• The Korean Journal of Physiology and Pharmacology
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• v.10 no.6
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• pp.297-302
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• 2006

Melittin, a major component of bee venom, produces a sustained decrease in mechanical threshold, and an increase in spontaneous flinchings and paw thickness, which are characteristics similar to those induced by whole bee venom. Melittin-induced nociception has been known to be modulated by the changes in the activity of excitatory amino acid receptors, voltage-dependent calcium channels, cyclooxygenase and serotonin receptors. The present study was undertaken to investigate the role of calcium chelators (TMB-8 & Quin 2) in melittin-induced nociceptive responses. Changes of mechanical threshold and spontaneous flinching behaviors were measured at a given time point following intraplantar injection of melittin ($30{\mu}g/paw$). Intrathecal or intraplantar pre-administration and intrathecal posttreatment of TMB-8 and Quin 2 significantly prevented the melittin-induced reduction of mechanical threshold, and intraplantar or intrathecal pre-treatment of TMB-8 and Quin 2 suppressed melittininduced flinching behaviors. These results indicate that calcium ion in the spinal dorsal horn neurons and peripheral nerves plays an important role in the production and maintenance of mechanical allodynia and spontaneous pain by melittin.

• The Mathematical Education
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• v.53 no.2
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• pp.291-312
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• 2014

This study has to do with creative product in mathematics. We analyze Taylor's creative product according to a different developmental level of creativity, Taylor's creative product inventory, Besemer & Treffinger's creative products analysis matrix, O'Quin & Besemer's creative products semantic scale(CPSS) etc. The purpose of this study is to make creative products semantic scale in mathematics. O'Quin & Besemer's CPSS consists of 55 items, bipolar adjective checklist. We confirm that O'Quin & Besemer's CPSS is not fit to use for mathematics creative products. So we develop Creative Product Semantic Scale in Mathematics(MCPSS) which consists of 33 items, bipolar adjective checklist. Our result will provide convenience to mathematics teacher who guides a student make a creative product.

• YAKHAK HOEJI
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• v.35 no.1
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• pp.11-14
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• 1991

Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseove-rticillatum, induced platelet aggregation and serotonin release simultaneously. LDH release was not observed. Addition of peptide to rat platelet, loaded with $Ca^{2+}$ chelator quin-2, caused immediate rise in cytosolic free $Ca^{2+}$. Liposomal membrane containing phosphatidylethanolamine was damaged by peptide and released $^{45}Ca$ dose dependently.

• Carbon letters
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• v.17 no.1
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• pp.45-52
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• 2016

The attachment of 2-aminobenzamide to carboxylated multi-wall carbon nanotubes (MWCNTs)-COOH was achieved through the formation of amide bonds. Then, the functionalized MWCNTs, MWCNT-amide, were treated by phosphoryl chloride to produce MWCNT-quin. The products were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, thermogravimetric analysis, derivative thermogravimetric, steady-state fluorescence spectroscopy, and solubility testing. MWCNT-quin showed photo-electronic properties, which is due to the attachment of the 4-hydroxyquinazoline groups to them as proved by steady-state fluorescence spectroscopy. This suggests intramolecular interactions between the tubes and the attached 4-hydroxyquinazoline. The toxicity of the samples was evaluated in human embryonic kidney HEK293 and human breast cancer SKBR3 cell lines, and the viable cell numbers were measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) after the cells were cultured for 24 h. Cellular investigations showed that the modified MWCNTs, particularly MWCNT-quin, have considerably significant toxic impact on SKBR3 as compared to HEK293 at the concentration of 5 µg/mL.

• Toxicological Research
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• v.6 no.1
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• pp.109-119
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• 1990

Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseoverticillatum, induced lysis of erythrocytes. Ro-09-0198-induced hemolysis was temperature-dependent and the sensitivity of hemolysis differed greatly among animal species. Preincubation of the peptide with phosphatidylethanolamine reduced the hemolytic activity, whereas other phospholipids present in erythrocytes in nature had no effect. A study of the structural requirements on phosphatidylethanolamine necessary for interaction with the peptide indicates that Ro09-0198 recognizes strictly a particular chemical structure of phosphatidylethanolamine: dialkylphosphoethanolamine as well as 1-acylglycerophosphoethanolamine showed the same inhibitory effct on hemolysis induced by Ro09-0198 as diacylphosphatidyl-ethanolamine, whereas phosphoethanolamine gave no inhibitory effect. Neither phosphatidyl-N-monomethylethanolamine nor alkylphosphopropanolamine had an inhibitory effect. Proton resonances of the peptide were observed in dimethyl sulfoxide solution in the presence of 1-dodecanoyl-sn-glycerophosphoethanolamine. This peptide caused permeability increase and aggregation of liposomes containing phosphatidylethanolamine. A glycerol backbone and a primary amino group of phosphatidylethanolamine are necessary for interaction with Ro09-0198 to cause membrane damage. Ro09-0198 induced a selective permeability change on liposomes. Glucose and umbelliferyl phosphate were effluxed significantly, but sucrose was only slightly permeable and inulin could not be released. Platelet aggregation and serotonin release simultaneously induced by Ro09-0198. Addition of peptide to rat platelet, loaded with the fluorescent $Ca^{++}$ chelator quin-2, caused immediate rise in cytosolic free $Ca^{++}$ to liposomal membrane containing phosphatidylethanolamine was observed dose dependently.

