• 분석과학
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• 제36권4호
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• pp.180-190
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• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• 한국인터넷방송통신학회논문지
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• 제9권5호
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• pp.109-114
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• 2009

현재 건물은 예전에 비해 더 높고 더 복잡하면서 다양한 형태로 설계되고 있다. 그러므로 잠재적인 위험 요소는 더 증가하고, 화재, 정전, 지진, 호수, 태풍 등의 재해가 발생할 수 있다. 이들 재난은 가능한 신속하게 건물 안의 사람들을 대피시켜야 한다. 본 논문에서는 건물 내부에서의 센서와 유도등 네트워크를 통합 구축하여 신속하게 재난을 감지하고 내부 지리 정보를 이용하여 정확하게 대피 유도할 수 있는 새로운 재난 대피 유도 개념을 제시한다. 본 논문에서는 이 개념을 이용하여 건물 내부에서 화재 재난을 관리하기 위해 센서와 유도등 네트워크 기반의 통합 논리 모델을 제시한다. 더불어 제안된 논리 모델을 지도 상에 가시화하고 운영 실험을 실시하여 검증한다.

• 제어로봇시스템학회논문지
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• 제19권8호
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• pp.718-724
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• 2013

In today's automotive industry, there exist several systems that help drivers reduce the possibility of accidents, such as the ADAS (Advanced Driver Assistance System). The ADAS helps drivers make correct and quick decisions during dangerous situations. This study analyzed the performance of the IMM (Interacting Multiple Model) method based on multiple Kalman filters using the data acquired from a driving simulator. An IMM algorithm is developed to identify the current discrete state of neighboring vehicles using the sensor data and the vehicle dynamics. In particular, the driving modes of the neighboring vehicles are classified by the cruising and maneuvering modes, and the transition between the states is modeled using a Markovian switching coefficient. The performance of the IMM algorithm is analyzed through realistic simulations where a target vehicle executes sudden lane change or acceleration maneuver.

• Bulletin of the Korean Chemical Society
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• 제25권2호
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• pp.172-176
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• 2004

A highly selective membrane electrode based on1,3,5-triphenylpyrylium perchlorate (TPPP) is presented. The proposed electrode shows very good selectivity for sulfate ions over a wide variety of common inorganic and organic anions. The sensor displays a nice Nernstian slope of -29.7 mV per decade. The working concentration ranges of the electrode is 1.0{\times}10^{-1}-6.3{\times}10^{-6} $M with a detection limit of $4.0{\times}10^{-6}$ M (480 ng per mL). The response time of the sensor in whole concentration ranges is very short (< 6 s). The response of the sensor is independent on the pH range of 2.5-9.5. The best performance was obtained with a membrane composition of 32% PVC, 59% benzyl acetate, 5% TPPP and 4% hexadecyltrimethylammonium bromide. It was successfully used as an indicator electrode for titration of sulfate ions with barium ions. The electrode was also applied for determination of salbutamol sulfate and paramomycine sulfate.

• 한국자동차공학회논문집
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• 제7권9호
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• pp.36-47
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• 1999

Three-way catalyst converter, cleaning up the exhaust gas contamination of SI engine, has the best efficiency when A/F ratio is near the stoichiometry . The feedback control using oxygen sensors in the exhaust manifold has limits caused by the system delays. So the accurate measurement of air flow rate to an engine is essential to control the fuel injection rate especially on transient condition like the rapid throttle opening and closing. To measure the rapid change of flow rates. the air flow meter for the engine requires quick response, flow reversal detection, and linearity . Tjhe proposed integration type air flow meter (IFM), composed of an ultrasonic flow meter with an integration circuit, has significantly improved the measurement accuracy of air mass inducted through the throttle body. The proposed control method estimated the air mass at the cylinder port using the measured air mass at the throttle . For the fuel dynamic model, the two constant fuel model is introduced . The control parameters from air and fuel dynamics are tuned to minimize the excursion of the air fuel ratio. As a result A/F ratio excursion can be reduced within 5% when throttle rapidly opens and closes at the various engine conditions.

• 대한의생명과학회지
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• 제16권3호
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• pp.193-196
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• 2010

