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http://dx.doi.org/10.20307/nps.2016.22.1.35

Chemical Composition of Clausena lansium (Lour.) Skeels Leaves and Antifungal Activity  

Vu, Duc Nam (National Institute of Medicinal Materials)
Teruhisa, Fujimatsu (R&D Biological Science Research, KAO Corporation)
Hirofumi, Takigawa (R&D Biological Science Research, KAO Corporation)
Hiroshi, Kusuoku (R&D Biological Science Research, KAO Corporation)
Nguyen, Minh Khoi (National Institute of Medicinal Materials)
Le, Viet Dung (National Institute of Medicinal Materials)
Do, Thi Ha (National Institute of Medicinal Materials)
Hiroshi, Hashimoto (KAO Consumer Products (Southeast Asia) Co., Ltd.)
Publication Information
Natural Product Sciences / v.22, no.1, 2016 , pp. 35-40 More about this Journal
Abstract
The first study on chemical constituents and biological activities of Clausena lansium (Lour.) Skeels (Rutaceae) growing in Vietnam has been done. Phytochemical investigation of n-hexane extract led to the isolation of five compounds: dihydroindicolactone (1), 8-geranyloxy psoralen (2), imperatorin (3), heraclenol (4) and indicolactone (5), in which this is the first report on the presence of dihydroindicolactone (1). Their structures were elucidated based on LC/MS/NMR hyphenated techniques as well as comparison with those of literature data. The n-hexane extract and its subfractions, ethanol 95% extract and several isolated compounds were evaluated for antifungal activity.
Keywords
Antifungal; Clausena lansium; Dihydroindicolactone; Furanocoumarin;
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