• Journal of the Korean Chemical Society
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• v.30 no.1
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• pp.76-83
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• 1986

Four oxovandium(IV) complexes with carboxylate ligands, $VO(picn)_2$, $VO(htmq)_2$, $VO(quin)_2$ and $VO(pyra)_2{\cdot}2H_2O)$ have been prepared and studied. Infrared spectral data coupled with the results of magnetic susceptibility study strongly suggest that there are relatively strong intermolecular interactions in $VO(picn)_2$ and $VO(htmq)_2$. In all oxovanadium(IV) complexes studied in this work, the carboxylate ligand coordinates to the metal ion in the unidentated fashion. Some fundamental vibration modes of oxovanadium(IV) complexes were empirically assigned from the difference in the spectrum of metal complex with free ligand.

• Journal of Korea Port Economic Association
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• v.29 no.3
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• pp.1-23
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• 2013

This paper estimates and forecasts the container throughput of Busan port using the monthly data for years 1992-2011. To do this, this paper uses the several seasonal multiplicative ARIMA models. Among several ARIMA models, the seasonal multiplicative ARIMA model $(1,0,1){\times}(1,0,1)_{12}$ is selected as the best model by AIC, SC and Hannan-Quin information criteria. According to the forecasting values of the selected seasonal multiplicative ARIMA model $(1,0,1){\times}(1,0,1)_{12}$, the container throughput of Busan port for 2013-2020 will increase steadily annually, but there will be some volatile variations monthly due to the seasonality and other factors. Thus, to forecast the future container throughput of Busan port and to develop the Busan port efficiently, we need to use and analyze the seasonal multiplicative ARIMA model $(1,0,1){\times}(1,0,1)_{12}$.

• YAKHAK HOEJI
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• v.40 no.1
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• pp.19-24
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• 1996

The 6,7-dichloroquinolone-5,8-dione(I) was reacted with ethyl acetoacetate in the presence of sodium ethoxide to yield 6-(${\alpha}$-acetyl-${\alpha$-ethoxycarbonyl-methyl)-7-chloro-quin oline-5,8-dione(II). When this compound II was reacted with some alkylamine (methylamine, ethylamine, propylamine, isopropylamine, cyclopropylamine, methoxyethylamine, ethanolamine, benzylamine, furfurylamine), 1N-alkyl-2-methyl-3-ethoxycarbonyl-pyridino(2,3f)-indole-4,9-dione(IIIa-i) were obtained via intramolecular cyclization.

• Speech Sciences
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• v.12 no.1
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• pp.123-134
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• 2005

Confidence measure (CM) is used for the rejection of mis-recognized words in an automatic speech recognition (ASR) system. Rahim, Lee, Juang and Cho's confidence measure (RLJC-CM) is one of the widely-used CMs [1]. The RLJC-CM is calculated by averaging phone-level CMs. An extension of the RLJC-CM was achieved by Kim et al [2]. They devised the normalized CM (NCM), which is a statistically normalized version of the RLJC-CM by using the tri-phone based CM normalization. In this paper we verify the NCM by generalizing tri-phone to n-phone unit. To apply various units for the normalization, mono-phone, tri-phone, quin-phone and $\infty$-phone are tested. By the experiments in the domain of the isolated word recognition we show that tri-phone based normalization is sufficient enough to enhance the rejection performance of the ASR system. Also we explain the NCM in regard to two class pattern classification problems.

• Ocean and Polar Research
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• v.23 no.2
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• pp.189-194
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• 2001

A practical algorithm for prediction of the sea surface temperatures (SST)from the satellite remote sensing data is presented in this paper. The fluctuations of SST consist of deterministic normals and stochastic anomalies. Due to large thermal inertia of sea water, the SST anomalies can be modelled by autoregressive or Markov process, and its near future values can be predicted provided the recent values of SST are available. The actual SST is predicted by superposing the pre-known SST normals and the predicted SST anomalies. We applied this prediction algorithm to the NOAA AVHRR weekly SST data for 18 years (1981-1998) in the seas adjacent to Korea (115-$145^{\circ}E$, 20-$55^{\circ}N$). The algorithm is applicable not only for prediction of SST in near future but also for nowcast of SST in the cloud covered regions.