Multiplex PCR-based short tandem repeat (STR) analysis is considered as a good tool for monitoring bone marrow engraftment after sex-mismatched allogeneic transplantation and provides a sensitive and accurate assessment of the contribution of both donor and/or recipient cells in post-transplantation specimens. Forensic STR analysis and quantitative real time PCR are used to determine the proportion of donor versus recipient each contained within the total DNA. The STR markers were co-amplified in a single reaction by using commercial $PowerPlex^{(R)}$ 16 system and $AmpFISTR^{(R)}$ $Identifiler^{(R)}$ / $Yfiler^{(R)}$ PCR amplification kits. Separation of the PCR products and fluorescence detection were performed by ABI $PRIS^{(R)}$ 3100 Genetic Analyzer with capillary electrophoresis. The $GeneMapper^{TM}$ ID software were used for size calling and analysis of STR profiles. Extracted DNA was quantified by the $Quantifiler^{TM}$ Human DNA / Y Human Male DNA Quantification Kit The intent of this study was to analyze the ratio of donor versus recipient cells in the post-transplant peripheral blood, spleen, lung and kidney specimens. Specimens were taken from the traffic accident male victim who had been engrafted from bone marrow female donor. Blood and spleen specimens displayed female donor DNA profile. Kidney specimen showed male recipient DNA profile. Interestingly, lung tissue showed mixed profiles. The findings of this study indicate that the forensic STR analysis using fluorescence labeling PCR combined with capillary electrophoresis is quick and reliable enough to assess the ratio of donor versus recipient cells and to monitor the mixed chimeric patterns.

• 한국화재소방학회논문지
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• 제18권4호
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• pp.78-85
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• 2004

본 연구에서 Clean Room 재해사례를 분석하였고, Factory Mutual Property Loss Prevention Data Sheets(FM), Industrial Risk Insurers(IRI), NFPA Code 등의 Clean Room 설계 주요 방화기준에 대하여 비교 분석을 하였다. 그리고 화재시뮬레이션을 통한 위험성 평가를 통해서 화재 시 공조설비의 작동으로 인한 연기산란 현상으로 Clean Room 내의 피해규모가 상상을 초월하는 결과를 얻을 수 있었으며, 또한 스프링클러설비의 작동으로 열온도가 더 낮아지고, 연기의 확산속도를 더 줄여줄 수 있는 것으로 분석되었다. 따라서, Clean Room내의 화재 시 화재감지기에 의해 공조설비를 정지시키고, 스프링클러설비를 설치하는 것이 안전성을 확보하는데 중요한 요소임을 유추하였다. 그러므로 본 연구에서 Clean Room 에 대한 안전성을 확보하는데 기여하고자 한다.

• 분석과학
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• 제30권2호
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• pp.82-88
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• 2017

Adenophorae Radix (AR) is a frequently used medicinal herb; because of its popularity, products containing similar herbal products are often sold as substitutes, especially if their morphology is similar. However, any analytical method to identify AR based on quantitative analysis is not registered in Korea, Japan and China Pharmacopoeias. This study developed a simple HPLC method to discriminate between authentic AR and substitutes. Linoleic acid was used as a marker compound of AR. Our optimized HPLC-UV conditions included a mobile phase of 90 % acetonitrile under isocratic condition, and a flow rate of 1.0 mL/min at room temperature. Detection wavelength was set at 205 nm. Linoleic acid was detected at 13.5 minutes for a total analysis time of 20 minutes. The standard herb of AR contained 0.025 % of linoleic acid, while four authentic AR samples and eight substitutes contained 0.040~0.071 % and 0.004~0.014 %, respectively. Comparison of the linoleic acid concentrations of the sample types to reference AR showed that among 12 samples, only the four samples were authentic. Thus, our HPLC-UV method, along with our suggested content criterion for linoleic acid concentration, can be used for the quick and accurate determination whether the herbal products are authentic AR or substitute.

• 전기학회논문지
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• 제60권5호
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• pp.1049-1054
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• 2011

Color is discerned due to the reflectance of object and its hue is determined by the Ratio of RGB spectrum. The aim of this study is to evaluate the Color information using by the optical system in terms of convenience and simplicity. Firstly, the differential Ratio of RGB is evaluated by photodiode Sensor which achieves a high efficiency with quick tranducer output. To extract the information of RGB Ratio, light emitting diode is built in Color sensing system with photodiode. Our proposed method is very economical, simple, and convenient. Our results can be applied to confirm the accurate information of Color in the research environments and commercial purposes. Thus RGB information can be determined subjectively and thus, the inherent characteristic of Color will be revealed precisely and its related features can be resolved in a real time mode.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.1-12
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• 2003

Instead of sensory evaluation, we designed an evaluation method of the setting function of hairstyling products, based on an original theory focusing on changes in bending stress observed when a load with continuous bending is applied to human hair. Specifically, we developed a device to measure bending stress to quickly and objectively evaluate the condition of human hair, particularly its dynamic properties such as the setting function, following the application of hairstyling products. This device generates a load with continuous bending while applying a pendulum motion to a hair tress, one end of which is anchored. The setting function and holding power of resins of various molecular weight and ionic properties were evaluated using this device. The results demonstrated a close correlation with those obtained by experts' sensory evaluation. The evaluation results of bending stress and holding rate confirmed that the combined use of two different resins could improve the function of setting preparations. Evaluation using this device was able to substitute for sensory evaluation, and offers quick objective evaluation and detection of changes in the holding power of hairstyling products over time. We conclude that evaluation using this device is a promising new method.