

Diabetic db/db Mice에 산약추출물(DA-9802) 투여에 따른 소장내의 Disaccharidases 활성에 미치는 영향

  • Lee, Tae-Ho (R&D Center, Donga-A Pharm. Co. Ltd) ;
  • Son, Mi-Won (R&D Center, Donga-A Pharm. Co. Ltd) ;
  • Choi, Sang-Zin (R&D Center, Donga-A Pharm. Co. Ltd) ;
  • Ha, Sang-Keun (East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee, Pyeong-Jae (Dept. of Natural Medicine Resources, Semyung University) ;
  • Kang, Dong-Ho (Dept. of Oriental Medicinal Materials and Processing, College of Life Science, Kyung Hee University) ;
  • Kim, Sun-Yeou (East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University)
  • Published : 2009.06.30
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Abstract

The present study was designed to clarify the antidiabetic activity and mechanism of Dioscorea rhizome in diabetic db/db mice. Mice were administered Dioscorea rhizome and rosiglitazone orally for 7 weeks and the effects of these compounds on fasting blood glucose, glucose tolerance and intestinal disaccharidase activity in db/db mice were evaluated. The fasting serum glucose of the D. rhizome treated group was reduced when compared with that of the db/db control group. In addition, the disaccharidase activities in homogenates of the proximal, middle and distal segment of the small intestine were significantly decreased response to D. rhizome treatment, especially in the middle segment. These results suggest that D. rhizome decreases blood glucose via a decrease in the activity of disaccharidase in the mucosa of the middle region of the small intestine in db/db mice.

Keywords

References

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